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| Number | Title | Issue Date |
| 8084646 | Process for production of hydroxyadamantaneamine Disclosed is a process for producing 1-hydroxy-4-aminoadamantane. ... | 12/27/2011 |
| 7994364 | Crystalline forms of (−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride A hitherto unknown crystalline form of (−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use includin... | 08/09/2011 |
| 7807854 | Effective use method of medicaments and method of preventing expression of side effect To provide a medicament which efficiently expresses an immunosuppressive agent or an anti-inflammatory agent and reduces expression of side effect. A medicament includes diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure having... | 10/05/2010 |
| 7781617 | Effective use method of medicaments and method of preventing expression of side effect A medicine which effectively functions as an immunosuppressant or anti-inflammatory agent and is effective in diminishing the occurrence of side effects. The medicine comprises a combination of: a diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propaned... | 08/24/2010 |
| 7745664 | Processes for preparing venlafaxine and venlafaxine hydrochloride of form I A process for preparing venlafaxine in a high yield as well as processes for producing venlafaxine hydrochloride of form I having a very high polymorphic purity are described. ... | 06/29/2010 |
| 7674935 | Crystal forms of O-desmethylvenlafaxine Methods for preparing crystalline forms of O-desmethylvenlafaxine are described. ... | 03/09/2010 |
| 7576241 | Derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them A compound of the formula wherein the substituents are defined as in the specification useful as intermediates. ... | 08/18/2009 |
| 7491848 | Process for making desvenlafaxine Desvenlafaxine is formed from venlafaxine by the use of a demethylating agent comprising a metal sulfide, such as sodium sulfide, and optionally selenium. ... | 02/17/2009 |
| 7468459 | Process for the preparation of chiral beta amino acid derivatives by asymmetric hydrogenation The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation o... | 12/23/2008 |
| 7435854 | Methods for preparing O-desmethylvenlafaxine The present invention provides an efficient method of making O-desmethyl-venlafaxine. ... | 10/14/2008 |
| 7432399 | Diols formed by ring-opening of epoxies A polyol monomer comprising the formula: R1 and R3 are —H, aliphatic, aromatic, or ether; R2 is aliphatic, aromatic, ester, ether, or acrylic, and R1 contains a hydroxyl group, ... | 10/07/2008 |
| 7408084 | Process for producing optically active β-amino alcohol A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to y... | 08/05/2008 |
| 7405262 | Preparation of functionalized anionic polymerization initiators A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound. ... | 07/29/2008 |
| 7402698 | Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia,... | 07/22/2008 |
| 7384434 | Reaction of phenols with intermediate triazines An improved process for preparing a Mannich product employs an intermediate or pre-formed triazine. The product is useful as a detergent in fuel compositions. The fuel compositions containing the Mannich product are useful for controlling intake valve deposits in en... | 06/10/2008 |
| 7385064 | Catalysts for use in enantioselective synthesis Disclosed are compounds having the following formula: in which Z11 is selected from a substituted or unsubstituted saturated adamantyl or other polycyclic group and a substituted or unsubstituted branched acyclic... | 06/10/2008 |
| 7378552 | Monoamine re-uptake inhibitors and methods relating thereto Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The compounds of this invention hav... | 05/27/2008 |
| 7365076 | Substituted aryl cycloalkanol derivatives and methods of their use The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor sym... | 04/29/2008 |
| 7355079 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 04/08/2008 |
| 7345048 | Heterocyclic compounds and uses thereof as D-alanyl-D-alanine ligase inhibitors The invention relates to D-Ala-D-Ala ligase inhibitors having the formula: wherein R1 is NH2; R2 is NH2; R3 is selected from hydrogen, alkyl, amino, hydroxy, alkoxy, an... | 03/18/2008 |
| 7345202 | Use of sulfamic acids as resolving agent The invention relates to the use of chiral sulfamic acids as resolving agents, the sulfamic acid having the formula (R1,R2)N—SO3H, wherein: R1 and R2, being the same or different, represent a hydrogen atom or a C1 | 03/18/2008 |
| 7342133 | Substituted amino compounds as 5-HT/NA uptake inhibitors The invention relates to substituted amino compounds, to processes for their preparation, to pharmaceutical formulations containing these compounds and to the use of these substances in the preparation of pharmaceutical formulations, especially for the treatment or ... | 03/11/2008 |
| 7339079 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 03/04/2008 |
| 7332512 | Halogenated nitrobutadienes for controlling animal pests The present invention relates to novel halonitrobutadienes, to processes for their preparation and to their use for controlling animal pests. ... | 02/19/2008 |
| 7323597 | Method for the production of diaminoxylene by continuous hydrogenation of liquid phthalonitrile A process for preparing xylylenediamine by continuously hydrogenating liquid phthalonitrile over a heterogeneous catalyst in the presence of liquid ammonia in a reactor, in which a portion of the reactor effluent is recycled as a liquid circulation stream continuous... | 01/29/2008 |
| 7321065 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 01/22/2008 |
| 7297820 | Stilbene derivatives and their use for binding and imaging amyloid plaques This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 11/20/2007 |
| 7288571 | Thyroid receptor ligands and method II New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or dif... | 10/30/2007 |
| 7271291 | 1,3,5-tris (arylamino) benzenes The invention provides 1,3,5-tris(arylamino)benzenes represented by the general formula (I) wherein A is naphthyl, anthryl or phenanthryl group, and R is hydrogen atom or diarylamino group. These 1,3,5-tr... | 09/18/2007 |
| 7253211 | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for ... | 08/07/2007 |
| 7253189 | Cannabinoid receptor ligands A compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: R1, R2, L1, L2, M1, M2, n, p, q, A, D, X, Y and Z are... | 08/07/2007 |
| 7250533 | Process for preparing Cinacalcet hydrochloride Processes for preparing cinacalcet are provided. ... | 07/31/2007 |
| 7235576 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. ... | 06/26/2007 |
| 7230018 | Substituted propane-1,3-diamine derivatives and the pharmaceutical use thereof Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or prophylaxis of pain, urinary incontinence, itching, tinitus aurium, or diarrh... | 06/12/2007 |
| 7227040 | Process for forming branched composition catalytically by carbon-hydrogen bond activation in a saturated moiety A branched composition can be formed by reacting a reagent containing a saturated hydrocarbon moiety in the presence of (a) a catalyst capable of activating a carbon-hydrogen bond therein and (b) a branching reagent having a moiety that binds to the carbon atom in t... | 06/05/2007 |
| 7226950 | Sodium channel modulators The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the pr... | 06/05/2007 |
| 7211695 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 05/01/2007 |
| RE39530 | 3-amino-3-arylpropan-1-ol-compounds, their preparation and use 3-amino-3-arylpropan-1-ol compounds corresponding to the formula I in which R1 to R5, A and X have the meanings according to claim 1, and their preparation and use as medicaments. ... | 03/27/2007 |
| 7189878 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative disease in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl ... | 03/13/2007 |
| 7186864 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, or a tautomer, ... | 03/06/2007 |
