Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7683216 | Continuous process for the preparation of alkyleneimines A process for the preparation of alkyleneimines by subjecting sulfuric acid monoesters of aminoalkanols to an at least two-stage reaction with aqueous bases at a temperature of at least 110° C. under pressure, relieving the pressure of the reaction mixture and dist... | 03/23/2010 |
| 7355080 | Method of preparing memantine hydrochloride A new method of preparing memantine hydrochloride, comprising the following steps: reacting 1-bromo-3,5-dimethyl adamantane and urea/formic acid, with formic acid also acting as the solvent; hydrolyzing with aqueous inorganic acid; alkalifying, extracting and acidif... | 04/08/2008 |
| 7317128 | Process for preparing TCD-diamine A process for preparing 3(4),8(9)-bis(aminomethyl)tricycle-[5.2.1.02,6]decane by hydroformylating dicyclopentadiene with subsequent reductive amination wherein the hydroformylation of dicyclopentadiene is carried out in two stages, and, in a first hydrofo... | 01/08/2008 |
| 7235695 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearin... | 06/26/2007 |
| 7038087 | Process for the production of optically active amino alcohols An object of the present invention is to provide a process for the production of an optically active amino alcohol, particularly an optically active amino alcohol of a trans-form, being excellent in economy and efficiency, and suitable for industry using easily avai... | 05/02/2006 |
| 6982351 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearin... | 01/03/2006 |
| 6891068 | Water as promoter in the nucleophilic substitution of chloride Disclosed is a one step method for preparing a β-substituted sulfide by treating a β-halosulfide with a nucleophile in water. ... | 05/10/2005 |
| 6828345 | O-substituted 6-methyltramadol derivatives The invention relates to O-substituted 6-methyl-tramadol derivatives, to methods for producing them, to medicaments containing these compounds, to the use of O-substituted 6-methyl-tramadol derivatives for producing medicaments for treating pain and other symptoms o... | 12/07/2004 |
| 6774270 | Method of removing hexafluoropropylene dimers A method of removing hexafluoropropylene dimers (“HFP dimers”), dimer hydrides and other oligomers from a fluid is described. The method comprises heating the fluid to isomerize the HFP dimers to the thermodynamic isomer, and contacting the fluid with a tertiary... | 08/10/2004 |
| 6723879 | Process for preparing amino compounds by using salen-manganese complexes as the catalyst Disclosed is a process for the enantioselective production of an optically active amino compound by the amination of the C—H bond of an organic compound. The amino compound is produced by converting the C—H bond at the allyl position of an alkene or the C—H bo... | 04/20/2004 |
| 6540793 | Coupler for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): ##STR1## wherein R is selected from the group consisting of C1 to C2 alkyl and hydroxyethyl; R1 is selected from the gr... | 04/01/2003 |
| 6423871 | Efficient synthesis of secondary amines by selective alkylation of primary amines A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. C... | 07/23/2002 |
| 6414207 | Preparation of a basic catalyst avoiding high temperatures A catalyst comprising at least one alkali metal and at least one metallic or semimetallic promoter selected from the group consisting of Ca, Sr, Ba, Ag, Au, Zn, Cd, Hg, In, Tl, Sn, As, Sb and Bi, on a support which may be doped with one or more compounds ... | 07/02/2002 |
| 6403834 | Method for preparing tris(ether-amine) The invention concerns a method for preparing tris(ether-amines) of formula (I): N[A--O--(B--O)n --R]3 wherein R, A, B and n are as defined in Claim 1, comprising the reaction, in liquid phase, of an alkylene-glycol monoether of form... | 06/11/2002 |
| 6362373 | Chiral amino alcohols and process for preparation of same The disclosed invention comprises a compound having the formula: ##STR1## in which R1 and R2 independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a process for the preparation of the... | 03/26/2002 |
| 6353136 | Process for preparing aromatic amines in the presence of palladaphosphacyclobutane catalysts Aromatic amines of the formula (I) Ar--[NR6 R7 ]n (I) are prepared by reacting a haloaromatic of the formula (II) Ar--Hal (II) with an amine of the formula (III) R6 R7 NH (III) in the presence of a palladaphospha... | 03/05/2002 |
| 6166234 | Tripodal cyclopentadiene derivatives and their use Novel tripodal cyclopentadiene derivatives have the formula (I) ##STR1## where E are identical or different and are --N(R)(R), --P(R)(R), --As(R)(R), --Sb(R)(R), --OR, --SR, --SeR, --TeR, where R are identical or different and are each hydrogen, a C | 12/26/2000 |
| 6143934 | Preparation of amines from olefins over boron beta-zeolites In a process for preparing amines of the general formula I ##STR1## where R1, R2, R3, R4, R5, R6 are hydrogen, C1 -C20 -alkyl, C2 -C20 -alkenyl, ... | 11/07/2000 |
| 6043393 | Method for preparing cyclopropylamines The present invention relates to a process for preparing cyclopropylamines of the formula ##STR1## wherein R1, R2, R3, R4, and R5 have specified meanings, by reacting (1) a carboxamide of the for... | 03/28/2000 |
| 6011179 | Process for the production of amines from imines of nitriles A process for the production of primary and/or secondary amines from imines or nitriles, comprising an aminating hydrogenation of imine or of nitrile with hydrogen in the presence of ammonia, of a hydrogenation catalyst based on cobalt, nickel, ruthenium ... | 01/04/2000 |
| 5874621 | Preparation of amines from olefins over NU-85 zeolites Amines of the general formula I ##STR1## where R1, R2, R3, R4, R5 and R6 : are each hydrogen, C1 -C20 -alkyl, C2 -C20 -alkenyl, C2 ... | 02/23/1999 |
| 5801202 | Amine derivatives for treatment of skin disorders Disclosed is an amine derivative represented by the following formula (1) or an acid addition salt thereof: ##STR1## wherein R1 represents a group ##STR2## a cyclopentyl group, cyclohexyl group, or a cycloheptyl group, R2 i... | 09/01/1998 |
| 5786405 | Amine-initiated polyether polyols and a process for their production Clear, amine-initiated polyether polyols are made by epoxidizing an amine in the presence of an alkali metal hydroxide catalyst. After the desired degree of epoxidation has been achieved, a hydroxy-carboxylic acid is added to the epoxidized mixture in an ... | 07/28/1998 |
| 5773660 | Preparation of amines from olefins over hexagonal faujasites A process for preparing amines of the formula I ##STR1## where R1,R2,R3,R4,R5 and R6 are each hydrogen, C1 -C20 -alkyl, C2 -C20 -alkenyl, C2... | 06/30/1998 |
| 5763668 | Process for aminating a mixture obtained in cracking a mineral oil fraction with ammonia or a primary or secondary amine over specific heterogeneous catalysts Amines are prepared by reacting a mixture obtained in the cracking of mineral oil fractions with ammonia or a primary or secondary amine of the general formula I ##STR1## where R1 and R2 are each hydrogen, C1 -C2... | 06/09/1998 |
| 5739397 | Process for the production of secondary amines and the amines produced by the process Secondary amines having a hydrocarbon backbone, a functionality of at least 1 and a molecular weight of at least 74 are produced by reacting a hydrocarbon containing a leaving group with a primary amine, primary diamine, primary polyamine or ammonia at a ... | 04/14/1998 |
| 5693864 | Process for the production of secondary amine terminated polyethers Disclosed herein is a process for preparing an amine terminated polyether comprising reacting a polyether containing a leaving group with a primary amine or ammonia at a temperature of about 70 to 250 degrees Centigrade.... | 12/02/1997 |
| 5684132 | Preparation of protected amines or alkylated amino acids The present invention relates to a process for preparing protected amines or amino acids. The invention furthermore relates to the use of tocopheryl radicals or radicals derived therefrom as protective groups for amines and amino acids, and to compounds o... | 11/04/1997 |
| 5504254 | Process for the preparation of isophoronediamine A process is disclosed for the continuous preparation of 3-aminomethyl-3,5,5-trimethylcyclohexylamine (isophoronediamine) in high yield and high purity from 3-cyano-3,5,5-trimethylcyclohexanone (isophoronenitrile) by aminating hydrogenation with hydrogen ... | 04/02/1996 |
| 5440049 | Process for producing enyne derivatives A compound of the formula: ##STR1## wherein R11 is hydrogen, lower alkyl, haloloweralkyl, lower alkenyl, lower alkynyl or cycloalkyl and R21 is a group selected from the group consisting of: ##STR2## wherein R3 | 08/08/1995 |
| 5405998 | Process for the manufacture of cycloalkyl and haloalkyl o-aminophenyl ketones There is provided an improved method for the production of o-aminophenyl ketones of formula I wherein R is C3 -C6 cycloalkyl or C1 -C6 haloalkyl. ##STR1## Compounds of formula I are key intermediates in the... | 04/11/1995 |
| 5347053 | Process for preparing alkylamines This invention relates to an improvement in a process for producing an alkylamine from olefin and amine by hydrohalogenating the olefin to form haloalkane then reacting the haloalkane with amine to form an alkylamine. The improvement comprises heat-treati... | 09/13/1994 |
| 5344990 | Process for the preparation of a renin inhibiting compound Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sul... | 09/06/1994 |
| 5288910 | Palladium catalyzed addition of amines to 3,4-epoxy-1-butene 4-amino-2-buten-1-ol is formed by the regioselective addition of primary amines or ammonia to 3,4-epoxy-1-butene. A quantity of a the primary amine or ammonia is reacted with 3,4-epoxy-1-butene in a reaction medium in the presence of a catalyst. The react... | 02/22/1994 |
| 5284976 | Method of producing primary amines in high yields A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMe2 wherein R is an organo group, R* is a chiral... | 02/08/1994 |
| 5276195 | Process for producing dimethylorganoboranes A process for preparing a dimethylorganoborane represented by the formula R*BMe2 wherein R* is a chiral organyl group attached to the boron, B is boron and Me is methyl comprising treating a chiral boronic ester R*B(OR')2 with a meth... | 01/04/1994 |
| 5254707 | Preparation of cyclopentadiene derivatives The process for preparing a compound of the formula: Cp'YNHR wherein: Cp' is a cyclopentadienyl or a substituted cyclopentadienyl group, Y is a covalent bridging group which contains one or more group 14 elements, and R is a C1 to C20 hyd... | 10/19/1993 |
| 5214209 | Method of producing primary amines in high yields and novel intermediates therefor A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMe2 wherein R is an organo group, R* is a chiral... | 05/25/1993 |
| 5210310 | Optically active dimethylorganoboranes A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMe2 wherein R is an organo group, R* is a chiral... | 05/11/1993 |
| 5055618 | Process for the preparation of ,ω-diamines The object of this invention is the preparation of ,ω-diamines from , ω-dialdehydes in a method which comprises the reaction of a starting mixture of said dialdehyde, a primary amine, and water to form a reaction mixture, followed by treat... | 10/08/1991 |
