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Class 564/428 - Bicyclo ring system


Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the polycyclo ring system is bicyclo.
No. of patents: 273
Last issue date: 12/27/2011


1              
NumberTitleIssue Date
8084647Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe
A two-photon probe for real-time monitoring of intracellular calcium ions is provided. The two-photon probe is very suitable for real-time imaging of intracellular calcium ions, shows 20˜50-fold TPEF enhancement in response to Ca2+, has a dissociation co...
12/27/2011
8039674Compound having S1P receptor binding potency and use thereof
Provided are: a compound represented by formula (I): (wherein ring A and ring D each represent a cyclic group which may have a substituent(s); E and G each represent a bond or a spacer having 1 to 8 atoms in its main chain;...
10/18/2011
7838703Diaromatic amine derivatives as antioxidants
A diaromatic amine compound having the general formula: wherein R1 and R2 together with the carbon atoms to which they are bonded are joined together to form a C3-C30 ring, and R
11/23/2010
7649115MAO-B inhibitors useful for treating obesity
The invention provides novel compounds of formulae I and II: that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, h...
01/19/2010
73684482-(arylalkoxy)-1-phenylethylamine derivatives as NKantagonist and serotonin reuptake inhibitors
Compounds of the following formula (I) wherein R1 R2, n, Ar1 and A2 are as defined in the specification, in vivo-hydrolysable precursors thereof, pharmaceutically acceptable salts thereof, the use in therapy and pharmaceut...
05/06/2008
7365231Compound with antitumor activity and preparation method therefor
The present invention provides the diaminophenyladamantane derivatives with antitumor activities and the preparation method therefore. The method includes a step of reacting an aromatic diol with at least one 5-halo-2-nitrophenol in the presence of at least one inor...
04/29/2008
7319171Sertraline hydrochloride form II and methods for the preparation thereof
The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be...
01/15/2008
7309497Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients
The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i...
12/18/2007
7264890Electroluminescent material, electroluminescent element and color conversion filter
An electroluminescent element is disclosed, comprising an electroluminescent material and a fluorescent substance emitting light having an emission maximum at the wavelength different from that of light emitted from the electroluminescent material upon absorption of...
09/04/2007
7262327Recycling process for preparing sertraline
Provided is a recycling process for preparing sertraline, which may be carried out on an industrial scale. ...
08/28/2007
7259271Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkyl...
08/21/2007
7252894Anthracene compound for organic electroluminescent device
An anthracene compound for an organic electroluminescent device, having formula (I) or (II) wherein R1, R2, R3, R4, R5, and R6 ...
08/07/2007
7189876Methods for preparing sertraline hydrochloride polymorphs
This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation. ...
03/13/2007
7186863Sertraline compositions
An acid salt of sertraline, wherein the acid is citric acid, fumaric acid, malic acid, maleic acid, malonic acid, phosphoric acid, succinic acid, sulfuric acid, L-tartaric acid, HBr, acetic acid, benzoic acid, benzenesulfonic acid, ethanesulfonic acid, lactic acid, ...
03/06/2007
7173153Sertraline hydrochloride form II and methods for the preparation thereof
This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II. ...
02/06/2007
7049337Derivatives of 2-aminotetralins and pharmaceutical analogs thereof exhibiting differential CNS receptor activity and behavior
Aminotetralin derivatives and pharmacological analogs thereof which contain an N-propynyl group exhibit differential dopaminergenic receptor activity. The subject compounds are useful in affecting dopamine receptor activity, particularly in exhibiting differing acti...
05/23/2006
70417032-aminotetralines and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory ...
05/09/2006
7026498Ligands for metals and improved metal-catalyzed processes based thereon
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react...
04/11/2006
6949575Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives
The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R1 and R2 include alkyl and phenylalkyl; R3 is hydrogen or alkyl; and R4 and R
09/27/2005
6943195Cycloalkenone derivative
(−)-3-[3-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyanilino]-2-methyl-2-cyclopenten-1-one, or its hydrate or solvate, or a pharmaceutical composition containing the same. ...
09/13/2005
6939992Polymorphic forms of sertraline hydrochloride
A crystalline form of sertraline hydrochloride was found, referred to hereinafter as polymorphic form CSC2 having a dissolution rate which surprisingly will increase rate of absorption of a drug. Furthermore, different crystalline forms of sertraline hydrochl...
09/06/2005
6933410Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine
A process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine and acid addition salts thereof from 2-aminoindan. The process comprises protecting the amino group of 2-aminoindan, acetylating the ring in the protected compound, reducing the acetyl group to ethyl t...
08/23/2005
6933411Aromatic diamine and polyimide thereof
The aromatic diamine compound of the present invention is represented by the following formula (1), and from the aromatic diamine compound a polyimide having a repeating unit represented by the following formula (4), which has low-temperature adherability, can be ob...
08/23/2005
6897340Processes for preparation of polymorphic form II of sertraline hydrochloride
Provided are processes for preparation of crystalline sertraline hydrochloride Form II substantilly free of other polymorphic forms of sertraline hydrochloride, preferably on an industrial scale. ...
05/24/2005
6890959Aminomethyl-phenyl-cyclohexanone derivatives
Aminomethyl-phenyl-cyclohexanone derivatives of formula I or Ia, their diastereomers, enantiomers and salts formed with a physiologically tolerated acid. Also disclosed are processes for preparing the same, pharmaceuti...
05/10/2005
6870070Process to prepare 2-aminoindan derivatives
The present invention relates to (2S)-enantiomers of 2-aminoindan derivatives of formula I: and a novel process for the preparation of them. ...
03/22/2005
6858652Sertraline hydrochloride polymorphs, processes for preparing them, compositions containing them and methods of using them
The present invention is directed to novel polymorphic Forms XI, XII, XIII, XIV, XV and XVI of sertraline hydrochloride, to processes for preparing them, methods of using them to treat disease, methods of using them to make other sertraline hydrochloride forms, and ...
02/22/2005
6849345Organic electroluminescent devices with high luminance
Disclosed is a multilayer electroluminescent device comprising a cathode, an anode, a light emitting layer (LEL) and a layer disposed between the cathode and anode containing a naphthalene compound represented by formula (1):
02/01/2005
6844368Compounds useful in pain management
The present invention relates to novel oxo-aminotetralin compounds of the formula (I) wherein X, R1, R2, R3, R4, R5, and R6 are defined herein. ...
01/18/2005
6809221Process for preparing (+)-cis-sertraline
The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio greater than 3:1, greater than or equal to 8:1, or between about 8:1 and ab...
10/26/2004
6784210Compound and a novel process for their preparation
The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of ...
08/31/2004
6753128Photoresist additive for preventing acid migration and photoresist composition comprising the same
Photoresist additives for preventing the acid generated in the exposed area during the course of a photolithography process from being diffused to the unexposed area, photoresist compositions containing the same, and a process for forming a photoresist pattern using...
06/22/2004
6747149Glucamine salts for treating hepatitis virus infections
N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent ...
06/08/2004
6723455Organic electro-luminescent element and material of organic electro-luminescent element
An electro-luminescent element comprising an organic compound layer is disclosed. The organic compound layer contains a compound represented by Formula I or Formula V: wherein R1 and R2 are each a s...
04/20/2004
6710089Substituted N-fused-phenyl-N-benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle...
03/23/2004
6696608Transfer hydrogenation process
A catalytic transfer hydrogenation process is provided. The process can be employed to transfer hydrogenate N-substituted imines and iminium salts, which are preferably prochiral. The catalyst employed in the process is preferably a metal complex with one...
02/24/2004
6646164Triphenylamine derivative and organic electroluminescence device comprising the same
A triphenylamine derivative represented by the following general formula (1): ##STR1## wherein R1, R2, R3, R4, R5 and R6 may be the same or different and each represents a hydrogen atom, al...
11/11/2003
6624201HIGH PURITY (1R,2S,4R)-(-)-2-[(2'-{N,N-DIMETHYLAMINO}-ETHOXY)]-2-[PHENYL]-1,7,7 -TRI-[METHYL]-BICYCLO [2.2.1]HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF AND A PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS MEDICAMENTS CONTAINING 1 OR MORE OF THESE COMPOUNDS AND THEIR USE
The invention relates to high purity (1R,2S,4R)-(-)-2-[(2'-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[m ethyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2% of (1R,3S,4R)-3-[(2'...
09/23/2003
6586120Electro luminescent device comprising fluorene compounds
This invention relates to fluorene compounds and their use as a hole transport material in an electro-luminescence device....
07/01/2003
6552227Process for preparing (+)-cis-sertraline
The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio greater than 3:1, greater than or equal to 8:1, or between about...
04/22/2003
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