Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 7745665 | Substituted phenethylamines Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. ... | 06/29/2010 |
| 7465831 | Levalbuterol hydrochloride Polymorph A The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D... | 12/16/2008 |
| 7335753 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using... | 02/26/2008 |
| 7135500 | Dihydroxymethylphenyl derivatives, processes for preparing them, and their use as pharmaceuticals A compound of formula 1 wherein the groups R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, and thei... | 11/14/2006 |
| 7091196 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents,... | 08/15/2006 |
| 7084165 | Monoamine reuptake inhibitors for treatment of CNS disorders The present invention relates to compounds that are useful exhibit activity as serotonin, norepinephrine and dopamine reuptake inhibitors, and their pharmaceutically acceptable salts, and their use in the treatment of central nervous system and other disorders. ... | 08/01/2006 |
| 6995286 | Process for preparing isomers of salbutamol A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving a racemic or optically impure mixture of enantiomers of salbutamol o... | 02/07/2006 |
| 6964963 | Preparation of 4-amino-1-naphthol ethers The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl g... | 11/15/2005 |
| 6900203 | Optically active fluorinated vasoconstrictors, methods for making them, and anesthetic formulations comprising them (R)-6F-phenylephrine, essentially free of (S)-6F-phenylephrine, and an anesthetic formulation comprising (R)-6F-epinephrin or (R)-6F-phenylephrine and having improved stability compared to formulations containing their non-fluorinated analog, are disclosed. Further ... | 05/31/2005 |
| 6825382 | Trifluoromethylepinephrine compounds and methods of making and using thereof Disclosed herein are trifluoromethylepinephrine compounds having the following structural formula (I) wherein R1-R5 are each independently selected from the group consisting of H, alkyl, alkoxyl, ... | 11/30/2004 |
| 6730792 | β3 adrenergic agonists The present invention relates to a β3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II diabetes and/or obe... | 05/04/2004 |
| 6653323 | Aryl aniline 댢 adrenergic receptor agonists The invention provides novel 댢 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 댢 | 11/25/2003 |
| 6576793 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p... | 06/10/2003 |
| 6521667 | Calcilytic compounds The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial e... | 02/18/2003 |
| 6362371 | 댢- adrenergic receptor agonists The present invention is directed to multibinding compounds which are 댢 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the... | 03/26/2002 |
| 5654331 | Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics Diaromatic compounds, characterised in that they correspond to the following general formula: ##STR1## in which: R1 is --CH3, --CH2 OH, --COR8 or --CH2 OCOR9, R8 is H, OH, -... | 08/05/1997 |
| 5545745 | Enantioselective preparation of optically pure albuterol The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of methyl 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-(phenylmethoxy)benzoate or -[[(1,1-dimethylethyl)amino]methyl]-4-(phenylmethoxy... | 08/13/1996 |
| 5538999 | Medicament inhalation device and formulation A compacted body of powdered medicament for use in a device for the administration by inhalation of a medicament in powdered form. The compacted body is made by compressing a loose powder containing the medicament in powdered form under pressure to create... | 07/23/1996 |
| 5527821 | Pharmacologically active alpha-[tertiary-aminomethyl]-benzenemethanol derivatives | 06/18/1996 |
| 5449694 | (-)-ritodrine, therapeutic compositions and use, and method of preparation (-)-Ritodrine, that is (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-propan ol or a salt thereof substantially free from the (+)-isomer is disclosed. The compound has a strong suppressive effect on uterine contraction in comparis... | 09/12/1995 |
| 5442118 | Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones A method for the enantioselective reduction of an -iminoketone to an -aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole as the catalyst. The method is applied to the s... | 08/15/1995 |
| 5399765 | Enantioselective preparation of optically pure albuterol The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-hydroxybenzoate using ditoluoyltartaric acid.... | 03/21/1995 |
| 5296612 | Process for producing enyne derivatives A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a co... | 03/22/1994 |
| 5243076 | Phenethanolamine derivatives Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R1 | 09/07/1993 |
| 5235103 | Process for the preparation of phenylethanolaminotetralins A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and Ro is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy... | 08/10/1993 |
| 5231183 | Process for producing enyne derivatives A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane.epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a co... | 07/27/1993 |
| 5204468 | Substituted 4,5,6,7-tetrahydrothiens[2,3-C]pyridine compounds This invention provides the single species (-)-(S)-4-(3,4-dihydroxyphenyl)-7, 8-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride hydrate, which is useful as a nephrovascular dilator.... | 04/20/1993 |
| 5198586 | Process for the preparation of phenylethanolaminotetralins A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R° is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, wh... | 03/30/1993 |
| 5198587 | Phenethylamine derivatives Phenethylamine derivatives shown by the general formula ##STR1## wherein Ro represents a lower alkyl group; R1 represents a lower alkyl group or a lower alkoxy group; R2 represents hydrogen atom or a hydroxyl group; R3 | 03/30/1993 |
| 5171753 | Derivatives of 2-amino-1-phenylethanol having antiulcer activity Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted phenyl and C is a linking group or terminal group. T... | 12/15/1992 |
| 5130339 | Phenylethanolaminomethyltetralins and pharmaceutical use New phenylethanolaminomethyltetralins of formula (I) ##STR1## wherein E represents hydrogen, (C1 -C4)alkyl, (C1 -C4)alkoxy, phenyl, nitro, halogen, or trifluoromethyl, L represents hydrogen, (C1 -C | 07/14/1992 |
| 5126375 | Phenethanolamine derivatives Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R1 | 06/30/1992 |
| 5124334 | Benzylalcohol phospholipase A2 inhibitors The invention relates to benylalcohol phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by administration of a therapeutically effective... | 06/23/1992 |
| 5105017 | Leukotriene antagonist intermediates This invention provides novel benzene derivatives which are leukotriene antagonists, formulations of those derivatives, intermediates for preparing the derivatives, and a method of using those derivatives for the treatment of conditions characterized by a... | 04/14/1992 |
| 5066678 | Phenethandamine derivatives and pharmaceutical use thereof The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof; wherein; R1 and R2 each independently represent a hydrogen atom or a C1-3 -alkyl group with ... | 11/19/1991 |
| 5047433 | N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline and pharmaceutical compositions having antihypertensive activity containing same N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline having general formula (I) ##STR1## wherein R is selected from hydrogen, ethyl, n-propyl and methyl cyclopropyl; R1 is selected from hydrogen, hydroxy and --OR3 wherein R | 09/10/1991 |
| 4952729 | Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydr... | 08/28/1990 |
| 4906781 | Method for the preparation of 4'-(substituted)-amino-2-(substituted) amino-3',5'-dichloroacetophenone and salts thereof A method for the preparation of 4'-(substituted)-amino-2-(substituted)amino-3',5'-dichloroacetophenone and salts thereof. The method involves the chlorination of the corresponding 4'-(substituted)amino-2-(substituted) aminoacetophenone and acid addition ... | 03/06/1990 |
| 4876261 | Substituted tetrahydroisoquinoline compounds and composition containing them A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## wherein ##STR2## represents the formula ##STR3## (wherein R4 is ... | 10/24/1989 |
| 4754047 | Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and/or improving the efficiency of feed utilization thereby There is provided a method for enhancing the growth rate of meat-producing animals and/or improving the efficiency of feed utilization thereby, which involves, orally or parenterally, administering to said animals a growth-enhancing amount of a phenyletha... | 06/28/1988 |
