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| Number | Title | Issue Date |
| 7737302 | Process for preparing bupropion hydrochloride This invention described a synthesis method of bupropion hydrochloride. m-chloropropiophenone was brominated directly with bromine, then aminated with t-butylamine and finally reacted with HCl to obtain crude product of bupropion hydrochloride. Pure product was obta... | 06/15/2010 |
| 7408084 | Process for producing optically active β-amino alcohol A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to y... | 08/05/2008 |
| 6846957 | Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of 1-phenyl-3-methylamino-2-propen-1-one with sodium borohydride and acetic acid. ... | 01/25/2005 |
| 6683214 | Process for producing -aminoketones An amino group of an -amino acid ester is protected as an imine, and it is then reacted with a halomethyllithium to obtain an N-protected--aminohalomethylketone. Further, this N-protected--aminohalomethylketone is treated with an acid... | 01/27/2004 |
| 6538160 | Process for producing -aminohalomethyl ketone derivatives Herein is disclosed a process for producing an -aminohalomethyl ketone derivative which comprises subjecting to catalytic reduction the corresponding -aminodihalomethyl ketone derivative, and which process is efficient and suited for industr... | 03/25/2003 |
| 6482987 | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer Novel, stable formulations of bupropion hydrochloride are provided which will maintain at least 80% of initial bupropion hydrochloride potency after one year. Methods of inhibiting degradation of bupropion hydrochloride and methods of preparing stable for... | 11/19/2002 |
| 6462237 | Cyclodextrin stabilized pharmaceutical compositions of bupropion hydrochloride An inclusion complex of bupropion hydrochloride with beta cyclodextrin that stabilizes the bupropion hydrochloride against degradation. A method of preparing an inclusion complex of bupropion hydrochloride with beta cyclodextrin that stabilizes the buprop... | 10/08/2002 |
| 6420606 | Method for producing alkoxy arylamine compounds Disclosed are methods of producing of alkoxy arylamine compounds which find particular use in the syntheses of pharmaceutical drug. The alkoxy arylamine compounds generally have the formula: H2 N--Ar--OR wherein Ar is an unsubstituted or substituted... | 07/16/2002 |
| 6281393 | Polyols useful for preparing water blown rigid polyurethane foam Mannich polyols having a viscosity of from 300 to 3,500 cps (0.3 to 3.5 Pa*s) at 25° C. are prepared by admixing a phenol, an alkanolamines, and formaldehyde mixed in molar ratios of from 1:1:1 to 1:2.2:2.2 resulting in an initiator which can be alkoxyla... | 08/28/2001 |
| 6147253 | N-protected/N-substituted-beta-amino-hydroxy sulfonates N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates which can be readily converte... | 11/14/2000 |
| 5962743 | Process for preparing acylaromatic compounds This invention provides a process for preparing acylaromatics comprising reacting an aromatic compound with a carboxylic acid in the presence of a reaction medium comprising polyphosphoric acid and a strong protic acid. In one embodiment, the invention pr... | 10/05/1999 |
| 5939587 | N-protected/N-substituted-beta-amino hydroxy sulfonates N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates which can be readily converte... | 08/17/1999 |
| 5932766 | Process for the preparation of substituted keto-enamines The present invention discloses a process for the preparation of a compound having formula 4: ##STR1## The process comprises the step of reacting an enolate having the formula: ##STR2## with a Grignard reagent. The enolate salt is formed in situ... | 08/03/1999 |
| 5795985 | Phenyl alkyl ketone substituted by cyclic amine and a process for the preparation thereof A novel process for the preparation of compounds of formula I ##STR1## by aminolysis of a p-halophenyl alkyl ketone of formula II ##STR2## with a cyclic amine of formula III ##STR3## in water at a temperature of at least 130° C., in which ... | 08/18/1998 |
| 5688985 | Process for producing keto nitrile derivative A process for producing a (4S)-4-(N,N-dibenzyl)amino-5-phenyl-3-oxo-pentanenitrile derivative which comprises reacting a (2S)-2-(N,N-dibenzyl)aminophenylalanine ester derivative with acetonitrile in the presence of a lithium compound or a magnesium c... | 11/18/1997 |
| 5631405 | Method of forming amino acid-derived diaminopropanols useful as chemical intermediates for protease-inhibitors The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl... | 05/20/1997 |
| 5618966 | Method forming protease inhibitor synthetic intermediates The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl... | 04/08/1997 |
| 5599994 | Amino acid-derived diaminopropanols The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method inclu... | 02/04/1997 |
| 5565432 | Smooth muscle cell proliferation inhibitors This invention comprises polyanionic benzylglycosides of benzene triacid amides of the general formula I ##STR1## wherein each of R1, R2, R3, and R4 are, independently, H, SO3 M, or ##STR2##... | 10/15/1996 |
| 5561135 | N,N,N',N'-tetrasubstituted-1,2-ethanediamine derivative compounds The invention relates to new N,N,N'N'-tetra-substituted-1,2-ethanediamine compounds of the general formula (I): ##STR1## wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or p-fluorophenyl-methylen (p--F--C6 H4 --CH) group an... | 10/01/1996 |
| 5510538 | Process for the oxidation of primary and secondary alcohols to aldehydes and ketones and for the oxidation of 1,2-diols to -ketols and -diketones A process for the selective oxidation of a primary or secondary alcohol to an aldehyde or ketone and for the oxidation of a 1,2-diol to an -ketol or -diketone, which comprises contacting the alcohol or 1,2-diol with o-iodoxybenzoic acid. Thi... | 04/23/1996 |
| 5475138 | Method preparing amino acid-derived diaminopropanols The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method incl... | 12/12/1995 |
| 5466873 | Process for preparing arylketoamines Arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and a liquid carboxylic acid at a temperature of less than about 600° C.... | 11/14/1995 |
| 5457231 | Process for preparing arylketoamines Arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and a liquid carboxylic acid at a temperature of less than about 60° C.... | 10/10/1995 |
| 5442119 | Catalytic asymmetric reduction of trisubstituted olefins A catalytic asymmetric reduction process, which, by hydrogenating trisubstituted olefins, yields a corresponding organic compound having a high level of enantiomeric purity is disclosed. The reduction process utilizes a chiral metal catalyst that includes... | 08/15/1995 |
| 5410066 | Process for the preparation of substituted pyrazolines A new process for the preparation of pyrazolines of formula ##STR1## is provided, in which R1 and R3 are identical or different and each represent optionally substituted aryl or optionally substituted and/or benzo-fused heterocy... | 04/25/1995 |
| 5399764 | Process for preparing arylketoamines Arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and a liquid carboxylic acid at a temperature of less than about 60° C.... | 03/21/1995 |
| 5399763 | Process for preparing optically active 2-aminopropanal A process for preparing an optically active 2-aminopropanal through oxidative cleavage of the corresponding optically active 3-amino-1,2-butanediol of the following formula (2): ##STR1## wherein R1 is a hydrocarbon group having 3 to 6 carbon atoms; R... | 03/21/1995 |
| 5395971 | Molybdenum-catalyzed amination of olefins A process for making unsaturated -amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen atmosphere. The catalyst may be described by the general ... | 03/07/1995 |
| 5380946 | Process for preparing p-nitroaromatic amides and products thereof A process for preparing p-nitroaromatic amides is provided which comprises contacting a nitrile, nitrobenzene, a suitable base and water in the presence of a suitable solvent system to form a mixture, and reacting the mixture at a suitable temperature in ... | 01/10/1995 |
| 5349090 | Process for preparing arylketoamines Arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and a liquid carboxylic acid at a temperature of less than about 60° C.... | 09/20/1994 |
| 5322964 | Process for the preparation of alpha-aminoketone salts There is disclosed a process for the preparation of an alpha-aminoketone salt of formula I ##STR1## which comprises reacting a nitrosated keto ester of formula II ##STR2## with a carboxylic anhydride of formula IV ##STR3## under the co... | 06/21/1994 |
| 5322963 | Method for preparing -amino-ଲ, δ-diol derivatives Intermediate compounds (formula [III]and [IV]) useful as starting materials for the synthesis of amino acid derivatives which have renin inhibitory activity and which are useful as remedies for hypertension are prepared stereoselectively in high yield, wi... | 06/21/1994 |
| 5284962 | Multistage process for making methyl carbamates A continuous process employing at least two reaction stages for manufacturing pesticides from methyl isocyanate and oxime or phenol reactants in water.... | 02/08/1994 |
| 5276191 | Process for the preparation of ketones According to the invention, there is provided a process for the preparation of an aminoalkyl p-hydroxyphenyl ketone comprising reacting phenol with a nitrile, in the presence of a Lewis acid catalyst, to cause condensation thereof, the process being chara... | 01/04/1994 |
| 5198585 | Method for the preparation of arylketoamines Acid addition salts of arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and strong acid in a dipolar aprotic solvent.... | 03/30/1993 |
| 5182401 | Preparation of 3-amino-2-(het)aroyl-acrylic acid derivatives A process for the preparation of a 3-amino-2-(het)aroyl-acrylic acid derivative fo the formula ##STR1## in which Y represents a nitrile, or an ester group, --COOR1, or an acetyl group, where R1 denotes C1 -C4 | 01/26/1993 |
| 5132457 | Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP) In a method for producing 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP), a chiral ester of the formula ##STR1## wherein R is an alkyl of from 1 to about 5 carbon atoms, is provided. The chiral easter of formula (I) is converted into a chiral a... | 07/21/1992 |
| 4980377 | 1-(aminophenyl)-2-aminopropanone derivatives The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH2, Y is H or a halogen atom, Z is H or a halogen atom, R1 is C1 -C | 12/25/1990 |
| 4978773 | Process for the preparation of 2,6-dichlorodiphenylaminoacetic acid derivatives A new process for the preparation of 2,6-dichlorodiphenylamine derivatives is described, which process provides the desired active compound in a high yield and with a very high degree of purity by a technically simple and realizable procedure.... | 12/18/1990 |
