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| Number | Title | Issue Date |
| 7368607 | Toremifene crystallization method The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to crystallize in said first solv... | 05/06/2008 |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 7323594 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/29/2008 |
| 7247606 | Branched reaction products A compound of formula: wherein each R group independently is C6-C10 arylene group, a straight or branched chain C2-C°alkylene group optionally containing an arylene gr... | 07/24/2007 |
| 7226950 | Sodium channel modulators The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the pr... | 06/05/2007 |
| 7193084 | Polymorphic form of itraconazole The present invention provides a polymorphic form of itraconazole. ... | 03/20/2007 |
| 7179926 | Aryloxyalkylamine NK-1/SSRI inhibitors The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both. | 02/20/2007 |
| 7166745 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/23/2007 |
| 7141613 | Flame resistant rigid foams and formulations for the production thereof The invention relates to flame resistant rigid foams and formulations useful for the production thereof. The polyol formulation must include at least one substance which is inert with respect to isocyanates, does not deplete the ozone layer and has a boiling point b... | 11/28/2006 |
| 7112340 | Compositions of and method for preparing stable particles in a frozen aqueous matrix The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The ... | 09/26/2006 |
| 7037528 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 05/02/2006 |
| 6977085 | Method for preparing submicron suspensions with polymorph control The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) d... | 12/20/2005 |
| 6963012 | Diaryl ether derivative, addition salt thereof, and immunosuppressant The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): | 11/08/2005 |
| 6916956 | Calcium receptor antagonist A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 c... | 07/12/2005 |
| 6911560 | Process for preparing salmeterol Accordingly, the present invention provides a process for the preparation of a compound of formula (I) or a single enantiomer thereof, or a salt or a solvate thereof, wherein W is a chiral auxilary or hydrogen and P1 and P2 are each independent... | 06/28/2005 |
| 6887871 | Use of phenylheteroakylamine derivatives There is disclosed the use of a compound of formula (I) wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the t... | 05/03/2005 |
| 6846958 | Synthesis of benzimidate from benzoic acid Benzimidates can be reacted with a large number of nucleophiles, leading to a wide variety of products. The present invention discloses a facile synthesis for ethyl 2,4-dihydroxybenzimidate, and ethers and diethers thereof, from 2,4-dihydroxybenzoic acid or 2,4-dibe... | 01/25/2005 |
| 6583246 | Modifiers for anionic polymerization The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.... | 06/24/2003 |
| 6495722 | Mannich polyols for rigid spray foams Provided herein are polyurethane foams which may be prepared by spray techniques. The foams of the invention are prepared using conventional isocyanates and a novel Mannich condensate polyol having a hydroxy number in the range of 250-340 and a viscosity ... | 12/17/2002 |
| 6485799 | Aniline derivatives, liquid-crystal composition containing the same, and liquid-crystal display element A aniline derivative represented by general formula (1) ##STR1## wherein R and R' represent independently each other alkyl with 1 to 10 carbon, alkoxyalkyl with 1 to 10 carbon, or hydrogen; x represents cyano, halogen, haloalkyl, haloalkyloxy, or 2-cyanoe... | 11/26/2002 |
| 6441237 | Substituted 3-phenoxy- and 3-phenylalkyloxy-2-phenyl-propylamines The present patent application relates to new substituted 3-phenoxy- or 3-phenylalkyloxy-2-phenyl-propylamines of general formula 1, processes for preparing them and their use as pharmaceutical compositions. ##STR1##... | 08/27/2002 |
| 6388134 | Derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing Salmeterol The present invention refers to new derivatives of the 6-(4-phenylbutoxy)hexylamine of the general formula (I): ##STR1## wherein: R1 is CHO or CHOR3 OR4, where R3 and R4 independently are C1 | 05/14/2002 |
| 6355632 | Naphthyl compounds, intermediates, compositions, and methods The present invention provides pharmaceutically active compounds formula I ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl), --OCOC6 H5, --OCO(C1 -C6 alkyl), or --OSO2 (... | 03/12/2002 |
| 6239078 | Matter of composition and method for using the same as plant bioregulators The present invention is directed to a new matter of composition in the form of chemical compounds and to a method for enhancing plant growth and the properties exhibited by plants treated with the compounds in accordance with this method. In particular, ... | 05/29/2001 |
| 6150558 | Bis-o-amino(thio)phenols, and their preparation The invention relates to novel bis-o-aminophenols, and bis-o-aminothiophenols of the following structure: ##STR1## where A1 to A6 are--independently of one another--H, F, CH3, CF3, OCH3, OCF... | 11/21/2000 |
| 6090983 | Matter of composition and method for using the same as plant bioregulators The present invention is directed to a new matter of composition in the form of chemical compounds and to a method for enhancing plant growth and the properties exhibited by plants treated with the compounds in accordance with this method. In particular, ... | 07/18/2000 |
| 6063145 | Fuel compositions containing etheramine alkoxylates This invention concerns a fuel additive comprising an etheramine alkoxylate, and fuel compositions and additive concentrates made therefrom. The etheramine alkoxylate may be of formula: ##STR1## where R1 is a straight or branched alkyl, or... | 05/16/2000 |
| 5998401 | Naphthyl compounds, intermediates, compositions, and methods A class of substituted phenoxy naphthalene compounds of the structure: ##STR1## where n is 2 or 3; R1 is hydrogen, hydroxy, C1 -C4 alkoxy, phenoxycarbonyl, C1 -C6 alkoxycarbonyl, or C2 -C | 12/07/1999 |
| 5952316 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 09/14/1999 |
| 5877214 | Polyaryl-poly(ethylene glycol) supports for solution-phase combinatorial synthesis The present invention is directed to the certain polyaryl-poly(ethylene glycol) compounds ("polyaryl-PEG" compounds) which are useful as soluble polyvalent supports in the preparation of combinatorial libraries of compounds. The resultant combinatorial li... | 03/02/1999 |
| 5731399 | Di- and polyamino compounds for use in the preparation of polyurethanes Compounds are disclosed which correspond to general formula (I) ##STR1## wherein: R and R' each independently represent an alkyl chain of 1 to 10 carbon atoms, which may be branched, and which may be partially or fully fluorinated; n and n' each inde... | 03/24/1998 |
| 5719176 | 2-amino-1,3-propanediol compound and immunosuppressant A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substituted linear or branc... | 02/17/1998 |
| 5710099 | Bioactive compounds Novel bioactive compounds which when applied to plants in bioregulatory amounts, enhance plant development responses, resulting in enhanced plant properties such as increased total biomass, increased yield, and increased plant quality. Some of the compoun... | 01/20/1998 |
| 5674909 | Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system Compounds of formula ##STR1## wherein R, R', R", R1, R2, R3, R4, R5, R6, X, Y, m, n and p have the meanings reported in the description; and their pharmaceutically acceptable salts are desc... | 10/07/1997 |
| 5650541 | Ethacrynic acid-like compounds and use thereof to treat glaucoma Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are capable of effectively penetrating the cornea. Methods of co... | 07/22/1997 |
| 5616803 | Substituted amic acid derivatives A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## wherein each of the substituents are herein defined.... | 04/01/1997 |
| 5610183 | Phenylglycine derivatives pharmaceutical compositions containing them and their use in therapy Compounds of Formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein Q is optionally substituted phenyl or naphthyl; X and Y are each H, C1-6 alkyl, C2-6 alkenyl or X and Y are together .dbd.O; Z is O or S; R... | 03/11/1997 |
| 5604229 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 02/18/1997 |
| 5583259 | 2-(RO)-1-(R) ethylamines A compound of formula (I), or a salt or solvate thereof, ##STR1## in which R1 and R2 each independently represents hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl; R3 represents alkyl, o... | 12/10/1996 |
| 5557006 | 1-Alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fu... | 09/17/1996 |
