Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7592488 | Method for preparing optically active amines The present invention relates to a method of preparing optically active amines and chiral amines prepared thereby. The method includes reacting an amine compound, a metal catalyst, a biocatalyst including a lipase, and an acyl donor compound in an organic solvent to... | 09/22/2009 |
| 7319171 | Sertraline hydrochloride form II and methods for the preparation thereof The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be... | 01/15/2008 |
| 7317127 | Process for the optical resolution and recycling of tomoxetine The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention furthe... | 01/08/2008 |
| 7262327 | Recycling process for preparing sertraline Provided is a recycling process for preparing sertraline, which may be carried out on an industrial scale. ... | 08/28/2007 |
| 7189876 | Methods for preparing sertraline hydrochloride polymorphs This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation. ... | 03/13/2007 |
| 7173153 | Sertraline hydrochloride form II and methods for the preparation thereof This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II. ... | 02/06/2007 |
| 7122700 | Arylamine processes A method for bisformylation an arylamine compound by reacting an arylamine compound with an alkyleneamine in a reaction mixture while refluxing an acid in the reaction mixture. ... | 10/17/2006 |
| 7078226 | Method for producing optically active amines A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active amines and optically active amides are described. ... | 07/18/2006 |
| 7067700 | Process for preparing sertraline hydrochloride polymorphic form II Sertraline hydrochloride, (1Scis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenaminehydrochloride, polymorph II is prepared by extracting or dissolving the sertraline base into ethyl acetate, adding isopropanol as a solvent, adding hydrogen chloride... | 06/27/2006 |
| 7030276 | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol A process for preparing 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol with high stereoselectivity and high yield by reacting 2-[(dimethylamino)methyl]-cyclohexanone in a Grignard reaction with a Grignard compound of 3-bromoanisole in a suitable solvent a... | 04/18/2006 |
| 7018538 | Use of a composite polymer-coated sorbent for separation, purification, desalting and concentration of biopolymers Use of a composite sorbent having an at least partial coating on a support, which coating comprises essentially polyanilines or derivatives of polyanilines for the separation, isolation, identification, purification and/or detection of biomolecules in particular nuc... | 03/28/2006 |
| 6939992 | Polymorphic forms of sertraline hydrochloride A crystalline form of sertraline hydrochloride was found, referred to hereinafter as polymorphic form CSC2 having a dissolution rate which surprisingly will increase rate of absorption of a drug. Furthermore, different crystalline forms of sertraline hydrochl... | 09/06/2005 |
| 6906087 | Crystalline forms of venlafaxine hydrochloride Crystalline forms of Venlafaxine hydrochloride were found, referred to hereinafter as polymorphic Forms A, B and D. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceutical compositions comprising ... | 06/14/2005 |
| 6897340 | Processes for preparation of polymorphic form II of sertraline hydrochloride Provided are processes for preparation of crystalline sertraline hydrochloride Form II substantilly free of other polymorphic forms of sertraline hydrochloride, preferably on an industrial scale. ... | 05/24/2005 |
| 6586634 | Process for the preparation on (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate Process for the preparation of (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate, in which in a solvent a mixture of enantiomers of cis-1-amino-2-indanol reacts at an elevated temperature with (R,R)-tartaric acid and methanol and in which opticall... | 07/01/2003 |
| 6547933 | Process for the purification of aromatic polyamines A process for the purification of a mixture of aromatic polyamines obtained by hydrogenation of the corresponding aromatic polynitro compounds, said mixture including the various isomers of the said amines as well as reaction by-products, including the st... | 04/15/2003 |
| 6538159 | -sulfin-and -sulfonamino acid amides The invention relates to -sulfin- and -sulfonamino acid amides of the general formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1 -C12... | 03/25/2003 |
| 6521792 | Process for separating the diastereomeric bases of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cylohexanol A method for separating the diastereomer bases of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol in which the separation of the diastereomer bases takes place through formation of a base hydrate.... | 02/18/2003 |
| 6469212 | Separation of 2,4-toluenediamine from an isomeric mixture of toluenediamines A mixture comprised of about 60-85% of 2,4-toluenediamine (2,4-TDA) and about 15-40% of 2,6-toluenediamine (2,6-TDA) is melted, the temperature of the mixture is lowered to a 2,4-TDA nucleation temperature, and the temperature of the mixture is gradually ... | 10/22/2002 |
| 6399829 | Synthesis and purification of (r*,r*)-2-[ (dimethylamino) methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride (R*,R*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product than is obtained in the absence of the additive. The Grignar... | 06/04/2002 |
| 6359177 | Process for separating mixtures of materials having different boiling points A mixture of materials having different boiling points is separated into fractions having different boiling points. The separated fraction containing the desired product is stripped using the vapors of a lower boiling fraction. The process of the present ... | 03/19/2002 |
| 6265615 | Chiral recognition polymer and its use to separate enantiomers A new polymeric material, a process for forming the material and method of using the material to separate enantiomers of chiral compounds, particularly amino acids and pharmaceuticals are disclosed. A polymeric material can be formed from polyaniline doped wit... | 07/24/2001 |
| 6118025 | Method for preparing optically active -substituted benzyl alcohols The invention concerns a method for preparing an optically active alcohol of formula (I) in which the carbon atom indicated by the symbol * can have the configuration (R) or (S) and X represents a non-substituted amino group or a mono- or di-(C1 | 09/12/2000 |
| 6060625 | Process for the production of etheramine alkoxylates A process for the alkoxylation of a polyetheramine to form an etheramine alkoxylate. In the process, a polyetheramine is reacted with an alkylene oxide in the presence of an alcohol to form the etheramine alkoxylate. The alcohol serves as a catalyst to al... | 05/09/2000 |
| 5969186 | Process for racemizing of optically active amines The present invention provides a process for effectively racemizing an amine compound in which an asymmetric carbon is located at the ଲ-position of the amino group or more distant therefrom, which comprises reacting the amine compound with a complex... | 10/19/1999 |
| 5905167 | Separation of optically active amides The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol... | 05/18/1999 |
| 5874620 | Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride The invention provides a process for the separation of (RR,SS) 2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol hydrochloride (RR,SS)-Tramadol!, from a mixture consisting of (RR,SS) Tramadol and (RS,SR)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cy... | 02/23/1999 |
| 5728880 | Process for the separation of high-boiling materials from the reaction mixture generated during the production of diaminotoluene Amine mixtures generated during the production of diaminotoluene by hydrogenating dinitrated aromatic compounds are treated to separate high boiling materials from the desired amine products. In this process, any water of reaction and any solvent are firs... | 03/17/1998 |
| 5723672 | Process for racemization of optically active 1-phenylethylamine derivative A process for racemization of an optically active 1-phenylethylamine derivative represented by formula (I): ##STR1## wherein R1 represents a phenyl group substituted at least at the ortho-position, which comprises reacting the optically ac... | 03/03/1998 |
| 5679857 | Method of preparing D-amino acid-N-(S)--alkylbenzylamide L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)--alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, w... | 10/21/1997 |
| 5672755 | Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts The invention provides a process for the purification and isolation of (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol from mixtures also containing the (RS,SR) isomer comprising reacting the above mixture in a solvent at elevated temperatur... | 09/30/1997 |
| 5616811 | Etheramine alkoxylates Etheramine alkoxylates are described which have the formula: ##STR1## where R1 is a straight or branched alkyl, aryl or alkylaryl group of 6 to 22 carbon atoms; R3 are independently hydrogen or C1 to C3 alk... | 04/01/1997 |
| 5516943 | Process for preparing cyclic CIS-1-amino-2-alkanols A two-step process for the conversion of a trans-1-amino-2-hydroxycycloalkane stereoselectively to a cis-1-amino-2-hydroxycycloalkane is disclosed. The novel step, a one-step hydrolysis with formal inversion, can be used to convert an amide of a tran... | 05/14/1996 |
| 5367073 | Asymmetric synthesis of ଲ-amino alcohols from chiral or achiral enamines The present invention relates to a process for the synthesis of chiral enantiomerically pure ଲ-amino alcohols which are extraordinarily important as therapeutic agents for the treatment of a variety of human disorders and as chiral auxiliaries in or... | 11/22/1994 |
| 5360724 | Process for the preparation of chiral 1-aryl-2-aminopropanes One chiral form of a 1-aryl-2-aminopropane is produced in preference to its enantiomer by allowing a 1-arylpropan-2-one to react with a 1-amino-1-phenylethane of predominantly one chiral form and reducing the resultant 1-(1-arylprop-2-ylideneimino)-1-phen... | 11/01/1994 |
| 5306826 | Process for preparation of an optically active amino acid amide The present invention relates to a process for the preparation of optically active amino acid amide. L-amino and D-amino acid amides are mixed in the presence of 0.5-4 equivalents of an aldehyde, relative to the quantity of amino acid amide, in the presen... | 04/26/1994 |
| 5177302 | Process for separating isomers of disubstituted benzenes and agents to be used therefor This invention is concerned with a process for separating isomers of disubstituted benzenes, wherein a mixture of isomers of disubstituted benzenes is contacted with a substituted cyclodextrin to form inclusion complexes, and desired isomers are recovered... | 01/05/1993 |
| 5082970 | Process for recycling amine isomer A novel process for converting trans-isomeric N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine to cis-isomeric N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine is disclosed. The process involves contacting tr... | 01/21/1992 |
| 4720583 | Process for the isomerization of o-, m- and/or p-toluidine The invention relates to a process for the isomerization of o-, m- or p-toluidine, or of a mixture of them, on a zirconium-containing zeolite catalyst of the pentasil type. Catalysts of this type are distinguished by particularly high activity and a long ... | 01/19/1988 |
| 4687871 | Process for the resolution of a racemate A racemate may be resolved into its enantiomers by stereoselective adsorption on a crystalline molecular sieve having an assymetric crystal structure for example zeolite ZSM11. The resolution may be assisted by the presence of an enantiomer of a compound ... | 08/18/1987 |
