Did You Know...
...During the Civil War, the Confederacy established its own Patent Office which issued 266 patents, a third of which concerned implements of war.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8063251 | Process for the preparation of optically pure R (−) salbutamol and its pharmaceutically acceptable salts A process for the preparation of optically pure R (−) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate and C1 to C | 11/22/2011 |
| 7884247 | Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and metho... | 02/08/2011 |
| 7317127 | Process for the optical resolution and recycling of tomoxetine The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention furthe... | 01/08/2008 |
| 7262327 | Recycling process for preparing sertraline Provided is a recycling process for preparing sertraline, which may be carried out on an industrial scale. ... | 08/28/2007 |
| 7122700 | Arylamine processes A method for bisformylation an arylamine compound by reacting an arylamine compound with an alkyleneamine in a reaction mixture while refluxing an acid in the reaction mixture. ... | 10/17/2006 |
| 6965832 | Investigating different physical and/or chemical forms of materials Apparatus and a method are described for investigating polymorphs of a material, isomers of a material which allow different isomeric forms to be resolved, different hydrates/solvates and/or different salts of a material. The apparatus comprises an assembly (2 | 11/15/2005 |
| 6909017 | Method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol The invention relates to a method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol as a saccharinate from a mixture of the diastereomers (1SR,2)RS-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol and (1SR-2RS... | 06/21/2005 |
| 6906087 | Crystalline forms of venlafaxine hydrochloride Crystalline forms of Venlafaxine hydrochloride were found, referred to hereinafter as polymorphic Forms A, B and D. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceutical compositions comprising ... | 06/14/2005 |
| 6586634 | Process for the preparation on (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate Process for the preparation of (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate, in which in a solvent a mixture of enantiomers of cis-1-amino-2-indanol reacts at an elevated temperature with (R,R)-tartaric acid and methanol and in which opticall... | 07/01/2003 |
| 6521792 | Process for separating the diastereomeric bases of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cylohexanol A method for separating the diastereomer bases of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol in which the separation of the diastereomer bases takes place through formation of a base hydrate.... | 02/18/2003 |
| 6469213 | Tramadol, salts thereof and process for their preparation Cis-Tramadol hydrochloride is prepared by forming a Mannich hydrochloride, liberating the Mannich base, reacting the Mannich base with a Grignard reagent to form a base hydrate of cis-Tramadol which is used to form pure cis-Tramadol hydrochloride. Also cl... | 10/22/2002 |
| 6399829 | Synthesis and purification of (r*,r*)-2-[ (dimethylamino) methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride (R*,R*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product than is obtained in the absence of the additive. The Grignar... | 06/04/2002 |
| 6008412 | Process to make chiral compounds The present invention relates to processes for resolving N-methyl-3(R,S)-hydroxy-3-phenylpropylamine and N,N-dimethyl-3 (R,S) -hydroxy-3-phenylpropylamine with the isomers of mandelic acid and the resulting salts.... | 12/28/1999 |
| 5952528 | Process for enhancing the optical purity A process for enhancing the purity of 2R-1-hydroxy-1-trifluoromethyl-3-cyclopropylpropyn-2-yl!-4-chloroaniline comprising the formation of an acid addition salt which is capable of rejecting the racemate in the selected organic solvent.... | 09/14/1999 |
| 5919990 | Reclamation of bisphenol tars as feedstock in the synthesis of aminophenylhydroxphenylalkanes The disclosure is of a process for recovering valuable by-products of the condensation of phenol and a ketone from a mother liquor obtained for example upon crystallization of a 1:1 adduct of phenol and bisphenol, said mother liquor containing phenol, bis... | 07/06/1999 |
| 5877351 | Preparation and purification process for 2-(dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts A process for the isolation and purification of (RR,SS)-2-(dimethylamino)methyl!-1-(3-methoxyphenyl)cyclohexanol and its salts from a Grignard reaction mixture which includes the (RR,SS) isomer, the (RS,SR) isomer and Grignard reaction side products. An... | 03/02/1999 |
| 5863952 | Enantiomers of 1-(3,4-dichlorobenzyl)-2-methylaminoindane The single enantiomers of formula (I) and salts thereof ##STR1## are calcium channel antagonists useful in the treatment of ischaemic conditions e.g., stroke.... | 01/26/1999 |
| 5856579 | Adduct salts of novel substituted benzylamines and a process for optically resolving them A process for optical resolution of a racemic substituted benzylamine is provided that involves reacting the racemic substituted benzylamine in a solvent with an optically active N-acyl-phenylalanine, -aspartic acid, or -glutamic acid, and separating the ... | 01/05/1999 |
| 5679857 | Method of preparing D-amino acid-N-(S)--alkylbenzylamide L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)--alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, w... | 10/21/1997 |
| 5672755 | Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts The invention provides a process for the purification and isolation of (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol from mixtures also containing the (RS,SR) isomer comprising reacting the above mixture in a solvent at elevated temperatur... | 09/30/1997 |
| 5629450 | Addition salt of acyl-amino acid and -aryl amine and process for optical resolution of -arylamine To produce optically active -arylalkylamine from optically impure -arylalkylamine. Optically impure -arylalkylamine is mixed with optically active N-acyl-aspartic acid or glutamic acid in a solvent and the resulting two types of diast... | 05/13/1997 |
| 5414129 | Process for the purification of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol and its salts A process for the improved purification and separation of trans 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride from a reaction mixture containing the trans isomer, the cis isomer and Grignard reaction side products, comprising com... | 05/09/1995 |
| 5306826 | Process for preparation of an optically active amino acid amide The present invention relates to a process for the preparation of optically active amino acid amide. L-amino and D-amino acid amides are mixed in the presence of 0.5-4 equivalents of an aldehyde, relative to the quantity of amino acid amide, in the presen... | 04/26/1994 |
| 5284975 | Method of preparing -d-phenylalkylbenzyl carbinol A method of preparing an -d-phenylalkylbenzyl carbinol by the reaction of a phenylbenzyl ketone with an alkali metal enolate of an amide to form an aldol adduct, which is reduced and purified to form an -d-phenylalkylbenzyl carbinol, wherein... | 02/08/1994 |
| 5082970 | Process for recycling amine isomer A novel process for converting trans-isomeric N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine to cis-isomeric N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine is disclosed. The process involves contacting tr... | 01/21/1992 |
| 4960952 | Alkoxylation process catalyzed by lanthanum silicates and metasilicates Alkylene oxide adducts of organic compounds having active hydrogen atoms are prepared by a process which comprises contacting and reacting an alkylene oxide reactant comprising one or more vicinal alkylene oxides with an active hydrogen containing reactan... | 10/02/1990 |
| 4652563 | Vasodilators and ଲ-adrenoceptor antagonists This invention relates to dihydropyridazinone compounds having a cyclopropylmethoxyethyl group in the 6-substituent. These compounds are vasodilators and ଲ-adrenoceptor antagonists. A particular compound of the invention is 6-[4-[3-[2-hydroxy-3-[4-(... | 03/24/1987 |
| 4489209 | Separation of amines by preferential aqueous salt extraction A process of separating amines having different basicity constants is disclosed. The more reactive amine is converted to a salt which is extracted with water in a multiple stage countercurrent extractor. The salt form of the amine is converted to the free... | 12/18/1984 |
| 4224246 | Process for the synthesis and separation of the threo and erythro isomers of 2-amino-1-phenyl-1-propanol A process for the synthesis and separation of the threo and erythro isomers of 2-amino-1-phenyl-1-propanol comprising the steps of catalytically reducing 2-nitro-1-phenyl-1-propanol to form the acetate salt of the racemic mixture of 2-amino-1-phenyl-1-pro... | 09/23/1980 |
| 4174351 | Separation of dissimilar amines Amines which are dissimilar in nature by virtue of possessing different substituents, different structures or position isomers may be selectively separated by treatment with a reactive carbonyl compound and an acid. The separation may be effected at react... | 11/13/1979 |
| 4150032 | 9-Oxobenzomorphan process and intermediates Improved processes for preparing 2'-alkoxy-2,5-di-substituted-9-oxo-6,7-benzomorphans from benz[e]indolines and synthesis of the benz[e]indoline intermediates are described. A representative example involves synthesis of 9b-allyl-8-methoxy-3-methyl-5... | 04/17/1979 |
