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| Number | Title | Issue Date |
| 8063249 | Substituted triphenyl butenes The present invention is directed to compounds, compositions thereof, and the use of the compounds and compositions for the treatment and prevention of breast cancer. In one embodiment, the present invention relates to the use of a substituted triphenyl butene or pr... | 11/22/2011 |
| 7355077 | Process for preparing tolterodine A process for preparing tolterodine with high purity. ... | 04/08/2008 |
| 7342038 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a ther... | 03/11/2008 |
| 7094550 | Method to determine TGF-beta A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1–C4)alkyl, R1 | 08/22/2006 |
| 7084171 | Compounds and therapies for the prevention of vascular and non-vascular pathologies The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compound... | 08/01/2006 |
| 6875775 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH3 | 04/05/2005 |
| 6723738 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2 , which are the same or different are a) H, halogen, OCH3, OH; or | 04/20/2004 |
| 6562080 | Primary intermediates for oxidative coloration of hair Primary intermediates useful hair coloring systems comprise 2-arylaminomethyl-4-aminophenols. The invention provides new 2-arylaminomethyl-4-aminophenol compounds of Formula (1): ##STR1## wherein R is a moiety selected from formulae (2), (3) or (4) #... | 05/13/2003 |
| 6451817 | Alpha-substituted-1-benzyl-napthyls This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are -substituted with ether, thioether, amino, hydrazino, cyano or halo that are useful for the treatment of the various medica... | 09/17/2002 |
| 6391892 | Naphthyl pharmaceutical compounds The present invention provides a compound of formula I ##STR1## wherein R1 is H, OH, halo, OCO(C1 -C6 alkyl), OCO(aryl), OSO2 (C4 -C6 alkyl), OCOO(C1 -C6 alkyl), OCOO(aryl)... | 05/21/2002 |
| 6384053 | -substituted-1-benzyl-napthyls This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are -substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indication... | 05/07/2002 |
| 6204067 | Methods of identifying modulators of the estrogen receptor The present invention discloses the mechanism of tamoxifen mediated inhibition of acidification. This mechanism information is then used to design methods of identifying compounds that will have the pharmaceutical effect of tamoxifen without the correspon... | 03/20/2001 |
| 6096301 | Combined interferon/antiestrogen therapy for treatment of breast cancer Proliferation of breast cancer is treated by a combined type I interferon/non-steroidal antiestrogen therapy. Preferably antiestrogen treatment is sequential to treatment with interferon.... | 08/01/2000 |
| 6034275 | Tertiary amines Tertiary amines of the formula ##STR1## wherein A1, A2, A3, A4, L, M, p, T, and Q are as defined herein, have antimycotic and cholesterol-lowering activity.... | 03/07/2000 |
| 5958916 | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods The instant invention provides dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods for use in the treatment of bone loss or bone resorption.... | 09/28/1999 |
| 5773469 | Diaryl antimicrobial agents The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and ... | 06/30/1998 |
| 5693863 | Method for the production of E-1-4'- (2- Dimethylaminoethoxy) - Phenyl!-1-(3-Hydroxyphenyl) -2-Phenyl-1-Butene The present invention relates to methods for the production of E-1-4'-(2-dimethylaminoethoxy)-phenyl!-1-(3'-hydroxyphenyl)-2-phenyl-1-bu tene of formula (I) which comprises heating the compound of formula (II) in the presence of an organic solvent and HC... | 12/02/1997 |
| 5691384 | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention bone tissue loss or osteoporosis.... | 11/25/1997 |
| 5643950 | Triphenylalkyl antimicrobial agents The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the acti... | 07/01/1997 |
| 5637771 | Compound useful for lowering cholesterol A method of lowering cholesterol which comprises administering to a host requiring such treatment an effective amount of a compound of the formula ##STR1## wherein one of R1 and R2 is C1-7 -alkyl and the other is C | 06/10/1997 |
| 5589500 | Substituted 1,1,2-triphenylbutenes and their use in the treatment of cancer Compounds of the general formula (2) ##STR1## wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R1 and R2, which may be the same or different, represent C1-3 alkyl, especiall... | 12/31/1996 |
| 5565611 | Process for preparing acid addition salt of Z-isomer of triphenylethylene compound The present invention provides a process for preparing an acid addition salt of the Z-isomer of a compound of the formula ##STR1## wherein R1 and R2 represent a lower alkyl group, or taken together with the nitrogen atom to whic... | 10/15/1996 |
| 5525633 | Triaryl-ethylene derivatives The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.... | 06/11/1996 |
| 5495048 | Amino alkenyloxybenzene derivatives A method of lowering cholesterol which comprises administering to a host requiring such treatment an effective amount of a compound of the formula ##STR1## wherein one of R1 and R2 is C1-7 -alkyl and the other is C | 02/27/1996 |
| 5491173 | Tri-phenyl alkene derivatives and their preparation and use The invention provides novel compounds of the formula: ##STR1## wherein R1 and R2, which can be the same or different are H or OH, R3 is ##STR2## wherein R4 and R5, which can be the same or ... | 02/13/1996 |
| 5464836 | Benzophenones having an antifungal activity A description follows of benzophenones having an antifungal activity and responding to the general formula (I): ##STR1## wherein: R1 and R2, the same or different, represent C1 -C6 alkyl groups, C7 | 11/07/1995 |
| 5410080 | Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors Compounds of the formula: ##STR1## wherein R1 and R2 are each selected from the group consisting of C1 -C2 lower alkyl; X is NH or S; and n is a whole number within the range of 1-4 inclusive; and when n=0,... | 04/25/1995 |
| 5219548 | High affinity halogenated-tamoxifen derivatives and uses thereof Applicants describe the synthesis of fluorotamoxifen and iodotamoxifen analogs with the halogen atom positioned on the aliphatic chain of the tamoxifen molecule. The halogenated-tamoxifen derivatives possess superior binding affinities to estrogen recepto... | 06/15/1993 |
| 5214046 | Substituted aminoalkoxybenzene anti-fungicidal compositions and use The compound of the formula ##STR1## wherein each of R1 and R2 individually is hydrogen, lower alkyl or lower alkenyl or together signify straight-chain alkylene with 2 to 4 carbon atoms, R3 is hydrogen, halogen or lo... | 05/25/1993 |
| 5192799 | Coumaran group containing amine compounds and their acid addition salts and quaternary ammonium salts and the use thereof as anti arrhythmic agents and as psychotropic agents Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for t... | 03/09/1993 |
| 5091574 | Polyoxyethylene diamine derivatives of diglycidyl ethers Tetrafunctional amine derivatives of digyclidyl ethers of Bisphenol A that are liquid at ambient temperatures and that are useful as curing agents for epoxy resins are disclosed together with the method by which they are prepared which comprises the steps... | 02/25/1992 |
| 5089529 | Butanol derivatives 4-mono- and di-isobutylamino butanols of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof wherein R1 and R2 are the same or different and each is selected from the group consisting of hydrogen, halo, hydro... | 02/18/1992 |
| 5047431 | 1,1,2-triphenylbut-1-ene derivatives Novel (E)-1-[4'-(2-alkylaminoethoxy)phenyl]-1- (3'-hydroxyphenyl)-2-phenylbut-1-enes of the general formula ##STR1## wherein R1 and R2 may be the same or different, provided that, when R1 and R2 are the sam... | 09/10/1991 |
| 4973755 | Stable solvent adducts of Z-1-(p-ଲ-dimethylaminoethoxy-phenyl)-1-(p-hydroxyphenyl)-2-phenyl-b ut-1-ene This invention relates to new stereochemically pure and stable adducts of Z-1-(p-ଲ-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenyl-but- 1-ene and certain solvents which by virtue of their marked antioestrogenic activities may be used for the ... | 11/27/1990 |
| 4960937 | Process for the preparation of trans-1,1,2-triphenyl-but-1-ene derivatives The invention concerns the direct preparation of trans-1,1,2-triphenyl-but-1-ene derivatives having the general formula 1 by dehydration of carbinols having the general formula 2 by heating in a strongly hydrochloric or sulphuric acid medium with the excl... | 10/02/1990 |
| 4861916 | Photoinitiators for photopolymerization of unsaturated systems Compounds of the general formula I ##STR1## wherein Z is CR1 R2 (OR3) or phenyl, R1 being H, C1-6 -alkyl or phenyl, R2 being H, C1-6 -alkyl or C1-6 -alkoxy and R3 | 08/29/1989 |
| 4839155 | Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy Iodotamoxifen derivatives which are compounds of formula (3) ##STR1## wherein X represents 3- or 4- iodo and R1 and R2, which may be the same or different, represent C1-3 alkyl, especially methyl or ethyl, groups or R... | 06/13/1989 |
| 4826672 | Astatinated organic compounds Methods and kits for incorporating a radioactive astatine isotope (particularly 211 At) into an organic compound by electrophilic astatodestannylation of organostannanes.... | 05/02/1989 |
| 4806685 | 1,1,2-triphenylpropane and -propene derivatives A novel 1,1,2-triphenylpropene derivative, namely: ##STR1## acts on the endocrine system of rats. It exerts oestrogenic or antioestrogenic effects of varying strength in rats, and furthermore inhibits the growth of the mammary tumor induced by 7... | 02/21/1989 |
| 4696949 | Novel tri-phenyl alkane and alkene derivatives and their preparation and use The invention provides novel compounds of the formula: ##STR1## wherein n is 0 to 4, R1 and R2, which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or methoxymethoxy; R3 is H, OH, ha... | 09/29/1987 |
