Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8263806 | Method for producing sulfonamides The invention relates to methods for producing sulfonamides of formula I, wherein the variables have the designations cited in the description, by reacting m-nitro-benzoic acid chlorides of formula II with aminosulfons of formula III, under the influence of B equiva... | 09/11/2012 |
| 8188312 | Acyclic sulfamide derivatives The present invention is related to acyclic sulfamide derivatives, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treat... | 05/29/2012 |
| 7842836 | N-aryl-N'alkyl sulfamides as MEK inhibitors This invention concerns N-(ortho phenylaminoaryl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases. ... | 11/30/2010 |
| 7291620 | N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also direct... | 11/06/2007 |
| 7199158 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,... | 04/03/2007 |
| 7192606 | Drugs for treating viral infections A series of imidodisulfamide derivatives encapsulated in liposomes have been prepared and are useful to treat antiviral infections, especially infections caused by orthopox viruses. ... | 03/20/2007 |
| 7135487 | Sulphonamide derivatives The present invention relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them. ... | 11/14/2006 |
| 7037941 | Alpha-and Beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors: ... | 05/02/2006 |
| 6951886 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors and in particular as inhibitors o... | 10/04/2005 |
| 6949567 | Compounds for the treatment of protozoal diseases The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to pro... | 09/27/2005 |
| 6939867 | β3 agonists and uses thereof Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity, diabetes, hypertension, gastrointestinal hypo- or hyper-motility and ... | 09/06/2005 |
| 6908947 | Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them The present invention relates to compounds of formula I, in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in ... | 06/21/2005 |
| 6906094 | 1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase The present invention provides compounds of formula (I) wherein R, Z, Y, W, R5, V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the treatment of diseases responsive to the inhibition of the e... | 06/14/2005 |
| 6900353 | Cyclopentyl sulfonamide derivatives The present invention provides compounds of formula (I): useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ... | 05/31/2005 |
| 6852738 | Acyl sulfamides for treatment of obesity, diabetes and lipid disorders A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin dependent diabetes mellitus (... | 02/08/2005 |
| 6683201 | Analine derivatives as OSC inhibitors The present invention relates to compounds of formula (I) ##STR1## wherein U, Y, V, W, L, X, A1, A2, A3, A4, A5 and A6 are as defined in the description and claims and pharmaceutically acce... | 01/27/2004 |
| 6653347 | IL-8 receptor antagonists This invention relates to the novel use of diphenyl sulfamido in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 11/25/2003 |
| 6639107 | Cyclopentyl sulfonamide derivatives The present invention provides certain cyclopentyl sulfonamide derivatives of formula (I): useful for potentiating glutamate receptor function in a mammal. It also relates to novel cyclopentyl sulfonamide derivatives, to processes for their preparation an... | 10/28/2003 |
| 6596771 | Drugs for treating viral infections A series of imidodisulfamide derivatives have been prepared and are useful to treat antiviral infections, especially infections caused by orthopox viruses.... | 07/22/2003 |
| 6545053 | Tricyclic compounds and drug compositions containing same Compounds having a ଲ-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts thereof, and a process for producing these, and thei... | 04/08/2003 |
| 6538159 | -sulfin-and -sulfonamino acid amides The invention relates to -sulfin- and -sulfonamino acid amides of the general formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1 -C12... | 03/25/2003 |
| 6515024 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/04/2003 |
| 6498253 | Acylated aminophenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators Compounds of the formula (I) and salts thereof ##STR1## in which W1, W2, R, n, R1, R2, R4, X, Y and Z are as defined in claim 1 and R3 is an acyl radical, are suitable as herbicides and pla... | 12/24/2002 |
| 6482859 | Microbicidal N-sulfonylglycin alkynyloxyphenethyl amide derivatives The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsu... | 11/19/2002 |
| 6469005 | Propargylether derivatives Propargylether derivatives of formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen... | 10/22/2002 |
| 6433187 | Certain polycyclic compounds useful as tubulin-binding agents Derivatives of known tubulin-binding compounds are provided in which a (poly)fluorobenzene, a fluoropyridine, or a fluoronitrobenzene moiety is incorporated or added to the structure. These derivatives can be used as antimitotic agents and can be consider... | 08/13/2002 |
| 6433016 | Drugs for treating viral infections A series of substituted sulfonamide derivatives have been prepared and may be used to treat antiviral infections, especially infections caused by orthopoxviruses.... | 08/13/2002 |
| 6369073 | Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase Compounds of formula (I) ##STR1## wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medi... | 04/09/2002 |
| 6277849 | N-sulphonyl and N-sulphinyl amino acid amides as microbiocides The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsubs... | 08/21/2001 |
| 6194611 | N-sulphonyl and N-sulphinyl amino acid derivatives as microbicides -Amino acid amides of formula (I) wherein the substituents are defined as follows: n is the number zero or one; R1 to R7 are as herein defined; R8 is C1 -C6 alkyl, C3 -C6 ... | 02/27/2001 |
| 6194463 | N-sulphonyl and N-sulphinyl amino acid amides as microbicides -Amino acid amides of formula (I) wherein the substituents are defined as follows: n is a number zero or one; R1 to R7 are as defined herein; R8 is C1 -C6 alkyl, C3 -C6 al... | 02/27/2001 |
| 6169206 | 4-(n,n-dialkylamino)aniline compound, photographic processing composition containing the same and color image-forming method 4-(N,N-Dialkylamino)aniline compounds of the following general formula (I): ##STR1## wherein R1 represents an alkyl group, an aryl group or a heterocyclic group, R2 to R5 each represent a hydrogen atom or a substituent, an... | 01/02/2001 |
| 5852007 | Cysteine and serine protease inhibitors containing D-amino acid at the P2 position, methods of making same, and methods of using same The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 12/22/1998 |
| 5756498 | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. In accordance with the present invention, compounds of Formula (I) are disclosed ... | 05/26/1998 |
| 5728875 | Microbicides -Amino acid amides of the formula I ##STR1## in which n is the number zero or one; R1 is C1 -C12 alkyl, which is unsubstituted or can be substituted by C1 -C4 alkoxy, C1 -C4 | 03/17/1998 |
| 5691366 | Nitro compounds, process for preparation thereof and use thereof A new nitro compound of the formula: ##STR1## wherein R1 and R2 are each lower alkyl or lower alkoxy(lower)-alkyl, or ##STR2## is cyclized to form ##STR3## X is --O--, --S-- or --NH--, m is an integer 0 or 1, and... | 11/25/1997 |
| 5602119 | Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfamic acid derivative compounds which are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/11/1997 |
| 5585519 | Microbicides -Amino acid amides of the formula I ##STR1## in which n is the number zero or one; R1 is C1 -C12 alkyl, which is unsubstituted or can be substituted by C1 -C4 alkoxy, C1 -C4 | 12/17/1996 |
| 5530128 | N-sulphonylamino derivatives of dipetide compounds as metalloproteinase inhibitors Compounds of formula (1) are described wherein R represents a --CONHOH, carboxyl, carboxyl ester, or --P(O)(X1 R8)X2 R9, where X1 and X2 are the same or different and each is oxygen or sulp... | 06/25/1996 |
| 5449812 | Intermediates for the preparation of phenylsulfonylurea herbicides and plant growth regulators The compounds of the formula (I) ##STR1## in which R1 -R4, W, X, Y and Z are as defined in claim 1 are suitable for controlling harmful plants in crops. Their preparation may employ the intermediates of the formulae II and III: ... | 09/12/1995 |
