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Class 564/367 - The chain contains nitrogen between the aryl ring or ring system and amino nitrogen


Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein an additional amino nitrogen is part of
No. of patents: 183
Last issue date: 07/12/2011


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NumberTitleIssue Date
7977512Amine derivative, and production method and use thereof
Disclosed is a benzonitrile derivative which is useful as a production intermediate for benzylamine derivative represented by the general formula (5) below and s secondary amine derivative represented by the general formula (9) below. Also disclosed are a method for...
07/12/2011
7371459Electrical devices having an oxygen barrier coating
An electrical device includes two electrodes and a conductive polymer layer, containing a mixture of a polymer and a conductive filler, separating the electrodes. A oxygen barrier material containing a thermosetting polymer component is present on the exposed surfac...
05/13/2008
7179926Aryloxyalkylamine NK-1/SSRI inhibitors
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.
02/20/2007
7060851Method of preparing retroviral protease inhibitor intermediates
Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtai...
06/13/2006
7045550Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
Polyamine effectors are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more polyamine effectors formulated fo...
05/16/2006
7022882NMDA receptor channel blocker with neuroprotective activity
Neuroprotectant agents are provided which do not contain peptides and axe protected from the degradation that limits the use of peptide-based drugs in systemic circulation. With great selectivity for NMDA receptors, the agents exert an open channel block on NMDA rec...
04/04/2006
7012047Amine reaction compounds comprising one or more active ingredient
The present invention relates to a product of reaction between an amino functional polymer comprising at least one primary and/or secondary amine and one or more active ingredient. By the present invention, there is provided a release of the active component over a ...
03/14/2006
7001925Compounds and method for enhancing the efficacy of anti-cancer drugs
Polyamine compounds, method of synthesis and method of use for anti-cancer purposes, and for enhancing the activity of existing anti-cancer drugs are provided. This disclosure has identified certain polyamine motifs that can be attached to toxic agents to facilitate...
02/21/2006
6900243Phenylheteroalkylamine derivatives
There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their pre...
05/31/2005
6872852Polyamine analogues as cytotoxic agents
Cytotoxic polyamine analogues are provided that are useful for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury. ...
03/29/2005
6849760Method of preparing retroviral protease inhibitor intermediates
Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtai...
02/01/2005
6768024Triamine derivative melanocortin receptor ligands and methods of using same
The invention provides triamine derivative melanocortin receptor ligands of the formula: wherein R1 to R8 and n have the meanings provided herein. The invention further provides methods of using the...
07/27/2004
6649587Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as c...
11/18/2003
6576793댢-adrenergic receptor agonists
Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p...
06/10/2003
6521667Calcilytic compounds
The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial e...
02/18/2003
6514297Detergents for use in preventing formation of iron complexes in hydrocarbon fuels
An improved detergent for use in hydrocarbon fuels comprising the composition produced by mixing (1) the Mannich reaction product of a polyisobutene-substituted phenol, (preferably, where the polyisobutene from which the substituted phenol is derived cont...
02/04/2003
6472426Sterically hindered tetraamines and method for their production
Polyamines having the formula: ##STR1## wherein R1 and R2 are alkyl, aralkyl or aryl having up to 10 carbon atoms; and a and b may be the same or different and are integers from 1 to 8; or a salt thereof with a pharmaceutically accep...
10/29/2002
6455591Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
Anti-diarrheal, anti-secretory, nitric oxide agonist, nitric oxide synthase activating or gastrointestinal anti-spasmodic compounds of the formula: ##STR1## R1 --N1 H--(CH2)3 --N2 H--(C2)
09/24/2002
6441238N-(aminopropyl)-toluenediamines and their use as epoxy curing agents
The invention provides N-aminopropylated toluenediamines, processes for synthesizing them, compositions containing them and methods for using them to cure epoxy resins. In preferred embodiments, the N-aminopropylated toluenediamines are represented by the...
08/27/2002
6413987Dermal anesthetic agents
The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as dermal and topical anesthetics in mammals, including man, as w...
07/02/2002
6329523Compounds having a plurality of nitrogenous substitutents
Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear grou...
12/11/2001
6270539Mannich dispersants with enhanced lubricity
Reaction products of i) a compound containing at least one primary or secondary amine group and at least one hydroxyl group; ii) a polyamine containing at least two amine groups wherein at least one of the amine groups is a primary or secondary amine, and...
08/07/2001
6147262Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
A compound having the formula: ##STR1## wherein: R1 -R6 may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; exclud...
11/14/2000
6024768Diaminoalkane and oxidation colorants
A diaminoalkane of general formula (I) in which R1 to R10 stand independently of each other for hydrogen, a (C1 -C4)-alkyl group, a hydroxy-(C2 -C3)-alkyl group, a (C1 -C4
02/15/2000
60180692-isoxazoline derivative and process for producing the same and process for producing related derivatives from the same
A purified acid addition salt of a (2S, 3S, 5S)-2,5-diamino-1,6-diphenyl-3-hydroxyhexane, e.g., (2S, 3S, 5S)-2-tert-butoxycarbonylamino-3-hydroxy-5-amino-1,6-diphenylhexane, is obtained from its mixture, in an arbitrary ratio, with its (2S, 3S, 5R) s...
01/25/2000
59945582-isoxazoline derivative and process for producing the same; and process for producing related derivatives from the same
The invention provides methods for preparing a 2-isoxazoline compound represented by formula (1) and a 2,5-diamino-1,6-diphenyl-3-hydroxyhexane compound obtainable by reducing the 2-isoxazoline compound and represented by formula (6): ##STR1## w...
11/30/1999
5976202Reaction products of polyolefins with vinyl esters and their use as fuel and lubricant additives
Reaction products of polyolefins having predominantly a terminal double bond and a number average molecular weight of from 250 to 10,000, which possess an aliphatic hydrocarbon skeleton which is straight-chain or carries C1 -C4 -alky...
11/02/1999
5973205Process for the preparation of 1, 3-diaminopropane derivatives and intermediates useful in this process
A process for preparing a compound of formula (I) or an addition salt thereof and/or a solvate thereof: ##STR1## wherein R1, R2, R4 and R5 are each independently C1-4 alkoxy and R3 is ...
10/26/1999
5922744Ethane-1-2-diamine derivatives and tachykinin antagonists
The present invention provides a compound of formula: ##STR1## wherein R, R1, R2, R3, R4, R5, R6a and R6b are defined herein or a pharmaceutically acceptable salt thereof, a...
07/13/1999
58746182-nitro-para-phenylenediamines substituted by sulphur in the 5-position, the process for their preparation, dyeing compositions in which they are present and their use in the dyeing of keratin fibers
Novel nitrobenzene compounds of the nitroparaphenylene-diamine type substituted by sulphur in the 5-position are disclosed. These compounds are intended especially for the dyeing of keratin fibers and in particular human hair. A process for their preparat...
02/23/1999
5808003Polyaminocarboxylate chelators
A compound according to the formula: ##STR1## and conjugates thereof....
09/15/1998
5756475Isoprene derivatives
Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3, n is an integer of 5 to 12, A is cyclo(C3 -C6)alkylene, phenylene, fluorenylene, pyrrolidinylene, piperazinylene, 9-aza-3-oxabicyclo›3.3.1!-nonylene, R
05/26/1998
57537152-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use....
05/19/1998
5753714Polyamine derivatives
This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of parasitic protozoa....
05/19/1998
5686609Aromatic amine compounds, Their method of preparation and pharmaceutical compositions in which they are present
The invention relates to compounds of the formula ##STR1## in which: m is 2 or 3; Ar and Ar' independently are a thienyl group; a substituted or unsubstituted phenyl group; or an imidazolyl group; it also being possible for Ar' to be a benzothienyl g...
11/11/1997
5677351Sterically hindered tetraamines and method for their production
Polyamines having the formula: ##STR1## wherein R1 and R2 are alkyl, aralkyl or aryl having up to 10 carbon atoms; and a and b may be the same or different and are integers from 1 to 8; or a salt thereof with a pharmaceutically ...
10/14/1997
5674909Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system
Compounds of formula ##STR1## wherein R, R', R", R1, R2, R3, R4, R5, R6, X, Y, m, n and p have the meanings reported in the description; and their pharmaceutically acceptable salts are desc...
10/07/1997
5633407Process for preparing substituted aromatic amines
A process for preparing substituted aromatic azo compounds is provided which comprises contacting a nucleophilic compound and an azo containing compound in the presence of a suitable solvent system, and reacting the nucleophilic compound and the azo conta...
05/27/1997
5618979Process for preparing substituted aromatic amines
A process for preparing substituted aromatic amines which comprises contacting a nucleophilic compound and a substituted aromatic azo compound in the presence of a suitable solvent system, and reacting the nucleophilic compound and the substituted aromati...
04/08/1997
5578685Curing component for epoxy resins comprising Mannich base from alkylated polyhydroxy aromatic
Curing components containing amino groups for curing epoxy resins are obtained by the reaction of alkylated polyhydroxy aromatics (A) with polyamines (B) and aldehydes (C) by the mechanism of the Mannich reaction. The preparation of curable mixtures and v...
11/26/1996
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