The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to ...
|7115664||Peptidomimetic ligands for cellular receptors and ion channels|
One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands—agonists or antagonists—for various cellular receptors, e.g., G-protein-co...
|7105567||3-substituted urea derivatives and medicinal use thereof|
The present invention relates to a urea derivative of the formula (1) wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compo...
The present invention provides N-aryloxypropanolyl-N′-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of obesity wherein R is select...
Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy...
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-c...
Described herein are novel 1-aryl-3-(2-chloroalkanylureas derivatives. These derivatives are useful anticaner agents having excellent specifilty towards cell targets and potent antineoplastic activity without systemic toxicity derivatives mutagenicity. Mo...
|6372933||Process for preparing certain phenyl urea compounds|
This invention relates to a process for making certain phenyl urea compounds by using a Lewis acid to effect the ring opening of a benzoxazolinone by an amine....
|6362229||Inhibitors of multidrug transporters|
The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or...
The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The compounds and compo...
The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,...
|6127423||Phenylamidine derivatives, a process for preparing the same and their use as medicaments|
The invention relates to new phenylamidine derivatives, processes for preparing them and their use as pharmaceutical compositions. The phenylamidines according to the invention correspond to the general formula I ##STR1##...
|6043284||Anti-atherosclerotic diaryl compounds|
The present invention is concerned with diaryl compounds of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of a clinical condition for which an ACAT inhibitor is indicated, such as hyperlipidaema or atherosclero...
|5952386||Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production|
The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen...
|5824705||Carbamates and crop protection agents containing them|
Carbamates of the formula I ##STR1## where the substituents have the following meanings: Z is methoxy, NH2, NHCH3, N(CH3)2, CH3, C2 H5, CF3 or CCl3, X ...
A compound of the formula (I): ##STR1## wherein R1 is a hydrogen atom or lower alkyl; R2 is a lower alkoxy, lower alkylamino, lower cycloalkyl, optionally substituted phenyl or optionally substituted heterocyclic group; R3
|5728874||Anti-HIV achiral polyurea oligomers, a process for creating them, formulations using them, and their use in the treatment of AIDS|
The present invention relates to achiral polyurea oligomers, their uses and formulations as anti-HIV pharmaceuticals and to a process for the preparation of narrow mono- and polydispersed oligomers as an emodiment of the invention. The achiral oligomers a...
|5621010||Urea derivatives and their use as ACAT inhibitors|
Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of ...
|5530026||Certain aryl-ureido anti-cancer agents|
The present invention is concerned with novel anticancer agents having potent antineoplastic activity without systemic toxicity and mutagenicity. The novel anticancer agents of the present invention are derivatives of formula I: ##STR1## wherein...
|5481035||Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates and substituted isocyanates|
Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates or substituted isocyanates by reaction of an adduct of isocyanic acid and a tertiary amine with a primary and secondary amine, an alcohol, a thiol or a compound ha...
|5463059||Process for the preparation of intermediates useful in the preparation of pyranyl cyanoguanidine derivatives|
A process for preparing compounds of the formula ##STR1## where a, b, c, R1, R2, and R3 are as defined herein including the step of alkylating a phenol of formula ##STR2## with an acetylene of formula ##STR3...
|5423905||Moth- and beetle-proofing formulation|
The invention relates to a formulation for protecting keratinous material from attack by pests that feed on keratin, comprising (A) at least one diphenylurea of formula ##STR1## wherein R1 is hydrogen or 4-chlorophenoxy-6-sulfonate, R
|5420348||Urea derivatives and salts thereof|
Urea derivatives of the general formula (I) ##STR1## and salts thereof, pharmaceutical compositions containing the same, and methods for producing the same are-disclosed. The urea derivatives of the general formula (I) and salts thereof are novel com...
|5407959||(Trans-1,4-dialkoxycyclohexyl) substituted arylalkylaryl-arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase|
Compounds of structure ##STR1## where W is selected from the group consisting of ##STR2## where Q is oxygen or sulfur, R7 and R8 are independently selected from hydrogen and alkyl, or R7 and R8, togeth...
|5384425||Diurea derivatives useful as medicaments and processes for the preparation thereof|
Diurea derivatives are provided which can be represented by the following general formula and salts thereof: ##STR1## wherein, R1 and R2 are the same or different, and each represents C1 -10 alkyl group, a C3
|5380941||Preparation of aromatic ureas which contain a thioether or sulfonyl group|
A process for preparing ureas of the formula ##STR1## where the ring A can be substituted and benzo-fused and n is 0 or 2, R4 and R5 are hydrogen, C1 -C4 -alkyl or phenyl, L is unsubstituted or substituted C2
|5302724||Antitumor compositions and methods of treatment|
This invention provides certain sulfonamide compounds, formulations and method of use of certain sulfonamide compounds in treating susceptible neoplasms....
|5283362||Process for the preparation of pure N,N'-asymmetrically substituted phenylureas|
Process for the preparation of very pure ureas of the formula phenyl--(NH--CO--NR1 R2)n in which phenyl represents an unsubstituted or substituted phenyl or phenylene group and R1 and R2 are either id...
|5276182||Process for preparing polyurea oligomers|
The preferred oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a number average molecular weight of
|5264441||Disubstituted ureas and thioureas derivatives|
The invention provides new ureas and thioureas derivatives of general formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are useful as therapeutic agents such as for the prevention of coronary heart disease and as antidysl...
|5258405||Urea derivatives and salts thereof in method for inhibiting the ACAT enzyme|
Urea derivatives of the general formula (I) ##STR1## and salts thereof, pharmaceutical compositions containing the same, and methods for producing the same are disclosed. The urea derivatives of the general formula (I) and salts thereof are novel com...
|5231216||Trans-2-acylaminocyclohexyloxyacyldipeptides in the form of mixtures of diastereoisomers thereof and in the form of pure diasteredisomers, process for the preparation thereof and pharmaceutical compositions containing the same|
There are described novel trans-2-acylaminocyclohexyloxyacyldipeptides of formula I ##STR1## wherein R1 represents --CO--R6, --SO2 --R7 or ##STR2## R6 is C1 -C18 alkyl ...
|5227492||Diurea derivatives useful as medicaments and processes for the preparation thereof|
Diurea derivatives are provided which can be represented by the following general formula and salts thereof: ##STR1## Illustrative derivatives include 1,3-bis[[1-cycloheptyl-3-(3-pyridyl)ureido]-methyl]benzene, 1,3-bis[[1-cycloheptyl-3-(2-pyridy...
|5225436||Aryl substituted naphthalene derivatives|
Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflammation....
|5223529||N-phenylamides and medicinal products containing them|
Compounds of formula: ##STR1## in which R1 is (a) a phenyl radical or a substituted phenyl radical, (b) a chain --CH(R8)--COOR4, (c) a chain --CH2 --CO--NR5 R6 or (d) a phenylalkyl rad...
|5198582||Process for preparing symmetric N,N'-disubstituted aromatic urea|
A process for preparing N,N'-disubstituted urea derivatives of the following formula (I) ##STR1## wherein Ar represents an unsubstituted aromatic radical or an aromatic radical substituted with a halogen atom, an alkyl group, or an alkoxy group,...
|5166429||Diurea derivatives useful as medicaments and processes for the preparation thereof|
Diurea Derivatives represented by the following general formula and salts thereof: ##STR1## The above compounds inhibit acyl-coenzyme A chloresterol acyl-transferase (ACAT enzyme), and thereby control the accumulation of cholesterol ester to the...
Novel 1-phenylakyl-3-phenylurea derivatives represented by the following formula (I): ##STR1## wherein R1 is an alkyl group of 1 to 8 carbon atoms, an alkoxy group of 1 to 5 carbon atoms or a halogen atom, R2 is an alkyl group o...
This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds contain two urea or thiourea, amide, or amine moieties or combinations of said moieties and have the following ge...
|5099021||Process for the preparation of pure, unsymmetrically disubstituted ureas|
Process for the preparation of pure, unsymmetrically disubstituted ureas of the general formula ##STR1## in which R denotes a phenyl radical which is unsubstituted, or monosubstituted or polysubstituted by halogen atoms or alkyl, alkoxy, aryloxy...