A simulation environment for the sport of boxing utilizing a robotic machine interface system which carries a person.
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| Number | Title | Issue Date |
| 7977512 | Amine derivative, and production method and use thereof Disclosed is a benzonitrile derivative which is useful as a production intermediate for benzylamine derivative represented by the general formula (5) below and s secondary amine derivative represented by the general formula (9) below. Also disclosed are a method for... | 07/12/2011 |
| 7371459 | Electrical devices having an oxygen barrier coating An electrical device includes two electrodes and a conductive polymer layer, containing a mixture of a polymer and a conductive filler, separating the electrodes. A oxygen barrier material containing a thermosetting polymer component is present on the exposed surfac... | 05/13/2008 |
| 7179926 | Aryloxyalkylamine NK-1/SSRI inhibitors The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both. | 02/20/2007 |
| 7060851 | Method of preparing retroviral protease inhibitor intermediates Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtai... | 06/13/2006 |
| 7045550 | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy Polyamine effectors are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more polyamine effectors formulated fo... | 05/16/2006 |
| 7022882 | NMDA receptor channel blocker with neuroprotective activity Neuroprotectant agents are provided which do not contain peptides and axe protected from the degradation that limits the use of peptide-based drugs in systemic circulation. With great selectivity for NMDA receptors, the agents exert an open channel block on NMDA rec... | 04/04/2006 |
| 7012047 | Amine reaction compounds comprising one or more active ingredient The present invention relates to a product of reaction between an amino functional polymer comprising at least one primary and/or secondary amine and one or more active ingredient. By the present invention, there is provided a release of the active component over a ... | 03/14/2006 |
| 7001925 | Compounds and method for enhancing the efficacy of anti-cancer drugs Polyamine compounds, method of synthesis and method of use for anti-cancer purposes, and for enhancing the activity of existing anti-cancer drugs are provided. This disclosure has identified certain polyamine motifs that can be attached to toxic agents to facilitate... | 02/21/2006 |
| 6900243 | Phenylheteroalkylamine derivatives There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their pre... | 05/31/2005 |
| 6872852 | Polyamine analogues as cytotoxic agents Cytotoxic polyamine analogues are provided that are useful for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury. ... | 03/29/2005 |
| 6849760 | Method of preparing retroviral protease inhibitor intermediates Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtai... | 02/01/2005 |
| 6768024 | Triamine derivative melanocortin receptor ligands and methods of using same The invention provides triamine derivative melanocortin receptor ligands of the formula: wherein R1 to R8 and n have the meanings provided herein. The invention further provides methods of using the... | 07/27/2004 |
| 6649587 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as c... | 11/18/2003 |
| 6576793 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p... | 06/10/2003 |
| 6521667 | Calcilytic compounds The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial e... | 02/18/2003 |
| 6514297 | Detergents for use in preventing formation of iron complexes in hydrocarbon fuels An improved detergent for use in hydrocarbon fuels comprising the composition produced by mixing (1) the Mannich reaction product of a polyisobutene-substituted phenol, (preferably, where the polyisobutene from which the substituted phenol is derived cont... | 02/04/2003 |
| 6472426 | Sterically hindered tetraamines and method for their production Polyamines having the formula: ##STR1## wherein R1 and R2 are alkyl, aralkyl or aryl having up to 10 carbon atoms; and a and b may be the same or different and are integers from 1 to 8; or a salt thereof with a pharmaceutically accep... | 10/29/2002 |
| 6455591 | Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment Anti-diarrheal, anti-secretory, nitric oxide agonist, nitric oxide synthase activating or gastrointestinal anti-spasmodic compounds of the formula: ##STR1## R1 --N1 H--(CH2)3 --N2 H--(C2) | 09/24/2002 |
| 6441238 | N-(aminopropyl)-toluenediamines and their use as epoxy curing agents The invention provides N-aminopropylated toluenediamines, processes for synthesizing them, compositions containing them and methods for using them to cure epoxy resins. In preferred embodiments, the N-aminopropylated toluenediamines are represented by the... | 08/27/2002 |
| 6413987 | Dermal anesthetic agents The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as dermal and topical anesthetics in mammals, including man, as w... | 07/02/2002 |
| 6329523 | Compounds having a plurality of nitrogenous substitutents Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear grou... | 12/11/2001 |
| 6270539 | Mannich dispersants with enhanced lubricity Reaction products of i) a compound containing at least one primary or secondary amine group and at least one hydroxyl group; ii) a polyamine containing at least two amine groups wherein at least one of the amine groups is a primary or secondary amine, and... | 08/07/2001 |
| 6147262 | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives A compound having the formula: ##STR1## wherein: R1 -R6 may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; exclud... | 11/14/2000 |
| 6024768 | Diaminoalkane and oxidation colorants A diaminoalkane of general formula (I) in which R1 to R10 stand independently of each other for hydrogen, a (C1 -C4)-alkyl group, a hydroxy-(C2 -C3)-alkyl group, a (C1 -C4 | 02/15/2000 |
| 6018069 | 2-isoxazoline derivative and process for producing the same and process for producing related derivatives from the same A purified acid addition salt of a (2S, 3S, 5S)-2,5-diamino-1,6-diphenyl-3-hydroxyhexane, e.g., (2S, 3S, 5S)-2-tert-butoxycarbonylamino-3-hydroxy-5-amino-1,6-diphenylhexane, is obtained from its mixture, in an arbitrary ratio, with its (2S, 3S, 5R) s... | 01/25/2000 |
| 5994558 | 2-isoxazoline derivative and process for producing the same; and process for producing related derivatives from the same The invention provides methods for preparing a 2-isoxazoline compound represented by formula (1) and a 2,5-diamino-1,6-diphenyl-3-hydroxyhexane compound obtainable by reducing the 2-isoxazoline compound and represented by formula (6): ##STR1## w... | 11/30/1999 |
| 5976202 | Reaction products of polyolefins with vinyl esters and their use as fuel and lubricant additives Reaction products of polyolefins having predominantly a terminal double bond and a number average molecular weight of from 250 to 10,000, which possess an aliphatic hydrocarbon skeleton which is straight-chain or carries C1 -C4 -alky... | 11/02/1999 |
| 5973205 | Process for the preparation of 1, 3-diaminopropane derivatives and intermediates useful in this process A process for preparing a compound of formula (I) or an addition salt thereof and/or a solvate thereof: ##STR1## wherein R1, R2, R4 and R5 are each independently C1-4 alkoxy and R3 is ... | 10/26/1999 |
| 5922744 | Ethane-1-2-diamine derivatives and tachykinin antagonists The present invention provides a compound of formula: ##STR1## wherein R, R1, R2, R3, R4, R5, R6a and R6b are defined herein or a pharmaceutically acceptable salt thereof, a... | 07/13/1999 |
| 5874618 | 2-nitro-para-phenylenediamines substituted by sulphur in the 5-position, the process for their preparation, dyeing compositions in which they are present and their use in the dyeing of keratin fibers Novel nitrobenzene compounds of the nitroparaphenylene-diamine type substituted by sulphur in the 5-position are disclosed. These compounds are intended especially for the dyeing of keratin fibers and in particular human hair. A process for their preparat... | 02/23/1999 |
| 5808003 | Polyaminocarboxylate chelators A compound according to the formula: ##STR1## and conjugates thereof.... | 09/15/1998 |
| 5756475 | Isoprene derivatives Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3, n is an integer of 5 to 12, A is cyclo(C3 -C6)alkylene, phenylene, fluorenylene, pyrrolidinylene, piperazinylene, 9-aza-3-oxabicyclo3.3.1!-nonylene, R | 05/26/1998 |
| 5753715 | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.... | 05/19/1998 |
| 5753714 | Polyamine derivatives This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of parasitic protozoa.... | 05/19/1998 |
| 5686609 | Aromatic amine compounds, Their method of preparation and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: m is 2 or 3; Ar and Ar' independently are a thienyl group; a substituted or unsubstituted phenyl group; or an imidazolyl group; it also being possible for Ar' to be a benzothienyl g... | 11/11/1997 |
| 5677351 | Sterically hindered tetraamines and method for their production Polyamines having the formula: ##STR1## wherein R1 and R2 are alkyl, aralkyl or aryl having up to 10 carbon atoms; and a and b may be the same or different and are integers from 1 to 8; or a salt thereof with a pharmaceutically ... | 10/14/1997 |
| 5674909 | Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system Compounds of formula ##STR1## wherein R, R', R", R1, R2, R3, R4, R5, R6, X, Y, m, n and p have the meanings reported in the description; and their pharmaceutically acceptable salts are desc... | 10/07/1997 |
| 5633407 | Process for preparing substituted aromatic amines A process for preparing substituted aromatic azo compounds is provided which comprises contacting a nucleophilic compound and an azo containing compound in the presence of a suitable solvent system, and reacting the nucleophilic compound and the azo conta... | 05/27/1997 |
| 5618979 | Process for preparing substituted aromatic amines A process for preparing substituted aromatic amines which comprises contacting a nucleophilic compound and a substituted aromatic azo compound in the presence of a suitable solvent system, and reacting the nucleophilic compound and the substituted aromati... | 04/08/1997 |
| 5578685 | Curing component for epoxy resins comprising Mannich base from alkylated polyhydroxy aromatic Curing components containing amino groups for curing epoxy resins are obtained by the reaction of alkylated polyhydroxy aromatics (A) with polyamines (B) and aldehydes (C) by the mechanism of the Mannich reaction. The preparation of curable mixtures and v... | 11/26/1996 |