Did You Know...
...During the Civil War, the Confederacy established its own Patent Office which issued 266 patents, a third of which concerned implements of war.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8183415 | Methods of synthesizing cinacalcet and salts thereof Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepa... | 05/22/2012 |
| 8044243 | Compounds for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein ... | 10/25/2011 |
| 7994365 | Basic acetophenones as inhibitors of NO-synthases Use of the substance characterized by general structural formula (I) for the preparation of an agent inhibiting the enzymatic activity of NO-synthase, R1, R2, R3, R4 and/or R5 being hydrogen, an alkyl group, an aryl group o... | 08/09/2011 |
| 7592487 | Chiral tertiary aminoalkylnaphthols The invention relates to the compounds of formula: (I) which are as defined in the specification. Their use as chiral ligands in catalytic aryl transfer reactions to aromatic aldehydes is also described. ... | 09/22/2009 |
| 7563930 | Crystal forms of Cinacalcet HCI and processes for their preparation Provided are crystalline forms of Cinacalet HCl and processes for their preparation. ... | 07/21/2009 |
| 7449603 | Process for the preparation of cinacalcet base Provided is a process for preparing Cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine and intermediates thereof. ... | 11/11/2008 |
| 7446227 | Process for preparation of 5H-dibenzo[a,d] cycloheptene derivatives A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate... | 11/04/2008 |
| 7423181 | Aminoalkoxy-functional chalcones The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention f... | 09/09/2008 |
| 7417169 | Amino alcohol derivatives, medicinal composition containing the same, and use of these The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independentl... | 08/26/2008 |
| 7368462 | Melanin concentrating hormone antagonists The present invention relates to compounds capable of serving as moderators of human and mammalian appetite and as such provide a means for reducing body mass and controlling obesity. ... | 05/06/2008 |
| 7368606 | Amorphous cinacalcet hydrochloride and preparation thereof Provided is amorphous cinacalcet hydrochloride, processes for the preparation thereof, and pharmaceutical compositions therewith. ... | 05/06/2008 |
| 7361789 | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, th... | 04/22/2008 |
| 7342133 | Substituted amino compounds as 5-HT/NA uptake inhibitors The invention relates to substituted amino compounds, to processes for their preparation, to pharmaceutical formulations containing these compounds and to the use of these substances in the preparation of pharmaceutical formulations, especially for the treatment or ... | 03/11/2008 |
| 7279600 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents This invention provides estrogen receptor modulators having the structure: wherein R1 to R6 and R8 are as defined in the specification; or a pharmaceutically acceptable salt there... | 10/09/2007 |
| 7273952 | Substituted C-cyclohexylmethylamine derivatives Substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds, the use of substituted C-cyclohexylmethylamine derivatives for producing pharmaceuticals, and method of pain treatment using the pharmaceu... | 09/25/2007 |
| 7271291 | 1,3,5-tris (arylamino) benzenes The invention provides 1,3,5-tris(arylamino)benzenes represented by the general formula (I) wherein A is naphthyl, anthryl or phenanthryl group, and R is hydrogen atom or diarylamino group. These 1,3,5-tr... | 09/18/2007 |
| 7247751 | Processes for preparing cinacalcet hydrochloride crystal Form I The invention provides processes for the preparation of cinacalcet hydrochloride crystalline Form I. ... | 07/24/2007 |
| 7244703 | Pharmaceutical compositions and methods for peptide treatment Compositions and methods for treating a patient with a pharmaceutically active peptide that combines a pharmaceutically active peptide, a permeation enhancer, and a carrier, are disclosed. ... | 07/17/2007 |
| 7211695 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 05/01/2007 |
| 7186864 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, or a tautomer, ... | 03/06/2007 |
| 7169817 | Bis-aromatic alkanols The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them. Compounds according to the present invention are based upon the chemical formula: | 01/30/2007 |
| 7112561 | Pharmaceutical compositions and methods for insulin treatment Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed. ... | 09/26/2006 |
| 7105701 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 09/12/2006 |
| 7030160 | Propanolaminotetralines, preparation thereof and compositions containing same The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action. ... | 04/18/2006 |
| 6984738 | Process for production of optically active amino alcohols The present invention is to provide a process for producing an optically active amino alcohol which is useful for the synthesis of natural substances and as an intermediate for drugs and agricultural chemicals in a high yield, a high selectivity and an economical ma... | 01/10/2006 |
| 6924391 | Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, ... | 08/02/2005 |
| 6770786 | Process for preparing a substituted allylamine derivative and the salts thereof The antifungal agent (E)-N-methyl-N-(1-naphthylmethyl)-6,6-dimethyl-hept-2-ene-4-ynyl-1-amine of formula (I) and acid addition salts thereof are prepared by reacting a chloro-compound of formula (IIIb) ... | 08/03/2004 |
| 6762330 | Catalysis using phosphine oxide and sulfoxide compounds Phosphine oxide and sulfoxide compounds were used with transition metals, preferably palladium and nickel, to produce biaryls, arylthiols, arylphosphine oxides and arylamines via cross-coupling reactions with aryl halides and arylboronic acids, aryl Grignard reagent... | 07/13/2004 |
| 6710080 | Substituted 2-dialkylaminoalkylbiphenyl derivatives Substituted 2-dialkylaminoalkylbiphenyl derivatives, processes for their preparation, pharmaceutical compositions comprising these compounds and methods using these compounds for the preparation of medicaments and for the treatment of diseases. ... | 03/23/2004 |
| 6689913 | Process for preparing terbinafine and HCI salt thereof Provided is a process for preparing terbinafine or its HCl salt comprising: reacting a furan derivative with a base to form a second compound; performing a reductive alkylation of the second compound obtained in the step with N-methyl-1-naphthalenemethyla... | 02/10/2004 |
| 6573399 | Synthesis of -amino-', '-dihaloketones and process for the preparation of ଲ-amino acid derivatives by the use of the same The present invention provides a commercially profitable process for producing a ଲ-amino acid ester derivative which comprises reacting an -amino acid ester derivative with a base and a dihalomethane, reacting the same with a lithium amide and an ... | 06/03/2003 |
| 6482986 | Benzene derivatives, preparation method and pharmaceutical compositions containing same The invention concerns compounds of formula (I) wherein A, X, Y, n, R1, R2 and R3 are as defined in claim 1. Said compounds are specifically binding to sigma receptors particularly those of the peripheral nervous system. ... | 11/19/2002 |
| 6417357 | Coupling reactions with palladium catalysts This invention relates to a novel, inventive process for the preparation of biphenyls or aromatic olefins by coupling reactions of the Suzuki coupling and Heck coupling type, using allylpalladium catalysts of the μ-halo(triisopropylphosphine)(η3 | 07/09/2002 |
| 6410736 | Biaryl ether derivatives useful as monoamine reuptake inhibitors The present invention relates to compounds of formula I, ##STR1## and to their pharmaceutically acceptable salts. Compounds of formula I exhibit activity as serotonin, norepinephrine, and dopamine reuptake inhibitors and can be used in the treatment of ce... | 06/25/2002 |
| 6365775 | Biphenyl compounds and their use as oestrogenic agents Compounds of formula (I), wherein [X] represents aromatic carbocyclic rings (A) and (B), where R1, R2, R3, R4, R5, R6 and R7 are as defined in the description, salts thereof, a method... | 04/02/2002 |
| 6335366 | Naphthyloxy acetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient The naphthyloxyacetic acid derivatives of the formula (I) ##STR1## wherein A is H, -(alkylene)COOR1, -(alkylene)CONR2 R3, -(alkylene)OH, -(alkylene)tetrazole, -(alkylene)CN; E is single bond or alkylene; G is --S--, --SO--... | 01/01/2002 |
| 6323369 | Substituted cycloheptenes, their preparation and use This invention provides substituted cycloheptenes of the general formula I ##STR1## in which R1 represents OH, O-(C1 -C6)-alkyl, O-(C3 -C7)-cycloalkyl, O-aryl, C1 -C6 -alkyl-COO-, ary... | 11/27/2001 |
| 6268520 | Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.... | 07/31/2001 |
| 6235791 | Use of amines to produce drugs for preventing tumor cell proliferation The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl [3-(3-chloro-4-cyclohexylphenyl)-allyl]amine from its receptors for the preparation of pharmaceutical compositions intended to combat cell ... | 05/22/2001 |
| 6221871 | Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands Disclosed are compounds of the formula: ##STR1## where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR' where R' is an organic or inorganic substituent; R is hydrogen or an alkyl group; R1 | 04/24/2001 |
