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| Number | Title | Issue Date |
| 7285681 | Biguanide derivatives The present invention relates to biguanide derivatives of formula (I), wherein R1, R2, R3 and R4 have the meanings as given in claim (1). Compounds are useful in the treatment of pathologies associated with hyperglycaemia, such as diabetes. | 10/23/2007 |
| 7265156 | Medicinal association of a biguanine and a carrier, for example metformin and arginine The present invention relates to a compound of formula III, method of making the same and its use in the treatment of diabetes. ... | 09/04/2007 |
| 7122505 | Composition for controlling the growth of algae, fungi and pathogenic organisms in water A stable aqueous concentrate comprising a polymeric biguanide, a chelating agent and a water-miscible organic solvent for controlling the growth of algae, fungi and pathogenic organisms in water. ... | 10/17/2006 |
| 6960689 | Method for preparing nitrogen-containing compounds A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not o... | 11/01/2005 |
| 6936640 | Biguanide/quaternary ammonium containing copolymeric biocides and use thereof in pharmaceutical compositions Biguanide/quaternary ammonium compounds and the use of same as antimicrobial agents in pharmaceutical compositions are described. The biguanide/quaternary ammonium compounds are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharm... | 08/30/2005 |
| 6916958 | Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions Aminobiguanides and the use of same as antimicrobial agents in pharmaceutical compositions are disclosed. The aminobiguanides are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions for trea... | 07/12/2005 |
| 6423748 | Amido polybiguanides and the use thereof as antimicrobial agents Amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of amido polybiguanides is also disclosed. The amido polybiguanides are useful in the preservation of pharmaceutical composition... | 07/23/2002 |
| 6100300 | Metformin formulations and method for treating intermittent claudication employing same Novel metformin formulations are provided which include metformin or metformin salts preferably the hydrochloride salt in doses below that employed for treating diabetes such as metformin in daily amounts of 400 mg or below. A method for treating peripher... | 08/08/2000 |
| 5824239 | Method to remove biguanide from an aqueous source A method for removing biguanide from aqueous sources, such as swimming pools, is disclosed. The method includes the steps of bringing at least one polymeric metaphosphate into contact with the aqueous source in a sufficient concentration to form particles... | 10/20/1998 |
| 5322858 | N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines There are provided compounds of the formula ##STR1## wherein R1 is a substituted or unsubstituted divalent aliphatic group of 1 to 16 carbon atoms; wherein the substituents are mono or poly and are selected from the group consisting of low... | 06/21/1994 |
| 5242948 | Bisguanidines and fungicides containing them The present invention relates to bisguanidine derivatives of the formula I ##STR1## where R1 and R2 are each, independently of one another, hydrogen, alkyl, alkenyl, alkenyl, alkoxyalkyl, haloalkenyl; or cycloalkyl which has 5-1... | 09/07/1993 |
| 5221693 | Antimicrobial and antiviral bis-adamantanamine compounds Several bis-adamantanamine compounds have been found to have a broad range of antiviral and antibacterial activities. Demonstrated activity against enveloped viruses, yeasts, fungi, gram positive and gram negative bacteria is shown.... | 06/22/1993 |
| 4954636 | Antimicrobial polymeric bisbiguanides Antimicrobial polymeric bisbiguanides capped with alkylene pyrrolidonyl groups having the formula: ##STR1## where X is C2 -C4 alkylene; Y is a bivalent bridging group; and n is at least 2; and acid addition salts thereof.... | 09/04/1990 |
| 4952704 | Bis-(pyrrolidonyl alkylene) biguanides Antimicrobial bis-(pyrrolidonyl alkylene) biguanides having the formula: A--Z--A where A is: ##STR1## X is C2 -C4 alkylene; and Z is a bivalent bridging group, and acid addition salts thereof, are provided herein.... | 08/28/1990 |
| 4558159 | Polyether biguanide surfactants Polyether biguanide salts of the formula: ##STR1## wherein: y ranges from 0 to 6, z ranges from 2 to 7, A is an anion selected from the group consisting of chloride, bromide, sulfate, bisulfate, phosphate, dihydrogen phosphate and hydrogen phosphate,... | 12/10/1985 |
| 4340755 | Biguanide diperchlorate and process for preparation thereof Biguanide diperchlorate, ##STR1## is prepared by the reaction of 1 mole of biguanide with 2 moles of perchic acid at a temperature of from 0° to 20° C. Biguanide diperchlorate is an explosive which combines good impact sensitivity, high energ... | 07/20/1982 |
| 4022834 | Antibacterially active hexamethylene-bis-biguanides There are disclosed new hexamethylene-bis-biguanides having antibacterial activity, and two processes for the preparation thereof. The new compounds have the general formula ##STR1## wherein R represents H, and R' represents an hexyl or pentyl group ... | 05/10/1977 |
| 4017539 | Biguanide compounds and anti-diabetic compositions New biguanide compounds of the formula: ##STR1## wherein A is saturated or unsaturated cycloaliphatic hydrocarbyl, and the physiologically compatible salts thereof; display outstanding anti-diabetic effectiveness in the treatment of diabetes mellitus... | 04/12/1977 |
| 3984537 | Oral preparations The invention relates to an oral preparation, i.e. dentifrice, which contains non-toxic amino-cyano polymeric diguanide or salt thereof as an anti-bacterial agent.... | 10/05/1976 |
| 3960949 | 1,2-Biguanides 1,2-Substituted biguanides of the formula ##EQU1## wherein R1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group ... | 06/01/1976 |
