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| Number | Title | Issue Date |
| 7262223 | Amidine derivatives for treating amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a t... | 08/28/2007 |
| 7220781 | Meta-benzamidine derivatives as serine protease inhibitors Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted... | 05/22/2007 |
| 7115666 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therape... | 10/03/2006 |
| 6936719 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents. ... | 08/30/2005 |
| 6852761 | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety ... | 02/08/2005 |
| 6803464 | Process for the preparation of pyrazine compounds The present invention relates to a process for the preparation of both the phenyl pyrazine derivative 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine and an intermediate in the synthesis of 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine, 2-{[Cyano-(2,3,5-trichloropheny... | 10/12/2004 |
| 6794545 | Conformationally restricted polyamine analogs as disease therapies Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of d... | 09/21/2004 |
| 6740682 | Meta-benzamidine derivatives as serine protease inhibitors The novel compound 3-amidinobenzoyl-D-phenylglycine-3-phenylanilide is useful as a serine protease inhibitor. ... | 05/25/2004 |
| 6699994 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating a... | 03/02/2004 |
| 6677369 | Antithrombotic agents This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well a... | 01/13/2004 |
| 6555711 | -amino-N-allylamidino nitrobenzene compound and synthesis Disclosed is a process comprising reacting an N-allylimino nitrobenzene compound with a diaminodinucleophile to form an -amino-N-allylamidino nitrobenzene compound and the compound itself.... | 04/29/2003 |
| 6534546 | Aniline derivatives possessing an inhibitory effect of nitric oxide synthase Compounds represented by the general formula (1): ##STR1## (where R1 is SR6 or NR7 R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having ... | 03/18/2003 |
| 6489365 | Amidine derivatives, the preparation and use thereof as medicaments with Itb4 antagonistic effect Compounds of the formula ##STR1## which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.... | 12/03/2002 |
| 6417200 | Antithrombotic agents This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its... | 07/09/2002 |
| 6414020 | Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically accepta... | 07/02/2002 |
| 6399784 | Efficient method for the conversion of nitriles to amidines The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thromb... | 06/04/2002 |
| 6376710 | Amidine compounds and their use as pesticides The present invention provides novel amidine compounds and novel pesticides containing these amidine compounds as active ingredients. The amidine compounds are expressed by formula I: ##STR1## wherein X and Y are the same or different and are independentl... | 04/23/2002 |
| 6143790 | L-N6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors There is disclosed a novel amino glycol derivatives of L-N6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.... | 11/07/2000 |
| 6133315 | Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically ac... | 10/17/2000 |
| 6051164 | Methods and compositions for protecting polymers from UV light A polymeric article, such as an extruded or molded article or a biaxially oriented tape or film, and a method of stabilizing such a polymeric article to protect the article from degradation due to exposure to UV light. The article is formed by blending a ... | 04/18/2000 |
| 5962693 | Efficient method for the conversion of nitriles to amidines The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thromb... | 10/05/1999 |
| 5929120 | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption Compounds of the following general structure X--Y--Z-Aryl-A--B, ##STR1## which inhibit osteoclast mediated bone resorption.... | 07/27/1999 |
| 5866612 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase A class of acetamidine derivatives of general formula (I) ##STR1## wherein R1 is hydrogen, C1-6 hydrocarbyl group optionally substituted by halo, halo, nitro, cyano or a group XR3 wherein X is oxygen, C(O)m... | 02/02/1999 |
| 5807885 | Amidine derivatives with nitric oxide synthetase activities Amidine derivative compounds of formula I as defined in the Specification having nitric oxide synthetase inhibitory activity as well as processes for the preparation of and compositions containing said compounds are described.... | 09/15/1998 |
| 5731332 | Substituted benzamidine compounds which have useful pharmaceutical activity Compounds of formula ##STR1## and their therapeutic use, inter alia, as LTB4 -antagonists. Exemplary compounds are: (Methoxycarbonyl-imino-{4'-2-(2-propylphenoxy)-ethoxy!-biphenyl-4-yl}-meth yl)-amine; (Benzyloxycarbonyl-imino-{4'-2-(2-... | 03/24/1998 |
| 5728737 | N-alkoxy-amidine derivatives The present invention relates to novel N-alkoxy-arnidine derivatives of the formula (I), to a process for their preparation and to their use as pesticides. In addition, the invention also relates to novel intermediates and to a process for their preparati... | 03/17/1998 |
| 5710166 | N-acyl beta amino acid derivatives useful as platelet aggregation inhibitors Novel N-Acyl Beta Amino Acid derivatives of the formula ##STR1## are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.... | 01/20/1998 |
| 5668257 | Phenylboronic acid complexing reagents derived from aminolalicylic acid The present invention relates to a novel class of phenylboronic acid complexing reagents useful for the preparation of bioconjugates, and the method of making and using such reagents. In the present invention, in the place of prior art Avidin-Biotin and D... | 09/16/1997 |
| 5594151 | Phenylboronic acid complexing reagents derived from aminosalicylic acid The present invention relates to a novel class of phenylboronic acid complexing reagents useful for the preparation of bioconjugates, and the method of making and using such reagents. In the present invention, in the place of prior art Avidin-Biotin and D... | 01/14/1997 |
| 5308869 | Substituted amidines having high binding to the sigma receptor and the use thereof N,N'-disubstituted-amidines, e.g., of the formula ##STR1## wherein R, R' and R" are substituted or unsubstituted hydrocarbon and/or heterocyclic groups. Methods are provided for the treatment or prophylaxis of anxiety in an animal, for treating psych... | 05/03/1994 |
| 4797391 | ((5,6-dichloro-3-oxo-9,9a-d isubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides The invention relates to novel [(5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydro-fluoren-7-yl)o xy]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the ... | 01/10/1989 |
| 4775695 | Substituted amidinoalkoxy and amidinoalkylamino indanones and salts thereof This invention relates to novel substituted amidinoalkoxy and amidinoalkylamino indanones and salts thereof. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), ... | 10/04/1988 |
| 4567188 | Hypotensive 2-nitro-1,1-ethenediamines Compounds of the formula ##STR1## in which R1 is an optionally substituted aryl or heteroaryl radical, R2 is an alkyl or alkenyl radical which is optionally substituted by alkoxy or cycloalkyl, or an optionally substituted aryl or he... | 01/28/1986 |
| 4389236 | Herbicidal 3-phenoxymethylene-anilines The invention relates to 3-phenoxymethylene-anilines of the formula ##STR1## wherein R is a ##STR2## radical or C1 -C4 alkoxy, R is halogen or C1 -C2 haloalkyl, R2, R3 and R... | 06/21/1983 |
| 4353830 | Process for the preparation of substituted amidines Amidines are one of the strongest organic bases and find application where this property is needed, such as in phase transfer catalysis, in the form of their substituted derivatives. Their use, however, has been hampered by their expensive nature due to t... | 10/12/1982 |
| 4324792 | Antihistaminic imidazoles The present invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts and bioprecursors thereof in which ##STR2## represents either ##STR3## R1 represents hydrogen, halogen, C1-4 | 04/13/1982 |
| 4275217 | Process for the preparation of optically active -amino acids and their derivatives A chiral -amino acid having a hydrogen substituent in a position alpha to the carboxylic function thereof is prepared by subjecting a corresponding optical antipode with a chiral amino acid to a strong base whereby the proton in a position alpha to... | 06/23/1981 |
| 4206142 | Styrylamidine process Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics, and... | 06/03/1980 |
| 4146647 | Substituted phenyl-amidines The present invention provides compounds of the formula: ##STR1## in which A is CH2, CHOH, CH2 O, CH2 S, CH2 NH, OCH2, SCH2, NH, NHCH2, NHCOCH2 or CH2 NHCH | 03/27/1979 |
| 4144128 | Polymeric carrier bound ligands A process for bonding a ligand to a carrier through the use of a pyrimidine derivative of the formula: ##STR1## in which R1, R2, R3 and R4 are each independently hydrogen, hydroxyl, halogen, lower alkyl, lo... | 03/13/1979 |
