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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
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| Number | Title | Issue Date |
| 8168829 | Synthesis of quaternary salt compounds The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists. ... | 05/01/2012 |
| 8143450 | Process for the preparation of derivatives of tetraaminobenzene A process is provided for preparing complexes of 1,2,4,5-tetraminobenzene with an aromatic diacid. The process design eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicit... | 03/27/2012 |
| 8093428 | Synthesis of quaternary salt compounds The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists. ... | 01/10/2012 |
| 7399863 | Amino-substituted ethylamino βadrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 07/15/2008 |
| 7342135 | 3(4),7(8)-Bis(aminomethyl)bicyclo[4.3.0]nonane and a process for its preparation 3(4),7(8)-bis(aminomethyl)bicyclo[4.3.0]nonane and a process for its preparation, wherein bicyclo[4.3.0]nona-3,7-diene is reacted with synthesis gas in a homogeneous organic phase in the presence of transition metal compounds of Group VIII of the Periodic Table cont... | 03/11/2008 |
| 7301053 | Modified cyclic aliphatic polyamine An object of the present invention is to provide a modified cyclic aliphatic polyamine having a low viscosity and a small content of unreacted polyamine which can provide, when it is used as a curing agent for epoxy resin, an epoxy resin composition having an improv... | 11/27/2007 |
| 7276518 | Substituted cyclohexane-1,4-diamine compounds Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds. ... | 10/02/2007 |
| 7230018 | Substituted propane-1,3-diamine derivatives and the pharmaceutical use thereof Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or prophylaxis of pain, urinary incontinence, itching, tinitus aurium, or diarrh... | 06/12/2007 |
| 7183435 | Triphenylene compound, method for making The present invention relates to triphenylene compounds useful, for example, in an electrophotographic photoreceptor, and to a method for manufacturing these compounds. ... | 02/27/2007 |
| 7132571 | Self-assembled calixarene-based guest-host assemblies for guest storage by van der Waals confinement A guest-host assembly having a generally spheroidal host assembly formed of trimers of calixarene molecules in a hexagonal close-packed assembly and its preparation. The calixarene trimers are associated together predominantly by van der Waals forces to provide dila... | 11/07/2006 |
| 7105701 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 09/12/2006 |
| 7101911 | Tryptase inhibitors Compounds of the formula I, in which M, A1, A2, K1 and K2 have the meanings given in the description are novel effective tryptase inhibitors. ... | 09/05/2006 |
| 7074243 | N-benzyl-m-phenylenediamine derivatives and dyes containing said compounds N-benzyl-m-phenylenediamine derivatives of general formula (I) or the physiologically tolerated, water-soluble salts thereof and dyeing agents for keratin fibers containing these compounds. ... | 07/11/2006 |
| 6962964 | Hydrogenation of methylenedianiline homologs and epoxy resins cured with same This invention relates to improved polyepoxide resins cured with a mixture of methylene bridged poly(cycloaliphatic-aromatic)amines and a process for preparing such polyepoxide resins as well as to the methylene bridged poly(cycloaliphatic-aromatic)amine composition... | 11/08/2005 |
| 6942236 | Fifth wheel hitch with rocker A fifth wheel hitch includes a head assembly having a skid plate with an opening for receiving a king pin of a trailer and a locking jaw assembly for securing the king pin in proper position with the trailer over the skid plate. Additionally, the fifth wheel hitch i... | 09/13/2005 |
| 6936077 | 1,3-diamino-4-(aminomethyl)—benzene derivatives and colorants containing the said compounds 1,3-Diamino-4-(aminomethyl)-benzene derivatives of the general Formula (I) or their physiologically tolerated, water-soluble salts, as well as agents for the oxidative dyeing of fibers, containing these compounds. ... | 08/30/2005 |
| 6919482 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 07/19/2005 |
| 6914079 | Polyamine analogs that activate antizyme frameshifting Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by ornithine decarboxylase (ODC) and the transp... | 07/05/2005 |
| 6906104 | Aminediols for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treat... | 06/14/2005 |
| 6872852 | Polyamine analogues as cytotoxic agents Cytotoxic polyamine analogues are provided that are useful for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury. ... | 03/29/2005 |
| 6806372 | Coupler for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R2SO4; R3 is selected from C1 to... | 10/19/2004 |
| 6800097 | Substituted 2-aminoalkyl-1,4-Diaminobenzene compounds and oxidation dye precursor compositions containing same The oxidation hair dye precursor composition contains from 0.005 to 20.0 percent by weight of at least one coupler compound and from 0.005 to 20.0 percent by weight of at least one developer compound, which includes at least one substituted 2-aminoalkyl-1,4-diaminob... | 10/05/2004 |
| 6780998 | Substituted 2-aminoalkyl-1,4-diaminobenzene compounds and oxidation dye precursor compositions containing same The oxidation hair dye precursor composition contains from 0.005 to 20.0 percent by weight of one or more coupler compounds and from 0.005 to 20.0 percent by weight of one or more developer compounds. The one or more developer compounds include at least one substitu... | 08/24/2004 |
| 6749644 | 2-hydroxy-5-amino-biphenyl-derivatives and oxidative hair coloring agents containing said compounds The object of the present invention are colorants for oxidative dyeing of keratin fibers, particularly hair, based on a developer-coupler combination containing as the developer at least one 2-hydroxy-5-amino-biphenyl derivative of general formula (I), and novel 2-h... | 06/15/2004 |
| 6703526 | Coupler for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): ##STR1## wherein X is selected from of halogen and R5 SO4 R3 is selected from C1 to C2 alkyl and hydr... | 03/09/2004 |
| 6664424 | Stereoisomers with high affinity for adrenergic receptors The present invention provides stereoscopically-pure diastereomers of Formula I: ##STR1## In a preferred embodiment, the stereoisomers of the present invention are of Formula II, depicted below: ##STR2## R2, R3 and R4... | 12/16/2003 |
| 6589295 | Coupler for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): ##STR1## wherein X is selected from of halogen and R5 SO4 R3 is selected from C1 to C2 alkyl and hydr... | 07/08/2003 |
| 6583246 | Modifiers for anionic polymerization The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.... | 06/24/2003 |
| 6555959 | Material for light emitting device, light emitting device using thereof, and amine compound A material for a light emitting device which is a compound represented by the following formula (I): ##STR1## wherein Ar1 and Ar6, which are the same or different, each represents a divalent aryl group or a divalent heterocyclic grou... | 04/29/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6395762 | Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists This invention provides compounds of Formula I having the structure ##STR1## wherein, ##STR2## R1, R2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting ... | 05/28/2002 |
| 6392097 | Process for the preparation of derivatives of octafluoro-[2,2] paracylophane Processes for the preparation of parylene dimers, and more particularly to processes for the preparation of derivatives of octafluoro-[2,2]paracylophane, otherwise known as AF4.... | 05/21/2002 |
| 6384031 | Cyclobutene derivatives useful as antagonists of the motilin receptor The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the ... | 05/07/2002 |
| 6323243 | Tyrosine-derived compounds as calcium channel antagonists The present invention provides compounds that block calcium channels and have the Formula I: ##STR1## and pharmaceutically acceptable salts, esters, and pro-drugs thereof, wherein R1 and R2 are independently H, phenylcyclopentylcarbo... | 11/27/2001 |
| 6248785 | IL-8 receptor antagonists This invention relates to novel compounds, pharmaceutical compositions comprising these compounds and their use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 06/19/2001 |
| 6228130 | Primary intermediate in oxidative hair dyeing 5-Nitroisatin is reacted with sodium hydroxide to produce an -keto acid sodium salt that is reduced with borane-tetrahydrofuran complex and then hydrogenated to produce 1-(2,5-diaminophenyl)ethylene glycol, a novel compound useful as a primary inte... | 05/08/2001 |
| 6191165 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof.... | 02/20/2001 |
| 6162807 | Thio acid derived monocyclic N-heterocyclics as anticoagulants This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invent... | 12/19/2000 |
| 6124280 | Substituted phenols as novel calcium channel blockers The present invention relates to novel substituted phenols and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compositions containing th... | 09/26/2000 |
| 6039895 | Benzoquinoneimines as vinyl aromatic polymerization inhibitors This invention relates to a vinyl aromatic, especially styrene, polymerization inhibitor system comprising an N-phenyl-1,4-benzoquinoneimine compound and optionally an aryl-substituted phenylenediamine.... | 03/21/2000 |
