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| Number | Title | Issue Date |
| 7355078 | Processes for the preparation of tomoxetine Provided are processes for preparing tomoxetine comprising reacting N-methyl-3-hydroxy-3-phenylpropylamine with dimethylsulfoxide (DMSO) and 2-fluorotoluene in the presence of an alkali base to form tomoxetine. Also provided is the conversion of said tomoxetine into... | 04/08/2008 |
| 7335659 | Substituted 10-aryl-11-benzo[]fluorenes and 7-aryl-5, 6-dihydro-benzo[]anthracenes for selective effects on estrogen receptors This invention provides a compound, or its possible salt, having the formula, wherein: Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2CH2— or... | 02/26/2008 |
| 7297794 | Phenoxy amine compounds and compositions for delivering active agents Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 11/20/2007 |
| 7183323 | Sodium channel modulators The invention provides sodium channel modulating compounds of formula I: wherein X, Y, Q, R1, w, and R2 have any of the values defined in the specification, and salts thereof, which are usef... | 02/27/2007 |
| 7169818 | Lysophosphatidic acid receptor agonists and antagonists The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of... | 01/30/2007 |
| 7005647 | Photoelectric converter and radiation reader A photoelectric conversion apparatus having (i) a photoelectric conversion device for converting an incident light into an electric charge and (ii) a reading circuit including at least one thin film transistor for amplifying a signal from the photoelectric conversio... | 02/28/2006 |
| 6939895 | Calcium receptor-active compounds A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9 | 09/06/2005 |
| 6756508 | Cinnamic acid salts, processes for their preparation, and their use as medicaments The present invention relates to new cinnamic acid salts of salmeterol, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions. ... | 06/29/2004 |
| 6750255 | Calcium receptor-active compounds A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R | 06/15/2004 |
| 6649800 | Process for the preparation of polyalkylphenoxyaminoalkanes An improved process for the preparation of polyalkylphenoxyaminoalkanes which comprises the aminoethylation of a polyalkylphenol compound in the presence of a basic catalyst with 2-oxazolidinone or a derivative thereof having the following formula: #... | 11/18/2003 |
| 6486352 | Process for the preparation of polyalkylphenoxyaminoalkanes A process for the preparation of polyalkylphenoxyaminoalkanes which comprises the aminoethylation of a polyalkylphenol compound in the presence of a basic catalyst with ଲ-amino alcohol or derivative thereof having the following structure: R1 | 11/26/2002 |
| 6441205 | Synthetic precursors to 4-(P-methoxyphenyl)-2-amino-butane The invention provides a novel compound 4-(p-methoxy-phenyl)-2-aminobutane exhibiting growth inhibition and antifeedant activity and represented by the structural formula. ##STR1## C11 H17 ON=4-(p-methoxy phenyl)-2-amino butane and a... | 08/27/2002 |
| 6420354 | Sodium channel drugs and uses The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.... | 07/16/2002 |
| 6384280 | Process for the preparation of polyalkylphenoxyaminoalkanes A process for the preparation of polyalkylphenoxyaminoalkanes which comprises the aminoethylation of a polyalkylphenol compound in the presence of a basic catalyst with 2-oxazolidinone or a derivative thereof having the following formula: ##STR1## wh... | 05/07/2002 |
| 6350913 | 3-alkoxybenzylamine derivatives and their use as medicines for treating schizophrenia The present invention relates to novel 3-alkoxybenzylamine derivatives of general formula (1): ##STR1## which are useful as medicinal products and in particular as antipsychotic agents.... | 02/26/2002 |
| 6313350 | Form a of fluoxetine hydrochloride The present invention provides novel processes for the preparation of Form A of fluoxetine hydrochloride.... | 11/06/2001 |
| 6310250 | Form A of fluoxetine hydrochloride The present invention provides novel amorphous fluoxetine hydrochloride as a useful intermediate for the preparation of Form A of fluoxetine hydrochloride.... | 10/30/2001 |
| 6310251 | Form a of fluoxetine hydrochloride The present invention provides novel processes for the preparation of Form A of fluoxetine hydrochloride.... | 10/30/2001 |
| 6057371 | Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of c... | 05/02/2000 |
| 6057358 | Amine derivatives, processes for producing them and a use of them as antiarrhythmic drugs Novel amine derivatives of the following general formula (I): ##STR1## (wherein) A may denote --(CH2)--O--, --(CH2)2 --O--, or --(CH2)2 --NH--; B may denote --(CH2)2 --; R1 | 05/02/2000 |
| 6017965 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cogniti... | 01/25/2000 |
| 5952350 | Naphthyl compounds and compositions, as estrogen receptor binding agents The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions containing a compound of formula I, and methods of using a compound of formula I for inhibiting bone loss o... | 09/14/1999 |
| 5889000 | Naphthofluorene compounds, intermediates, compositions and methods The invention provides naphthofluorene compounds, intermediates, formulations, processes, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia, and estr... | 03/30/1999 |
| 5792762 | Dihydrobenzofluorene compounds, intermediates, compositions and methods The invention provides dihydronaphthofluorene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions.... | 08/11/1998 |
| 5736568 | 2-(aminoalkoxy) phenylalkylamines with antiinflammatory activity Compounds of the formula I ##STR1## including pharmaceutically acceptable salts thereof are disclosed in which R1, R2, R3, and R4 independently represent hydrogen, hydroxy, halo, halogenated alkyl, halogena... | 04/07/1998 |
| 5688830 | Treatment of neuropathic pain This invention relates to a compound of the Formula I: ##STR1## as a racemic mixture and its individual enantiomers, in particular the (R)-enantiomer, and their pharmaceutically acceptable salts. These compounds are useful as sodium channel blockers,... | 11/18/1997 |
| 5684200 | Process for the preparation of hydroxylamine ethers and their salts and intermediates for this purpose Hydroxylamine ethers I ##STR1## (where X is NO2, CN, halogen, alkyl or haloalkyl, Y is H, NO2, CN, halogen, alkyl or haloalkyl, n is 0-2 or 1-4 where Y and all radicals X are halogen and Alk is unsubstituted or substituted alkyl... | 11/04/1997 |
| 5669939 | Polyalkylphenoxyaminoalkanes and fuel compositions containing the same Polyalkylphenoxyaminoalkanes having the formula: ##STR1## wherein R is a polyalkyl group having an average molecular weight in the range of about 600 to 5,000; R1 and R2 are independently hydrogen or lower alkyl having 1 to 6 ca... | 09/23/1997 |
| 5637771 | Compound useful for lowering cholesterol A method of lowering cholesterol which comprises administering to a host requiring such treatment an effective amount of a compound of the formula ##STR1## wherein one of R1 and R2 is C1-7 -alkyl and the other is C | 06/10/1997 |
| 5556864 | -ω-diarylalkane compounds serotonin-2 receptor agonists Compounds of formula (I): ##STR1## [wherein: R1 is aryl; R2 is hydrogen, alkyl, alkoxy, halogen or cyano; R3 is a group of formula --B--NR4 R5, where R4 and R5 are independe... | 09/17/1996 |
| 5495048 | Amino alkenyloxybenzene derivatives A method of lowering cholesterol which comprises administering to a host requiring such treatment an effective amount of a compound of the formula ##STR1## wherein one of R1 and R2 is C1-7 -alkyl and the other is C | 02/27/1996 |
| 5430062 | Stilbene derivatives as anticancer agents The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can be utilized in a method of treating such cancers. Pharmaceu... | 07/04/1995 |
| 5420352 | Process for the production of 1-phenoxy-2-aminopropane 1-Methyl-2-phenoxy ethanol of the formula, ##STR1## [wherein R is hydrogen or an alkyl group having 1 to 6 carbon atoms, and n is an integer of 0 or 1 to 5] is allowed to react with ammonia in a solvent in the presence of a copper-chromium catalyst a... | 05/30/1995 |
| 5409957 | Phenoxyalkylamine and agricultural and horticultural bactericide Disclosed are a phenoxyalkylamine represented by the following general formula I and a salt of said phenoxyalkylamine represented by the following general formula II: ##STR1## wherein R represents a linear saturated hydrocarbon having 7 to 12 carbon ... | 04/25/1995 |
| 5385892 | Ethylamino phenyl ethers having antifungal activity The ethylamino phenyl ethers of the invention and compositions thereof are endowed with high activities as inhibitors of the growth of several species of pathogen fungi and are applied to plants or to plant parts and are effective in preventing the diseas... | 01/31/1995 |
| 5358971 | Substituted 2-aminotetralins Optically active or racemic compounds are provided having the formula ##STR1## where R2, R3 and R4 are selected from the group consisting of H and OA with the provision that at least one of R2, R3 and... | 10/25/1994 |
| 5347049 | Processes for preparing diamino compounds Di-amines endowed with chain extension activity for formulations such as polyureas and polyurethanes are disclosed, and which have the general formula: ##STR1## wherein n is 0-1000; R1, R2, R5, and R6 are e... | 09/13/1994 |
| 5344984 | Method for preparing "twin-tailed" polyoxyalkylene tertiary amines A method for preparing "twin-tailed" tertiary amines which have two moles of alkoxylated phenol bonded to each nitrogen function of a molecule of methylamine and represented by the formula: ##STR1## wherein x represents zero to about 30 which compris... | 09/06/1994 |
| 5331011 | N-benzyl-n-phenoxyethylamines and agricultural and horticultural bactericides Disclosed is an N-benzyl-N-phenoxyethylamine selected from the group consisting of the N-benzyl-N-phenoxyethylamine represented by the following formula (I): ##STR1## and an agriculturally acceptable acid addition salt represented by the followi... | 07/19/1994 |
| 5320825 | Serotonin reuptake inhibitors for S.P.E.C.T. imaging Disclosed are novel compounds for CNS neurotransmitter systems, especially for the neurotransmitter serotonin, which have the formula ##STR1## where each of U, V, W, X, Y and Z is independently selected from the group consisting of hydrogen; halogen;... | 06/14/1994 |
