Class 564/237 - Benzene ring containing

Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein a guanidine contains a benzene ring.
No. of patents: 109
Last issue date: 03/26/2013

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Number	Title	Issue Date
5955507	Therapeutic substituted guanidines The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	09/21/1999
5922772	Therapeutic substituted guanidines The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	07/13/1999
5883133	Substituted cinnamic acid guanidides, a process for their preparation, their use as medicaments or diagnostic agents and medicaments comprising them Compounds of the formula I ##STR1## are described in which at least one of the substituents R(1), R(2), R(3), R(4) and R(5) is a nitrogen-containing heterocyclic radical. They are outstanding cardiovascular therapeutic agents. They are obtained by ...	03/16/1999
5856344	Sulfonylamino-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic aid, and medicament containing them Benzoylguanidines of the formula I ##STR1## in which R(1) to R(6) have the meanings stated in the claims, are antiarrhythmic pharmaceuticals which have excellent activity and a cardioprotective component and are highly suitable for the prophylaxis of...	01/05/1999
5847006	Therapeutic guanidines The present invention provides N,N'-diaryl substituted guanidines having therapeutic utility. The compounds of the present invention are represented by the formula: ##STR1## wherein R and R1 represent hydrogen or other group and Ar and ...	12/08/1998
5830917	L-N⁶ -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors There is disclosed a novel amino alcohol amine derivatives of L-N6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors....	11/03/1998
5807896	Arylbenzoylguanidines Arylbenzoylguanidines of the formula I ##STR1## in which R1 R2, R3 and Ph have the given meanings herein, and also the physiologically harmless salts thereof, exhibit antiarrhythmic properties and act as inhibitors of...	09/15/1998
5798390	Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce...	08/25/1998
5792769	Guanidino protease inhibitors Compounds of the formula: ##STR1## wherein R1 --R4, R7 --R8, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically ...	08/11/1998
5773469	Diaryl antimicrobial agents The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and ...	06/30/1998
5767162	Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce...	06/16/1998
5753715	2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use....	05/19/1998
5753710	Substituted benzyloxycarbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them Substituted benzyloxycarbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them. There are described compounds of the formula I ##STR1## in which the substituents R(1) to R(7) and X ...	05/19/1998
5739142	4-aminobenzoylguanidine derivatives 4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R1, R2 and R3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitor...	04/14/1998
5733934	Antiarrythmic and cardioprotective substituted indenoylguanidines Indenoylguanidines of formula I and formula II, the process for their preparation, their use as medicaments, medicaments containing them, their use as diagnostic agents and medicaments containing them are described. Compounds I are useful for treating car...	03/31/1998
5723133	Cosmetics containing guanidine derivatives A guanidine derivative represented by formula (1), (2), (3) or its acid addition salt and a production process thereof ##STR1## wherein each of A and B is a C2 -C8 alkylene, D is a single bond, --CO-- or a C1 -C5...	03/03/1998
5719187	Compounds having a guanidine structure and pharmaceutical composition containing same Guanidine derivatives are provided useful for promoting growth, repair and regeneration of a neuronal axon and for treating neuropathies and myopathies. The compounds have the formula: ##STR1## wherein R1 is an isopropyl radical, a benzyl ...	02/17/1998
5696290	Synthesis of penta-substituted guanidines The present invention is the novel synthesis of sterically hindered penta-substituted guanidines by a process in which (1a) an isocyanate is reacted first with a di-substituted amine or (1b) a urea is reacted with two moles of a mono-substituted amine to ...	12/09/1997
5696138	Urea derivatives and their use A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein X, Z, Y, A, D, E, F, R1, R2, R3, R4, R11, R12 have the meanings set forth in the specification,...	12/09/1997
5693672	3,4,5-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them 3,4,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them Benzoylguanidines of the formula I ##STR1## where R(1) is R(4)--SOm or R(5)R(6)N--SO2 --, wher...	12/02/1997
5670544	Substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicament containing them There are described benzoylguanidines of the formula I ##STR1## where R(1) is hydrogen, Hal, --NO2, --CN, --CF3, R(4)--SOm or R(5)R(6)N--SO2 --, where m is zero to 2, R(4) and R(5) are alk(en)yl or --C...	09/23/1997
5646188	Polyamine derivatives of 1-aminoindan A compound of general formula I ##STR1## wherein n is 1 or 2; R1 and R2 are each independently hydrogen, hydroxy, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 alkoxy or halogen...	07/08/1997
5643950	Triphenylalkyl antimicrobial agents The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the acti...	07/01/1997
5637621	Methods and compositions for treating Botrytis infections The invention provides fungicidal compounds having the general formula: X1 -A1 -B1 -C-B2 -A2 -X2 (I) wherein X1 is an amidine, a guanidine, or an imidazole group. A1 is either a ...	06/10/1997
5629348	Methods and compositions for treating septoria infections The invention provides fungicidal compounds having the general formula: X1 -A1 -B1 -C-B2 -A2 -X2 (I) wherein X1 is an amidine, a guanidine, or an imidazole group. A1 is either a...	05/13/1997
5614630	Acenaphthyl substituted guanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	03/25/1997
5574054	Quaternary ammonium salts and use thereof as medicine Novel quaternary ammonium salts having utility in the medical field for treating gastrointestinal disorders....	11/12/1996
5565185	Process for the preparation of radiolabeled meta-halobenzylguanidine The present invention provides a no-carrier-added synthesis of radiolabeled meta-halobenzylguanidine by halodestannylation which comprises reacting a meta-trialkylstannylbenzylguanidine with a source of radionuclide of a halogen. The present invention als...	10/15/1996
5559154	Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce...	09/24/1996
5494934	Guanidine compounds A compound of formula (I): ##STR1## in which: R1 represents substituted or unsubstituted phenyl or (C3 -C7) cycloalkyl, R2 represents trifluoromethyl or (C3 -C4) cycloalkyl, A represents --...	02/27/1996
5489709	Preparation of substituted guanidines A process for the preparation of a substituted guanidine by reacting a substituted cyanamide with ammonia or a substituted amine in the presence of a Lewis acid catalyst. Also disclosed is a process for the preparation of a tri-substituted guanidine by re...	02/06/1996
5428065	1,3-benzenedimethanamines useful as central nervous system active agents Pharmaceutical compounds of the formula: ##STR1## R1 to R8 are each hydrogen or C1-4 alkyl, m, n and p are each 0, 1, or 2, q is 0, 1, 2 or 3, X and Z are each C1-4 alkyl, C1-4 alkoxy, hydroxy, n...	06/27/1995
5399570	Aspartic acid derivatives, and their use for inhibiting platelete aggregation Aspartic acid derivatives of the formula ##STR1## in which X denotes, for example, ##STR2## and R denotes, for example, cyclohexylamino, have useful pharmacological properties....	03/21/1995
5395853	Anti-atherosclerotic diaryl compounds The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1; W is hydrogen, a C1-16 straight, branched, or cyclic alkyl group, or a C2-16 straight, branched, or cyclic alkenyl or alkynyl group, or Ph...	03/07/1995
5373024	3,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament of diagnostic and medicament containing them Benzoylguanidines of the formula I ##STR1## are described where R(1) is R(4)--SOm or R(5)R(6)N--SOz --, where R(4) and R(5) are alk(en)yl or --Cn H2n --R(7), and where R(7) is a cycloalkyl or phenyl, where ...	12/13/1994
5364868	Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them Benzoylguanidines of the formula I ##STR1## are described in which R(1) or R(2) is an amino group --NR(3)R(4), where R(3) and...	11/15/1994
5360938	Asymmetric syntheses This invention relates to asymmetric syntheses in which a prochiral or chiral compound is contacted in the presence of an optically active metal-ligand complex catalyst to produce an optically active product....	11/01/1994
5336689	Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce...	08/09/1994
5296498	Guanidine compounds A compound of formula (I): ##STR1## in which: R1 represents substituted or unsubstituted phenyl or (C3 -C7) cycloalkyl, R2 represents trifluoromethyl or (C3 -C4) cycloalkyl, A represents --...	03/22/1994
5292755	USPA benzolyguanidines Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O)n -- or R(7)R(8)N--O2 S-- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)--S(O)...	03/08/1994

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Class 564/237 - Benzene ring containing