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| Number | Title | Issue Date |
| 7268166 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 09/11/2007 |
| 7196226 | Fluoraminoolefins and fluorination reagents which can be prepared therefrom The present invention relates to fluorination reagents comprising 1-fluoro-1-aminoolefins and also processes for preparing fluorination reagents comprising 1-fluoro-1-aminoolefins. ... | 03/27/2007 |
| 6919336 | Hallogenated aminobenzophenones and aminobenzoylpyridines as inhibitors of IL-1 and TNF Compounds of formula I and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof wherein the symbols are as defined are MAP kinase inhibitors, useful pharmaceutically for treating TNFα and IL-1 mediated diseases such as rheumatoi... | 07/19/2005 |
| 6858650 | Stable salts of novel derivatives of 3,3-diphenylpropylamines The present invention concerns highly pure, crystalline, stable compounds of novel derivatives of 3,3-diphenylpropylamines in the form of their salts, a method for the manufacture and highly pure, stable intermediate products. The method is in particular char... | 02/22/2005 |
| 6759435 | Antidepressant drugs and methods Novel amines are potent and selective serotonin reuptake inhibitors and as such can be used in the treatment of depression and other mental disorders. ... | 07/06/2004 |
| 6342532 | Inorganic ion receptor active compounds The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium o... | 01/29/2002 |
| 6313174 | Aminobenzophenones as inhibitors of interleukin and TNF The compounds of the present invention are represented by general formula (I) in which formula R1 and R2 stand independently for one or more, similar or different substituents selected from the group consisting of hydrogen, halogen, ... | 11/06/2001 |
| 6306912 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method for identifying a compound useful for the therapeutic treatment of a neurological disease or disorder such as stroke, head trauma, spinal cord injury, epilepsy, anxiety, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Diseas... | 10/23/2001 |
| 6191165 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof.... | 02/20/2001 |
| 6172263 | Tamoxifen and analogues thereof A method of preparing a first geometric isomer of tamoxifen or an analogue comprises allowing the first isomer to crystallize in hexanol and the product thereof to crystallize in methanol and then derivatising the product of the methanol crystallization t... | 01/09/2001 |
| 6096874 | High affinity tamoxifen derivatives The synthesis of tamoxifen derivatives, most particularly halo, halo alkyl, hydroxy, and amino tamoxifen derivatives is disclosed. The native tamoxifen molecule includes a substituted chemical group positioned on the aliphatic chain of the tamoxifen molec... | 08/01/2000 |
| 6071970 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, epilepsy, anxiety, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Dise... | 06/06/2000 |
| 5773469 | Diaryl antimicrobial agents The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and ... | 06/30/1998 |
| 5382687 | Enamine derivatives An enamine derivative containing a fluoroalkyl group, a fluoroaryl group or a fluoroaralkyl group is effective as a charge transport material in an electrophotographic member excellent in sensitivity, residual potential, durability and the like electropho... | 01/17/1995 |
| 5233089 | Enamine derivatives A novel enamine derivative is effective as a charge transport material and can provide an electrophotographic plate excellent in sensitivity, photoresponse and durability.... | 08/03/1993 |
| 5057556 | Coating compositions comprising non-gelled amine-epoxide reaction products A non-gelled amine-epoxide reaction product and acid addition salts thereof where the product is obtained by co-reacting; a) a secondary amine NHR1 R2, wherein R1 and R2 the same or different are C2 or C | 10/15/1991 |
| 5041666 | Method for the production of 3,3'4,4'-tetraaminobiphenyl A method is provided for the production of 3,3', 4,4'-tetraaminobiphenyl (TAB) from biphenyl comprising the following steps: 1) acetylating the biphenyl in the presence of an appropriate Friedel-Crafts catalyst to obtain 4,4'-diacetylbiphenyl (DAcB); 2) oximat... | 08/20/1991 |
| 4942261 | Process for preparation of allyl type amine An allyl type amine is prepared by reacting an allyl type alcohol represented by the following formula: ##STR1## wherein R1, R2 and R3 independently stand for a hydrogen atom, an aliphatic hydrocarbon group or alicycl... | 07/17/1990 |
| 4892949 | Stilbene derivatives An electrophotograhic photoconductor is disclosed which comprises an electroconductive support material and a photosensitive layer comprising at least one of the stilbene compounds of the formula ##STR1## wherein R1 represents hydrogen or ... | 01/09/1990 |
| 4381305 | Ethylenediamine derivatives and pharmaceutical compositions containing same New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.... | 04/26/1983 |
| 4327228 | 3-Nitro-1-phenyl-1-(m-chlorophenyl)-propan-2-ol. A process for the preparation of 3-dimethylamino-1-phenyl-(m-chlorophenyl)propan-2-ol and its salts which comprises the Raney nickel catalysed reduction of 3-nitro-1-phenyl-(1-m-chlorophenyl)propan-2-ol with simultaneous or subsequent dimethylation a... | 04/27/1982 |
| 4242274 | Process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile A process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile. A charge mixture is prepared comprising diphenylacetonitrile, 1-(dimethylamino)-2-halopropane, a base, water, a water-immiscible organic solvent, and a quaternary salt select... | 12/30/1980 |
| 4079081 | 1,1-Diaryl-3-amino-prop-1-enes 3-Amino-prop-1-enes substituted in the 1-position by various specified combinations of phenyl, biphenylyl and fluorenyl groups and optionally substituted in the amino group by alkyl or benzyl groups, which have been found to be active against infections o... | 03/14/1978 |
| 4028415 | Diphenylpropylamines 1,1-DIPHENYL-2-HYDROXY-3-AMINOPROPANE DERIVATIVES ARE USEFUL FOR THEIR PSYCHOTROPIC ACTIVITY AND, IN PARTICULAR ARE USEFUL AS ANTIDEPRESSANTS.... | 06/07/1977 |
| 4001328 | Diarylbutanolamines 4,4-Diphenyl-2-hydroxybutylamines are prepared by condensing amines with 1,2-epoxy-4,4-diphenylbutanes. The new compounds exist in the free base form, as acid addition salts and quaternary ammonium salts, and exhibit antiarrhythmic activity.... | 01/04/1977 |
| 3972935 | Antiarrhythmic agents Novel 1-aryl-1-benzocycloalkyl-4-aminobutanes and 1-aryl-1-benzocycloalkyl-4-amino-1-butenes are useful as antiarrhythmic agents.... | 08/03/1976 |
| 3954869 | 1-(Halo-biphenyl)-1-(halo-phenyl)-3-aminoprop-1-enes and the salts thereof Novel substituted 3-aminoprop-1-enes of formula (I) ##SPC1## wherein X1 and X2 are the same or different and each may represent a halogen atom, methods of preparing them and pharmaceutical formulations containing them. The above comp... | 05/04/1976 |
| 3936450 | Anti-inflammatory agents and method for their preparation Tetra-substituted ethylenes having the general formula ##EQU1## in which R is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and ##SPC1## AND A is selected from the group consisting of ##EQU2## and... | 02/03/1976 |
| 3932663 | Certain 3-amino-prop-1-enes for treating Trypanosoma cruzi infections 3-Amino-prop-1-enes substituted in the 1-position by various specified combinations of phenyl, biphenylyl and fluorenyl groups and optionally substituted in the amino group by alkyl or benzyl groups, which have been found to be active against infections o... | 01/13/1976 |
