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| Number | Title | Issue Date |
| 8138376 | Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine The present invention relates to an improved process for the preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine which is an intermediate for the preparation of the analgesic tapentadol. ... | 03/20/2012 |
| 8017807 | Tetrahydroxy compound, method for preparing the tetrahydroxy compound, and photoreceptor using the tetrahydroxy compound A new tetrahydroxy compound having a specific structure including two 2,3-dihydroxypropyloxy groups is provided. The compound has good charge transport property. In addition, a charge transport layer including the tetrahydroxy compound or a reaction product of the t... | 09/13/2011 |
| 7960588 | Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resis... | 06/14/2011 |
| 7858826 | Process for producing 6-dimethylaminomethyl-phenyl-cyclohexane-1,3-diols A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydroge... | 12/28/2010 |
| 7667078 | Asymmetric reaction catalyst and method for preparing optically active compound using the same An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula: | 02/23/2010 |
| 7642381 | Two step process for preparing substituted anisidines The process of the present invention can be briefly summarized as depicted in the following scheme: R1 is C1-Calkyl, R2 is C1-C6alkyl and Hal is a halogen atom. ... | 01/05/2010 |
| 7423030 | 1-amino-phthalazine derivatives, the preparation and the therapeutic use thereof A 1-amino-phthalazine derivative of general formula (I) wherein the substituents are as defined herein. Also disclosed are a method for preparing such compounds, intermediates for use in such method and medical treatments u... | 09/09/2008 |
| 7390927 | Process for preparing 3-aminophenylacetylenes A process for preparing a 3-aminophenylacetylene compound of formula (5), including: a) reacting a 3-haloaniline compound of formula (1) with an acetylene compound of formula (2) in the presence of a palladium compound, a copper compound, and an amine compound of fo... | 06/24/2008 |
| 7365085 | Compounds and methods Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined... | 04/29/2008 |
| 7365231 | Compound with antitumor activity and preparation method therefor The present invention provides the diaminophenyladamantane derivatives with antitumor activities and the preparation method therefore. The method includes a step of reacting an aromatic diol with at least one 5-halo-2-nitrophenol in the presence of at least one inor... | 04/29/2008 |
| 7250525 | Stilbene derivatives and their use for binding and imaging amyloid plaques This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 07/31/2007 |
| RE39667 | 3,3-Diphenylpropylamines, their use and preparation The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a terti... | 05/29/2007 |
| 7214827 | Method for Friedel-Crafts acylation of anilides An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to groups 3 to 5 and groups 13 to 15 in periods 4 to 6 of the periodic table, thereby bonding an acyl group to the benzene... | 05/08/2007 |
| 7141696 | Smooth muscle spasmolytic agents The present invention relates to smooth muscle spasmolytic agents, pharmaceutical compositions containing them and method of using said compounds and compositions for the treatment of urinary incontinence, and other smooth muscle contractility conditions. More parti... | 11/28/2006 |
| 7101538 | Polyesteramine ingredient and use of same The present invention provides a polyesteramine, a composition having a polyesteramine according to the present invention as an active ingredient and methods for improving hair detangling, wet and dry combing, shine, gloss, conditioning, surface smoothening, water r... | 09/05/2006 |
| 7094812 | Colorant compositions Disclosed are colorant compounds of the formula wherein R, R1, R2, R3, and R4 each, independently of the others, is an alkyl group, an aryl group, an arylalkyl group, o... | 08/22/2006 |
| 7087778 | Process for producing benzoxazine derivative and production intermediate thereof Processes for producing antibacterial agents and intermediates useful in producing antibacterial agents are provided and include producing compound (VI-a) in accordance with the following reaction schema, as well as production intermediates thereof | 08/08/2006 |
| 7034185 | Colorant precursor compositions Disclosed are colorant precursor compounds of the formula wherein R is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, and wherein R can be joined to the phenyl moiety to form a ring, each R′... | 04/25/2006 |
| 7030276 | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol A process for preparing 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol with high stereoselectivity and high yield by reacting 2-[(dimethylamino)methyl]-cyclohexanone in a Grignard reaction with a Grignard compound of 3-bromoanisole in a suitable solvent a... | 04/18/2006 |
| 6974839 | Method of delaying ejaculation The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation. ... | 12/13/2005 |
| 6969759 | Colorant compositions Disclosed is a colorant composition of the formula wherein R is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, and wherein R can be joined to the phenyl moiety to form a ring, R′ is an arom... | 11/29/2005 |
| 6951654 | Intravaginal drug delivery devices for the administration of an antimicrobial agent An intravaginal antimicrobial drug delivery device is disclosed having an antimicrobial agent dispersed throughout a biocompatible elastomeric system. Also disclosed is a method of making the antimicrobial drug delivery device. ... | 10/04/2005 |
| 6916347 | Primary intermediates for oxidative coloration of hair Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R1 and R2 are each individually selected from a hydrogen atom, a C1 | 07/12/2005 |
| 6890959 | Aminomethyl-phenyl-cyclohexanone derivatives Aminomethyl-phenyl-cyclohexanone derivatives of formula I or Ia, their diastereomers, enantiomers and salts formed with a physiologically tolerated acid. Also disclosed are processes for preparing the same, pharmaceuti... | 05/10/2005 |
| 6891067 | Optical polyimide precursor, optical polyimide compound and fabricating method thereof The present invention provides an optical polyimide precursor for use in making a polyimide. The precursor is defined by the following formula: wherein X is Cl, Br, oxo-halide, or fully halogenated alkyl, and A is a di... | 05/10/2005 |
| 6887904 | Substituted arylcycloalkanes, compositions containing them and use thereof Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology. ... | 05/03/2005 |
| 6849766 | 1,4-diamino-2-alkenylbenzene derivatives, and dyes containing these compounds 1,4-Diamino-2-alkenylbenzene derivatives of general formula (I) or physiologically tolerated water-soluble salts thereof as well as agents for oxidative dyeing of fibers, containing these compounds. ... | 02/01/2005 |
| 6784318 | Vinyl polymer and organic electroluminescent device An organic electroluminescent device has an organic layer between a pair of electrodes. The organic layer (in particular, a hole-transporting layer) has a polymer of a vinyl compound represented by the following formula (1): | 08/31/2004 |
| 6784319 | Synthesis of (±)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods of preparing (±)-cis-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylamino)methyl)-1-(3-methoxypheny... | 08/31/2004 |
| 6759555 | Process for the preparation of combretastatins The present invention provides novel processes for the preparation of combretastatins or stilbene compounds of formulae (I) and (III) wherein A is NH2 or and PG is... | 07/06/2004 |
| 6750355 | Primary intermediates for oxidative coloration of hair Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R1 and R2 are each individually selected from a hydrogen atom, a C1 | 06/15/2004 |
| 6747149 | Glucamine salts for treating hepatitis virus infections N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent ... | 06/08/2004 |
| 6673932 | Primary intermediates for oxidative coloration of hair Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): ##STR1## wherein R is hydrogen, hydroxy, nitro, amino, halogen, C1 to C5 alkyl or haloalkyl, C1 to C5... | 01/06/2004 |
| 6673794 | Substituted aminomethyl-phenyl-cyclohexane derivatives A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, ##STR1## and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are method for preparing the substituted aminomethyl-pheny... | 01/06/2004 |
| 6649783 | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols Compositions comprising (&#b1;)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods of preparing (&#b1;)-cis-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols, in particular (&#b1;)-cis-2-((dimethylamino)methy... | 11/18/2003 |
| 6624201 | HIGH PURITY (1R,2S,4R)-(-)-2-[(2'-{N,N-DIMETHYLAMINO}-ETHOXY)]-2-[PHENYL]-1,7,7 -TRI-[METHYL]-BICYCLO [2.2.1]HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF AND A PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS MEDICAMENTS CONTAINING 1 OR MORE OF THESE COMPOUNDS AND THEIR USE The invention relates to high purity (1R,2S,4R)-(-)-2-[(2'-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[m ethyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2% of (1R,3S,4R)-3-[(2'... | 09/23/2003 |
| 6593374 | Tubulin binding ligands and corresponding prodrug constructs A diverse set of tubulin binding ligands have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl--aryl, pseudo pi stacking distances appropriate for molecular recogniti... | 07/15/2003 |
| 6576793 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p... | 06/10/2003 |
| 6562871 | Dry granulation of pharmaceutical formulation comprising mexiletine Compaction of mexiletine hydrochloride crystals is described, which provides a powder suitable for use in capsules without use of organic solvents.... | 05/13/2003 |
| 6548534 | Nonsteroidal gestagens This invention describes the new, nonsteroidal gestagens of general formula I ##STR1## in which A, B, Ar1, R1, R2 and R3 have the meanings that are indicated in more detail in the description. The new compounds ... | 04/15/2003 |
