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| Number | Title | Issue Date |
| 7601874 | Indene derivatives as pharmaceutical agents Compounds of formula (Ia): wherein R1, R2, R3, R4a, R4b, R5 and R6 are defined herein, as well as other indene derivative... | 10/13/2009 |
| 7388112 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from 0 to 12, X equals NH or CH... | 06/17/2008 |
| 7273952 | Substituted C-cyclohexylmethylamine derivatives Substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds, the use of substituted C-cyclohexylmethylamine derivatives for producing pharmaceuticals, and method of pain treatment using the pharmaceu... | 09/25/2007 |
| 7235695 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearin... | 06/26/2007 |
| 7214828 | Durable coating compositions containing novel aspartic amine compounds A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: ... | 05/08/2007 |
| 7196226 | Fluoraminoolefins and fluorination reagents which can be prepared therefrom The present invention relates to fluorination reagents comprising 1-fluoro-1-aminoolefins and also processes for preparing fluorination reagents comprising 1-fluoro-1-aminoolefins. ... | 03/27/2007 |
| 7164034 | Alpha2delta ligands for fibromyalgia and other disorders This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by a... | 01/16/2007 |
| 7026514 | Compounds used to treat alcoholism N,N′-bis(3-aminopropyl)cyclohexane-1,4-diamine, of formula (I), is a new compound that is prepared by hydrogenation with Raney nickel catalyst of N,N′-bis(2-cyanoethyl)-cyclohexane-1,4-diamine, the latter being prepared by reaction between 1,4-cyclohexanediamine... | 04/11/2006 |
| 7019149 | Thromboxane ligands without blood clotting side effects A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffe... | 03/28/2006 |
| 7018978 | Fragrance pro-accords and aldehyde and ketone fragrance libraries The present invention relates to novel heterocyclic pro-fragrances, preferably oxazolidines, tertahydro-1,3-oxazines, thiazolidines, or tetrahydro-1,3-thiazines, more preferably oxazolidines, or tertahydro-1,3-oxazines, most preferably oxazolidines, which are capabl... | 03/28/2006 |
| 6982351 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearin... | 01/03/2006 |
| 6943272 | Norbornane and norbornene derivatives, use thereof and perfumed products containing same The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present —CHCH3OH or —CHCH3OCOR or —CHCH3XCH2... | 09/13/2005 |
| 6919483 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNFα and other involved cytokines. As pharmaceuticals, thes... | 07/19/2005 |
| 6861402 | Pro-fragrances The present invention relates to fragrance delivery systems which comprise: A) from about 0.01% by weight of a pro-fragrance component which comprises pro-fragrances or pro-accords selected from at least two of the following: i) aldehyde and ketone releasing pro-fra... | 03/01/2005 |
| 6828318 | 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission Compounds of formula (1): wherein R1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl, aryl and... | 12/07/2004 |
| 6828462 | Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists Unsaturated 1-Amino-alkylcyclohexane compounds which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which invo... | 12/07/2004 |
| 6794545 | Conformationally restricted polyamine analogs as disease therapies Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of d... | 09/21/2004 |
| 6747149 | Glucamine salts for treating hepatitis virus infections N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent ... | 06/08/2004 |
| 6642398 | Mono-and disubstituted 3-propyl gamma-aminobutyric acids The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I ##STR1## The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, ... | 11/04/2003 |
| 6583246 | Modifiers for anionic polymerization The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.... | 06/24/2003 |
| 6551987 | Pro-fragrances The present invention relates to fragrance delivery systems which comprise: a) one or more pro-fragrances having formula (I) wherein G1 and G2 are methyl, or a cyclic hydrocarbyl unit derived from the isomers of ionone and/or damasco... | 04/22/2003 |
| 6329523 | Compounds having a plurality of nitrogenous substitutents Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear grou... | 12/11/2001 |
| 6214859 | Ethylamine derivatives Ethylamine derivatives of the formula (I): ##STR1## (wherein R1 is hydrogen, hydroxyl, lower alkoxy or halogen; R2 is alkyl having 2 to 5 carbon atoms; R3 is hydrogen, alkyl having 2 to 5 carbon atoms, alkylcarbonyl having... | 04/10/2001 |
| 6166234 | Tripodal cyclopentadiene derivatives and their use Novel tripodal cyclopentadiene derivatives have the formula (I) ##STR1## where E are identical or different and are --N(R)(R), --P(R)(R), --As(R)(R), --Sb(R)(R), --OR, --SR, --SeR, --TeR, where R are identical or different and are each hydrogen, a C | 12/26/2000 |
| 6137019 | Process for converting a geminally substituted cyclopentadiene Process for converting a geminally substituted cyclopentadiene containing 2-6 substituents into a non-geminally substituted cyclopentadiene by reacting the geminally substituted cyclopentadiene with a base, sodium or potassium at a temperature of 0-200° ... | 10/24/2000 |
| 6034134 | 1-Amino-alkylcyclohexane NMDA receptor antagonists Certain 1-aminoalkylcyclohexanes are systemically-active uncompetitive NMDA receptor antagonists having rapid blocking/unblocking kinetics and strong voltage-dependency and are therefore useful in the alleviation of conditions resulting from disturbances ... | 03/07/2000 |
| 6028225 | Method of making hydroxy-substituted hydroxylamines and color developers containing same Hydroxy-substituted hydroxylamine antioxidants can be prepared by reacting hydroxylamine or a mono-substituted hydroxylamine, in free base form, with an epoxide. The antioxidant reaction product can be used without isolation from the reaction solution, an... | 02/22/2000 |
| 5952316 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 09/14/1999 |
| 5849802 | Fungicidal spirocyclic amines New antimicrobial spirocarbocyclic compounds are described, having the general formula I, ##STR1## or an acid-addition salt thereof, in which R1 represents an optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, cycloalk... | 12/15/1998 |
| 5817698 | Substituted cycloalkylamine derivatives and their use as calcium channel antagonists A method of treatment of a condition or disease related to the accumulation of calcium in the brain cells of a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I), wherein X is O, S, C.dbd.O o... | 10/06/1998 |
| 5739397 | Process for the production of secondary amines and the amines produced by the process Secondary amines having a hydrocarbon backbone, a functionality of at least 1 and a molecular weight of at least 74 are produced by reacting a hydrocarbon containing a leaving group with a primary amine, primary diamine, primary polyamine or ammonia at a ... | 04/14/1998 |
| 5674910 | 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these novel compounds Compounds of the formula ##STR1## where the dotted line represents a bond or the absence of a bond, the wavy lines represent bonds which are either in cis or trans configuration; R1 represents H, or CO--R2 where R2 is... | 10/07/1997 |
| 5604229 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 02/18/1997 |
| 5554795 | Process for preparing cyclopentadienyl-type ligands In accordance with the present invention there is provided a cyclopentadienyl-type ligand represented by the formula ZA, wherein Z is a cyclopentadienyl-type group, wherein A is --YPR2, --YNR2, or --NR2, wherein Y is an al... | 09/10/1996 |
| 5545665 | Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by a... | 08/13/1996 |
| 5399763 | Process for preparing optically active 2-aminopropanal A process for preparing an optically active 2-aminopropanal through oxidative cleavage of the corresponding optically active 3-amino-1,2-butanediol of the following formula (2): ##STR1## wherein R1 is a hydrocarbon group having 3 to 6 carbon atoms; R... | 03/21/1995 |
| 5382684 | Nitrogenous 1,3-substituted adamantanes The invention is directed to nitrogenous 1,3-substituted adamantanes, their preparation and use in synthesis of inorganic porous solids. The nitrogenous 1,3-substituted adamantanes are compounds having the formula: ##STR1## wherein R is a nitrogenous... | 01/17/1995 |
| 5342981 | Substantially isomerically pure hexane or hexene compounds The present invention relates to intermediates useful in a process for the preparation of a compound of the formula: ##STR1## wherein R2a is hydrogen or loweralkyl, R2b is hydrogen, loweralkyl, cycloalkyl or phenyl and R1 | 08/30/1994 |
| 5296632 | Continuous reduction of a hindered nitro moiety in aliphatic nitro polyamines Nitro polyamines, and especially dinitro polyamines, can be readily reduced by a catalyst of zerovalent nickel on silica where the silica contains not more than 10% alumina and where the nickel content of the finished catalyst may be as high as 85%. The r... | 03/22/1994 |
| 5288911 | Preparation of ,ω-aminoalcohols Preparation of ,ω-aminoalcohols of the general formula I HO--CH2 --X--CH2 --NH2 (I), in which x denotes a C1 -C20 -alkylene chain optionally substituted by inert radicals and/or opt... | 02/22/1994 |
