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| Number | Title | Issue Date |
| 8093429 | Fluoroamine having perfluoroalkyl group, process for producing the same, method of fluorination therewith, and method of recovering amide having perfluoroalkyl group Provided are a fluorous-tag-introduced fluoroamine of a general formula (I), its production method, a method of fluorination of a substrate having functional group containing oxygen with the fluoroamine serving as a fluorinating agent, and a method of recovering a f... | 01/10/2012 |
| 7351863 | Method of fluorination A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcoho... | 04/01/2008 |
| 7288678 | Process for preparing terbinafine by using platinum as catalyst A process for the preparation of terbinafine, comprising the reaction of a compound of formula (II), or a salt thereof, wherein X is a leaving group, with tert-butylacetylene, in the presence of a platinum catalyst ... | 10/30/2007 |
| 7196226 | Fluoraminoolefins and fluorination reagents which can be prepared therefrom The present invention relates to fluorination reagents comprising 1-fluoro-1-aminoolefins and also processes for preparing fluorination reagents comprising 1-fluoro-1-aminoolefins. ... | 03/27/2007 |
| 7186864 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, or a tautomer, ... | 03/06/2007 |
| 7064236 | Substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds The invention relates to substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds, to a method for the production thereof, to medicaments containing said compounds and to their use in the production of medicaments. ... | 06/20/2006 |
| 6784175 | Use of substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compounds as medicaments The use of at least one substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compound and/or one of the enantiomers thereof and/or one of the diastereomers thereof and/or one of the physiologically acceptable salts thereof for producing a medi... | 08/31/2004 |
| 6765022 | Cyclohexylamine derivatives as subtype selective nmda receptor antagonists Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel complexes useful for treating... | 07/20/2004 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6586633 | Amine derivatives The present invention relates to amine derivatives represented by formula (1) or salts thereof. ##STR1## R3 represents C1-C3 alkyl, hydroxylated C1-C5 alkyl, C1-C5 acyl; C2-C5 alkenyl, or a halogen atom; and k, l, and m are each an integer of 1... | 07/01/2003 |
| 6495685 | Process for preparing piperazine derivatives A process for preparing a piperazine derivative represented by the formula (V): ##STR1## comprising reacting 1-methyl-3-phenylpiperazine with 2-chloro-3-cyanopyridine in an aprotic polar organic solvent in the presence of a base and an alkali metal h... | 12/17/2002 |
| 6485799 | Aniline derivatives, liquid-crystal composition containing the same, and liquid-crystal display element A aniline derivative represented by general formula (1) ##STR1## wherein R and R' represent independently each other alkyl with 1 to 10 carbon, alkoxyalkyl with 1 to 10 carbon, or hydrogen; x represents cyano, halogen, haloalkyl, haloalkyloxy, or 2-cyanoe... | 11/26/2002 |
| 6451792 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.... | 09/17/2002 |
| 6441237 | Substituted 3-phenoxy- and 3-phenylalkyloxy-2-phenyl-propylamines The present patent application relates to new substituted 3-phenoxy- or 3-phenylalkyloxy-2-phenyl-propylamines of general formula 1, processes for preparing them and their use as pharmaceutical compositions. ##STR1##... | 08/27/2002 |
| 6057371 | Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of c... | 05/02/2000 |
| 6011068 | Calcium receptor-active molecules The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can m... | 01/04/2000 |
| 5977413 | Method for producing bis(3-amino-4-hydroxyphenyl) compounds Disclosed is a method for producing bis(3-amino-4-hydroxyphenyl) compounds, which comprises reducing bis(3-nitro-4-hydroxyphenyl) compounds with hydrazines in the presence of a catalyst. The method produces bis(3-amino-4-hydroxyphenyl) compounds of high q... | 11/02/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5939588 | Asymmetric fluorine-containing primary amines and their preparation The present invention, which is aimed at providing a novel reaction for converting a fluorine-containing carbonyl compound to an asymmetric fluorine-containing primary amine, relates to a method in which a Schiff base obtained by the condensation of a flu... | 08/17/1999 |
| 5679854 | Process for the preparation of (epsilon)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane and novel intermediate thereof The present invention relates to a novel process for preparing (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, also known in the art as (E)-(p-fluorophenethyl)-3-fluoroallylamine, novel intermediates thereof, a novel process for the preparing ... | 10/21/1997 |
| 5639895 | Process for producing ଲ-nitroenamine Disclosed is a process for producing ଲ-nitroenamine represented by the formula I: ##STR1## wherein R1 and R2 are the same or different and independently indicate a hydrogen atom or a C1 -C10 alkyl gro... | 06/17/1997 |
| 5639906 | Fluorescent and NMR sensitive pH indicators This invention relates to compositions and methods useful for measuring pH generally, and intracellular pH specifically, and, more particularly, to a new class of fluorescent and fluorinated (NMR sensitive) aromatic compounds having excitation emission wa... | 06/17/1997 |
| 5550291 | Process for key intermediates for HIV protease inhibitors Disclosed herein is a stereospecific synthesis amenable to the large scale preparation of a hydrochloric acid addition salt of a chlorohydrin of the formula ##STR1## wherein R1 and R2 are amino protective groups and R3 | 08/27/1996 |
| 5539120 | Arylalkyl-amines having anticonvulsant and neuroprotective properties There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar1 and Ar2, which may be the s... | 07/23/1996 |
| 5508280 | 5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists This invention relates to novel derivatives of 5H-dibenzo (a,d)cycloheptenes, to the processes for their preparation, to their muscarinic receptor antagonist properties and to their end-use application for treating Parkinson's Disease, tardive dyskinesia,... | 04/16/1996 |
| 5380850 | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, a... | 01/10/1995 |
| 5356893 | Benzanilide derivatives The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt or solvate thereof wherein R1 represents a halogen or hydrogen atom or a C1-6 alkyl or C1-6 alkoxy group; R2 re... | 10/18/1994 |
| 5296612 | Process for producing enyne derivatives A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a co... | 03/22/1994 |
| 5274118 | Process for preparing (2R)-methyl-4,4,4-trifluorobutylamine A process for the preparation of (2R)-methyl-4,4,4-trifluorobutylamine, or an acid addition salt thereof which comprises a) acylating an optically active amine with 2-methyl-4,4,4-trifluorobutanoic acid or a reactive derivative thereof to afford a butyram... | 12/28/1993 |
| 5234680 | Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI The present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group f... | 08/10/1993 |
| 5231183 | Process for producing enyne derivatives A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane.epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a co... | 07/27/1993 |
| 5166439 | Composition containing a mannich base of a partially sulfurized hindered phenol mixture A sulfurized, phenolic antioxidant having a low chlorine content and good copper corrosion properties is prepared by reacting a partially sulfurized mixture of reactive, hindered phenols with formaldehyde or formaldehyde and an amine.... | 11/24/1992 |
| 5095057 | Halobenzyl polyamines and polymers made flame retardant therewith A new class of compounds, is disclosed, defined by the formula: R'2 N(CH2 CH2 NR")y R where R, R' and R" are equal or different and are ##STR1## wherein x is bromine or chlorine, n is an integer from 3 to 5 inclusive... | 03/10/1992 |
| 5086074 | 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes Compounds of the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R2 is selected from hydroxy and lower alkoxy, R5 is lower alkyl, and R11 and R12 are independently selected from hydro... | 02/04/1992 |
| 4960938 | Preparing 2-chlorobenzylamine from 2-chlorobenzylchloride via 2-chlorobenzylphthalimide 2-Chlorobenzylamine is prepared from 2-chlorobenzylchloride in a two-step process. In the first step, 2-chlorobenzylchloride is reacted with alkali metal phthalimide, preferably formed in situ from potassium carbonate and phthalimide, to form the novel in... | 10/02/1990 |
| 4853141 | Polyfluorinated amino alcohols and their esters, preparation of these compounds and their use as lubricant additives The invention relates to new polyfluorinated compounds which are usable as anti-wear additives for lubricants. These compounds are of general formula: ##STR1## in which RF is a perfluoroalkyl radical, R1 and R3 each d... | 08/01/1989 |
| 4847295 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation The invention relates to cycloalkyl substituted 4-aminophenyl halo derivatives of formula (I) ##STR1## wherein n is an integer of 1 to 5; A is >C.dbd.O or --CH2 -- and B is, independently, --O--, --NH-- or --CH2 --; and either R... | 07/11/1989 |
| 4847303 | Tert-butylphenyl compounds useful as anti-inflammatory agents The present invention involves compounds having the structure: ##STR1## wherein: (a) --A1 is selected from the group consisting of --OH, --H, and --O2 CR; (b) --A2 is selected from the group consisting of unsubstituted or ... | 07/11/1989 |
| 4832859 | Lubricants and new polyfluorinated compounds which can be used as additives In order to improve the wear resistance properties of lubricants, at least one compound of the following formula is incorporated therein: ##STR1## Rf is a perfluorinated radical, a=0 to 10, b=0 or 1 (if a=o and c=1), c=1 to 4 (2 if a.noteq.0), m=0 or 1, n... | 05/23/1989 |
| 4808625 | Phenanthrene derivatives The present invention relates to compounds of formula (I) or a monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a ... | 02/28/1989 |
