Class 564/361 - Plural hydroxy groups bonded directly to the aryl ring or ring system (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)

Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the aryl ring or ring system has more
No. of patents: 44
Last issue date: 10/28/2008

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Number	Title	Issue Date
7442839	Phenethanolamine derivative for the treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis an...	10/28/2008
7087765	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits...	08/08/2006
6951888	Betamimetics with a prolonged duration of activity, processes for preparing them, and their use as pharmaceutical compositions A compound of formula 1 wherein: R1 is C1-C4-alkyl; R2 is C1-C4-alkyl; and R3 is C1-C4-alkyl or phenyl, each optionally...	10/04/2005
6784175	Use of substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compounds as medicaments The use of at least one substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compound and/or one of the enantiomers thereof and/or one of the diastereomers thereof and/or one of the physiologically acceptable salts thereof for producing a medi...	08/31/2004
6730792	β3 adrenergic agonists The present invention relates to a β3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II diabetes and/or obe...	05/04/2004
6653508	3-amino-2-benzyl-1-phenylpropane derivatives Substituted 3-amino-2-benzyl-1-phenlypropane derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat various medical conditions....	11/25/2003
6576793	댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p...	06/10/2003
6495722	Mannich polyols for rigid spray foams Provided herein are polyurethane foams which may be prepared by spray techniques. The foams of the invention are prepared using conventional isocyanates and a novel Mannich condensate polyol having a hydroxy number in the range of 250-340 and a viscosity ...	12/17/2002
6410791	Nitric esters and nitrate salts of specific drugs A nitrate salt of a compound selected from the group consisting of: salbutamol having the formula (I) ##STR1##...	06/25/2002
6211245	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hyproxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognit...	04/03/2001
6057371	Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of c...	05/02/2000
5962737	2-amino-1-phenylpropanols, stereospecific synthesis thereof, and method of optically resolving the same Stereospecific synthesis of the racemic threo isomers of 2-nitro-1-phenylpropanols by reacting a benzaldehyde derivative with nitroalkane in the presence of a tertiary amine and reducing 2-nitro-1-phenylpropanols with, for example, lithium aluminum hydrid...	10/05/1999
5910513	Substituted benzyl derivatives of polyalkylene polyamines and their use in cosmetic and pharmaceutical compositions A compound being a substituted benzyl derivative of polyalkylene polyamine and corresponding to the following formula: ##STR1## in which: n and m=2, 3 or 4, p=2 or 3, x=0, 1 or 2, R1 and R4, which may be identical or different, ...	06/08/1999
5775329	Method and compounds for diagnosing coronary artery disease The present invention relates generally to methods of diagnosis, evaluation and treatment of coronary artery disease in mammals using substituted catecholamines and compounds therefore. It also relates to the preparation, use and administration of these c...	07/07/1998
5750575	Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy...	05/12/1998
5686609	Aromatic amine compounds, Their method of preparation and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: m is 2 or 3; Ar and Ar' independently are a thienyl group; a substituted or unsubstituted phenyl group; or an imidazolyl group; it also being possible for Ar' to be a benzothienyl g...	11/11/1997
5538999	Medicament inhalation device and formulation A compacted body of powdered medicament for use in a device for the administration by inhalation of a medicament in powdered form. The compacted body is made by compressing a loose powder containing the medicament in powdered form under pressure to create...	07/23/1996
5482523	Mannich condensation products of poly(oxyalkylene) hydroxyaromatic ethers and fuel compositions containing the same Mannich condensation products prepared by the condensation of a compound of the formula: ##STR1## wherein R1 is hydrogen, hydroxy, lower alkyl or lower alkoxy; R3 and R4 are independently hydrogen or lower alkyl; R	01/09/1996
5468854	Characterization of specific drug receptors with fluorescent ligands Conjugates of fluorescent labels with specific, selective, and high affinity ligands for receptors have been synthesized and used to directly measure binding to receptors. In the examples, fluorescein conjugates of the high-affinity benzodiazepine recepto...	11/21/1995
5442118	Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones A method for the enantioselective reduction of an ଱-iminoketone to an ଱-aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole as the catalyst. The method is applied to the s...	08/15/1995
5395970	1-(3,4-dihydroxyphenyl)-2-(4-(4-hydroxyphenyl)butaylamino)ethanol Methods and devices for the diagnosis, evaluation and treatment of coronary artery disease (CAD) by means of a closed-loop drug delivery system that delivers an exercise simulating agent, including novel exercise simulating agents which elicit both acute ...	03/07/1995
5252575	Antiviral purine derivatives with improved gastrointestinal absorption Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R1 is hydrogen or hydroxy; and R2 is C1-6 alkyl; which are pro-drugs for 9-(3-hydroxyprop-1-oxy)guanine having antiviral activity, a ...	10/12/1993
5143938	Propanamines, their pharmacological properties and their application for therapeutic in particular antidiarrheal, purposes A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted, or is a 5- or 6-membered monocyclic heteroaryl radical in which the single heteroatom is nitrogen, oxygen or sulfur...	09/01/1992
5066678	Phenethandamine derivatives and pharmaceutical use thereof The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof; wherein; R1 and R2 each independently represent a hydrogen atom or a C1-3 -alkyl group with ...	11/19/1991
5023378	Amine derivatives The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable acid addition salts, metabolically labile esters and solvates thereof in which R1 represents a halogen atom or a methyl, ethyl, n-propyl or n-bu...	06/11/1991
4755599	3-phenyl-2-propeneamine derivatives, their preparation and composition containing them The invention provides compounds of formula: ##STR1## in which R=H, halogen, alkyl, alkyloxy, alkythio, NH2, alkylamino, dialkylamino or CF3, R3 =H or alkyl, either R4 and R5 =H and R1 and ...	07/05/1988
4725602	Acetylene amines and their use as vasodilators and antihypertensives Acetylenes of the following formula (I): ##STR1## wherein Y, m, R1, R2, R3, n and R4 are defined herein and R5 is hydrogen, alkyl, cycloalkyl or substituted alkyl are useful vasodilators and anti...	02/16/1988
4661635	Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives Acetylenes of the formula (I): ##STR1## wherein Y, m, R1, R2 q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of fo...	04/28/1987
4582649	Phenolamines Compounds of formula I ##STR1## in which R1 is an aliphatic C6-22 residue R2 is an optionally substituted salicyl group each R3, independently, is H or an optionally substituted salicyl group n is 0 or an intege...	04/15/1986
4453007	Method for increasing the purity of amphoteric compound compositions Provided is a method of increasing the purity of amphoteric compound compositions. The method is: (a) providing an amount of a crude amphoteric compound composition, (b) using a portion of the crude composition to prepare in solution a cationic salt of th...	06/05/1984
4408074	Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride A process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride is described by reacting 2,6-dimethoxyphenol with anhydrous chloral in the presence of a catalyst, hydrolyzing 1-(3,5-dimethoxy-4-hydroxyphenyl)2,2,2-trichl...	10/04/1983
4396627	Secondary amines, their preparation and use in pharmaceutical compositions Compounds having the formula: ##STR1## where R1, R2, R3, R4, R5, Y and X are as defined hereinbelow, are useful for the reduction of abnormally high blood glucose and lipid levels in the treatmen...	08/02/1983
4284587	Radioenzymatic assay of catecholamines A new radioenzymatic assay for catecholamines utilizing the catechol-O-methyl transferase transfer of a methyl group from a labeled methyl donor to the catecholamines followed by isolation of the O-methylated(3 H)catecholamine and the subsequen...	08/18/1981
4276304	Novel benzylalcohol derivative and process for preparing the same A benzylalcohol derivative of the formula: ##STR1## wherein R is hydroxy, benzyloxy, alkoxy of one to 4 carbon atoms or halogen, and Ring A is monomethoxyphenyl, dimethoxyphenyl, trimethoxyphenyl or 3,4-methylenedioxyphenyl is prepared by reducing a ...	06/30/1981
4169108	5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols Aminoalkylnaphthols and esters thereof, useful as cardiotonic agents, prepared from the corresponding RO-naphthalenealkylamines, certain of which are also useful as cardiotonic agents, are disclosed....	09/25/1979
4137328	Phenyl-alkanolamine, alkylamine and ଱-aminoalkyl ketone derivatives as heart stimulants Novel substituted 1-phenyl-2-alkylamino-alkanols, 1-phenyl-2-alkylaminoalkanes and ଱-aminoalkyl phenyl ketones useful as heart stimulants are disclosed....	01/30/1979
4131686	Novel benzylalcohol derivatives and processes for preparing the same A compound of the formula: ##STR1## wherein R is lower alkyl, may be prepared, for example, by reducing a compound of the formula: ##STR2## wherein R is same as above. Other methods for preparing the compound [I] are also disclosed. The com...	12/26/1978
4108989	2,3,4,5-Tetrahydro-1H-3-benzazepine-7,8-diones Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful pr...	08/22/1978
4051186	Amino-propranolol Biologically active substances having labile aryl groups can be converted to the corresponding aryl amine derivatives. The biologically active substances are reacted with a diazonium compound which optionally can be linked to a solid, inorganic carrier su...	09/27/1977
4021485	N,N'-bis-[(ଲ-hydroxy-ଲ-phenyl)-ethyl]-polymethylenediamines and salts thereof Compounds of the formula ##STR1## WHEREIN R1 is hydrogen or methyl, m is 0 or an integer from 1 to 8, inclusive, and Ar is ##STR2## WHERE R is hydrogen or acyl, and R2 is hydrogen or --OR, as defined above, ##STR3## ...	05/03/1977

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Class 564/361 - Plural hydroxy groups bonded directly to the aryl ring or ring system (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)