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| Number | Title | Issue Date |
| 7772434 | Crystalline form of a βadrenergic receptor agonist The invention provides a novel β2 adrenergic receptor agonist in crystalline salt form. The invention also provides pharmaceutical compositions comprising the novel β2 adrenergic receptor agonist in crystalline salt form, formulations contain... | 08/10/2010 |
| 7557247 | Crystalline form of βadrenergic receptor agonist The invention provides a novel β2 adrenergic receptor agonist in crystalline salt form. The invention also provides pharmaceutical compositions comprising the novel β2 adrenergic receptor agonist in crystalline salt form, formulations contain... | 07/07/2009 |
| 7365199 | Dye-forming coupler, silver halide photographic light-sensitive material, and azomethine dye compound A dye-forming coupler of formula (I), a silver halide photographic light-sensitive material containing the coupler, and an azomethine dye compound derived from the coupler: wherein Q is a residue that forms, together with t... | 04/29/2008 |
| 7268252 | Binaphthol derivatives and their use in optical resolution or optical transformation Disclosed herein are novel binaphthol derivatives and methods for the optical resolution of amino acids or amino alcohols and for the optical transformation of D, L-forms of amino acids using the same. ... | 09/11/2007 |
| 7182932 | Catalyst preparation A TS-1 catalyst suitable for the production of oxirane compounds is prepared by subjecting conventionally formed TS-1 to a size reduction treatment such as milling such that the average particle size weighted by volume of the TS-1 is reduced to less than 10 microns ... | 02/27/2007 |
| 7173152 | One-pot reductive acetamidation of aryl nitro compounds The present invention provides a method for the reductive acetamidation of an aryl nitro compound by reacting a substituted acid with an aryl nitro compound and adding a catalytic amount of a base with the substituted acid and the aryl nitro compound to form an acet... | 02/06/2007 |
| 7169748 | Fragrance compounds Novel compounds having the structure (I) where R=methyl, ethyl or propyl, R1=methyl or H, R2=methyl, ethyl or propyl, R3=methyl or H, R4=methyl or ethyl, R5═H or methyl, and where R3 and R5 | 01/30/2007 |
| 7163909 | Authenticity indicator A rapidly reversing authenticity indicator for substrates such as secure documents, tags and labels is described. The authenticity indicator comprises a substrate having provided thereon a coating of a colorless chromogenic material, a binder material and optional p... | 01/16/2007 |
| 6992218 | Method for obtaining aqueous formulations of oxidation-sensitive active principles A method for obtaining aqueous formulations with easily oxidizable active principles, notably phenols, stable over a prolonged period, comprising subjecting them to extreme deoxygenation by bubbling with an inert gas and/or placing wider vaccum, protecting them agai... | 01/31/2006 |
| 6969775 | Method of producing organic compounds in presence of oxyethylene ether catalyst and in a solvent minimized environment A process of producing organic compounds, such as acetaminophen, nitroalcohols and indoles, employs a catalyst system of an oxyethylene ether and a metal containing inorganic or organic reagent. The oxyethylene ether at least partially complexes the metal of the ino... | 11/29/2005 |
| 6964963 | Preparation of 4-amino-1-naphthol ethers The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl g... | 11/15/2005 |
| 6888015 | Sphingolipid synthesis inhibitor A inhibitor of sphingolipids synthesis comprising a compound represented by general formula A. Desirably, a novel inhibitor of sphingolipids synthesis comprising (1R, 3R) N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl) alkaneamide, wherein carbon number of alkanoyl gro... | 05/03/2005 |
| 6706765 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra | 03/16/2004 |
| 6657083 | 5-acylamino-2-amino-4-substituted-phenol compounds and method of using them Disclosed is a 2-amino-5-acylamino-4-substituted-phenol compound having the structural formula I: ##STR1## wherein Y is a substituent group, and R' is a ballast group. Also disclosed is a simplified method for preparing a photographic coupler usin... | 12/02/2003 |
| 6613943 | 4-acylamino-2-hydroxy-5-substituted-acylanilide compounds and method of using them Disclosed is a 4-acylamino-2-hydroxy-5-substituted-acylanilide compound having the structural formula I: ##STR1## wherein R is hydrogen or an alkyl group, Y is a group linked to the rest of the compound by a --O--, --S--, or --N-- atom; and R'... | 09/02/2003 |
| 6576793 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p... | 06/10/2003 |
| 6518310 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 02/11/2003 |
| 6372800 | Benzene compound and pharmaceutical use thereof A benzene compound of the formula ##STR1## wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredie... | 04/16/2002 |
| 6255496 | Trifluoromethyl ketone analogs as selective cPLA2 inhibitors Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1##... | 07/03/2001 |
| 6242646 | Method of producing 2,4-dichloro-5-hydroxyacetanilide The present invention relates to a process for preparing 2,4-dichloro-5-hydroxyacetanilide by reacting 3-hydroxyacetanilide with sulfuryl chloride in the presence of from 3 to 30 parts by weight of an aliphatic carboxylic acid having from 1 to 6 carbon at... | 06/05/2001 |
| 6242609 | Method for manufacturing a color coupler used in a silver halide photographic light-sensitive material A method for manufacturing a color coupler used in a silver halide photographic light-sensitive material using an ammonium trihalide. Said method for manufacturing the color coupler comprising the following step: a step for halogenating a coupling position of ... | 06/05/2001 |
| 6187819 | Protein kinase C activators and their use in decreasing expression of cell antigens A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells ... | 02/13/2001 |
| 6169206 | 4-(n,n-dialkylamino)aniline compound, photographic processing composition containing the same and color image-forming method 4-(N,N-Dialkylamino)aniline compounds of the following general formula (I): ##STR1## wherein R1 represents an alkyl group, an aryl group or a heterocyclic group, R2 to R5 each represent a hydrogen atom or a substituent, an... | 01/02/2001 |
| 6069174 | Protein kinase C activators and their use in increasing expression of cell antigens A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells ... | 05/30/2000 |
| 6028222 | Stable liquid paracetamol compositions, and method for preparing same Novel stable paracetamol compositions for use in therapeutic chemistry and specifically galenic pharmacy are disclosed. The compositions contain a solution of paracetamol in an aqueous solvent combined with a buffer having a pH of 4 to 8, and a free radic... | 02/22/2000 |
| 6004565 | Compositions and methods of using compositions with accelerated lymphocyte homing immunosuppressive properties The methods and compositions of the invention and the compounds used in the invention involve a novel immunosuppression mechanism, accelerated lymphocyte homing immunosuppression (ALH-immunosuppression). For example, the compound FTY720 specifically direc... | 12/21/1999 |
| 5990173 | 2,3,5-trimethyl-4-hydroxyanilide derivatives, preparation thereof and therapeutical use thereof Novel 2,3,5-trimethyl-4-hydroxyanilide derivatives of general formula I, wherein, e.g., R1 is phenyl, R2 is H, R3 is C12 H25, and A is a sulphur atom, are disclosed. A method for preparing said deriva... | 11/23/1999 |
| 5981799 | Method for the purification of acetaminophen A method is provided for purifying a crude N-acetyl-para-aminophenol (APAP) containing color bodies or their precursors, the method comprising: a) forming a hot aqueous solution of the crude APAP; and b) subsequently contacting the hot solution with an ac... | 11/09/1999 |
| 5948820 | Benzene compound and pharmaceutical use thereof A benzene compound of the formula ##STR1## wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ... | 09/07/1999 |
| 5880158 | Propionamide anticonvulsants The present invention is directed to a compound of the following formula: ##STR1## pharmaceutical compositions containing the same and the use thereof as an anticonvulsant.... | 03/09/1999 |
| 5872299 | Method of preparing intermediates for retroviral protease inhibitors A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amin... | 02/16/1999 |
| 5856575 | Process for the preparation of N-acetyl aminophenols This invention provides a process for the manufacture of N-acetyl amino phenol, which process comprises reacting an appropriate phenol and an amide in the presence of a heteropoly acid or its alkali metal salt catalyst.... | 01/05/1999 |
| 5786509 | Method and compositions for authenticating a product or document A method and compositions for authenticating a document or article comprises applying a mixture of a carrier, a leuco dye and an activator to a surface of a document or article, wherein the leuco dye and activator react in response to a rubbing force appl... | 07/28/1998 |
| 5770772 | Intermediates for the preparation of aminocoumaran derivatives Disclosed are intermediates for the preparation of novel aminocoumaran derivatives of the general formula (I): ##STR1## wherein R1 and R2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromati... | 06/23/1998 |
| 5734063 | 4-acylaminophenylacetylenealcohol compounds The present invention provides a method for preparation of a compound of the formula (I) useful as a fog restrainer for a silver halide light-sensitive material, especially for a heat-developing light-sensitive material and a synthetic intermediate for th... | 03/31/1998 |
| 5681860 | Method of increasing expression of HLA, cell surface and TAA antigens of cells using 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells ... | 10/28/1997 |
| 5663442 | Process for the preparation of sulphones The invention relates to a process for the preparation of compounds of the formula ##STR1## characterized in that the radical X in sulphones of the formula X--(CH2 --CH2 --O)m --(CH2)n --SO2 | 09/02/1997 |
| 5536876 | Formylamino-aminophenol compounds and their use in preparation of fiber-reactive formazan dyes Fiber-reactive formazan dyes are prepared by diazotizing a protectively formylated hydroxyphenylenediamine, coupling with a hydrazone compound, metallizing, eliminating the protective group, and reacting with a halotriazine and optionally thereafter with ... | 07/16/1996 |
| 5510389 | Concentrated acetaminophen solution compositions Improved concentrated liquid pharmaceutical compositions containing acetaminophen wherein said acetaminophen is formed by adding a Beckman rearrangement catalyst to 4-hydroxyacetophenone oxime.... | 04/23/1996 |
| 5484953 | O-phenylenediamines containing fluoroalkyl(ene) groups Novel o-phenylenediamines of the formula containing fluoroalkyl(ene) groups ##STR1## in which the symbols used have the meaning given in the description, processes for their preparation and their use as intermediates.... | 01/16/1996 |
