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| Number | Title | Issue Date |
| 8013187 | 2-cyclopenten-1-one oxime derivatives inhibiting production of TNF-α 2-cyclopenten-1-one oxime derivatives represented by Formula (I), or pharmaceutically acceptable salts thereof inhibit the production of TNF-α or PDE4, and therefore show therapeutic effect in inflammatory or immunological disorders mediated through TNF-α or PDE4.... | 09/06/2011 |
| 7399577 | Halogenated oxime derivatives and the use thereof Compounds of the formula (I) or (II) wherein R1 is C1-C10haloalkylsulfonyl, halobenzenesulfonyl, C2- C10haloalkanoyl, halobenzoyl; R2 is halogen or C1-C10 haloalkyl; Arl is pheny... | 07/15/2008 |
| 7312361 | Inhibitors of transthyretin amyloid fibril formation Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin. ... | 12/25/2007 |
| 7279600 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents This invention provides estrogen receptor modulators having the structure: wherein R1 to R6 and R8 are as defined in the specification; or a pharmaceutically acceptable salt there... | 10/09/2007 |
| 7253319 | Disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity Compounds of the formula where the variables have the values described in the specification are antagonists of RARγ retinoid receptors. ... | 08/07/2007 |
| 7169817 | Bis-aromatic alkanols The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them. Compounds according to the present invention are based upon the chemical formula: | 01/30/2007 |
| 7161036 | Process for producing oxime A process for producing an oxime is provided, wherein the process comprises the step of reacting a ketone, hydrogen peroxide and ammonia in the presence of a crystalline titanosilicate having MWW structure under the condition that the ammonia concentration in the li... | 01/09/2007 |
| 7157491 | Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents This invention provides estrogen receptor modulators having the structure where R1–R5 are as defined in the specification; or a pharmaceutically acceptable salt thereof. ... | 01/02/2007 |
| 7115666 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therape... | 10/03/2006 |
| 7025899 | Concentrated solutions of oxime metal extractants and method of formulating extractant compositions therefrom The preparation of concentrated solutions of oxime metal extractants, such as aldoximes and ketoximes, or mixtures of aldoxime and ketoxime, and the use thereof in formulating or preparing extraction reagent compositions for use in an extractant organic phase in a p... | 04/11/2006 |
| 6998419 | 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1–R4 are as defined in the specification. The discl... | 02/14/2006 |
| 6949557 | Hydroanthracene based compounds as anticancer agents The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hy... | 09/27/2005 |
| 6852889 | Antioxidant nitroxides and nitrones as therapeutic agents The invention provides novel adamantane compounds having one of the following formulas: wherein: R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, an... | 02/08/2005 |
| 6849570 | Process for the production of a titanium silicalite shaped body The present invention relates to a process for the production of a titanium silicalite shaped body by: (a) forming a formable composition containing titanium silicalite, a binder and a pasting agent, so that the Curd curve of the formable composition has a plateau v... | 02/01/2005 |
| 6824954 | Sulfonyloxime compound, and radiation sensitive acid generator, positive type radiation sensitive resin composition and negative type radiation sensitive resin composition using same A sulfonyloxime compound is provided which is represented by a general formula (1): wherein, R1 represents a hydrogen atom, an alkyl group, an aryl group, or a heteroaryl group; R | 11/30/2004 |
| 6800658 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell prolifera... | 10/05/2004 |
| 6768019 | 3,4-dihydro-1H-naphthalene derivatives as a highly selective cyclooxygenase-2 inhibitor The present invention relates to a novel 3,4-dihydro-1H-naphthalene derivative having a structure of formula 1 or formula 2, its pharmaceutically acceptable salts and their geometric isomers as a highly selective cyclooxygenase-2 inhibitor. ... | 07/27/2004 |
| 6730700 | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclose... | 05/04/2004 |
| 6683213 | Substituted aniline compounds The present invention relates to substituted aniline compounds of the formula 1 ##STR1## in which R21, R22 and R23 have the meanings indicated in the description. The compounds according to the invention are intermediates ... | 01/27/2004 |
| 6673969 | Process for preparation of oximes and resulting products A new oxime mixture used as an extractant for metals, prepared from natural products containing alkylated phenols such as cashew nut shell liquid using mild reaction conditions, is expressed by the formula: ##STR1## The oxime mixture is suitable for extra... | 01/06/2004 |
| 6664422 | Process for the preparation of strobilurin intermediates The present invention relates to a novel improved process and intermediates for the process of preparing the oxime intermediates of formula (II) wherein R1 is hydrogen, fluoro or chloro, and R2 is methyl, ethyl, methoxy, ethoxy, trif... | 12/16/2003 |
| 6664423 | Two-phase ammoximation Oximes are prepared from ketones or aldehydes, hydrogen peroxide and ammonia. The reaction is carried out in a system of one aqueous phase and one phase of hydrocarbons inert under the reaction conditions in the presence of at least one interphase contact... | 12/16/2003 |
| 6660872 | Method of producing methoxyimino acetic amide The present invention relates to novel processes for preparing methoxyimino-acetamides.... | 12/09/2003 |
| 6653508 | 3-amino-2-benzyl-1-phenylpropane derivatives Substituted 3-amino-2-benzyl-1-phenlypropane derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat various medical conditions.... | 11/25/2003 |
| 6545056 | Aryl nitrone therapeutics and methods for treating inflammatory bowel disease Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.... | 04/08/2003 |
| 6509501 | Benzamidoxime derivatives, intermediates and processes for their preparation, and their use as fungicides Benzamidoxime derivatives of the formula I ##STR1## where R1 is difluoromethyl or trifluoromethyl R2 is hydrogen or fluorine R3 is C1 -C4 -alkyl which may be substituted by cyano, C1 -C4 | 01/21/2003 |
| 6485886 | Oxime derivatives and the use thereof as latent acids New oxime derivatives of formula (I) or. (II), wherein m is 0 or 1; R1 inter alia is phenyl, naphthyl, anthracyl, phenanthryl or a heteroaryl radical; R'1 is for example C2 -C12 alkylene, phenylene, naphthylene;... | 11/26/2002 |
| 6448444 | Oxime compounds, their use, and intermediates for their production Oxime compounds of formula (1) ##STR1## wherein R1, R2, and R3 are independently halogen, C1 -C3 alkyl, C1 -C3 halolalkyl, C1 -C3 alkoxy, C1 -C3 | 09/10/2002 |
| 6441032 | Alpha-(4-Ethoxyphenyl)-N-tert-butylnitrone, pharmaceutical compositions and their medical use Disclosed are novel -aryl-N-alkylnitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory condit... | 08/27/2002 |
| 6417400 | Methyl-phenyl derivatives, preparation method and use The present invention relates to: a) methylbiphenyl derivatives of general formula: ##STR1## in which R1 represents OH, C3 -C7 alkyl or C3 -C7 cycloalkyl, these compounds being in the form of individual is... | 07/09/2002 |
| 6342635 | Ketoximes, processes therefor, and copper extraction process Ketoximes, processes for their preparation, compositions containing them, and a copper extraction process using the compositions. One process for the preparation of the ketoximes comprises the following steps: A) reacting a phenol with a monocarboxylic acid, m... | 01/29/2002 |
| 6342523 | 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have the formula: ##STR1## where R1 -R4 are as defined in the specif... | 01/29/2002 |
| 6329359 | Substituted benzyl oximino compounds The present invention relates to benzyloxyimino compounds of the formula I, ##STR1## where: R1 to R4, X, Y, and Z are as defined in the specification.... | 12/11/2001 |
| 6316629 | Process for the preparation of 2,3-pyridinedicarboximides There is provided a process for the preparation of 2,3-pyridinedicarboximides having the structural formula I ##STR1## The 2,3-pyridinedicarboximides are useful as intermediates in the preparation of herbicidal 2-(2-imidazolin-2-yl)nicotinic acids, esters... | 11/13/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6277300 | Composition and use of composition for the extraction of metal values A composition for use in extracting metals from aqueous solutions of metals salts comprises at least one o-hydroxyaryloxime containing at least 5 aliphatic or alicyclic carbon atoms and at least one ester containing from 10 to 30 carbon atoms, the weight ... | 08/21/2001 |
| 6211232 | Process for producing benzamidoximes A process for producing benzamidoximes represented by general formula (II), which are useful as intermediates of pesticides and drugs, at a stable and high yield by reacting benzonitriles represented by general formula (I) with hydroxylamine in the presen... | 04/03/2001 |
| 6207716 | Non-steroidal ligands for the estrogen receptor Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 03/27/2001 |
| 6197826 | -(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation Disclosed are novel -(2-hydroxyphenyl) nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as anal... | 03/06/2001 |
| 6194461 | Nitrone derivatives A compound represented by the figure (1) or a pharmaceutically acceptable salt thereof is useful as medicament for treating retinal degenerative disorders: ##STR1## wherein Ar is optionally substitued phenyl or optionally substituted heteroaryl;. n i... | 02/27/2001 |
