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| Number | Title | Issue Date |
| 7271289 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 09/18/2007 |
| 7087599 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 08/08/2006 |
| 6660246 | Ligands and metal complexes thereof Novel compounds of the formula ##STR1## and novel complexes of these compounds with metals are useful in diagnostic and therapeutic methods.... | 12/09/2003 |
| 6171612 | Lipopolyamines as transfection agents and pharmaceutical uses thereof Lipopolyamines useful for the transfection of nucleic acid and methods of preparation thereof are disclosed. The lipopolyamines are of general formula I, in which R4 comprises at least one C10-C22 aliphatic radical. ##STR1##... | 01/09/2001 |
| 5874593 | Production process and intermediate of tetrazole compound There are disclosed an industrially favorable process for producing a tetrazole compound of general formula (1): ##STR1## characterized in that a nitrile of general formula (2): R1 CN (2) is react... | 02/23/1999 |
| 5869299 | Process for producing clavulanic acid A process for preparing clavulanic acid and other clavam derivatives using an enzyme system from Streptomyces, particularly S. Clavuligerus.... | 02/09/1999 |
| 5728737 | N-alkoxy-amidine derivatives The present invention relates to novel N-alkoxy-arnidine derivatives of the formula (I), to a process for their preparation and to their use as pesticides. In addition, the invention also relates to novel intermediates and to a process for their preparati... | 03/17/1998 |
| 5693860 | Amidrazones and their use as insecticidal and acaricidal agents There are provided substituted acid amide, arylhydrazone compounds (amaidrazones) of formula I ##STR1## the use thereof for the control of insect and acarid pests and methods and compositions for the protection of crops from the damage and loss cause... | 12/02/1997 |
| 5659041 | Hydrazino-type radionuclide chelators having an N3 S configuration Radionuclide chelating compounds are provided for conjugation to targeting molecules such as proteins, peptides or antibodies. The resulting labeled targeting molecules may be used in diagnosis and therapy.... | 08/19/1997 |
| 5639911 | Hydrazones Compounds of formula I ##STR1## wherein A, X, Z and R1 -R5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner kn... | 06/17/1997 |
| 5621145 | Bisamidoxime compound, process for preparing the same and a fluorine-containing elastomer composition comprising the same When a novel bisamidoxime compound represented by the following general formula: ##STR1## where R is an alkylidene group having 1 to 6 carbon atoms, or a perfluoroalkylidene group having 1 to 10 carbon atoms, is used as a vulcanizing agent for f... | 04/15/1997 |
| 5605973 | Bisamidrazone compound and vulcanizing agent for fluorine-containing elastomer comprising the same Novel compound, 2,2-bis(4-carboxyphenyl)hexafluoropropane bisamidrazone, obtained by conversion of the carboxy groups of 2,2-bis(4-carboxyphenyl)hexafluoropropane to acid chloride groups, followed by reaction with ammonia; dehydration reaction of the resu... | 02/25/1997 |
| 5599975 | Cyclised analogues of fatty acid metabolites A compound selected from those of formula (I): ##STR1## wherein A, X, Y, Z, R, R1, R2, R3 and R4 are as defined in the description. This compound or its physiologically tolerable salts may be used therapeut... | 02/04/1997 |
| 5478946 | Guanidino compounds as regulators of nitric oxide synthase Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, ... | 12/26/1995 |
| 5461076 | Hydrazones Compounds of formula I ##STR1## wherein A, X, Z and R1 -R5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner kno... | 10/24/1995 |
| 5451607 | Hydrazone derivatives, process for producing same, insecticides and/or acaricides containing same as active ingredient and intermediate compounds thereof There are disclosed hydrazone derivatives of the general formula [I]: ##STR1## wherein R1 is halogen, etc.; R2 is hydrogen or C1 -C6 alkyl, etc.; R3 is hydrogen or C1 -C6 alkyl, ... | 09/19/1995 |
| 5405871 | Benzophenonehydrazones Compounds of the formula ##STR1## wherein each of o and p, independently of the other, is 0, 1, 2, 3, 4 or 5, the radicals R1 being the same or different when o is greater than 1 and the radicals R2 being the same or different w... | 04/11/1995 |
| 5395855 | Hydrazones Compounds of formula I ##STR1## wherein A, X, Z and R1 -R5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner kno... | 03/07/1995 |
| 5380945 | Guanidino compounds as regulators of nitric oxide synthase Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, ... | 01/10/1995 |
| 5288727 | Hydrazone compounds, processes for their production, intermediates useful for their production and pesticidal compositions containing them The present invention relates to a hydrazone compound of the formula (I) or its salt, a process for its preparation, an intermediate of the formula (II-5), a pesticidal composition containing said hydrazone compound or its salt as the active ingredient, a... | 02/22/1994 |
| 4902835 | Fluorinated butene derivatives and methods for their preparation New chemical reactions of 1,1,2-trifluoro-1,3-butadiene provide simple access to a series of new fluorinated alkene derivatives. These derivatives provide a simple, general methodology for the stereocontrolled preparation of 2-fluoro-2-alkenoate esters an... | 02/20/1990 |
| 4731471 | (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents The invention relates to novel [(5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)]alkanoic acids and alkanimidamides bearing novel functional 9a-substituents, their derivatives and their salts. The compounds are useful for the treatment and preven... | 03/15/1988 |
| 4731470 | [(5,6-dichloro-3-oxo-2,9a-alkano-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy] alkanoic acids and alkanimidamides The invention relates to novel [(5,6-dichloro-3-oxo-2,9a-alkano--2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy] alkanoic acids and alkanimidamides, their derivatives, and their salts. The compounds are useful for the treatment and prevention of injury to the ... | 03/15/1988 |
| 4661522 | Cycloalkane-indene-carboximidamide derivatives The present invention is dealing with cycloalkane-indene-carboximidamide derivatives having the general formula: ##STR1## wherein Rx together with either Ry1 or Ry2 represent the moiety ##STR2## (the other Ry being hydroge... | 04/28/1987 |
| 4604396 | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimida mides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimid ic acid hydrazides, their derivatives and their salts The invention relates to novel [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-yl)oxy]ethanimidamid es and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts. The compoun... | 08/05/1986 |
| 4512997 | 4,5-Bis(aryl)-4H-1,2,4-triazole derivatives and analgesic use Novel 4H-1,2,4-triazoles of the formula ##STR1## wherein R1, R2, R3 and R4 may be in different positions of the benzene rings and are individually selected from the group consisting of hydrogen, --OH, alkyl... | 04/23/1985 |
| 4499105 | Carboxyimidamide derivatives The present invention is dealing with compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, in which n and m represent the number 1 or 2, X and Y hydrogen, alkyl (1-4 C), alkoxy (1-4 C), hydroxy, halogen, hydroxymethyl, tr... | 02/12/1985 |
| 4456769 | Preparation of hydrazidines A new one-step process for the preparation of hydrazidines of the general formula ##STR1## in which R represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group or an option... | 06/26/1984 |
| 4443629 | Preparation of hydrazidines A one-step process for the preparation of hydrazidines of the general formula ##STR1## in which R represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group or an optionally... | 04/17/1984 |
| 4426393 | Method of protecting useful plants and formulations for use in said method There are disclosed arylhydrazo-aldoximes which, as such, as tautomers, and in the form of organic or inorganic salts thereof, are active in preventing and treating infections of useful plants by fungi, and in immunizing plants against such infections.... | 01/17/1984 |
| 4331680 | Pesticidal compounds, compositions and methods Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are described. Methods of making the compounds, and novel intermedi... | 05/25/1982 |
| 4216162 | Novel derivatives of cyclopropanecarboxylic acid useful as intermediates for the preparation of insecticides Novel 2-(2,2-dihalogenovinyl)-3,3-dimethylcyclopropanecarboxylic acid derivatives of the formula ##STR1## e.g. amides, thioamides, oxazolines, amidoximes and hydroxamic acids, are produced by reacting the new compounds ##STR2## with a base ... | 08/05/1980 |
| 4191768 | Pentadienone hydrazones, method for preparing the same, and insecticidal use thereof There are provided insecticidal pentadienone hydrazones and methods of preparation thereof. There is further provided a method for using the aforesaid compounds for the control of insects, especially Lepidopterous insects, and for the control of ants, Fam... | 03/04/1980 |
| 4097525 | Aromatic amidines as antiviral agents in animals Novel [N,N-di(higher alkyl)aminomethyl]benzamidine and substituted compounds such as [N,N-di(higher alkyl)aminomethyl]-N-(2-propyl)-benzamidine and [N,N-di(higher alkyl)aminomethyl]-N-(p-hydroxyphenyl)-benzamidine and their non-toxic acid addition sa... | 06/27/1978 |
| 4049815 | Triazoles 3-Trihalomethyl-1,2,4-triazoles either unsubstituted or having substituents in the 4 and/or 5, 1 and/or 5, and 2 and/or 5 positions; and methods for their preparation. The compounds show biological activity; at least some have acaricidal activity.... | 09/20/1977 |
