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| Number | Title | Issue Date |
| 8173841 | Tetrahydro-naphthalene derivatives This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and usef... | 05/08/2012 |
| 7645903 | Use of urea variants as affinity ligands The present invention relates to an IgG-binding compound, which more specifically has affinity for human IgGs of κ-type and functional derivatives thereof. More specifically, the compound according to the invention comprises an N,N-alkylated urea moiety located bet... | 01/12/2010 |
| 7504538 | Amide or thioamide derivatives and their use in the treatment of pain The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of pain and disorders related thereto as well as a method for treatment of pain and disorders r... | 03/17/2009 |
| 7339020 | High-functionality polyisocyanates High-functionality polyisocyanates are prepared by a process which comprises (i) preparation of an addition product (A) which contains one group which is reactive toward isocyanate and at least two isocyanate groups by reacting | 03/04/2008 |
| 7304076 | Neuropeptide Y Y5 receptor antagonists The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well... | 12/04/2007 |
| 7291744 | N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity The present application describes modulators of chemokine receptors of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 11/06/2007 |
| 7271288 | Aromatic compounds Disclosed is an aromatic compound expressed by the general formula (I), wherein A represents of a fused aromatic hydrocarbon moiety such as triphenylene, X represents a hydrogen-bonding site such as an atomic group containing an amide linkage, Y represents a chain f... | 09/18/2007 |
| 7262220 | Urea- and urethane-substituted acylureas, process for their preparation and their use The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I | 08/28/2007 |
| 7230133 | Malonamides and malonamide derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid a... | 06/12/2007 |
| 7208528 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 04/24/2007 |
| 7160923 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 01/09/2007 |
| 7157601 | Alkylated urea and triaminotriazine compounds and phase change inks containing same Compounds of the formulae wherein Z is —OR1, —SR1, —NR1R2, Y is —OR3, —SR3, or —NR3R4, at least one of R1 | 01/02/2007 |
| 7105567 | 3-substituted urea derivatives and medicinal use thereof The present invention relates to a urea derivative of the formula (1) wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compo... | 09/12/2006 |
| 7049460 | Selective inhibitors of the urokinase plasminogen activator The present invention relates to novel selective inhibitors of the urokinase plasminogene activator (uPA, EC 3.4.21.31) of the aryl guanidine type. ... | 05/23/2006 |
| 6984647 | Aminotetralin-derived urea modulators of vanilloid VR1 receptor This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain ... | 01/10/2006 |
| 6924321 | Polyols with autocatalytic characteristics and polyurethane products made therefrom The present invention discloses a process for producing a polyurethane product with autocatalytic polyols. These autocatalytic polyols are based on an initiator that contains a tertiary amine. These autocatalytic polyols are reacted with a polyisocyanate in the pres... | 08/02/2005 |
| 6864380 | Benzylcycloalkyl amines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases. | 03/08/2005 |
| 6852738 | Acyl sulfamides for treatment of obesity, diabetes and lipid disorders A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin dependent diabetes mellitus (... | 02/08/2005 |
| 6838472 | Substituted urea retinoid agonists The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for de... | 01/04/2005 |
| 6815556 | Compounds having fungicidal activity and processes to make and use same A compound according to formula one that is useful as a fungicide is provided. Additionally, processes to make and use same are provided. ... | 11/09/2004 |
| 6777561 | Compounds Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy... | 08/17/2004 |
| 6765021 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of formula I having the structure wherein: B, D, C, and R1 as defined herein. ... | 07/20/2004 |
| 6750253 | Aminobenzophenones as inhibitors of il-1β and tnf-α The present invention relates to compounds of the formula wherein R1 independently represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifl... | 06/15/2004 |
| 6696487 | Fungicidal phenyl(thio)urea and phenyl(thio)carbamate derivatives The invention relates to compounds of formula (I), and also to salts thereof, which have fungicidal activities: ##STR1## in which the various radicals and substituents are as defined in the description, and also to the fungicidal compositions containing t... | 02/24/2004 |
| 6686394 | Aryl-chloro-ethyl ureas Described herein are novel 1-aryl-3-(2-chloroalkanylureas derivatives. These derivatives are useful anticaner agents having excellent specifilty towards cell targets and potent antineoplastic activity without systemic toxicity derivatives mutagenicity. Mo... | 02/03/2004 |
| 6673966 | Coupler for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): ##STR1## wherein X is selected from halogen and R5 SO4 ; R, R1, R2 and R5 are each individually s... | 01/06/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6635764 | Therapeutic ureas This invention relates to urea compounds that are muscarinic receptor antagonists and agonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds.... | 10/21/2003 |
| 6608227 | Benzylcycloalkyl amines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases.... | 08/19/2003 |
| 6548539 | Agents for regulation of colon cancer gene expression Compounds of the general structure according to Formula (I) ##STR1## wherein R1 is selected from alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl; R2 is s... | 04/15/2003 |
| 6545152 | R-isomers of nonnucleoside inhibitors Novel chiral derivitaves of non-nucleoside inhibitors (NNI), particularly R-isomers of halopyridyl and thiazoyl thiourea compounds are provided as potent inhibitors of reverse transcriptase (RT), and particularly of retroviral RT, most particularly HIV RT... | 04/08/2003 |
| 6541473 | Resorcinol derivatives The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.... | 04/01/2003 |
| 6534250 | Photo-reactive benzocyclobutenones and polymers thereform for self-photocuring, photo-crosslinking and photopatterning without catalysts Functionalized derivatives of benzocyclobutenone of formula I and II herein are photoreactive and may be employed in the production of a variety of self-curable polymer composition which may be employed as photoresist compositions, pressure sensitive adhe... | 03/18/2003 |
| 6531499 | Matrix metalloproteinase inhibitors and method of using same Peptoid compounds of Formula I and Formula II are disclosed ##STR1## The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.... | 03/11/2003 |
| 6506802 | Disulfide derivatives useful for treating allergic diseases Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivative... | 01/14/2003 |
| 6500864 | Disulfide derivatives useful for treating allergic diseases Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivative... | 12/31/2002 |
| 6492552 | Disulfide derivatives useful for treating allergic diseases Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivative... | 12/10/2002 |
| 6482985 | 2-benzyloxy-5-halo-acylanilide compounds and method of using them Disclosed is a compound comprising a 2-benzyloxy-5-haloacylanilide having the structural formula I: ##STR1## wherein R is hydrogen or an alkyl group, RA is a substituent and n is 0-5; and X is a halogen. Also disclosed is a method for preparing a co... | 11/19/2002 |
| 6468406 | Anion-complexing compound, method of preparing the same, an ion-selective membrane and a sensor provided with such a compound or membrane The invention is directed to an anion-complexing compound with the formula I ##STR1## wherein R1 is a six-membered ring, Y' is --NHC(X)NH--, and Y" is selected from the group consisting of --NHC(X')--, --C(X')NH--, and --NHC(X') NH--; and wherein X a... | 10/22/2002 |
| 6458998 | Naphthalene ureas as glucose uptake enhancers Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating t... | 10/01/2002 |
