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| Number | Title | Issue Date |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 6900203 | Optically active fluorinated vasoconstrictors, methods for making them, and anesthetic formulations comprising them (R)-6F-phenylephrine, essentially free of (S)-6F-phenylephrine, and an anesthetic formulation comprising (R)-6F-epinephrin or (R)-6F-phenylephrine and having improved stability compared to formulations containing their non-fluorinated analog, are disclosed. Further ... | 05/31/2005 |
| 6825231 | Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising them Substituted norbornylamino derivatives having exo-configured nitrogen and an endo-fused... | 11/30/2004 |
| 6586633 | Amine derivatives The present invention relates to amine derivatives represented by formula (1) or salts thereof. ##STR1## R3 represents C1-C3 alkyl, hydroxylated C1-C5 alkyl, C1-C5 acyl; C2-C5 alkenyl, or a halogen atom; and k, l, and m are each an integer of 1... | 07/01/2003 |
| 6576793 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p... | 06/10/2003 |
| 5962737 | 2-amino-1-phenylpropanols, stereospecific synthesis thereof, and method of optically resolving the same Stereospecific synthesis of the racemic threo isomers of 2-nitro-1-phenylpropanols by reacting a benzaldehyde derivative with nitroalkane in the presence of a tertiary amine and reducing 2-nitro-1-phenylpropanols with, for example, lithium aluminum hydrid... | 10/05/1999 |
| 5773617 | Deallylation reagent and deallylation method using said reagent The present invention relates to a reagent and to a process which are useful, when carrying out an organic synthesis, for cleaving an allylic group from a function which is protected with the latter. This reagent is defined in that it contains: a) a solvent sy... | 06/30/1998 |
| 5527830 | Drugs for the treatment of cardiac arrest and other shock states The invention relates to new drugs for augmenting perfusion pressure administered during cardiopulmonary resuscitation and other shock states. The compounds include phenylethanolamines and imidazolines, and fluorinated derivatives thereof, which act on ad... | 06/18/1996 |
| 5449694 | (-)-ritodrine, therapeutic compositions and use, and method of preparation (-)-Ritodrine, that is (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-propan ol or a salt thereof substantially free from the (+)-isomer is disclosed. The compound has a strong suppressive effect on uterine contraction in comparis... | 09/12/1995 |
| 5338884 | Method for the preparation of arylalkanolamineacylates Acylamides or amine acylate salts of arylalkanolamines are prepared by reacting an arylisonitrosoalkanone with hydrogen and a carboxylic acid, carboxylic acid anhydride or carboxylic acid ester or mixture thereof in the presence of a transition metal cata... | 08/16/1994 |
| 5283262 | Phenethanolamine derivatives The invention provides compounds of the general formula (I) ##STR1## or a physiologically acceptable salt or solvate thereof, wherein Q represents a 1- or 2-naphthalenyl group. The compounds have a stimulant action at 댢 -adrenoreceptors ... | 02/01/1994 |
| 5198587 | Phenethylamine derivatives Phenethylamine derivatives shown by the general formula ##STR1## wherein Ro represents a lower alkyl group; R1 represents a lower alkyl group or a lower alkoxy group; R2 represents hydrogen atom or a hydroxyl group; R3 | 03/30/1993 |
| 5171753 | Derivatives of 2-amino-1-phenylethanol having antiulcer activity Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted phenyl and C is a linking group or terminal group. T... | 12/15/1992 |
| 5109023 | Phenethanolamine derivatives The invention provides a method of treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis, utilizing the compounds of the formula ##STR1## or a physiological acceptable salt or solvate thereof, wher... | 04/28/1992 |
| 5099068 | Phenethanolamine derivatives The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof, wherein AR represents the group ##STR2## where Q1 represents a straight or branched C1-3 alkyl... | 03/24/1992 |
| 5096929 | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them 5,6-Dimethoxy-2-[2-(4-hydroxyphenyl)-2-hydroxy-2-methylethyl]amino- 1,2,3,4-tetrahydronaphthalene has inotropic and vasodilating activities and therefore can be used in the treatment of cardiocirculatory failure. The compound can be in the form of a singl... | 03/17/1992 |
| 5095017 | 1,2-dihydropyrido(3,4,-b)pyrazines as fungicides 1,2-dihydropyrido[3,4-b]pyrazines are provided which possess antimitotic activity. The compounds have the structure: ##STR1## wherein R is a lower alkyl group and OR1 is a member selected from the group consisting of aryl-alkyl ethers havi... | 03/10/1992 |
| 5047433 | N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline and pharmaceutical compositions having antihypertensive activity containing same N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline having general formula (I) ##STR1## wherein R is selected from hydrogen, ethyl, n-propyl and methyl cyclopropyl; R1 is selected from hydrogen, hydroxy and --OR3 wherein R | 09/10/1991 |
| 4997986 | Phenethanolamine derivatives The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof, wherein Ar represents the group ##STR2## where Q1 represents a straight or branched C1-3 alkyle... | 03/05/1991 |
| 4918231 | Process for the production of 1,2-amino alcohols A process for the production of 1,2-amino alcohols, in improved yields, comprising the steps of: (1) reacting a silylated cyanohydrin compound with a Grignard reagent; (2) treating the reaction product of Step 1 with either a reducing agent, or an organolithiu... | 04/17/1990 |
| 4880841 | Process of producing phenethylamine derivatives Phenethylamine derivatives shown by the general formula ##STR1## wherein Ro represents a lower alkyl group; R1 represents a lower alkyl group or a lower alkoxy group; R2 represents hydrogen atom or a hydroxyl group; R3 | 11/14/1989 |
| 4835179 | Antiulcer dihydrodibenzocycloheptyliden-ethylamine derivatives and process for the preparation of these compounds Dihydrodibenzocycloheptyliden-ethylene derivatives of the general formula: ##STR1## in which, R1 represents an alkyl group having from 1 to 4 carbon atoms; R2 represents a hydrogen atom or an alkyl group having from 1 to 4 carbo... | 05/30/1989 |
| 4820717 | Antimicrobial aromatic derivatives substituted by an (omega amino) alkanol group and compositions containing them The present invention relates to new aromatic derivatives of formula: ##STR1## wherein: Alk is an alkylene group with 1 to 10 carbon atoms, R1 is hydrogen or an alkyl with 1 to 6 carbon atoms, R2 and R3 are similar or different... | 04/11/1989 |
| 4806667 | Promoting production of useful livestock with silylated aminophenylethylamine derivatives A method for promoting production of useful livestock comprising administering to such livestock an amount effective therefor of a monosilylated aminopheylethylamine derivative of the formula ##STR1## in which X and Y are identical or different and r... | 02/21/1989 |
| 4777294 | N-substituted pseudo-aminosugars, their production and use A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydroc... | 10/11/1988 |
| 4701559 | N-substituted pseudo-aminosugars, their production and use A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydroc... | 10/20/1987 |
| 4695589 | Alpha-(aminoalkyl-4-hydroxy-3-(alkylthio)benzenemethanols Alpha-(aminoalkyl)-4-hydroxy-3-(alkylthio)benzenemethanols useful as intermediates and as antihypertensive agents are prepared by reduction of the corresponding aminoalkyl 4-hydroxy-3-(alkylthio)phenyl ketones.... | 09/22/1987 |
| 4661635 | Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives Acetylenes of the formula (I): ##STR1## wherein Y, m, R1, R2 q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of fo... | 04/28/1987 |
| 4542159 | Cycloaliphatic ketoamines There are prepared compounds of the formula: ##STR1## wherein X is the group >C.dbd.O or >CH(OH), Y is the group ##STR2## R2 is hydrogen or C1 to C6 alkyl, R3 is hydrogen or a hydroxy group and R1... | 09/17/1985 |
| 4486602 | Valienamine derivatives, their production and use A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group; or a cyclic hydroc... | 12/04/1984 |
| 4374149 | -{[(Arylalkyl)amino]alkyl}-4-hydroxy-3-(lower-alkylsul finyl)benzenemethanols The instant invention is directed to -(aminoalkyl)-4-hydroxy-3-(alkylsulfinylbenzenemethanols and to a method of utilizing the compounds for reducing blood pressure in mammals.... | 02/15/1983 |
| 4327224 | -[(alkylamino)alkyl]-4-hydroxy-3-(alkylthio)benzenemethanols, derivatives thereof and intermediates therefor Alpha-[(lower alkylamino)alkyl]-4-hydroxy-3-(alkylthio, akylsulfinyl or alkylsulfonyl)benzenemethanols which have ଲ-adrenergic blocking activity and which are therefore useful in controlling tachycardia are prepared by reduction of the corresponding... | 04/27/1982 |
| 4302456 | Process for therapeutic treatment This invention relates to a new method of therapy comprising the administration of a pro-drug to a human or animal, said pro-drug being a compound formed by a therapeutic compound chemically combined with another moiety by a photocleavable bond and irradi... | 11/24/1981 |
| 4282251 | Trans-n-cinnamyl-n-methyl-(1-naphthylmethyl)amine Cinnamylalkyl-1-naphthylmethylamines, useful as antimycotic agents, and processes for their production.... | 08/04/1981 |
| 4277420 | Ephedrine and pseudoephedrine precursors Preparation of novel prochiral olefinic compounds which can be asymmetrically hydrogenated to enantiomers, which are converted to ephedrine and pseudoephedrine by described procedures.... | 07/07/1981 |
| 4275074 | Catecholamine treatment of ocular hypertension Ocular hypertension can be treated by the topical administration of ophthalmic compositions that contain as the active ingredient an -methyl derivative of epinephrine or norepinephrine.... | 06/23/1981 |
| 4275219 | Novel process and intermediates useful in the preparation of sympathomimetic amines The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) ca... | 06/23/1981 |
| 4261890 | Substituted tetrahydrobenzazepines and tetrahydronaphthazepines and methods for their production Substituted tetrahydrobenzazepines and tetrahydronaphthazepines which are useful as pharmacological agents, especially in the treatment of cardiac arrhythmias, are disclosed. These compounds can be prepared by cyclizing an appropriately substituted (... | 04/14/1981 |
| 4237304 | Oxazolinium salts and method of preparation 1-Aryl-1-hydroxy-2-methylaminopropanes are rearranged from the erythro isomer to the threo isomer by the process of (1) forming the O,N-diacyl derivative of the arylpropanolamine; (2) reacting the product of step (1) with an anhydrous or substantially anh... | 12/02/1980 |
| 4137328 | Phenyl-alkanolamine, alkylamine and -aminoalkyl ketone derivatives as heart stimulants Novel substituted 1-phenyl-2-alkylamino-alkanols, 1-phenyl-2-alkylaminoalkanes and -aminoalkyl phenyl ketones useful as heart stimulants are disclosed.... | 01/30/1979 |
