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| Number | Title | Issue Date |
| 8063250 | Crystal forms of O-desmethylvenlafaxine fumarate Provided are crystalline forms of O-desmethylvenlafaxine fumarate, methods for their preparation, and pharmaceutical compositions thereof. ... | 11/22/2011 |
| 7402673 | Diamine βadrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 07/22/2008 |
| 7244725 | Acetyl 2-hydroxy-1, 3-diaminoalkanes Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and RC are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase en... | 07/17/2007 |
| 7138547 | Antitumoral compounds New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, CN, halogen, C(═... | 11/21/2006 |
| 7087765 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 08/08/2006 |
| RE39072 | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or ... | 04/18/2006 |
| 7022882 | NMDA receptor channel blocker with neuroprotective activity Neuroprotectant agents are provided which do not contain peptides and axe protected from the degradation that limits the use of peptide-based drugs in systemic circulation. With great selectivity for NMDA receptors, the agents exert an open channel block on NMDA rec... | 04/04/2006 |
| 6963012 | Diaryl ether derivative, addition salt thereof, and immunosuppressant The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): | 11/08/2005 |
| 6960678 | Silanol enzyme inhibitors Compounds of formula (I, II or III), wherein X is OH; Y is OH, H, lower alkyl of one to six carbons or heteroatoms or F; Z and Z′ are independently H, lower alkyl or Q3Si where Q is lower alkyl or aryl; n is 3-50; n′ is 2-50; A and B are independently... | 11/01/2005 |
| 6951888 | Betamimetics with a prolonged duration of activity, processes for preparing them, and their use as pharmaceutical compositions A compound of formula 1 wherein: R1 is C1-C4-alkyl; R2 is C1-C4-alkyl; and R3 is C1-C4-alkyl or phenyl, each optionally... | 10/04/2005 |
| RE38793 | Spisulosine compounds The present invention is directed to the isolation and bioactive characterization of compounds isolated from the clam Spisula polynyma. These compounds include three sphingoid-type bases, spisulosines 285, 299 and 313 (1-3), each of which shows unique cytotoxicity a... | 09/06/2005 |
| 6916960 | Diol-functionalized antioxidant and process for preparation thereof Diol-functionalized antioxidants and the process for the preparation thereof are disclosed and have the general formula (I): wherein: R1 is tert-butyl and R2 is C1 to C | 07/12/2005 |
| 6906087 | Crystalline forms of venlafaxine hydrochloride Crystalline forms of Venlafaxine hydrochloride were found, referred to hereinafter as polymorphic Forms A, B and D. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceutical compositions comprising ... | 06/14/2005 |
| 6878721 | Beta2-adrenoceptor agonists Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2... | 04/12/2005 |
| 6765022 | Cyclohexylamine derivatives as subtype selective nmda receptor antagonists Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel complexes useful for treating... | 07/20/2004 |
| 6762307 | Method for the preparation of citalopram The present invention relates to a method for the preparation of citalopram or any of its enantiomers and acid addition salts thereof comprising reaction of a compound of formula II with a diene having the formula | 07/13/2004 |
| 6717015 | Venlafaxine besylate Venlafaxine besylate compounds provide certain advantages over venlafaxine hydrochloride and are useful in forming pharmaceutical compositions and n treating venlafaxine-treatable diseases and conditions. Venlafaxine besylate can be easily formulated into an extende... | 04/06/2004 |
| 6703044 | Venlafaxine formulations The invention provides a method for treating a subject with venlafaxine, comprising administering to the subject a formulation having a therapeutically effective amount of venlafaxine or a pharmaceutically acceptable salt thereof, wherein the formulation ... | 03/09/2004 |
| 6653323 | Aryl aniline 댢 adrenergic receptor agonists The invention provides novel 댢 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 댢 | 11/25/2003 |
| 6576793 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p... | 06/10/2003 |
| 6495722 | Mannich polyols for rigid spray foams Provided herein are polyurethane foams which may be prepared by spray techniques. The foams of the invention are prepared using conventional isocyanates and a novel Mannich condensate polyol having a hydroxy number in the range of 250-340 and a viscosity ... | 12/17/2002 |
| 6362371 | 댢- adrenergic receptor agonists The present invention is directed to multibinding compounds which are 댢 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the... | 03/26/2002 |
| 6326369 | Bicyclic quinone compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the princi... | 12/04/2001 |
| 6242637 | Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH2 | 06/05/2001 |
| 6214873 | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same The present invention relates to a compound of the general formula ##STR1## wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof... | 04/10/2001 |
| 6211245 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hyproxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognit... | 04/03/2001 |
| 6107520 | Spisulosine compounds The present invention is directed to the isolation and bioactive characterization of compounds isolated from the clam Spisula polynyma. These compounds include three sphingoid-type bases, spisulosines 285, 299 and 313 (1-3), each of which shows unique cyt... | 08/22/2000 |
| 6057371 | Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of c... | 05/02/2000 |
| 6028225 | Method of making hydroxy-substituted hydroxylamines and color developers containing same Hydroxy-substituted hydroxylamine antioxidants can be prepared by reacting hydroxylamine or a mono-substituted hydroxylamine, in free base form, with an epoxide. The antioxidant reaction product can be used without isolation from the reaction solution, an... | 02/22/2000 |
| 5990151 | Optically active substituted phenylalkylamine derivatives The present invention relates to an optically active, substituted phenylalkylamine derivative represented by Formula [1]: ##STR1## wherein A is a substituted or non-substituted phenyl or thienyl; X1 is hydrogen, halogen, hydroxyl or a subs... | 11/23/1999 |
| 5958836 | Algistats The present invention relates to a method for the prevention of growth of algae by incorporating within liquids or coating on surfaces certain substituted amino alcohols. More precisely, this invention provides for algistat end uses for amino alcohol comp... | 09/28/1999 |
| 5861421 | 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds This invention relates to derivatives of 4,4-(disubstituted)cyclohexan-1-ones and related compounds which are useful for treating allergic and inflammatory diseases.... | 01/19/1999 |
| 5821387 | Polyarenes from aryl ketones with application to synthesis of crisnatol mesylate Alkyl-substituted polyarenes of the formula ##STR1## in which R is alkyl and Arres is an aryl residue, are prepared from aryl ketones by reaction of the latter with 1-cyclohexenyloxytrimethylsilane in the presence of a Friedel-Crafts ... | 10/13/1998 |
| 5808160 | Preparation of hydroxy-alkyl-substituted aminoalkynes with heterogenous catalysis Hydroxyalkyl-substituted aminoalkynes of the general formula I ##STR1## where at least one of the substituents R1, R4 or R5 is hydroxyalkyl are prepared in a reaction with heterogeneous catalysis.... | 09/15/1998 |
| 5659075 | Chemical process for preparing an optically active aminodiol A process is claimed for preparing [1S(1(, 2ଲ, 4ଲ)]-4-amino-2-hydroxymethyl -1-cyclopentanol from cis-4-((R)-benzoylamino)-2-cyclopentenecarboxylic acid, methyl ester in five steps. The invention also describes a number of novel interme... | 08/19/1997 |
| 5561152 | Antidepressants The present invention provides novel aryloxy indanamines which are useful as anti-depressants and as inhibitors of synaptic norepinephrine and serotonin uptake.... | 10/01/1996 |
| 5545750 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula A--X--B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl,... | 08/13/1996 |
| 5538986 | Tricyclic derivatives, compositions and methods of use Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted ... | 07/23/1996 |
| 5482523 | Mannich condensation products of poly(oxyalkylene) hydroxyaromatic ethers and fuel compositions containing the same Mannich condensation products prepared by the condensation of a compound of the formula: ##STR1## wherein R1 is hydrogen, hydroxy, lower alkyl or lower alkoxy; R3 and R4 are independently hydrogen or lower alkyl; R | 01/09/1996 |
| 5461148 | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists Disclosed are a process and intermediates of the formulae ##STR1## wherein R is --CH2 OH or --OH and R3 is H or C1 -C6 alkyl; useful for preparing benzazepines of the formula ##STR2## having activity a... | 10/24/1995 |
