Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 8148578 | Fast acting naratriptan composition The present invention relates to pharmaceutical compositions containing Naratriptan, a compound selected from the group consisting of 2-HPOD, 2-HPHM, 4-PPED, 4-BPED and 2-PPED, and optionally, a pharmaceutically acceptable excipient. ... | 04/03/2012 |
| 8134028 | Method for producing 1,2-diamino-3-methylcyclohexane and/or 1,2-diamino-4-methylcyclohexane A process for preparing 1,2-diamino-3-methylcyclohexane and/or 1,2-diamino-4-methylcyclohexane by reacting 2,3- and/or 3,4-diaminotoluene with hydrogen at elevated pressure and elevated temperature in the presence of a heterogeneous rhodium catalyst, wherein a mixtu... | 03/13/2012 |
| 8076516 | Amine derivative compounds for treating ophthalmic diseases and disorders Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. ... | 12/13/2011 |
| 8058476 | HCI polymorphs of 3-((2-(dimethylamino)methyl(cyclohex-1-yl)) phenol A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compos... | 11/15/2011 |
| 8039671 | Transition metal complex, catalyst composition including the same and olefin polymer using catalyst composition Provided are a novel transition metal complex where a monocyclopentadienyl ligand to which an amido group is introduced is coordinated, a catalyst composition including the same, and an olefin polymer using the catalyst composition. The transition metal complex has ... | 10/18/2011 |
| 8030520 | Process for preparing organic compounds by a transition metal-catalysed cross-coupling reaction of an aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide This invention relates to a process for preparing functionalized aryl, heteroaryl, cycloalkenyl, or alkenyl compounds, by a transition-metal-catalyzed cross-coupling reaction of a substituted or unsubstituted aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compoun... | 10/04/2011 |
| 8017805 | Diaromatic amines Diaromatic amine compounds or an isomer or isomeric mixture thereof is provided having the general formula: wherein n, m, R, R1, R2, R3, R4 and R5 are as defined herein... | 09/13/2011 |
| 7906682 | Synthesis of soluble functionalized lithium initiators This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desira... | 03/15/2011 |
| 7893300 | Process for the preparation of polymorphs of selective serotonin reuptake inhibitor The present invention is directed to Form II, III, IV and V of sertraline hydrochloride and methods for its preparation. According to the present invention, the various polymorphs of sertraline hydrochloride may be produced either, directly from sertraline base or s... | 02/22/2011 |
| 7767855 | Method for the continuous production of an amine Processes comprising: providing an aromatic alcohol; and reacting the aromatic alcohol with ammonia at a temperature of 80 to 350° C. in the presence of hydrogen and a heterogeneous catalyst to form a crude reaction product comprising a corresponding primary aromat... | 08/03/2010 |
| 7750187 | Crystallization method for benzphetamine There is disclosed a method for the crystallization of benzphetamine hydrochloride from an organic medium by the steps of removing water from the system to a very low level and then reducing the temperature of the organic medium to provide crystallization of the aci... | 07/06/2010 |
| 7750185 | Photoactive materials Diamine compounds, which in particular are useful as precursors for the production of liquid crystal alignment layers, represented by general formula (I), wherein A1 represents an organic group of 1 to 40 carbon atoms; A2 represents a hydrogen ... | 07/06/2010 |
| 7750186 | Methods for the manufacture of biphenyl amines The present invention relates to a new method for the manufacture of substituted biphenyl amines, new intermediate products and their manufacture, as well as a method for the manufacture of fungicidally active carboxamides. ... | 07/06/2010 |
| 7671237 | Synthesis of soluble functionalized lithium initiators This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desira... | 03/02/2010 |
| 7608739 | Mitotic kinesin inhibitors The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compo... | 10/27/2009 |
| 7576240 | Arylamine processes Processes for selectively hydrogenating double and/or triple bonds in organic molecules include providing at least one organic molecule containing a double and/or triple bond, providing at least one hydrogen donor molecule, and hydrogenating the double and/or triple... | 08/18/2009 |
| 7482489 | Enantiomerically pure (R)-albuterol dibenzoyltartrate and protected analogs thereof Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising at least one levalbuterol hyd... | 01/27/2009 |
| 7456316 | Anthraquinone dyes The present invention relates to a compound of formula (I) wherein R1 is a radical of formula (II) R2 is —NH2 or a radical of formula (II), R3 and R4 are each independently of the other hydrogen, hydroxy, —N... | 11/25/2008 |
| 7456317 | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety diso... | 11/25/2008 |
| 7446226 | Capsaicin derivates and the production and use thereof The invention relates to new compounds, namely capsaicin derivates, a new method for their production, and their use as micro-organism-repellent agents in paints and coatings, in particular for marine installations and ships, but also for land-based structures. ... | 11/04/2008 |
| 7435852 | Methods of producing a conjugated oligomer exhibiting supramolecular π-conjugation extension, and resulting products of such methods Methods for preparing an oligomer exhibiting supramolecular extension of π-conjugation are described. The manipulation of intra-oligomeric properties such as π-conjugation length and the precise architecture(s) resulting from inter-oligomeric variations resulting ... | 10/14/2008 |
| 7432399 | Diols formed by ring-opening of epoxies A polyol monomer comprising the formula: R1 and R3 are —H, aliphatic, aromatic, or ether; R2 is aliphatic, aromatic, ester, ether, or acrylic, and R1 contains a hydroxyl group, ... | 10/07/2008 |
| 7427260 | Efficient methods for solid phase synthesis using trityl chloride resins Disclosed are efficient methods for loading amino derivatives onto trityl chloride resins and for cleaving chemically modified amino derivatives from trityl chloride resins. Methods for making a library of discrete chemically modified amino derivatives also disclose... | 09/23/2008 |
| 7405325 | Process for the preparation of 4-hydroxalkylamino-2-nitro-anisoles A process for the preparation of 4-hydroxyalkylamino-2-nitro-anisoles of the general formula (I) wherein m is 2 or 3; by reaction of a 4-halogeno-3-nitro-aniline of formula (II) with a chloroalkyl-chloroformate of... | 07/29/2008 |
| 7396844 | Benzamidine derivatives Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of ... | 07/08/2008 |
| 7390927 | Process for preparing 3-aminophenylacetylenes A process for preparing a 3-aminophenylacetylene compound of formula (5), including: a) reacting a 3-haloaniline compound of formula (1) with an acetylene compound of formula (2) in the presence of a palladium compound, a copper compound, and an amine compound of fo... | 06/24/2008 |
| 7375249 | Process for the synthesis of enantiomeric indanylamine derivatives A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the... | 05/20/2008 |
| 7361788 | Direct alkylation of N-alkyl-N′-phenyl-p-phenylenediamine A single-step process is disclosed for the ring alkylation of at least one N-alkyl-N′-phenyl-phenylenediamine with at least one olefin wherein the process comprises heating a mixture of the N-alkyl-N′-phenyl-phenylenediamine(s) and olefin(s) in the presence of a... | 04/22/2008 |
| 7358214 | Pyrazolyl carboxanilides for controlling unwanted microorganisms This invention relates to novel pyrazolylcarboxanilides of the formula (I) in which R1, G and n are as defined in the disclosure, to a plurality of processes for preparin... | 04/15/2008 |
| 7354942 | Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to benzylether and benzylamino derivative compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secre... | 04/08/2008 |
| 7348354 | Cyclohexylurea compounds Cyclohexylurea compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and the use of such compounds as pharmaceutically active agents with nociceptin/ORL1 receptor sys... | 03/25/2008 |
| 7345051 | Mucin synthesis inhibitors The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds of Formula II in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and... | 03/18/2008 |
| 7345141 | Polymer material having carrier transport property, and organic thin film element, electronic device, and conductor line which use same The present invention provides a polymer material having a carrier transport property. The polymer material has first and second states in which degrees of the carrier transport property are different from each other, microscopic structures in the first and second s... | 03/18/2008 |
| 7338952 | Acetylenic compounds useful in treating inflammatory disorders This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder. ... | 03/04/2008 |
| 7326506 | Bridged charge transport materials having a central sulfur atom linkage Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 02/05/2008 |
| 7314958 | Phenylbenzamides This invention relates to novel phenylbenzamides of the formula (I) in which R1 represents trifluoromethyl, chlorine, bromine or iodine and R2 | 01/01/2008 |
| 7312368 | Method for selective reduction of aromatic compounds A method for the selective reduction of an aromatic compound. The present invention provides a method for pre-venting the reduction of at least one halogen substituted aromatic ring of an aromatic compound, while allowing the reduction of at least one functional gro... | 12/25/2007 |
| 7301053 | Modified cyclic aliphatic polyamine An object of the present invention is to provide a modified cyclic aliphatic polyamine having a low viscosity and a small content of unreacted polyamine which can provide, when it is used as a curing agent for epoxy resin, an epoxy resin composition having an improv... | 11/27/2007 |
| 7291646 | Ethers of O-desmethyl venlafaxine This invention provides O-α-acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimehtylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I): wherein the variables R1 and R2 ... | 11/06/2007 |
| 7285572 | CaSR antagonist The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis. A compound represented by the... | 10/23/2007 |
