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| Number | Title | Issue Date |
| 7884244 | Therapeutic fluoroethylcyano guanidines Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 02/08/2011 |
| 7439395 | Process for the preparation of guanidinium salts The present invention relates to a two-step process for the preparation of guanidinium salts of the formula (1), where the substituents R have a meaning indicated in Claim, and A− is a sulfonate, alkyl- or arylsulfate, hydrogensulfate, imide, methanide,... | 10/21/2008 |
| 7368605 | Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity Formula (I) compounds are described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents. They are useful for the prophyla... | 05/06/2008 |
| 7282538 | Preparation method of functional master batch of polyolefin and its application The present invention belongs to the field of polymerization and processing of polymer and relates to the preparation of a kind of functional polyolefin master batch. The functional master batch is produced by liquid phase, melt phase, or solid phase reaction after ... | 10/16/2007 |
| 7153881 | Compounds acting as melanocortin receptor ligands The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: Wherein X and Y are independently chosen from O, N, S and (CH2 | 12/26/2006 |
| 7145037 | Adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them The invention describes compounds represented by the general formula (I) given below: in which: n is an integer between 1 and 4; R1 and R2 | 12/05/2006 |
| 7141680 | Aromatic compounds possessing antifungal or antibacterial activity The present invention provides novel compounds possessing antibacterial, and/or antifungal activities. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided. ... | 11/28/2006 |
| 7109329 | Neurologically active compounds and compounds with multiple activities This invention provides pharmacologically active compounds having neurological and other bio-active capability. These active compounds comprise the derivatives of guanidino, aminoguanidino, 2-imadazolino, 2-hydrazinoimidazolino or 2-guanidinobenzimidazolino groups. | 09/19/2006 |
| 7078566 | Salts of guanidine derivatives and pharmaceutical preparations consisting thereof This invention relates to salts of guanidine derivatives of formula R—X—C(═NH)NH3+Z−, wherein X represents a valence bond, —CH2—NH—, —CH2—NH—NH— or —CH═N—NH—; R represents a linear ... | 07/18/2006 |
| 7067698 | Bi-directional synthesis of oligoguanidine transport agents Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds ... | 06/27/2006 |
| 7056855 | Liquid tetrabutyl ammonium phenolate formulation A process for preparing a formulation containing tetrabutylammonium phenolate and phenol is disclosed. The process entails combining a solution of tetrabutylammonium bromide in phenol with a solution of sodium phenolate to form a mixture, excess phenol is removed by... | 06/06/2006 |
| 6884912 | Aminoguanidine bicarbonate with particular properties and method for making same The invention concerns a method for making aminoguanidine bicarbonate from an aqueous solution of cyanamide and an aqueous solution of hydrazine in the presence of CO2. The invention is characterised in that it consists in proceeding with an amount of cya... | 04/26/2005 |
| 6774263 | Pharmaceutically active compound and methods of use This invention relates to racemic and optically active N-(2-chloro-5-methylthiophenyl)-N′-(3-methylsulfinylphenyl)-N′-methylguanidine, N-(2-chloro-5-methylsulfinylphenyl)-1-(7-trifluoromethyl- 1,2,3,4-tetrahydroquinolinyl)carboximidamide, and N-(3-methylsulfinyl... | 08/10/2004 |
| 6768024 | Triamine derivative melanocortin receptor ligands and methods of using same The invention provides triamine derivative melanocortin receptor ligands of the formula: wherein R1 to R8 and n have the meanings provided herein. The invention further provides methods of using the... | 07/27/2004 |
| 6740781 | Process for separating reaction mixtures and recycling quaternary salts and bases A process for the removal and recovery of quaternary salt (A) and base (D) from a reaction mixture is disclosed. The reaction mixture resulting from oxidative direct carbonylation contains in addition to (A) and (D), at least one hydroxyaromatic compound (B) and at ... | 05/25/2004 |
| 6734325 | Process for the separation of reaction mixtures and the recirculation of quaternary salts A process for the separation and recycling of catalyst components from a chemical reaction mixture is disclosed. The process entails at least one extraction step. ... | 05/11/2004 |
| 6680408 | Processes for the preparation of -substituted benzylnitroguanidines Processes for preparing -substituted benzylnitroguanidines include the steps of providing a reaction mixture comprising water, alcohol, an S-alkyl nitroisothiourea, and an -substituted benzylamine; heating the reaction mixture; steam distill... | 01/20/2004 |
| 6646137 | Non-peptide GnRH agents Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are of the following general formula, where X1, X2, Y, and Z are defined variables: ##STR1## Such compounds and their pharmaceutically accepta... | 11/11/2003 |
| 6632840 | Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them Monoacyl-substituted guanidines of formula III, or a salt or acid thereof, and their use as medicine or diagnostic aid: ##STR1## in which X(2) is ##STR2##... | 10/14/2003 |
| 6570038 | Aqueous hexasubstituted guanidinium chlorides and methods for their preparation and use Hexasubstituted guanidinium chlorides are prepared by a method which affords them in high yield as aqueous solutions, optionally also containing alkali metal chlorides. The solutions may be employed as sources of hexasubstituted guanidinium salts useful a... | 05/27/2003 |
| 6536492 | Silica-containing rubber composition vulcanizable with sulfur The present invention provides for a coupling system (white filler/diene elastomer) for a rubber composition based on diene elastomer reinforced with a white filler, formed by the association of a polysulphurized alkoxysilane, a zinc dithiophosphate and a... | 03/25/2003 |
| 6465686 | Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.... | 10/15/2002 |
| 6441176 | Method for preparing sodium-hydrogen exchanger type 1 inhibitor Methods of preparing NHE-1 disclosed. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.... | 08/27/2002 |
| 6436999 | Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them Diacyl-substituted guanidines of the formula I ##STR1## are described where X(1) and X(2) are ##STR2## as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis... | 08/20/2002 |
| 6420556 | Acyl isothiocyanate resins and their use in solid-supported synthesis of guanidines ##STR1## The subject invention involves novel acyl isothiocyanate resins of formula (I) and processes for making them: (a) starting with a phenyl carboxy resin, treating the resin with any reagent that converts the carboxy to an acyl halide, followed ... | 07/16/2002 |
| 6399819 | Process for purifying creatine A process for purifying creatine is described in which the creatine to be purified in the form free of water of crystallization is introduced into a saturated aqueous solution of creatine monohydrate, in which the creatine free of water of crystallization... | 06/04/2002 |
| 6329521 | Process for preparing substituted benzoyl cyanide amidinohydrazones The present invention provides a process for preparing a compound of the general formula (I): ##STR1## wherein R1 to R5 are independently selected from hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 | 12/11/2001 |
| 6310232 | Method for recycle of bromide-containing catalyst constituents Bromide source such as alkali metal bromide, alkaline earth metal bromide, or onium bromide, present as part of a catalyst mixture in an organic oxidative carbonylation mixture further comprising diaryl carbonate and a hydroxyaromatic compound, is often a... | 10/30/2001 |
| 6288123 | Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.... | 09/11/2001 |
| 6251948 | Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce... | 06/26/2001 |
| 6252072 | Method for producing nitroguanidine derivatives A process for the preparation of compounds of formula ##STR1## is described, wherein R1 is hydrogen or C1 -C4 -alkyl; R2 is hydrogen, C1 -C6 -alkyl, C3 -C6 -cycloalkyl or a... | 06/26/2001 |
| 6235934 | Aqueous hexasubstituted guanidinium chlorides and methods for their preparation and use Hexasubstituted guanidinium chlorides are prepared by a method which affords them in high yield as aqueous solutions, optionally also containing alkali metal chlorides. The solutions may be employed as sources of hexasubstituted guanidinium salts useful a... | 05/22/2001 |
| 6211186 | Enzyme Inhibitors The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in heal... | 04/03/2001 |
| 6187953 | Guanidinium phosphanes, their production and their use Guanidinium phosphanes of Formula I ##STR1## wherein the substituents are defined as in the specification which are useful catalyst ligands for the carbon-carbon linkage reactions of the hect reaction.... | 02/13/2001 |
| 6174924 | Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.... | 01/16/2001 |
| 6162925 | Antibiotic for methicillin resistant bacteria The present invention is directed to anti-bacterial and anti-tumor agents and the synthesis thereof.... | 12/19/2000 |
| 6147258 | Preparation of substituted guanidine derivatives Substituted guanidine derivatives of the formula I ##STR1## are prepared by reacting calcium cyanamide with a primary or secondary amino carboxylic acid or a primary or secondary amino sulfonic acid or their derivatives of the formula II ##STR2#... | 11/14/2000 |
| 6143932 | Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein The instant invention is directed to a single, selectively N-alkylated compound and libraries of such compounds as set forth in Formula I. Furthermore, the instant invention is directed to methods of effecting analgesia, a decrease in the postprandial ris... | 11/07/2000 |
| 6121489 | Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein The instant invention is directed to a single, selectively N-alkylated compound and libraries of such compounds as set forth in Formula I. Furthermore, the instant invention is directed to methods of effecting analgesia, a decrease in the postprandial ris... | 09/19/2000 |
| 6114392 | Agmatine, and polyaminoguanidine-bound heterocyclic compounds for neurotrauma and neurodegenerative diseases The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The invention further provides novel compounds of general formula I... | 09/05/2000 |
