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| Number | Title | Issue Date |
| 7402698 | Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia,... | 07/22/2008 |
| 7214826 | Amine compounds and inhibiting neurotransmitter reuptake The invention relates to amine compounds as well as methods and materials involved in modulating neurotransmitter reuptake. Specifically, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotransmitter re... | 05/08/2007 |
| 7166611 | Pharmaceutical compositions having appetite suppressant activity A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1... | 01/23/2007 |
| 7087765 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 08/08/2006 |
| 7064236 | Substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds The invention relates to substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds, to a method for the production thereof, to medicaments containing said compounds and to their use in the production of medicaments. ... | 06/20/2006 |
| 6995286 | Process for preparing isomers of salbutamol A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving a racemic or optically impure mixture of enantiomers of salbutamol o... | 02/07/2006 |
| 6700018 | Amine compounds and inhibiting neurotransmitter reuptake The invention relates to amine compounds as well as methods and materials involved in modulating neurotransmitter reuptake. Specifically, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotra... | 03/02/2004 |
| 6653508 | 3-amino-2-benzyl-1-phenylpropane derivatives Substituted 3-amino-2-benzyl-1-phenlypropane derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat various medical conditions.... | 11/25/2003 |
| 6586633 | Amine derivatives The present invention relates to amine derivatives represented by formula (1) or salts thereof. ##STR1## R3 represents C1-C3 alkyl, hydroxylated C1-C5 alkyl, C1-C5 acyl; C2-C5 alkenyl, or a halogen atom; and k, l, and m are each an integer of 1... | 07/01/2003 |
| 6576793 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p... | 06/10/2003 |
| 6545053 | Tricyclic compounds and drug compositions containing same Compounds having a ଲ-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts thereof, and a process for producing these, and thei... | 04/08/2003 |
| 6528686 | Processes for producing optically active 2-amino-1-phenylethanol derivatives An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) ##STR1## wherein R1 and R5 represent a hydrogen atom, etc.; R2, R3 and R4 independently represent a halogen atom, etc., or ... | 03/04/2003 |
| 6495685 | Process for preparing piperazine derivatives A process for preparing a piperazine derivative represented by the formula (V): ##STR1## comprising reacting 1-methyl-3-phenylpiperazine with 2-chloro-3-cyanopyridine in an aprotic polar organic solvent in the presence of a base and an alkali metal h... | 12/17/2002 |
| 6458817 | Substituted arylsulfides, arylsulfoxides and arylsulfones as beta-3 adrenergic receptor agonists This invention provides compounds of Formula I having the structure ##STR1## wherein R1, R2, R3, R4, R5, R6, Y, Z, m, n, ##STR2## and are as defined hereinbefore or a pharmaceutically acceptable... | 10/01/2002 |
| 6420613 | Process for preparing reductants of unsaturated organic compounds by the use of trichlorosilane and reducing agents A method of preparing a reduced product by efficiently reducing an unsaturated organic compound by using, as a reducing agent, a trichlorosilane which is industrially cheaply available and is easy to handle, and a reducing agent therefor. A reduced produc... | 07/16/2002 |
| 6211245 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hyproxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognit... | 04/03/2001 |
| 6114582 | Processes for producing optically active 2-amino-1-phenylethanol derivatives An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) ##STR1## wherein R1 and R5 represent a hydrogen atom, etc.; R2, R3 and R4 independently represent a halogen atom, etc.... | 09/05/2000 |
| 6008412 | Process to make chiral compounds The present invention relates to processes for resolving N-methyl-3(R,S)-hydroxy-3-phenylpropylamine and N,N-dimethyl-3 (R,S) -hydroxy-3-phenylpropylamine with the isomers of mandelic acid and the resulting salts.... | 12/28/1999 |
| 5545745 | Enantioselective preparation of optically pure albuterol The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of methyl 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-(phenylmethoxy)benzoate or -[[(1,1-dimethylethyl)amino]methyl]-4-(phenylmethoxy... | 08/13/1996 |
| 5527821 | Pharmacologically active alpha-[tertiary-aminomethyl]-benzenemethanol derivatives | 06/18/1996 |
| 5519062 | 1-alkyl, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fu... | 05/21/1996 |
| 5442118 | Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones A method for the enantioselective reduction of an -iminoketone to an -aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole as the catalyst. The method is applied to the s... | 08/15/1995 |
| 5283359 | Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereof The preparation of arylethanolamines, and in particular albuterol (salbutamol), together with their novel boron, acetal and hemi-acetal intermediates is described.... | 02/01/1994 |
| 5283262 | Phenethanolamine derivatives The invention provides compounds of the general formula (I) ##STR1## or a physiologically acceptable salt or solvate thereof, wherein Q represents a 1- or 2-naphthalenyl group. The compounds have a stimulant action at 댢 -adrenoreceptors ... | 02/01/1994 |
| 5248823 | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosme... | 09/28/1993 |
| 5235103 | Process for the preparation of phenylethanolaminotetralins A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and Ro is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy... | 08/10/1993 |
| 5198586 | Process for the preparation of phenylethanolaminotetralins A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R° is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, wh... | 03/30/1993 |
| 5198587 | Phenethylamine derivatives Phenethylamine derivatives shown by the general formula ##STR1## wherein Ro represents a lower alkyl group; R1 represents a lower alkyl group or a lower alkoxy group; R2 represents hydrogen atom or a hydroxyl group; R3 | 03/30/1993 |
| 5189219 | Method for the preparation of erythro vicinal amino-alcohols The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resul... | 02/23/1993 |
| 5171753 | Derivatives of 2-amino-1-phenylethanol having antiulcer activity Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted phenyl and C is a linking group or terminal group. T... | 12/15/1992 |
| 5130339 | Phenylethanolaminomethyltetralins and pharmaceutical use New phenylethanolaminomethyltetralins of formula (I) ##STR1## wherein E represents hydrogen, (C1 -C4)alkyl, (C1 -C4)alkoxy, phenyl, nitro, halogen, or trifluoromethyl, L represents hydrogen, (C1 -C | 07/14/1992 |
| 5128479 | Oxidized diphenylheteroalkanes Oxidized diphenylheteroalkanes of the formula I ##STR1## where R1 to R6 and A have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as... | 07/07/1992 |
| 5124334 | Benzylalcohol phospholipase A2 inhibitors The invention relates to benylalcohol phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by administration of a therapeutically effective... | 06/23/1992 |
| 5109023 | Phenethanolamine derivatives The invention provides a method of treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis, utilizing the compounds of the formula ##STR1## or a physiological acceptable salt or solvate thereof, wher... | 04/28/1992 |
| 5047433 | N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline and pharmaceutical compositions having antihypertensive activity containing same N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline having general formula (I) ##STR1## wherein R is selected from hydrogen, ethyl, n-propyl and methyl cyclopropyl; R1 is selected from hydrogen, hydroxy and --OR3 wherein R | 09/10/1991 |
| 5017619 | Phenethanolamine derivatives The invention is directed to phenethanolamine derivatives and their pharmaceutically compatible salts, having the formula ##STR1## wherein n is the number 1 or 2; L1 and L2 are hydrogen, C1-3 -(alkyl)carbonyl or C | 05/21/1991 |
| 4935409 | Aminophenylethylamine yield promoters Animal growth promoters of the formula ##STR1## The intermediates of the formula ##STR2## are also new.... | 06/19/1990 |
| 4918231 | Process for the production of 1,2-amino alcohols A process for the production of 1,2-amino alcohols, in improved yields, comprising the steps of: (1) reacting a silylated cyanohydrin compound with a Grignard reagent; (2) treating the reaction product of Step 1 with either a reducing agent, or an organolithiu... | 04/17/1990 |
| 4908386 | Ethanolamine derivatives The present invention provides compounds of general formula (I) ##STR1## wherein Ar represents an unsubstituted or substituted phenyl gorup; R1 and R2 each represents a hydrogen atom or a C1-3 alkyl group; X represents a b... | 03/13/1990 |
| 4883804 | Aromatic compounds There are described compounds of formula I, ##STR1## in which X represents a C2 to 8 alkylene chain optionally interrupted by a double bond or by S(O)n, wherein n is 0, 1 or 2; Y represents O or NH, l and m each independently represent 2, 3 or ... | 11/28/1989 |
