Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7439400 | Amino alcohol ligand and its use in preparation of chiral proparglic tertiary alcohols and tertiary amines via enantioselective addition reaction The invention disclosed a new process of asymmetric alkynylation of ketone or ketimine, involving the chiral ligand-mediated asymmetric addition of zinc or copper acetylide to a trifluoromethyl ketone or ketimine intermediate to give a chiral tertiary proparglic alc... | 10/21/2008 |
| 7358399 | Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine A process is described for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine comprising substitution of the sulfonyloxy group of the compound of the formula in which the substituents R an... | 04/15/2008 |
| 7355077 | Process for preparing tolterodine A process for preparing tolterodine with high purity. ... | 04/08/2008 |
| 7338953 | Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. ... | 03/04/2008 |
| 7276503 | Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine, or a pharmaceutically acceptable salt thereof, to the individual... | 10/02/2007 |
| 7241762 | Method of treating peripheral neuropathy Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. ... | 07/10/2007 |
| 7220883 | Process for the preparation of primary amines Process for the preparation of primary amines of formula (I): where R3 represents an alkyl, cycloalkyl or aralkyl group, by reaction of a triazolium salt of formula (II): | 05/22/2007 |
| 7101888 | Oral liquid tolterodine composition A pharmaceutical composition in a form of an orally deliverable liquid comprises water having in solution therein a pharmaceutically acceptable water-soluble salt of a tolterodine related compound at a therapeutically effective concentration in the composition. The ... | 09/05/2006 |
| 7026515 | Optically active amine derivatives and preparation process therefor A readily available and inexpensive natural α-amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to give an optically active 5-hydroxyoxazolidine represented by formula... | 04/11/2006 |
| 7005449 | Tolterodine salts The present invention concerns novel pharmaceutically active compounds, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. The present invention also concerns a... | 02/28/2006 |
| 6888029 | Transition-metal-catalyzed carbon-nitrogen bond-forming methods using carbene ligands The present invention relates to a process for the preparation of N-aryl amine and N-aryl amide compounds. Generally, the process of the present invention involves reacting a compound having a primary or secondary amino or amido group with an arylating compound, in ... | 05/03/2005 |
| 6790996 | Supported cobalt catalysts for nitrile hydrogenations The invention relates to a process for preparing primary amines by hydrogenating nitrites in the presence of a catalyst comprising cobalt and optionally, in addition, nickel and also at least one further doping metal on a particulate support material, the cobalt and... | 09/14/2004 |
| 6657085 | Process for the preparation of aniline compounds A process for the preparation of aniline compounds of formula: ##STR1## wherein n and R are as defined in claim 1, by reacting nitro compounds of formula: ##STR2## wherein n and R are as defined, with hydrazine at elevated temperature in the prese... | 12/02/2003 |
| 6649800 | Process for the preparation of polyalkylphenoxyaminoalkanes An improved process for the preparation of polyalkylphenoxyaminoalkanes which comprises the aminoethylation of a polyalkylphenol compound in the presence of a basic catalyst with 2-oxazolidinone or a derivative thereof having the following formula: #... | 11/18/2003 |
| 6646150 | Processes for producing (aminomethyl)trifluorocarbinol derivatives The present invention provides a process for industrially producing (aminomethyl)trifluoromethylcarbinol derivatives, in particularly, optically active compounds thereof, which are useful as starting compounds for drugs such as protease inhibitors, etc.... | 11/11/2003 |
| 6541668 | Methods for preparing 3-arloxy-3-arylpropylamines and intermediates thereof The present invention provides processes for the preparation of 3-aryloxy-3-arylpropylamines and intermediates thereof using an nucleophilic aromatic displacement in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone.... | 04/01/2003 |
| 6528687 | Ruthenium complexes and their use in asymmetric hydrogenation A process for the preparation of an enantiomerically enriched chiral amine of formula (10), or the opposite enantiomer thereof, from an inline of formula (11) ##STR1## wherein (i) R1 is aryl, R2 is alkyl and R3 is aryl or ... | 03/04/2003 |
| 6521564 | Modification of a hydrogenation catalyst A process for the modification of a hydrogenation catalyst of the Raney nickel, Raney cobalt, nickel-on-carrier or cobalt-on-carrier type, which process includes treating the hydrogenation catalyst at temperatures of about 0° C. to about 120° C. with ca... | 02/18/2003 |
| 6307067 | Palladium and boron co-catalyzed addition of oxygen nucleophiles to vinyl epoxides Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 1,2-diols and oxygen-containing h... | 10/23/2001 |
| 6225501 | Optically active 2-aminotetraline, process for its preparation and pharmaceutical compositions containing same, active in preventing and treating septic shock S(-)-amino-6-fluoro-7-methoxytetraline, a process for its preparation and pharmaceutical compositions containing same, active in preventing and treating septic shock, are disclosed.... | 05/01/2001 |
| 6040480 | Asymmetric synthesis of benzoxazinones The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) re... | 03/21/2000 |
| 6028225 | Method of making hydroxy-substituted hydroxylamines and color developers containing same Hydroxy-substituted hydroxylamine antioxidants can be prepared by reacting hydroxylamine or a mono-substituted hydroxylamine, in free base form, with an epoxide. The antioxidant reaction product can be used without isolation from the reaction solution, an... | 02/22/2000 |
| 5922914 | Process to prepare tolterodine Disclosed is a novel intermediate, 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-ol (IV) ##STR1## and an improved process for the preparation of tolterodine.... | 07/13/1999 |
| 5817875 | Methods for the manufacture of terbinafine Process for the manufacture of naphthylmethylamine derivatives and among them terbinafine as potential antimycotic agents.... | 10/06/1998 |
| 5801280 | Processes for preparing optically active alcohols and optically active amines A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which... | 09/01/1998 |
| 5780686 | Process for preparing 4-oxa-amines A process for preparing 4-oxa-amines comprising reacting 1,3-dioxanes with ammonia and hydrogen in the presence of hydrogenation catalysts.... | 07/14/1998 |
| 5739402 | Process for the preparation of mixtures of isomers of O-phenoxy-alkylhydroxylamines or O-phenoxyalkyloximes Preparation of mixtures of O-phenoxyalkylhydroxylamines Ia and Ib ##STR1## and the corresponding salt mixtures by a) converting mixtures of isomers of O-(2-hydroxyethyl)oximes IIa and IIb ##STR2## with a sulfonyl halide III ##STR3## in... | 04/14/1998 |
| 5521317 | Processes for the preparation of pesticides and intermediates There is disclosed a process for the preparation of an indanylamine compound of general formula ##STR1## wherein R1 represents an optionally substituted alkyl group, and R2, R3 and R4 independently represen... | 05/28/1996 |
| 5486609 | Preparation of carbocylic M-aminohydroxyaromatics A process for preparing carbocyclic m-aminohydroxyaromatics comprises reacting the corresponding o-- or m-halohydroxyaromatics or metal salts thereof with primary or secondary amines in the presence of a base and in the presence or absence of a diluent.... | 01/23/1996 |
| 5420353 | Regiospecific process to make cis-1-amino-2-alkanol from epoxide A regioselective process is disclosed for synthesis of 1R-amino-2S-indanol or 1S-amino-2R-indanol, wherein the stereochemical integrity of the carbon-oxygen bond at C-2 in the indene oxide starting material is retained.... | 05/30/1995 |
| 5410081 | Process for the preparation of amino-substituted thioethers Compounds of the formula (I) ##STR1## are prepared by reacting 2-mercaptoethanol with compounds of the general formula (II) ##STR2## the substituents having the definition given in the description.... | 04/25/1995 |
| 5344990 | Process for the preparation of a renin inhibiting compound Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sul... | 09/06/1994 |
| 5274135 | Process for preparing aminobenzocyclobutenes A process for preparing a 3- or 4-aminobenzocyclobutene comprises aminating a 3- or 4-halo- or sulfonyloxybenzocyclobutene reactant with an aminating agent by heating at a temperature from about 80° C. to a temperature at which dimerization or oligomeriz... | 12/28/1993 |
| 5214169 | N-(2,3-epoxycyclopentyl) carbamate derivatives The present invention as directed to a new class of N-(2,3-epoxycyclopentyl) carbamate derivatives as described by Formula V below, that are useful as chemical intermediates in the production of a new class of anti-hypertensives: ##STR1##... | 05/25/1993 |
| 5145958 | Process for the preparation of 2,4- or 2,6-dihalogeno-aniline 2,4- or 2,6-dihalogeno-aniline can be prepared by reacting an amino-benzoic acid ester of the formula ##STR1## in which R1, R2 and R3 have the meanings indicated in the description, with 2-2.5 moles of a chlorinating ... | 09/08/1992 |
| 5097029 | Process for preparing 2,3-dihydro-1,3-dialkyl-2,3-dialkyl perimidines and N,N-'-dialkyl-1,8-naphthalene diamines Processes for preparing 2,3-dihydro-1,3-dialkyl-2,2-dialkyl perimidines and N,N'-dialkyl-1,8-naphthalene diamines are disclosed. The 2,3-dihydro-1,3-dialkyl-2,2-dialkyl perimidines are prepared by alkylating 2,3-dihydro-2,2-dialkyl perimidines with an alk... | 03/17/1992 |
| 4992575 | Process for the preparation of N,N'-dimethyl aromatic diamines, intermediates and products N,N'-dimethyl aromatic diamines are prepared from the corresponding diprimary amines via a two step synthesis forming first the corresponding di-succinylimidomethylamine and then reductively cleaving the succinylimido group. The products are useful, e.g.,... | 02/12/1991 |
| 4973757 | Process for the preparation of nitroanilines The invention relates to a process for the preparation of nitroanilines, which consists in reacting an amine RNH2, or ammonia, with 3,4-methylenedioxynitriobenzene to give the products of the formula: ##STR1## in which R denotes hydrogen, ... | 11/27/1990 |
| 4910341 | Process for preparing N,N'-disubstituted nitro-para-phenylenediamines, N,N'-disubstituted nitro-para-phenylenediamines, and intermediate oxazolidones The present invention relates to a process for preparing a N,N'-disubstituted nitro-para-phenylenediamine (I) according to the following scheme: ##STR1## X denoting a halogen and R a lower alkyl, lower mono- or polyhydroxyalkyl, lower alkoxyalky... | 03/20/1990 |
| 4888445 | New 2,4-dinitro- or 2-amino-4-nitro- or 2-nitro-4-amino-6-hydroxyalkylanilines, the process for preparation thereof and their use in dyeing keratinous fibres, and especially human hair The invention relates to a compound of formula ##STR1## in which: X denotes a branched or unbranched alkylene radical containing 2 to 6 carbon atoms, optionally being able to be substituted with one or more hydroxyl radicals; R denotes a hydrogen ato... | 12/19/1989 |
