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| Number | Title | Issue Date |
| 7619116 | Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process. ... | 11/17/2009 |
| 7569729 | Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability Stable Atomoxetine hydrochloride, a process for the manufacture thereof, the use of stable Atomoxetine Hydrochloride for making a pharmaceutical formulation, a process for the preparation of any form of Atomoxetine Hydrochloride, and an analytical method for analyzi... | 08/04/2009 |
| 7507860 | Androgen modulators The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stim... | 03/24/2009 |
| 7507861 | Process for the preparation of atomoxetine hydrochloride The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HC... | 03/24/2009 |
| 7439398 | Enantiomerically pure atomoxetine and tomoxetine mandelate The present invention provides enantiomerically pure (R)-(−)-tomoxetine (S)-(+)-mandelate and atomoxetine HCl. The present invention further provides enantiomerically pure (R)-(−)-tomoxetine (S)-(+)-mandelate prepared from racemic tomoxetine. The present inventi... | 10/21/2008 |
| 7439399 | Processes for the preparation of atomoxetine hydrochloride The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HC... | 10/21/2008 |
| 7355079 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 04/08/2008 |
| 7342134 | Method for the distillative recovery of toluylenediamine The invention relates to a process for distillatively preparing TDA from a reactant stream comprising TDA, high boilers and low boilers in a dividing wall column in which a dividing wall is disposed in the longitudinal direction of the column to form an upper combin... | 03/11/2008 |
| 7339079 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 03/04/2008 |
| 7329766 | Process for stereoselectively reducing 4-aryl-4-oxobutanoic acid derivatives The present invention relates to a process for preparing stereoisomerically enriched 4-aryl-4-hydroxybutanoic acid derivatives by reducing 4-aryl-4-ketobutanoic acid derivatives in the presence of ruthenium-containing catalysts. ... | 02/12/2008 |
| 7326733 | Methods for increasing bone density Methods and compounds for remodeling bone and treating osteopenic conditions are described. Methods and compounds for increasing bone mineral density by decreasing serotonin levels in osteoblasts are also described. ... | 02/05/2008 |
| 7321065 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 01/22/2008 |
| 7307190 | Process for the preparation of toluenediamine Toluenediamine is produced and separated from by-products of the reaction by: a) hydrogenating dinitrotoluene in the presence of a catalyst, b) separating the catalyst, water and optionally solvent from the hydroge... | 12/11/2007 |
| 7303792 | Diaminobenzene derivative, polyimide precursor and polyimide obtained therefrom, and aligning agent for liquid crystal The present invention provides a novel diamine which is especially useful as a material for a resin for a liquid crystal alignment film, a polyimide precursor and a polyimide synthesized by using the diamine, and a treating agent for liquid crystal alignment contain... | 12/04/2007 |
| 7226950 | Sodium channel modulators The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the pr... | 06/05/2007 |
| 7217703 | 8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents The present invention provides 8-(2-hydroxyphenoxy)octyldiethanolamine) and salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents with the same. The delivery agents of the present invention are well... | 05/15/2007 |
| 7211695 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 05/01/2007 |
| 7105545 | N-p-propargyloxyphenethyl-thioacetic acid amides The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R | 09/12/2006 |
| 7011844 | Formulations for the administration of fluoxetine Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination wi... | 03/14/2006 |
| 6992037 | Precious metal catalyst for debenzylation One aspect of the invention relates to catalyst composite containing a metal catalyst and a specifically defined carbon support containing a carbonaceous material. For example, the carbon support may have a total pore surface area of about 800 m2/g or mor... | 01/31/2006 |
| 6943193 | Method for treating sexual dysfunction Treatment of sexual dysfunction disorders comprising administering an effective amount of atomoxetine. ... | 09/13/2005 |
| 6900243 | Phenylheteroalkylamine derivatives There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their pre... | 05/31/2005 |
| 6846957 | Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of 1-phenyl-3-methylamino-2-propen-1-one with sodium borohydride and acetic acid. ... | 01/25/2005 |
| 6812244 | Naphthyl compounds, intermediates, compositions, and methods of use The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use. ... | 11/02/2004 |
| 6797344 | Aromatic diamine derivatives, the preparation thereof and alignment film materials containing same for liquid crystal display cell New aromatic diamine derivatives and the preparation thereof are disclosed. The diamine derivatives of the present invention can be added to conventional polymerization reactions of tetracarboxylic acids or dianhydrides thereof and diamines to form new polyamic acid... | 09/28/2004 |
| 6765022 | Cyclohexylamine derivatives as subtype selective nmda receptor antagonists Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel complexes useful for treating... | 07/20/2004 |
| 6753429 | 1,4-disubstituted benzenes as insecticides Compounds of formula I: wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amo... | 06/22/2004 |
| 6713651 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 03/30/2004 |
| 6683115 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and prem... | 01/27/2004 |
| 6677485 | Process for the preparation of fluoxetine hydrochloride An improved and industrially advantageous process for the preparation of the antidepressant fluoxetine and its pharmaceutically acceptable salts, preferably hydrochloride.... | 01/13/2004 |
| 6646012 | Sodium channel modulators The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compoun... | 11/11/2003 |
| 6610705 | Process for the preparation of diaryl naphthyl methanes The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome, ##STR1## Pharmaceutical compositions comprising said nove... | 08/26/2003 |
| 6599920 | Naphthalene compounds, intermediates, formulations, and methods This invention relates to the field of pharmaceutical and organic chemistry and provides naphthalene compounds, intermediates, formulations, and methods.... | 07/29/2003 |
| 6593497 | 댢-adrenergic receptor agonists The present invention is directed to multibinding compounds which are 댢 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the... | 07/15/2003 |
| 6555287 | Non-subliming, difunctionalized ultraviolet dyes for use in anti-reflective coatings An improved light attenuating compound for use in the production of microdevices is provided. Broadly, the light attenuating compound is difunctional and can be directly incorporated (either physically or chemically) into photolithographic compositions su... | 04/29/2003 |
| 6541669 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and prem... | 04/01/2003 |
| 6541668 | Methods for preparing 3-arloxy-3-arylpropylamines and intermediates thereof The present invention provides processes for the preparation of 3-aryloxy-3-arylpropylamines and intermediates thereof using an nucleophilic aromatic displacement in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone.... | 04/01/2003 |
| 6538158 | Process for preparing 1,4-diaminonaphthalene and/or 1,5-diaminoNaphthalene 1,4-diaminonaphthalene and/or 1,5-diaminonaphthalene are produced by (a) reacting naphthalene with a halogen, (b) optionally, separating 1,4-dihalogen naphthalene or 1,5-dihalogen naphthalene from the mixture from step (a), and (c) reacting the mixture fr... | 03/25/2003 |
| 6525222 | Process for preparing amines Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst, wherein the cat... | 02/25/2003 |
| 6492556 | Form A of fluoxetine hydrochloride The present invention relates to novel polymorphic Form A of fluoxetine hydrochloride.... | 12/10/2002 |
