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| Number | Title | Issue Date |
| 8173844 | Method for producing O-alkylated cyclic aminoalcohols A process for preparing O-alkylated amino alcohols of the formula (I) by reacting N-unsubstituted or N-monosubstituted amino alkoxide salts with alkyl halides, the amino alkoxide salts being formed by means of alkoxides ... | 05/08/2012 |
| 7432399 | Diols formed by ring-opening of epoxies A polyol monomer comprising the formula: R1 and R3 are —H, aliphatic, aromatic, or ether; R2 is aliphatic, aromatic, ester, ether, or acrylic, and R1 contains a hydroxyl group, ... | 10/07/2008 |
| 7388112 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from 0 to 12, X equals NH or CH... | 06/17/2008 |
| 7276631 | Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable for... | 10/02/2007 |
| 7235695 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearin... | 06/26/2007 |
| 7211589 | Atisane compounds and use thereof The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury caused by radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound represented by the followin... | 05/01/2007 |
| 7196226 | Fluoraminoolefins and fluorination reagents which can be prepared therefrom The present invention relates to fluorination reagents comprising 1-fluoro-1-aminoolefins and also processes for preparing fluorination reagents comprising 1-fluoro-1-aminoolefins. ... | 03/27/2007 |
| 7164034 | Alpha2delta ligands for fibromyalgia and other disorders This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by a... | 01/16/2007 |
| 6982351 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearin... | 01/03/2006 |
| 6924394 | Low pressure process for the manufacture of 2-(aminomethyl)-1-cyclopentylamine Disclosed herein is a process for the manufacture of 2-(aminomethyl)-1-cyclopentylamine by low-pressure hydrogenation of 1-amino-2-cyano-1-cyclopentene using a combination catalyst system of nickel with palladium on carbon, or a single palladium-doped Raney-type cat... | 08/02/2005 |
| 6919483 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNFα and other involved cytokines. As pharmaceuticals, thes... | 07/19/2005 |
| 6828462 | Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists Unsaturated 1-Amino-alkylcyclohexane compounds which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which invo... | 12/07/2004 |
| 6794545 | Conformationally restricted polyamine analogs as disease therapies Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of d... | 09/21/2004 |
| 6642398 | Mono-and disubstituted 3-propyl gamma-aminobutyric acids The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I ##STR1## The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, ... | 11/04/2003 |
| 6583246 | Modifiers for anionic polymerization The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.... | 06/24/2003 |
| 6555959 | Material for light emitting device, light emitting device using thereof, and amine compound A material for a light emitting device which is a compound represented by the following formula (I): ##STR1## wherein Ar1 and Ar6, which are the same or different, each represents a divalent aryl group or a divalent heterocyclic grou... | 04/29/2003 |
| 6448445 | Method for catalytically disubstituting carboxylic acid amides with at least one grignard reagent The invention relates to a method for disubstituting carboxylic acid amides on the geminal carbonyl-C-atom using at least one grignard reagent in the presence of a metal alcoholate compound used as a catalyst and in the presence of another organometallic ... | 09/10/2002 |
| 6437186 | Process for the preparation of 3-aminomethyl-3,5,5-trimethylcyclohexylamine Process for the preparation of isophorone diamine from isophorone nitrile, isophorone nitrilimine or mixtures containing isophorone nitrile and/or isophorone nitrilimine by hydrogenation through to amine in the presence of at least ammonia, hydrogen and a... | 08/20/2002 |
| 6365708 | Polyamines and coating compositions with enhanced resistance to yellowing This invention relates to novel polyamines which are the reaction product of A) at least one nonaromatic diamine containing from 2 to 40 carbon atoms, wherein the amine groups are primary amine groups; and B) at least one epihalohydrin of the formula ##ST... | 04/02/2002 |
| 6329523 | Compounds having a plurality of nitrogenous substitutents Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear grou... | 12/11/2001 |
| 6114392 | Agmatine, and polyaminoguanidine-bound heterocyclic compounds for neurotrauma and neurodegenerative diseases The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The invention further provides novel compounds of general formula I... | 09/05/2000 |
| 6028225 | Method of making hydroxy-substituted hydroxylamines and color developers containing same Hydroxy-substituted hydroxylamine antioxidants can be prepared by reacting hydroxylamine or a mono-substituted hydroxylamine, in free base form, with an epoxide. The antioxidant reaction product can be used without isolation from the reaction solution, an... | 02/22/2000 |
| 5849802 | Fungicidal spirocyclic amines New antimicrobial spirocarbocyclic compounds are described, having the general formula I, ##STR1## or an acid-addition salt thereof, in which R1 represents an optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, cycloalk... | 12/15/1998 |
| 5801202 | Amine derivatives for treatment of skin disorders Disclosed is an amine derivative represented by the following formula (1) or an acid addition salt thereof: ##STR1## wherein R1 represents a group ##STR2## a cyclopentyl group, cyclohexyl group, or a cycloheptyl group, R2 i... | 09/01/1998 |
| 5679869 | Preparation of aldehydes A process for preparing aldehydes of the general formula I ##STR1## where R1, R2 and R3 are each hydrogen, C1 -C6 -alkyl, C3 -C8 -cycloalkyl, aryl, C7 -C12 ... | 10/21/1997 |
| 5594106 | Inhibitors of TNF- secretion Compounds and methods are disclosed that are useful in inhibiting the TNF- converting enzyme (TACE) responsible for cleavage of TNF- precursor to provide biologically active TNF-. The compounds employed in the invention are peptidyl d... | 01/14/1997 |
| 5545665 | Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by a... | 08/13/1996 |
| 5536879 | Process for preparing optically active amino alcohols Optically active amino alcohols are prepared by reducing optically active amino acids with hydrogen in the presence of ruthenium catalysts.... | 07/16/1996 |
| 5510538 | Process for the oxidation of primary and secondary alcohols to aldehydes and ketones and for the oxidation of 1,2-diols to -ketols and -diketones A process for the selective oxidation of a primary or secondary alcohol to an aldehyde or ketone and for the oxidation of a 1,2-diol to an -ketol or -diketone, which comprises contacting the alcohol or 1,2-diol with o-iodoxybenzoic acid. Thi... | 04/23/1996 |
| 5399763 | Process for preparing optically active 2-aminopropanal A process for preparing an optically active 2-aminopropanal through oxidative cleavage of the corresponding optically active 3-amino-1,2-butanediol of the following formula (2): ##STR1## wherein R1 is a hydrocarbon group having 3 to 6 carbon atoms; R... | 03/21/1995 |
| 5395958 | Cyclopropene derivatives The cyclopropene derivatives of the present invention are useful as the intermediates for producing cyclopropenone derivatives exhibiting strong inhibition activity of thiol protease such as calpain, papain, cathepsin B, cathepsin H, cathepsin L and the l... | 03/07/1995 |
| 5344990 | Process for the preparation of a renin inhibiting compound Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sul... | 09/06/1994 |
| 5326911 | Process for the preparation of ortho-amides Ortho-amides of the formula ##STR1## can be prepared by reacting salts of the formula ##STR2## with alcoholates of the formula M1 OR1 (III) where the radicals R1 to R4 | 07/05/1994 |
| 5310770 | Water reducible epoxy-amine adducts based on the diglycidyl ether of cyclohexane dimethanol Water-reducible curing agents for epoxy resins are made from the diglycidyl ether of cyclohexane dimethanol and a diamine selected from the group consisting of meta-xylylene diamine, isophorone diamine, diaminocyclohexane and 1,3-bisaminomethyl cyclohexan... | 05/10/1994 |
| 5298505 | Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension Compounds characterized generally as ethynyl alanine amino diol compounds having a piperazinyl-terminated or a piperazinyl-alkylamino-terminated group and derivatives thereof are useful as renin inhibitors for the treatment of hypertension. Compounds of p... | 03/29/1994 |
| 5288911 | Preparation of ,ω-aminoalcohols Preparation of ,ω-aminoalcohols of the general formula I HO--CH2 --X--CH2 --NH2 (I), in which x denotes a C1 -C20 -alkylene chain optionally substituted by inert radicals and/or opt... | 02/22/1994 |
| 5278161 | Amino acid derivatives useful as renin inhibitors Compounds of the formula ##STR1## wherein A, B, X, Y, R1, R2, R3, R4 and R5 are as set forth in the specification, in the form of optically pure diastereomers, mixtures of diastereomers, diastere... | 01/11/1994 |
| 5264606 | Process for the preparation of polyvinyl compounds A process for the preparation of monomeric polyvinyl compounds and/or oligomers thereof comprising: (i) preactivating a supported rhenium oxide catalyst with a hydrocarbyl metal compound; and (ii) reacting, under metathesis reaction conditions, norbornene or o... | 11/23/1993 |
| 5239120 | Preparation of 2-(3-aminopropyl)-cycloalkylamines A process for the preparation of a 2-(3-aminopropyl)-cycloalkylamine of the general formula I ##STR1## in which the subscript n is an integer from 1 to 4, from a 2-(2-cyanoethyl)-cycloalkanone of the general formula II ##STR2## in which the... | 08/24/1993 |
| 5206440 | Oxidation of fluorine containing sulfides to sulfones A process for production of fluorinated sulfones from fluorinated organic sulfides by oxidation of the sulfides with an oxidizing reagent made from fluorine, water and acetonitrile. The sulfones are useful as second order nonlinear optical dyes.... | 04/27/1993 |
