"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 7947854 | Bis-cationic compounds and use thereof The present invention relates to bis-cationic compounds comprising quaternary ammonium groups and/or quaternary phosphonium groups. The invention also relates to the use of bis-cationic compounds as Phospholipase B inhibitors and the use of bis cationic compounds fo... | 05/24/2011 |
| 7919656 | Linear amine functionalized poly(trimethylene ether) compositions The present invention relates to linear amine-functionalized poly(trimethylene ether) compositions, and processes to produce these compositions. ... | 04/05/2011 |
| RE41316 | Crosslinked amine polymers The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical com... | 05/04/2010 |
| 7589238 | Treatment of hyperphosphatemia using crosslinked small molecule amine polymers Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting... | 09/15/2009 |
| 7449605 | Crosslinked amine polymers The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical com... | 11/11/2008 |
| 7393978 | Method for producing ethylene-amines Process for the preparation of ethylenamines, in particular diethylenetriamine (DETA), by continuous reaction of ethylenediamine (EDA) in the presence of a heterogeneous catalyst, where the reaction is carried out in a reaction column. ... | 07/01/2008 |
| 7388113 | Volatile copper(II) complexes for deposition of copper films by atomic layer deposition The present invention relates to a process for the synthesis of novel 1,3-diimine copper complexes using amino-imines and novel amino-imines. ... | 06/17/2008 |
| 7388112 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from 0 to 12, X equals NH or CH... | 06/17/2008 |
| 7335795 | Crosslinked amine polymers The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical com... | 02/26/2008 |
| 7323594 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/29/2008 |
| 7226501 | Process for the manufacture of a bitumen-aggregate mix suitable for road pavement The present invention relates to an aqueous quick-setting bitumen-aggregate mix suitable for cold pavement of roads, parking places, sidewalks and the like. The bitumen-aggregate mix is manufactured by mixing a mineral aggregate, water, a de-emulsifier, containing h... | 06/05/2007 |
| 7166745 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/23/2007 |
| 7148024 | Busulfan immunoassay Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological flu... | 12/12/2006 |
| 7132556 | Alkaline earth metal complexes and their use Chelate complexes of calcium, strontium and barium formed with ligands that are beta-ketiminate compounds having a scorpion tail; intermediate compounds useful in producing the aforementioned complexes; a method for producing such complexes, and the use of such comp... | 11/07/2006 |
| 7094808 | Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment Polyamines having the formula: or a salt thereof with a pharmaceutically acceptable acid wherein: R1-R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having ... | 08/22/2006 |
| 7091285 | Adducts of mid-range vinylidene content polyisobutylene polymer products and methods for making the same A reaction product comprising an adduct of a mid-range vinylidene content PIB polymer composition and maleic anhydride, a phenolic compound or a compound having a reactive site for subsequent amination. The PIB composition comprises a relatively low molecular weight... | 08/15/2006 |
| 7045550 | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy Polyamine effectors are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more polyamine effectors formulated fo... | 05/16/2006 |
| 7022214 | Carrier ampholytes of high pH range Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH values. These substances are useful as carrier ampholytes in isoelectric ... | 04/04/2006 |
| 7002042 | Cationic liposomes for gene transfer The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells. ... | 02/21/2006 |
| 6972075 | Method for removing 6-aminocapronitrile from mixtures that contain 6-aminocapronitrile, adipodinitrile and hexamethylenediamine The invention relates to a method for removing, by distillation, 6-aminocapronitrile from mixtures that contain 6-aminocapronitrile, adipodinitrile and hexamethylenediamine, by a) removing the hexamethylenediamine from the mixture while obtaining a mixture (I) that ... | 12/06/2005 |
| 6951962 | Oil/grease- and water-sizing agent for treatment of cellulosics A water-dispersible oil/grease-sizing and water-sizing agent that provides oil/grease and water-sizing for paper and other cellulosic materials. The agent works effectively for both oil/grease and water sizing at high temperatures. The polymeric agent's key features... | 10/04/2005 |
| 6924315 | Gemini glycidyl ether adducts of polyhydroxyalkyl alkylenediamines The present invention provides compounds useful as surfactants having formula (1), including isomers thereof: wherein a and b are integers independently selected from about 3 to about 6; x is an integer from about 1 to... | 08/02/2005 |
| 6919483 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNFα and other involved cytokines. As pharmaceuticals, thes... | 07/19/2005 |
| 6762325 | Method for production of alkoxylated compound When the reaction solution formed during the addition of an alkylene oxide to an active hydrogen-containing compound has viscosity of not less than 10 mPa·s, this invention provides a method for stirring the reaction solution by the rotation of a vane or vanes cont... | 07/13/2004 |
| 6716882 | Highly packed polycationic ammonium, sulfonium and phosphonium lipids The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transfor... | 04/06/2004 |
| 6713653 | Polyamines and polymers made therewith A polyamine having the formula: H2N—A[NR—B]aNH2 or salt thereof, wherein A and B, which may be the same or different, are selected from aliphatic or aromatic substituents provided that at least fou... | 03/30/2004 |
| 6667382 | Polyamine The present invention provides an amine or polyamine, which has a surface activity not inferior to a solid tallow-based amine and an excellent workability. A salt of the amine is suited for emulsifying asphalt and the like, and also provides an asphalt em... | 12/23/2003 |
| 6605645 | Linear polyamine compounds and polyamine-based anti-tumor agents Nobel polyamine compounds and polyamine compounds having carcinostatic action are provided. There are also provided anticancer agents containing as active ingredient at least one of polyamine compounds represented by the following Formula (I) or (III) and... | 08/12/2003 |
| 6590106 | Amino acid derivatives and methods of making the same Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: ##STR1## R1, R2, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic ... | 07/08/2003 |
| 6555959 | Material for light emitting device, light emitting device using thereof, and amine compound A material for a light emitting device which is a compound represented by the following formula (I): ##STR1## wherein Ar1 and Ar6, which are the same or different, each represents a divalent aryl group or a divalent heterocyclic grou... | 04/29/2003 |
| 6492560 | Discrete-length polyethylene glycols The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.... | 12/10/2002 |
| 6492561 | Alkaline earth metal alkylene diamides, method for their production, and their use Alkaline earth metal alkylene diamides of Ba, Sr, Ca and a method for their production.... | 12/10/2002 |
| 6462220 | Method for simultaneous preparation of 6-aminocapronitrile and hexamethylene diamine A process for the coproduction of 6-aminocapronitrile and hexamethylenediamine starting from adiponitrile by a) hydrogenating adiponitrile in the presence of a catalyst comprising an element of the eighth transition group as catalytically active component, ... | 10/08/2002 |
| 6458837 | Lipophilic diesters of chelating agents The invention discloses stable diesters of chelating agents of divalent metal ions, processes for their preparation and pharmaceutical compositions thereof. Most preferred compounds according to the present invention are stable lipophilic diesters compris... | 10/01/2002 |
| 6444633 | Granular laundry detergent compositions comprising zwitterionic polyamines The present invention relates to laundry detergent compositions which provide enhance hydrophilic soil cleaning benefits, said compositions comprising: a) from about 0.01% by weight, of a zwitterionic hexamethylene diamine; b) from about 0.01% by weight, of a ... | 09/03/2002 |
| 6441240 | Method for inhibiting the deposition of white pitch in paper production Ethyleneamine compound(s), or mixtures thereof, are used in effective amounts to reduce or inhibit the deposition of white pitch on the paper making equipment during the processing to recycle coated paper.... | 08/27/2002 |
| 6399663 | Highly packed polycationic ammonium, sulfonium and phosphonium lipids The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-depende... | 06/04/2002 |
| 6395713 | Compositions for the delivery of negatively charged molecules This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.... | 05/28/2002 |
| 6369268 | Diester amine adducts Described are diester amine adducts of formula (1) wherein R1, R2, R3, R4 are each independently of one another C4 -C22 alkyl; C2 -C22 alkenyl; or C5 -C7 | 04/09/2002 |
| 6342534 | Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment Polyamines having the formula: ##STR1## or a salt thereof with a pharmaceutically acceptable acid wherein: R1 -R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at... | 01/29/2002 |