Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Number | Title | Issue Date |
| 7368608 | 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivatives and a process for preparing 2-amidomethyl-1,4-benzodioxane derivatives An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisti... | 05/06/2008 |
| 7030160 | Propanolaminotetralines, preparation thereof and compositions containing same The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action. ... | 04/18/2006 |
| 7005439 | Compounds The invention provides compounds of general formula (I) wherein m, n, Z1, Z2, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification, process... | 02/28/2006 |
| 6963012 | Diaryl ether derivative, addition salt thereof, and immunosuppressant The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): | 11/08/2005 |
| 6951874 | Compounds The invention provides compounds of general formula (I) wherein Q, R, R2, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions contai... | 10/04/2005 |
| 6521667 | Calcilytic compounds The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial e... | 02/18/2003 |
| 6376711 | Method for the preparation of aryl ethers The invention relates to a method for preparing aryl ethers that are useful as antidepressants. The invention also relates to intermediates useful in the method and to methods for preparing such intermediates.... | 04/23/2002 |
| 6239313 | Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides The invention relates to a process for the solid state synthesis of enantiopure ଲ-aminoalcohols by preparing inclusion complexes of aryloxyepoxide with cyclodextrin by adding an epoxide in equimolar ratio in an organic solvent to an aqueous solution... | 05/29/2001 |
| 6025517 | Fluoxetine process from benzoylacetonitrile A synthesis of fluoxetine is disclosed. The process begins with benzoylacetonitrile, which is reduced, optionally in the presence of a chiral ligand, to produce the corresponding aminoalcohol, and the amine is carbamoylated without isolation. The alcohol ... | 02/15/2000 |
| 6022894 | Method of using calcilytic compounds The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial e... | 02/08/2000 |
| 5618968 | N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation The invention provides the preparation procedure for N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3 -phenylpropylamine having the general formula (I), where R is hydrogen and the group of the general formula (II), in which R1 | 04/08/1997 |
| 5482964 | Substituted phenoxyhydroxypropyl amines as central nervous system agents Substituted phenoxyhydroxy amines and derivatives thereof are described as well as methods for the preparation and pharmaceutical compositions of same, which are central nervous system agents useful in the treatment of neurological disorders including tra... | 01/09/1996 |
| 5187190 | Phenoxypropanolamine compounds Compounds of the formula (I): ##STR1## wherein R1 is hydrogen or fluoro and R2 is hydrogen or C1-6 alkyl and salts thereof are described as agents for the treatment of obesity and related conditions. Processes for their preparat... | 02/16/1993 |
| 5147878 | Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S, --SO--, or --SO2 -- group, R1 and R2, which are identi... | 09/15/1992 |
| 5047425 | Amine derivatives having cardiovascular activity Compounds of the formula ##STR1## wherein Ar, R, R1, R2, R3, R4, X and n have the meanings mentioned in the description, processes and intermediates for their preparation, pharmaceutical compositions which ... | 09/10/1991 |
| 4864061 | Substituted phenoxyalkanolamines and phenoxyalkanol-cycloalkylamines, and intermediate products New substituted phenoxyalkanolamines and phenoxyalkanol-cycloalkylamines of the general formula I ##STR1## in which R1 and R2, which can be identical or different, denote alkyl groups with in each case 1 to 4 carbon atoms, or R | 09/05/1989 |
| 4772631 | Phenyl ethers The invention concerns a series of novel phenoxyacetic acid ethers (and pharmaceutically acceptable salts thereof) of the formula I in which R1 is H or F, R2 and R3 are H or (1-3C)alkyl, Z is CH2 OH or a group -... | 09/20/1988 |
| 4665094 | Oculoselective beta-blockers for treatment of elevated intraocular pressure Hydroxyalkyl-phenoxy-propan-2-olamines and novel esters thereof are oculoselective ଲ-blockers useful in the treatment of elevated intraocular pressure with little or no effect on the pulmonary or cardiovascular system.... | 05/12/1987 |
| 4652584 | Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension Phenoxypropanol derivatives having a 2-acetylenic moiety on the phenyl group thereof of the following formula (I): ##STR1## and their use as anti-hypertensives, e.g. in man. Also part of the invention are pharmaceutical compositions and intermediates... | 03/24/1987 |
| 4435426 | Ethers of phenol active on the cardiovascular system, process for preparing same and use thereof in drugs The present invention relates to novel products, responding to general formula: ##STR1## in which R1 and R2 taken together represent an atom of oxygen .dbd.O or R1 represents hydrogen and R2 represents an O... | 03/06/1984 |
| 4356322 | Phenoxyalkanolamine derivatives A series of novel derivatives of phenoxyalkanolamine of the general formula: ##STR1## wherein R1, R2 and R3 are the same or different and are hydrogen, alkyl of 1 to 2 carbon atoms, methoxy, halogen, nitro, amino or ... | 10/26/1982 |
| 4336267 | Heart active compounds and methods of use This invention relates to novel compounds of the general formula ##STR1## Representative compounds within the scope of the invention are ##STR2## The compounds are disclosed as being useful for treating symptoms and signs of cardiac failure by s... | 06/22/1982 |
| 4322437 | Spiro substituted indanones and tetralones The present invention relates to a compound of formula I, ##STR1## wherein A is straight chain alkylene of 2 to 4 carbon atoms, or straight chain alkenylene of 2 to 4 carbon atoms, n is 1, 2 or 3, R is hydrogen or halogen of atomic number from 9 to 35, an... | 03/30/1982 |
| 4302601 | Aromatic ketones having cardiovascular activity The present invention relates to phenoxypropane having the formula ##STR1## in which R1 and R2 are like or unlike and each is an alkyl group having 1-4 carbon atoms, R3 is hydrogen or an alkyl group having 1-4 carbon ... | 11/24/1981 |
| 4275058 | ଲ-Adrenergic blocking alkanolamine derivatives 1-Indanyloxy- or tetrahydronaphthyloxy-3-amino-2-butanol derivatives, especially erythro-1-(7-methylindan-4-yloxy)-3-isopropylaminobutan-2-ol, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess periphera... | 06/23/1981 |
| 4252825 | Compositions for treatment of cardiovascular conditions associated with overproduction of catecholamines Compositions having therapeutic value in the treatment of cardiovascular conditions associated with the overproduction of catecholamines include as the active ingredient 5-fluoro-2-(2-hydroxy-3-tertiary butyl-amino-propoxy) butyrophenone-, its optical iso... | 02/24/1981 |
| 4200654 | Ovicides It has been found that compounds of the structure ##STR1## wherein X is O, S or SO2, R represents H or one or more halogen, loweralkyl, --CH.dbd.CH--CH.dbd.CH--, CN, NO2, loweralkyloxy, loweralkylcarbonyl or loweralkylmercapto, ... | 04/29/1980 |
| 4157400 | Terpenophenoxyalkylamines and pharmaceutical compositions and uses thereof 1-ISOPROPYLAMINO-3-[2-(2-NORBORNYL EXO)PHENOXY]PROPAN-2-OL, ITS 1-ISOPROPYLAMINO-3-[2-NORBORNYL ENDO)PHENOXY]PROPAN-2-OL ISOMER AND THEIR ACID ADDITION SALTS AND THEIR QUATERNARY AMMONIUM SALTS. These compounds can be used as beta-blocking agents against disor... | 06/05/1979 |
| 4145442 | Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R1 is alkyl or hydroxyalkyl, R2 is alkoxyalkyl or alkylt... | 03/20/1979 |
| 4140789 | Etherified hydroxy-benzodiheterocyclic compounds A compound of the formula ##STR1## in which R1 denotes optionally substituted lower akyl which is optionally branched at the linking carbon atom, R2 represents hydrogen or lower alkanoyl and R3 is a group of the formu... | 02/20/1979 |
| 4070373 | Tricyclic aminoalkyl derivatives Novel tricyclic aminoalkyl derivatives are disclosed which are characterized by valuable pharmacological activities and namely by cardiac and circulatory activities. The tricyclic aminoalkyl derivatives are compounds of the formula: ##STR1## whe... | 01/24/1978 |
| 4061777 | Vasodilatory terpeno-phenoxyalkylamines New terpeno-phenoxyalkylamines of the general formula: ##STR1## in which n is 0, 1 or 2, R1 is a hydrogen atom, a lower alkyl radical having a straight or branched chain with 1 to 4 carbon atoms, or an OH group, R2 and R3 | 12/06/1977 |
| 4039685 | 1-Phenoxy-2-hydroxy-3-tert.-butylamino propane antiarrhythmic compounds A compound selected from the group consisting of racemates of 1-phenoxy-2-hydroxy-3-tert.-butylamino propanes of the formula ##STR1## wherein R is selected from the group consisting of alkynyloxy of 2 to 4 carbon atoms, and R1 is selected ... | 08/02/1977 |
| 4036988 | Therapeutic compositions and method A composition having bradycardia and isoproterenol activity comprising at least one compound selected from the group consisting of racemates of 1-phenoxy-2-hydroxy-3-tert.-butylamino propanes of the formula ##STR1## wherein R is --(CH2) | 07/19/1977 |
| 4018824 | 1-Aryloxy-3-aminopropane derivatives A process for the preparation of 1-aryloxy-3-aminopropane derivatives and acid addition salts thereof and such products per se, the process comprising ring opening of tertiary azetidinol derivatives. They possess ଲ-adrenegic block activity and an ac... | 04/19/1977 |
| 4018778 | Derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production The present invention relates to pharmacologically valuable new derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production. The new derivatives of 1-phenoxy-3-amino-propane-2-ol are suitable for the treatment and prophylaxis of disease... | 04/19/1977 |
| 4016202 | 1-Phenoxy-2-hydroxy-3-alkynylamino-propanes and salts thereof Racemic and optically active compounds of the formula ##STR1## wherein R1 is hydrogen; halogen; nitro; alkyl of 1 to 5 carbon atoms; alkoxy of 1 to 4 carbon atoms; alkenyl of 2 to 5 carbon atoms; alkynyl of 2 to 5 carbon atoms; alkylamino ... | 04/05/1977 |
| 3996382 | Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R1 is alkyl or hydroxy alkyl, R2 is alkoxyalkyl, alkylth... | 12/07/1976 |
| 3996284 | Naphthyl and tetrahydronaphthyl di-ethers Naphthyl and tetrahydronaphthyl diethers of the formula ##STR1## wherein A represents a naphthylene group or a 5,6,7,8-tetrahydronaphthylene group having their ether chains attached to the 1 and 2 or 2 and 3 positions or, when A represents a naphth... | 12/07/1976 |
| 3969363 | Derivatives of 1-phenoxy-3-amino-propan-2-ol and process for their production The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##EQU1## and the aldehyde condensation products and acid addition salts thereof wherein X is selected from the group consi... | 07/13/1976 |
