Quotables
"We live in a society exquisitely dependent on science and technology, in which hardly anyone knows anything about science and technology."
Carl Sagan
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7064236 | Substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds The invention relates to substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds, to a method for the production thereof, to medicaments containing said compounds and to their use in the production of medicaments. ... | 06/20/2006 |
| 6995286 | Process for preparing isomers of salbutamol A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving a racemic or optically impure mixture of enantiomers of salbutamol o... | 02/07/2006 |
| 6916961 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 07/12/2005 |
| 6686505 | Process for producing optically active amino alcohols and intermediates therefore A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst ... | 02/03/2004 |
| 6605744 | Production of 2-amin-2-[2-(2-(40-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols Disclosed is a process for the production of 2-amino-2-[2-(4-C2-20 -alkyl-phenyl)ethyl]propane-1,3-diols.... | 08/12/2003 |
| 6344558 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effect 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I ##STR1## a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.... | 02/05/2002 |
| 6028224 | Fluoxetine process from benzoylpropionic acid A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding γ-hydroxy ester, and the ester is cleaved. The free acid is t... | 02/22/2000 |
| 5936124 | Fluoxetine process from benzoylpropionic acid A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding γ-hydroxy ester, and the ester is cleaved. The free acid is t... | 08/10/1999 |
| 5631405 | Method of forming amino acid-derived diaminopropanols useful as chemical intermediates for protease-inhibitors The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl... | 05/20/1997 |
| 5618966 | Method forming protease inhibitor synthetic intermediates The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl... | 04/08/1997 |
| 5599994 | Amino acid-derived diaminopropanols The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method inclu... | 02/04/1997 |
| 5550291 | Process for key intermediates for HIV protease inhibitors Disclosed herein is a stereospecific synthesis amenable to the large scale preparation of a hydrochloric acid addition salt of a chlorohydrin of the formula ##STR1## wherein R1 and R2 are amino protective groups and R3 | 08/27/1996 |
| 5545745 | Enantioselective preparation of optically pure albuterol The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of methyl 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-(phenylmethoxy)benzoate or -[[(1,1-dimethylethyl)amino]methyl]-4-(phenylmethoxy... | 08/13/1996 |
| 5512680 | Process for the preparation of an optically pure aminoalcohol A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (I) by reaction of 3,4-dichlorophenylacetonitrile (II) with an alkali metal halogenoacetate, treatment of the 3-cyano-3-(3,4-dichlorophenyl)propionic acid (III) w... | 04/30/1996 |
| 5503640 | 3-substituted para-aminophenols, process for preparing them, their use for dyeing keratinous fibres and the intermediate compounds used in the preparation process 3-Substituted para-aminophenols of general formula: ##STR1## where X=H, halogen; Y=O--, --S--; R=alkyl, hydroxyalkyl, C1-4 aminoalkyl or C3 -C6 polyhydroxyalkyl; with the proviso that, when X=H, R is not methyl, and when X... | 04/02/1996 |
| 5491233 | Catalytic asymmetric reduction of trisubstituted olefins A catalytic asymmetric reduction process, which, by hydrogenating trisubstituted olefins, yields a corresponding organic compound having a high level of enantiomeric purity is disclosed. The process is also effective for the catalytic asymmetric reduction... | 02/13/1996 |
| 5489682 | Catalytic asymmetric reduction of enamines A catalytic asymmetric reduction process, which, by hydrogenating enamines, yields a corresponding amine having a high level of enantiomeric purity is disclosed. The reduction process utilizes a chiral metal catalyst that includes a metal or metal complex... | 02/06/1996 |
| 5475138 | Method preparing amino acid-derived diaminopropanols The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl... | 12/12/1995 |
| 5442118 | Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones A method for the enantioselective reduction of an -iminoketone to an -aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole as the catalyst. The method is applied to the s... | 08/15/1995 |
| 5412119 | Method of preparing vicinal aminoalcohols The present invention is concerned with the preparation of N-substituted vicinal aminoalcohol derivatives from the corresponding hydroxyl-protected cyanohydrin derivatives by successive partial reduction, transimination using a primary amine, reduction of... | 05/02/1995 |
| 5399765 | Enantioselective preparation of optically pure albuterol The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-hydroxybenzoate using ditoluoyltartaric acid.... | 03/21/1995 |
| 5364413 | 3-substituted para-aminophenols, process for preparing them, their use for dyeing keratinous fibres and the intermediate compounds used in the preparation process 3-Substituted para-aminophenols, process for preparing them, their use for dyeing keratinous fibres and the intermediate compounds used in the process of preparation. 3-Substituted para-aminophenols, of general formula: ##STR1## where X.dbd.H, haloge... | 11/15/1994 |
| 5344990 | Process for the preparation of a renin inhibiting compound Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sul... | 09/06/1994 |
| 5329023 | Method of preparing optically active alcohols which consist substantially or entirely of one enantiomer The invention relates to a method of preparing optically active alcohols which consist substantially (at least 75% e.e.) or entirely of one enantiomer of formula 4 ##STR1## wherein R and A are as defined therein. The method comprises, which main... | 07/12/1994 |
| 5292893 | Catalytic asymmetric and non-asymmetric reduction of times and oximes using metal catalysts A process is provided for catalytically reducing imines, oximes, hydrazones and related compounds. Moreover, there is provided a process for the catalytic asymmetric reduction of imines, oximes, hydrazones, and the like, using enantiomerically enriched ca... | 03/08/1994 |
| 5284975 | Method of preparing -d-phenylalkylbenzyl carbinol A method of preparing an -d-phenylalkylbenzyl carbinol by the reaction of a phenylbenzyl ketone with an alkali metal enolate of an amide to form an aldol adduct, which is reduced and purified to form an -d-phenylalkylbenzyl carbinol, wherein... | 02/08/1994 |
| 5276190 | Method for the preparation of an alcohol The invention relates to a method for the preparation of an ,-disubstituted -amino alcohol from the corresponding amide with the aid of sodium in the presence of an alcohol as solvent. The conversion of amino acid amide to amino alcoh... | 01/04/1994 |
| 5235103 | Process for the preparation of phenylethanolaminotetralins A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and Ro is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy... | 08/10/1993 |
| 5198586 | Process for the preparation of phenylethanolaminotetralins A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R° is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, wh... | 03/30/1993 |
| 5189219 | Method for the preparation of erythro vicinal amino-alcohols The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resul... | 02/23/1993 |
| 4952729 | Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydr... | 08/28/1990 |
| 4579972 | Intermediates for preparing secondary amines New intermediates and processes for preparing 6-halo-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepi nes involve the reaction of a p-methoxyphenylglyoxal, lower alkyl hemimercaptal with a 2-chloro-3,4-dimethoxyphenethylamine, followed b... | 04/01/1986 |
| 4540819 | Process for preparing secondary amines New intermediates and processes for preparing 6-halo-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepi nes involve the reaction of a p-methoxyphenylglyoxal, lower alkyl hemimercaptal with a 2-chloro-3,4-dimethoxyphenethylamine, followed b... | 09/10/1985 |
| 4408074 | Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride A process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride is described by reacting 2,6-dimethoxyphenol with anhydrous chloral in the presence of a catalyst, hydrolyzing 1-(3,5-dimethoxy-4-hydroxyphenyl)2,2,2-trichl... | 10/04/1983 |
| 4313005 | Inhibiting amidine formation during hydrogenation of organo nitriles This invention relates to a process for reducing amidine formation during reduction of organonitriles. The process comprises including a boron compound in the reaction medium in sufficient amount to complex the amidine compound as it is formed.... | 01/26/1982 |
| 4252824 | Amino-ethanol derivatives New compounds of the formula ##STR1## are disclosed wherein R1 =H, linear or branched alkyl-radical with from 1 to 6 carbon atoms, cycloalkyl radical with from 3 to 6 carbon atoms, alkylphenyl radical where the phenyl group may be in turn ... | 02/24/1981 |
| 4216329 | Method of producing γ-amino alcohols A process for the production of γ-amino alcohols from ଲ-dicarbonyl compounds is disclosed. The dicarbonyls are reacted with alkoxyamines and the resultant alkoximino compounds reduced to yield γ-amino alcohols. Also described are novel substituted... | 08/05/1980 |
| 4173649 | 5-Phenyl-2,4-pentadien-1-amines and method for inhibiting prostaglandin dehydrogenase 5-Phenyl-2,4-pentadien-1-amines and salts thereof are provided having the structure ##STR1## wherein R1 is hydrogen, lower alkyl, lower alkoxy, hydroxy, lower alkanoyloxy, nitro, cyano, amino, carboxy or lower alkoxycarbonyl, and R | 11/06/1979 |
| 4154761 | Pharmacologically active compounds Compounds of the general formula (I): ##STR1## in which R1 represents hydrogen or a straight or branched chain alkyl group, or an acyl group of the formula --COR5 (in which R5 represents a hydrogen atom or a straight ... | 05/15/1979 |
| 4131686 | Novel benzylalcohol derivatives and processes for preparing the same A compound of the formula: ##STR1## wherein R is lower alkyl, may be prepared, for example, by reducing a compound of the formula: ##STR2## wherein R is same as above. Other methods for preparing the compound [I] are also disclosed. The com... | 12/26/1978 |
