Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8071810 | C5a receptor antagonists The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21 and R22 are individually and independently selected f... | 12/06/2011 |
| 7285568 | Biaromatic compounds which activate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the field... | 10/23/2007 |
| 7230133 | Malonamides and malonamide derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid a... | 06/12/2007 |
| 7176222 | Syntheses of ureas The present invention provides intermediates, synthetic methods and novel urea compositions of matter. ... | 02/13/2007 |
| 7161034 | Lidocaine analogs and methods of making and using same Lidocaine analogs, latex particle-analog conjugates, and methods of making and using the same. The analogs have the formula: wherein Z comprises a nucleophilic group and optiona... | 01/09/2007 |
| 7157601 | Alkylated urea and triaminotriazine compounds and phase change inks containing same Compounds of the formulae wherein Z is —OR1, —SR1, —NR1R2, Y is —OR3, —SR3, or —NR3R4, at least one of R1 | 01/02/2007 |
| 7126010 | Benzylcycloalkyl amines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic disease... | 10/24/2006 |
| 7105567 | 3-substituted urea derivatives and medicinal use thereof The present invention relates to a urea derivative of the formula (1) wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compo... | 09/12/2006 |
| 7087752 | Alkylated urea and triaminotriazine compounds and phase change inks containing same Compounds of the formulae wherein Z is OR1, SR1, or NR1R2, Y is OR3, SR3, or NR3R4, at ... | 08/08/2006 |
| 7064229 | Succinic acid derivatives The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases ... | 06/20/2006 |
| 7034056 | Aryl and biaryl compounds having MCH modulatory activity In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations compr... | 04/25/2006 |
| 7030261 | Method for preparing 2-hydroxy-6-ureidocarbonyl naphthalene derivative Disclosed is a method for preparing a 2-hydroxy-6-ureidocarbonyl naphthalene derivative. The method comprises the step of reacting 2-hydroxy-6-aminocarbonyl naphthalene and a isocyanate in an organic solvent at a temperature of 90–200° C. According to the present... | 04/18/2006 |
| 7026357 | Diphenylurea compounds Compound of formula (I): and medicinal products containing the same are useful as dual α2/5-HT2c antagonist receptors. ... | 04/11/2006 |
| 6995285 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 02/07/2006 |
| 6962945 | N-aryloxypropanolyl-N′-phenethyl-urea The present invention provides N-aryloxypropanolyl-N′-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of obesity wherein R is select... | 11/08/2005 |
| 6949567 | Compounds for the treatment of protozoal diseases The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to pro... | 09/27/2005 |
| 6927271 | Hydroxyl and carbamate functional resins Coating compositions contain hydroxyl- or carbamate functional resins with a relatively low equivalent weight. The resins are based on a polyol core containing urea and hydroxyl groups, and made by reacting a polyisocyanate, preferably a triisocyanate, with an amino... | 08/09/2005 |
| 6911457 | Diabetes imaging probes The present invention relates to novel imaging probes and methods for using the probes in diagnostic imaging processes and other imaging processes to determine physiological functions. ... | 06/28/2005 |
| 6864380 | Benzylcycloalkyl amines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases. | 03/08/2005 |
| 6860928 | Alkylated urea and triaminotriazine compounds and phase change inks containing same Disclosed are compounds of the formulae wherein Z is a group of the formula —OR1, a group of the formula —SR1, or a group of the formula —NR1R... | 03/01/2005 |
| 6777561 | Compounds Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy... | 08/17/2004 |
| 6765009 | 1,4-Disubstituted benzo-fused compounds Disclosed are novel 1,4-disubstituted benzo-fused compounds wherein G, X, L, Q, n and Y are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory dis... | 07/20/2004 |
| 6750253 | Aminobenzophenones as inhibitors of il-1β and tnf-α The present invention relates to compounds of the formula wherein R1 independently represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifl... | 06/15/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6632840 | Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them Monoacyl-substituted guanidines of formula III, or a salt or acid thereof, and their use as medicine or diagnostic aid: ##STR1## in which X(2) is ##STR2##... | 10/14/2003 |
| 6630589 | Identification of compounds for the treatment or prevention of proliferative diseases The invention features screening assays for compounds that are potentially useful for treating or preventing a proliferative disease. The assays are based on contacting a candidate compound with a cell containing a nucleic acid including a HER2 regulatory... | 10/07/2003 |
| 6608227 | Benzylcycloalkyl amines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases.... | 08/19/2003 |
| 6602302 | Substituted 1,4 diaminobenzene compounds and oxidation dye precursor compositions containing same New substituted 2,5-diamino-1-aminomethylbenzene compounds of formula (I), or physiologically compatible water-soluble salts thereof, ##STR1## are described as well as methods for preparing them. In addition, oxidation dye precursor compositions for dyein... | 08/05/2003 |
| 6566554 | Aminobenzophenones as inhibitors of IL-1ଲ and TNF- The present invention relates to a compound of general formula (I) wherein R1, R2, and R3 represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluorome... | 05/20/2003 |
| 6525091 | Substituted diarylureas as stimulators for Fas-mediated apoptosis Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers, their pharmaceutically acceptable salts, and pharmaceutical co... | 02/25/2003 |
| 6482804 | Compositions and methods for delivery of genetic material A soluble ionic complex is formed by an aqueous mixture of a benzylammonium group-containing surfactant and a polynucleic acid sequence. When the mixture forms a vesicular complex, the sequence is packaged therein. This composition is useful in pharmaceut... | 11/19/2002 |
| 6458998 | Naphthalene ureas as glucose uptake enhancers Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating t... | 10/01/2002 |
| 6444691 | 1,3-disubstituted ureas as ACAT inhibitors, and method of preparing thereof The invention relates to 1,3-disubstituted ureas of general formula (I) where R1 is an aryl, R2 is nitro and/or amino, and X is oxygen and/or sulfur, and the method of preparing thereof which consists in treating aromatic amines with... | 09/03/2002 |
| 6436999 | Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them Diacyl-substituted guanidines of the formula I ##STR1## are described where X(1) and X(2) are ##STR2## as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis... | 08/20/2002 |
| 6372933 | Process for preparing certain phenyl urea compounds This invention relates to a process for making certain phenyl urea compounds by using a Lewis acid to effect the ring opening of a benzoxazolinone by an amine.... | 04/16/2002 |
| 6359061 | Amide compound libraries Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds. ... | 03/19/2002 |
| 6316478 | IL-8 receptor antagonists This invention relates to novel spiro compound derivatives of benzoisothiazolyl-urea and -thiourea and compositions thereof. These compounds are useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 11/13/2001 |
| 6218389 | Acyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of... | 04/17/2001 |
| 6214880 | Arylsulfonanilide ureas The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,... | 04/10/2001 |
| 6180676 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 01/30/2001 |
