Class 564/357 - By direct hydrogenation

Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Processes wherein the reduction is by direct hydrogenation.
No. of patents: 33
Last issue date: 08/19/2008

Number	Title	Issue Date
7414153	Process for preparation of optically active 1-erythro-2-amino-1-phenyl-1-propanol An efficient cost-effective process for preparation of 1-erythro-2-amino-1-phenyl-1-propanol from 1-1-phenyl-1-hydroxy-2-propanone, which comprises converting 1-1-phenyl-1-hydroxy-2-propanone to 1-1-phenyl-1-hydroxy-2-propanone oxime and reducing the oxime with a ca...	08/19/2008
6984738	Process for production of optically active amino alcohols The present invention is to provide a process for producing an optically active amino alcohol which is useful for the synthesis of natural substances and as an intermediate for drugs and agricultural chemicals in a high yield, a high selectivity and an economical ma...	01/10/2006
6686505	Process for producing optically active amino alcohols and intermediates therefore A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst ...	02/03/2004
6605744	Production of 2-amin-2-[2-(2-(40-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols Disclosed is a process for the production of 2-amino-2-[2-(4-C2-20 -alkyl-phenyl)ethyl]propane-1,3-diols....	08/12/2003
5672706	Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane A process is disclosed for the preparation of the substantially pure compound of the formula: ##STR1## comprising catalytic hydrogenation of a compound of the formula: ##STR2## wherein R6 and R7 are independently selected f...	09/30/1997
5631405	Method of forming amino acid-derived diaminopropanols useful as chemical intermediates for protease-inhibitors The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl...	05/20/1997
5618966	Method forming protease inhibitor synthetic intermediates The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl...	04/08/1997
5599994	Amino acid-derived diaminopropanols The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method inclu...	02/04/1997
5554794	Process for preparing a gasoline additive compound The invention includes a compound of formula I ##STR1## where R' is hydrogen, an alkyl, or aryl group; R"O is derived from R"OH which is a polyether mono-ol or hydrocarbyl mono-ol; and R"' independently is a hydrogen, an alkyl group or a substituted ...	09/10/1996
5550291	Process for key intermediates for HIV protease inhibitors Disclosed herein is a stereospecific synthesis amenable to the large scale preparation of a hydrochloric acid addition salt of a chlorohydrin of the formula ##STR1## wherein R1 and R2 are amino protective groups and R3	08/27/1996
5491233	Catalytic asymmetric reduction of trisubstituted olefins A catalytic asymmetric reduction process, which, by hydrogenating trisubstituted olefins, yields a corresponding organic compound having a high level of enantiomeric purity is disclosed. The process is also effective for the catalytic asymmetric reduction...	02/13/1996
5489682	Catalytic asymmetric reduction of enamines A catalytic asymmetric reduction process, which, by hydrogenating enamines, yields a corresponding amine having a high level of enantiomeric purity is disclosed. The reduction process utilizes a chiral metal catalyst that includes a metal or metal complex...	02/06/1996
5475138	Method preparing amino acid-derived diaminopropanols The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl...	12/12/1995
5442118	Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones A method for the enantioselective reduction of an ଱-iminoketone to an ଱-aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole as the catalyst. The method is applied to the s...	08/15/1995
5344990	Process for the preparation of a renin inhibiting compound Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sul...	09/06/1994
5319142	Process for preparing substituted and unsubstituted arylalkylamines An arylisonitrosoalkanone is hydrogenated in the presence of a noble metal catalyst and a weak carboxylic acid to form an arylalkanolamine which is then hydrogenated in the presence of a strong mineral acid and the transition metal catalyst to form an ary...	06/07/1994
5235103	Process for the preparation of phenylethanolaminotetralins A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and Ro is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy...	08/10/1993
5198586	Process for the preparation of phenylethanolaminotetralins A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R° is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, wh...	03/30/1993
5189219	Method for the preparation of erythro vicinal amino-alcohols The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resul...	02/23/1993
5099067	Use of ammonium formate as a hydrogen transfer reagent for reduction of chiral nitro compounds with retention of configuration The present invention relates to a method of converting ଲ-nitro compounds, specifically alcohols, into the corresponding hydroxy amines with retention of configuration by the use of ammonium formate....	03/24/1992
5004755	Pharmaceutical use of laevorotatory basic derivative of 9,10-ethanoanthracene The present invention relates to a new laevorotatory basic derivative of 9,10-ethanoanthracene, namely R-(-)-଱-[(methylamino)methyl]-9,10-ethanoanthracene-9(10H)-ethanol of the formula I ##STR1## and the acid addition salts thereof, to pha...	04/02/1991
4952729	Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydr...	08/28/1990
4603019	N-(methoxyphenacyl)-amine derivatives This invention relates to new N-(methoxyphenacyl)-amine derivatives selected from the group consisting of (i) the N-(methoxyphenacyl)-alkylamines of the general formula ##STR1## wherein A is OCH3, and R is C3 -C8 -alkyl o...	07/29/1986
4490392	Benzylalcohol derivative and process for preparing A benzylalcohol derivative of the formula: ##STR1## wherein R is hydroxy, benzyloxy, halogen or alkoxy having one to four carbon atoms, and Ring A is monomethoxyphenyl, dimethoxyphenyl, trimethoxyphenyl or 3,4-methylenedioxyphenyl, or a pharmaceutica...	12/25/1984
4461914	Method for the preparation of 1-(4'-amino-3',5'-dichlorophenyl)-2-alkyl(or dialkyl)aminoethanols A method for the preparation of 1-(4'-amino-3',5'-dichlorophenyl)-2-alkyl)or dialkyl)aminoethanols. The method involves preparation of the above compounds from the corresponding aminoketones by reduction with hydrogen in the presence of platinum oxide ...	07/24/1984
4408074	Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride A process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride is described by reacting 2,6-dimethoxyphenol with anhydrous chloral in the presence of a catalyst, hydrolyzing 1-(3,5-dimethoxy-4-hydroxyphenyl)2,2,2-trichl...	10/04/1983
4131686	Novel benzylalcohol derivatives and processes for preparing the same A compound of the formula: ##STR1## wherein R is lower alkyl, may be prepared, for example, by reducing a compound of the formula: ##STR2## wherein R is same as above. Other methods for preparing the compound [I] are also disclosed. The com...	12/26/1978
4075241	2-(Aryl)-3-(dimethylamino)butyl-3,4,5-trimethoxybenzoates The compounds 2-Aryl-3-amino-1-butanol derivatives of the formula ##STR1## wherein R represents hydrogen or acyl; R1 and R2 each independently represents hydrogen, phenyl lower alkyl, or lower alkoxy substituted phenyl lower alk...	02/21/1978
4058642	2-Amino-3-(3'-hydroxy-phenyl)-propanols and salts thereof Compounds of the formula ##STR1## wherein R1 is hydrogen, chlorine, hydroxyl, trifluoromethyl, methyl or methoxy, and R2 is hydrogen, alkyl of 1 to 2 carbon atoms or benzyl; And non-toxic, pharmacologically acceptable acid addition s...	11/15/1977
4021485	N,N'-bis-[(ଲ-hydroxy-ଲ-phenyl)-ethyl]-polymethylenediamines and salts thereof Compounds of the formula ##STR1## WHEREIN R1 is hydrogen or methyl, m is 0 or an integer from 1 to 8, inclusive, and Ar is ##STR2## WHERE R is hydrogen or acyl, and R2 is hydrogen or --OR, as defined above, ##STR3## ...	05/03/1977
4012528	଱-AMINOALKYL-3-(1,2-DIHYDROXYETHYL)-4-HYDROXY-BENZYL ALCOHOLS HAVING ଲ-ADRENERGIC STIMULANT ACTIVITY ଱-Aminoalkyl-3-(1,2-dihydroxyethyl)-4-hydroxy-benzyl alcohols having ଲ-adrenergic stimulant activity, particularly as selective bronchodilators, are disclosed....	03/15/1977
4011258	Orally active bronchospasmolytic compounds Novel compounds are disclosed having useful activity as bronchodilators of improved longevity of action and reduced incidence of side effects. These compounds are described by the formula: ##STR1## wherein R1 is a member of the class consi...	03/08/1977
3937838	Orally active bronchospasmolytic compounds and their preparation Novel compounds are disclosed having useful activity as bronchodilators of improved longevity of action and reduced incidence of side effects. These compounds are described by the formula: ##EQU1## wherein R1 is a member of the class consi...	02/10/1976

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Class 564/357 - By direct hydrogenation