Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 6765022 | Cyclohexylamine derivatives as subtype selective nmda receptor antagonists Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel complexes useful for treating... | 07/20/2004 |
| 6710210 | N-substituted-aminomethyl cyclopropyl ketone derivatives or salts thereof and production process therefor Novel N-substituted-aminomethyl cyclopropyl ketone derivatives are represented by following Formula (1): wherein R1, R2 and R3 are each a hydrogen atom or an aliphatic hydrocarbon group; ... | 03/23/2004 |
| 6653508 | 3-amino-2-benzyl-1-phenylpropane derivatives Substituted 3-amino-2-benzyl-1-phenlypropane derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat various medical conditions.... | 11/25/2003 |
| 6281393 | Polyols useful for preparing water blown rigid polyurethane foam Mannich polyols having a viscosity of from 300 to 3,500 cps (0.3 to 3.5 Pa*s) at 25° C. are prepared by admixing a phenol, an alkanolamines, and formaldehyde mixed in molar ratios of from 1:1:1 to 1:2.2:2.2 resulting in an initiator which can be alkoxyla... | 08/28/2001 |
| 6255496 | Trifluoromethyl ketone analogs as selective cPLA2 inhibitors Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1##... | 07/03/2001 |
| 6087346 | Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, neurological disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising ... | 07/11/2000 |
| 6057371 | Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of c... | 05/02/2000 |
| 6028224 | Fluoxetine process from benzoylpropionic acid A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding γ-hydroxy ester, and the ester is cleaved. The free acid is t... | 02/22/2000 |
| 5962743 | Process for preparing acylaromatic compounds This invention provides a process for preparing acylaromatics comprising reacting an aromatic compound with a carboxylic acid in the presence of a reaction medium comprising polyphosphoric acid and a strong protic acid. In one embodiment, the invention pr... | 10/05/1999 |
| 5789448 | Benzoylethylene derivative Disclosed is a benzoylethylene derivative represented by the following formula (I) or a salt thereof. ##STR1## R1 to R5 : a hydrogen atom, --OR9 (R9 : a hydrogen atom, a C1 -C5 alkyl g... | 08/04/1998 |
| 5741821 | Use of natural products and related synthetic compounds for the treatment of cardiovascular disease Use of a compound of formula (I), wherein Ar is an aromatic ring system comprising one or more optionally substituted phenyl rings optionally linked to or fused with one or more other optionally substituted phenyl rings or one or more 5 or 6-membered, opt... | 04/21/1998 |
| 5674909 | Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system Compounds of formula ##STR1## wherein R, R', R", R1, R2, R3, R4, R5, R6, X, Y, m, n and p have the meanings reported in the description; and their pharmaceutically acceptable salts are desc... | 10/07/1997 |
| 5459266 | Substituted pyrazines The present invention provides novel substituted pyrazines or pyrazine derivatives ("NPD") which are functional and have useful application as a monomer for a variety of high performance polymers such as polyester, polyarylate, polycarbonate, polyetherket... | 10/17/1995 |
| 5414127 | Calcium independent camp phosphodiesterase inhibitor antidepressant Antidepressant agents having the formula ##STR1## wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic het... | 05/09/1995 |
| 5198585 | Method for the preparation of arylketoamines Acid addition salts of arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and strong acid in a dipolar aprotic solvent.... | 03/30/1993 |
| 5159103 | 2-amino-7-hydroxytetraline ethers 2-amino-7-hydroxytetraline ethers of formula ##STR1## wherein R' represents methyl substituted by a carboxy group or lower carbalkoxy group or a salt thereof; a process for their preparation starting from the 2-amino-7-hydroxytetraline, N-protection,... | 10/27/1992 |
| 5086074 | 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes Compounds of the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R2 is selected from hydroxy and lower alkoxy, R5 is lower alkyl, and R11 and R12 are independently selected from hydro... | 02/04/1992 |
| 5037980 | Phenyl imidazo[1,2-a]pyrimidines A compound of the formula: ##STR1## wherein R1 is ##STR2## where R3, R4 and R5 may be the same or different and are hydrogen, trihalomethyl, halogen or lower alkoxy having from 1 to 3 carbon atom... | 08/06/1991 |
| 5017618 | Labile derivatives of ketone analogs of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers Compounds having the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein --X-- is --O--, --CH2 -- or --; .dbd.Y is .dbd.O or a derivatized keto group which is hydrolyzable or enzymatically convertible to a k... | 05/21/1991 |
| 4990669 | Optically active -amino aldehydes, process for the preparation thereof, and the use thereof for the stereoselective preparation of optically active ଲ-amino alcohols The invention relates to new optically active -amino aldehydes of the formulae ##STR1## in which R1 represents an optionally substituted alkyl, alkenyl, aralkyl or aryl radical, and R2 and R3, independently of ... | 02/05/1991 |
| 4973756 | Hydroxylated ene ketones, acetylenic grignards and hydroxylated yne ketones therefrom An alpha-hydroxyl-alpha,alpha-di(inert-substituted)-gamma',delta'-yne ketone can be prepared by a procedure comprising contacting an acetylenic Grignard reagent with an alpha-hydroxyl-alpha,alpha-di(inert substituted)-alpha',beta'-ene ketone, and the ... | 11/27/1990 |
| 4952729 | Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydr... | 08/28/1990 |
| 4948813 | Benzylketone phospholipase A2 inhibitors The invention relates to benzylketone phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by administration of a therapeutically effective... | 08/14/1990 |
| 4923882 | Novel amine derivatives, salts thereof and an anti-ulcer agent containing the same This invention relates to amine derivatives and salts thereof. These compounds have an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such compound, a process for the preparation thereof and an anti-ulcer ag... | 05/08/1990 |
| 4885314 | Novel HMG-CoA reductase inhibitors Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) or (II): ##STR1## and pharmaceutically acceptable salt... | 12/05/1989 |
| 4803225 | Dihydroxy-phenethylamino compounds useful as pharmaceuticals There are provided compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. card... | 02/07/1989 |
| 4774359 | Polyenamines from aromatic diacetylenic diketones and diamines The synthesis and characterization of several polyenamine ketones are discussed wherein conjugated diacetylenic diketones and aromatic diamines are used as a route to the formation of high molecular weight polyenamine ketones which exhibit good mechanical... | 09/27/1988 |
| 4749792 | Diamino ketones and alcohols as analgesic agents Analgesic activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R1, R2 and R4 are each independently hydrogen, alkyl, carboxyalkyl, halosubstituted alkyl,... | 06/07/1988 |
| 4739052 | Phenyl ketone derivatives Compounds of the formula I, II or III ##STR1## in which Ar and Ar' are an oxygen-containing aromatic radical, R1 and R2 are a monovalent hydrocarbon radical which is substituted or unsubstituted, or R1 and R2 | 04/19/1988 |
| 4728659 | Aminomethyl derivatives and preparation process thereof as well as platelet aggregation inhibitors containing same Disclosed herein are aminomethyl derivatives each of which is of the following general formula (I): ##STR1## wherein A represents a group --C.tbd.C-- or --CH.dbd.CH--, Y represents a group ##STR2## (in which R3 being a lower alky... | 03/01/1988 |
| 4723039 | Phenylacetaldehydes substituted by basic groups, their preparation and drugs containing these compounds Phenylacetaldehydes which are substituted by basic groups, of the formula ##STR1## where R1 to R8, m and n have the meanings stated in the description, and their preparation are described. The substances are useful for the treat... | 02/02/1988 |
| 4720586 | Substituted 3,4-dihydroxy-phenylethylamino compounds There are provided compounds of formula I, ##STR1## in which R1 represents OH, R2 and R3, which may be the same or different, each independently represent hydrogen, fluorine, chlorine, bromine, alkyl C1 to 6, nitro, n... | 01/19/1988 |
| 4695589 | Alpha-(aminoalkyl-4-hydroxy-3-(alkylthio)benzenemethanols Alpha-(aminoalkyl)-4-hydroxy-3-(alkylthio)benzenemethanols useful as intermediates and as antihypertensive agents are prepared by reduction of the corresponding aminoalkyl 4-hydroxy-3-(alkylthio)phenyl ketones.... | 09/22/1987 |
| 4657929 | Compounds There are provided pharmaceutical compounds useful in treating hypertension, heart diseases and renal failure. These compounds are 4-hydroxy phenethylamines wherein the 3 position on the phenyl nucleus is occupied by either an amino, amide, carbamyl, urea... | 04/14/1987 |
| 4603019 | N-(methoxyphenacyl)-amine derivatives This invention relates to new N-(methoxyphenacyl)-amine derivatives selected from the group consisting of (i) the N-(methoxyphenacyl)-alkylamines of the general formula ##STR1## wherein A is OCH3, and R is C3 -C8 -alkyl o... | 07/29/1986 |
| 4529556 | Bis((aryl)vinyl)benzenes The invention bis((aryl)vinyl)benzenes wherein the aryl and benzene moieties may be substituted, and the vinyl carbon alpha to the central benzene ring may be further substituted with an aliphatic group.... | 07/16/1985 |
| 4497740 | 2-Azidomethyl-1,4-benzodiazepine compounds New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I ##STR1## wherein R1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R2 is a hy... | 02/05/1985 |
| 4496755 | Optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl) amino-1-propanone, its derivatives and their halo analogs and the methods for their manufacture A manufacturing method is described for the preparation of optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl)amino-1-propanone, its derivatives and their halo analogs. The optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl)amino-1-propa... | 01/29/1985 |
| 4467094 | Precursors to ethylenediamine derivatives New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.... | 08/21/1984 |
| 4408074 | Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride A process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride is described by reacting 2,6-dimethoxyphenol with anhydrous chloral in the presence of a catalyst, hydrolyzing 1-(3,5-dimethoxy-4-hydroxyphenyl)2,2,2-trichl... | 10/04/1983 |
