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| Number | Title | Issue Date |
| 7439399 | Processes for the preparation of atomoxetine hydrochloride The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HC... | 10/21/2008 |
| 7271197 | Phenethanolamine derivatives The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing... | 09/18/2007 |
| 7217703 | 8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents The present invention provides 8-(2-hydroxyphenoxy)octyldiethanolamine) and salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents with the same. The delivery agents of the present invention are well... | 05/15/2007 |
| 6963012 | Diaryl ether derivative, addition salt thereof, and immunosuppressant The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): | 11/08/2005 |
| 6765022 | Cyclohexylamine derivatives as subtype selective nmda receptor antagonists Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel complexes useful for treating... | 07/20/2004 |
| 6538142 | Process for the preparation of metaxalone A process for the preparation of 5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone, which includes: a) reacting 3,5-dimethylphonel with epichlorohydrin to obtain a mixture of 1-(3,5-dimethylphenoxy)2,3-epoxy propane (1) and 1-(3,5-dimethylphenoxy)-3-chloro-2-... | 03/25/2003 |
| 6458999 | Ether diamines and derivatives The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonit... | 10/01/2002 |
| 6252113 | Manufacturing process of metoprolol A method for the manufacture of metoprolol wherein the process is performed in water as solvent.... | 06/26/2001 |
| 6150558 | Bis-o-amino(thio)phenols, and their preparation The invention relates to novel bis-o-aminophenols, and bis-o-aminothiophenols of the following structure: ##STR1## where A1 to A6 are--independently of one another--H, F, CH3, CF3, OCH3, OCF... | 11/21/2000 |
| 6063145 | Fuel compositions containing etheramine alkoxylates This invention concerns a fuel additive comprising an etheramine alkoxylate, and fuel compositions and additive concentrates made therefrom. The etheramine alkoxylate may be of formula: ##STR1## where R1 is a straight or branched alkyl, or... | 05/16/2000 |
| 6057371 | Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of c... | 05/02/2000 |
| 6025517 | Fluoxetine process from benzoylacetonitrile A synthesis of fluoxetine is disclosed. The process begins with benzoylacetonitrile, which is reduced, optionally in the presence of a chiral ligand, to produce the corresponding aminoalcohol, and the amine is carbamoylated without isolation. The alcohol ... | 02/15/2000 |
| 5877214 | Polyaryl-poly(ethylene glycol) supports for solution-phase combinatorial synthesis The present invention is directed to the certain polyaryl-poly(ethylene glycol) compounds ("polyaryl-PEG" compounds) which are useful as soluble polyvalent supports in the preparation of combinatorial libraries of compounds. The resultant combinatorial li... | 03/02/1999 |
| 5849048 | Substituted biphenyl poly (oxyalkylene) ethers and fuel compositions containing the same Substituted biphenyl poly(oxyalkylene) ethers having the formula: ##STR1## wherein R1 is hydrogen or hydroxyl; R2 is hydroxyl, cyano, nitro, amino, aminomethyl, N-alkylamino or N-alkylaminomethyl wherein the alkyl group contains... | 12/15/1998 |
| 5618968 | N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation The invention provides the preparation procedure for N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3 -phenylpropylamine having the general formula (I), where R is hydrogen and the group of the general formula (II), in which R1 | 04/08/1997 |
| 5618775 | Mixtures of optically active cyclohexenone oxime ethers, their preparation, intermediates for this purpose and their use as herbicides Mixtures of optically active cyclohexenone oxime ethers having R- and S-configuration in the oxime ether moiety of the formula I ##STR1## (R1 =C1 -C6 -alkyl; ##STR2## X=C1-C.sub.4 -alkyl, C1... | 04/08/1997 |
| 5569669 | Alkylaminoindane compounds The invention relates to a compound selected from those of formula (I): ##STR1## in which R1, R2, R2', R2", R2'", R3 and n are as defined in the description, an optical isomer, and an addit... | 10/29/1996 |
| 5556864 | -ω-diarylalkane compounds serotonin-2 receptor agonists Compounds of formula (I): ##STR1## [wherein: R1 is aryl; R2 is hydrogen, alkyl, alkoxy, halogen or cyano; R3 is a group of formula --B--NR4 R5, where R4 and R5 are independe... | 09/17/1996 |
| 5461175 | Method for separating enantiomers of aryloxipropanolamine derivatives, and chiral solid-phase chromatography material for use in the method A method for separating enantiomers of a derivative of an aryloxipropanolamine is disclosed, characterized in that the derivative is contacted with a chiral solid-phase chromatography material containing molecular imprints of an optically pure enantiomer ... | 10/24/1995 |
| 5430063 | Phenoxyphenyl derivatives, compositions thereof and methods for their use The invention concerns a phenoxyphenyl compound having the formula ##STR1## wherein R is one or two halogen atoms; and A is CH2 NR1 R2 or 4,5-dihydro-1H-imidazole, in which R1 and R2 are independently... | 07/04/1995 |
| 5424387 | Di-amino compounds and processes for preparing the same Di-amines endowed with chain extension activity for formulations such as polyureas and polyurethanes are disclosed, and which have the general formula: ##STR1## wherein n is 0-1000 and m is 0-100; R1, R2, R5, and R | 06/13/1995 |
| 5420294 | Cycloalkylaminoalkoxyindoles This invention provides a method of selectively antagonizing the 5-HT1A receptor in mammals by administering aryloxypropanolamines. Aryloxypropanolamines are also claimed.... | 05/30/1995 |
| 5391735 | Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new ... | 02/21/1995 |
| 5347049 | Processes for preparing diamino compounds Di-amines endowed with chain extension activity for formulations such as polyureas and polyurethanes are disclosed, and which have the general formula: ##STR1## wherein n is 0-1000; R1, R2, R5, and R6 are e... | 09/13/1994 |
| 5344984 | Method for preparing "twin-tailed" polyoxyalkylene tertiary amines A method for preparing "twin-tailed" tertiary amines which have two moles of alkoxylated phenol bonded to each nitrogen function of a molecule of methylamine and represented by the formula: ##STR1## wherein x represents zero to about 30 which compris... | 09/06/1994 |
| 5312990 | Di-amino compounds Di-amines endowed with chain extension activity for formulations such as polyureas and polyurethanes are disclosed, and which have the general formula: ##STR1## wherein n is 0-1000; R1, R2, R5, and R6 are e... | 05/17/1994 |
| 5270161 | Non-ionic surface active compounds Water-soluble, non-ionic surface active compounds are provided having the formula ##STR1## wherein R1 and R2 are each independently hydrogen or an alkyl group having from 1 to 4 carbon atoms; X is a hydrophobic substituted or un... | 12/14/1993 |
| 5068433 | Process for preparation of 3-substituted derivatives of 1-amino-2-hydroxy propane The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2- hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new... | 11/26/1991 |
| 5057556 | Coating compositions comprising non-gelled amine-epoxide reaction products A non-gelled amine-epoxide reaction product and acid addition salts thereof where the product is obtained by co-reacting; a) a secondary amine NHR1 R2, wherein R1 and R2 the same or different are C2 or C | 10/15/1991 |
| 5034535 | Process for S-metoprolol via oxazolidin-2-one A process for preparing S-metoprolol of the formula ##STR1## or a salt thereof, with high enantiomeric purity, is described, whereby a (S)-5-hydroxymethyl-3-isopropyloxazolidin-2-one sulfonic acid ester of the formula ##STR2## is prepared, ... | 07/23/1991 |
| 4959366 | Anti-arrhythmic agents A series of [N-alkyl-N-(nitro-, alkylsulphonamido, or amino-phenalkyl)amino]-alkyl, alkoxy or alkylthio phenyl derivatives having utility as anti-arrhythmic agents.... | 09/25/1990 |
| 4897425 | Fungicidal cyclohexylamines Cyclohexylamines of the formula ##STR1## where X is a single bond or an alkylene chain, Y is hydrogen or an aryl, cyclohexyl, 4-cyclohexylcyclohexyl, perhydro-1- or 2-naphthyl or piperidyl radical, R1 and R2 are hydrogen, alkyl,... | 01/30/1990 |
| 4892671 | 2-Propanol derivatives as corrosion inhibitors New composition comprises a functional fluid in contact with ferrous metal and a corrosion inhibiting amount of at least one compound of formula (I) ##STR1## or a derivative thereof in which R1, R2 and R3 are, indepen... | 01/09/1990 |
| 4846980 | Corrosion inhibiting system containing alkoxylated dialkylphenol amines A series of oil soluble to water-dispersible, corrosion inhibiting solutions are disclosed which contain about 2 ppm to about 70%, preferably about 3 ppm to about 200 ppm, of an ethoxylated, propoxylated dialkylphenol amine represented by the formula: ... | 07/11/1989 |
| 4767555 | Hydrophobic epoxide modified polyoxyalkylene diamines and thickened aqueous fluids Aqueous fluids are thickened with epoxide modified polyoxyalkylene diamines. The polyoxyalkylene diamines are of the formula: wherein: R is methyl or hydrogen and x is a number selected to give the diamine a molecular weight of 3000 to 9000. The epoxide is a h... | 08/30/1988 |
| 4749784 | Alkanol substituted disazo orange dye for nylon The specification describes a new group of alkanol substituted disazo compounds that are useful in dyeing polyamide textile fibers in orange hues. The new compounds are compatible with several acid blue dyes and several acid red dyes that are commercially... | 06/07/1988 |
| 4650865 | Process for preparing tertiary ether amines The invention relates to a process for preparing tertiary ether amines corresponding to the following general formula: ##STR1## by reacting in the presence of a strong base a tertiary amine corresponding to the following formula: ##STR2## w... | 03/17/1987 |
| 4636256 | Corrosion inhibiting system containing alkoxylated amines A series of water-soluble, or at least water-dispersible, corrosion inhibiting solutions are disclosed which contain about 2 ppm to about 70%, preferably about 3 ppm to about 200 ppm, of an ethoxylated, propoxylated alkylphenol amine represented by the fo... | 01/13/1987 |
| 4609758 | Phenoxyethylamine derivatives This invention provides a group of hydroxycycloalkanephenoxyethylamine antidepressant derivatives of the following structural formula: ##STR1## in which R1 is hydrogen or alkyl of 1 to 6 carbon atoms; R2 is alkyl of 1 to 6 carbon ato... | 09/02/1986 |
| 4608405 | Aqueous based epoxy resin curing agents The instant invention is an epoxy resin curing agent based upon an epoxidized polyol containing aromatic and polyalkylene ether moities in which substantially all of the epoxide groups are reacted with a polyamine wherein each primary amine in the resulti... | 08/26/1986 |
