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| Number | Title | Issue Date |
| 7408082 | Racemisation process The present invention relates to a novel process for obtaining (1S,4S)N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine from a mixture of its isomers. The process involves isomerising the 1-position and the 4-position and effecting separation of ... | 08/05/2008 |
| 7256313 | Method for the production of isophorondiamine (ipda, 3-aminomethyl-3,5,5-trimethyl- cyclohexylamine) having a high cis/tran-isomer ratio The invention relates to processes for preparing 3-aminomethyl-3,5,5-trimethylcyclo-hexylamine (isophoronediamine, IPDA) having a high cis/trans isomer ratio. IPDA having a cis/trans isomer ratio in the range from 63/37 to 66/34 can be obtained in any desired cis/tr... | 08/14/2007 |
| 6800764 | Process for the synthesis of chirally pure beta-amino-alcohols A process is provided for preparing chirally pure S-enantiomers of α-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R)2CH(CH2)nCH2X; b) adding the organome... | 10/05/2004 |
| 6753338 | Methods for treating hypertension, angina, and congestive heart failure using of optically pure (-) amlodipine Methods and compositions are disclosed utilizing the optically pure (−) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodi... | 06/22/2004 |
| 6649607 | Compositions and methods for treating or preventing convulsions or seizures The present invention relates to compositions comprising S-tofisopam substantially free of R-tofisopam, and methods for treating or preventing convulsions and/or seizures comprising administration of the composition to subjects in need of treatment theref... | 11/18/2003 |
| 6576795 | Racemization of optically active amines Optically active amines of the formula I ##STR1## where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 may also b... | 06/10/2003 |
| 6548704 | Racemization of optically active amines Optically active amines of the formula I ##STR1## where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 may also b... | 04/15/2003 |
| 6500986 | Process for preparing racemic amino derivatives Racemic amino derivatives of the formula ##STR1## are prepared by a new process which comprises reacting an optically active amide of the formula ##STR2## in which with a strong base, optionally in the presence of an organic diluent and, if desired, ... | 12/31/2002 |
| 6458955 | Process for preparation of pharmaceutically desired enantiomers Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is effected with high enantiomeric purity, and subsequent rea... | 10/01/2002 |
| 6455736 | Process for preparation of pharmaceutically desired sertraline and sertraline analogs Improved processes for preparation of sertraline or sertraline analogs in high enantiomeric purity centers on resolution using simulated moving bed chromatography of isomeric racemic sertraline or sertraline analogs. Resolution is effected with high enant... | 09/24/2002 |
| 6399826 | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed which comprise a dop... | 06/04/2002 |
| 6316671 | Method for splitting 1-amino-alkan-2-ol compounds This invention relates to a method of splitting 1-amino-alkan-2-ol compounds of general formula: ##STR1## in which the group R can represent a wide variety of linear, branched or cyclic alkyl groups, comprising up to about 20 to 25 carbon atoms and p... | 11/13/2001 |
| 6297196 | Benzoyl derivatives, process for their preparation and their use as herbicides and plant growth regulators Benzoyl derivatives of the formula (I), process for their preparation and their use as herbicides and plant growth regulators are described. ##STR1## In this formula (I), R1, R2, R3, R4 and R5 are var... | 10/02/2001 |
| 6162949 | Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine synthesis. Resolution is effected with high enantiomeric purity,... | 12/19/2000 |
| 6160178 | Racemization of optically active amines Optically active amines are racemized by reaction of the optically active amine in the gas phase at elevated temperature in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst.... | 12/12/2000 |
| 6153797 | Racemizing of optically active amines In a process for racemizing optically active amines by reacting the optically active amine in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst at elevated temperature, the reaction is carried out in liquid phase and the catalyst co... | 11/28/2000 |
| 6060624 | Racemization of optically active alkoxyamines A method for racemizing an enantiomer of an alkoxyamine represented by formula I ##STR1## in which R1 and R2 are the same or different C1 to C20 alkyl group. A feed containing an enantiomer of the alkoxyami... | 05/09/2000 |
| 6049007 | Racemization of optically active amines A process for the preparation of racemic amines of the formula I ##STR1## where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals ... | 04/11/2000 |
| 6034278 | Method for producing optically active 1-phenylethylamines The invention concerns a new method for producing optically active 1-phenylethylamines, wherein (a) racemic 1-phenylethylamines are reacted with (S)-(-)-N-phenylcarbamate lactic acid in the presence of an aliphatic or aromatic hydrocarbon and in the prese... | 03/07/2000 |
| 6002045 | Racemisation of amines A process for racemising an optically-enriched chiral amine of the formula: R1 --CH(NR3 R4)--R2, wherein R1 is aromatic or unsaturated alkyl; R2 is aromatic or alkyl; and R3 and R | 12/14/1999 |
| 5977409 | Method of using -substituted benzylamine chiral auxiliary synthetic reagents This invention relates to the use of a family of chiral -substituted benzylamine reagents during chemical synthesis. Specifically, the reagents can be used in an auxiliary manner to deliver either a substituted or unsubstituted nitrogen atom while ... | 11/02/1999 |
| 5889186 | Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine synthesis. Resolution is effected with high enantiomeric purity,... | 03/30/1999 |
| 5885787 | Process for preparing optically active amines In accordance with a novel process, (R)-amines of the formula ##STR1## in which R1, R2 and n have the meanings given in the description, can be prepared by reacting reating N-acyl-amines of the formula ##STR2## in whi... | 03/23/1999 |
| 5847215 | Racemization of optically active amines A process for the racemization of optically active amines of the formula (I), where Ar is an unsubstituted or substituted aryl and R is alkyl, in which a) (I) is reacted with the ketone (II) in which Ar and R have the same meanings as for (I), to give the... | 12/08/1998 |
| 5763647 | Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives A process for preparing an optically active 1,4-bridged-cyclohexane carboxylic acid derivatives which are clinically important thromboxane A2 thromboxane of formula (IV): ##STR1## wherein, R is phenyl or phenyl substituted with hydroxy, lo... | 06/09/1998 |
| 5728885 | Method of preparing the enantiomers of O-dimethyltramadol A method of preparing the enantiomers of O-demethyltramadol and the use of the enantiomers as pain-killing drugs are described.... | 03/17/1998 |
| 5723667 | Method of producing optically active tert-leucinol and its use A method of producing optically active tert-leucinol (formula I) of high enantiomeric purity ##STR1## by converting racemic (RS)-tert-leucinol into a diastereomeric salt pair by reaction with an optically active acid, removing the salt pair from ... | 03/03/1998 |
| 5663368 | Synthesis of acid addition salts of hydroxylamines This invention relates to novel diastereomeric acid addition salts of homochiral hydroxylamines, to processes for obtaining such, to processes for the conversion thereof to the corresponding homochiral hydroxylamines, to certain novel homochiral hydroxyla... | 09/02/1997 |
| 5639913 | Method for preparing optically active 1-aminoindan derivatives Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, con... | 06/17/1997 |
| 5510519 | Optically active secondary amine compound, process for producing optically active secondary amine compound and process for producing optically active carboxylic acid by using said compound Disclosed are optically active secondary amine compounds and salts thereof having the general formula (I): ##STR1## a process for the preparation of the optically active secondary amine compounds and salts thereof, and the use of such compounds. Such... | 04/23/1996 |
| 5476964 | Continuous racemization of benzylic alcohols, ethers, and esters by solid acid catalyst Benzyl alcohols having a chiral center at the benzylic carbon can be conveniently racemized by treatment with solid acids which are strongly acidic cation exchange materials. Racemization may be effected generally in the range from 20°-150° C. in aqueou... | 12/19/1995 |
| 5391634 | Optically-active, amphiphilic, water-soluble free-radical addition copolymers and their use in the resolution of racemic mixtures Optically-active, amphiphilic, free-radical addition copolymers having an optically-active hydrophobic portion and an ionic hydrophilic portion are effective resolving agents. This utility is based on a unique combination of properties, viz., water solubi... | 02/21/1995 |
| 5391735 | Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new ... | 02/21/1995 |
| 5298660 | Optically active secondary amine compound, process for producing optically active secondary amine compound and process for producing optically active carboxylic acid by using said compound Disclosed are optically active secondary amine compounds and salts thereof having the general formula (I): ##STR1## a process for the preparation of the optically active secondary amine compounds and salts thereof, and the use of such compounds. Such... | 03/29/1994 |
| 5292893 | Catalytic asymmetric and non-asymmetric reduction of times and oximes using metal catalysts A process is provided for catalytically reducing imines, oximes, hydrazones and related compounds. Moreover, there is provided a process for the catalytic asymmetric reduction of imines, oximes, hydrazones, and the like, using enantiomerically enriched ca... | 03/08/1994 |
| 5284976 | Method of producing primary amines in high yields A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMe2 wherein R is an organo group, R* is a chiral... | 02/08/1994 |
| 5284966 | Intermediates for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers Intermediates for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers are described. The final compounds are useful intermediates for the synthesis of antibiotics like Chloramphenicol, Thiamphenicol and Florfenicol.... | 02/08/1994 |
| 5281750 | Chiral polymers for the production of excess enantiomers The present invention relates to chiral supports and to their use in the asymmetric synthesis, deracemization and optical inversion of organic chiral compounds. In particular, the supports are used in combination with thermal equilibration of a species ha... | 01/25/1994 |
| 5280093 | Chiral polymers for the synthesis of pure enantiomers of amino acids The present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion. These polymers are characterized in that they comprise: a chiral unit a functionalizing unit an optional crosslinking un... | 01/18/1994 |
| 5276195 | Process for producing dimethylorganoboranes A process for preparing a dimethylorganoborane represented by the formula R*BMe2 wherein R* is a chiral organyl group attached to the boron, B is boron and Me is methyl comprising treating a chiral boronic ester R*B(OR')2 with a meth... | 01/04/1994 |
