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| Number | Title | Issue Date |
| 8138375 | Method for producing 1-formamido-3,5-dimethyladamantane The invention relates to a method for producing 1-formamido-3,5-dimethyladamantane in only two reaction steps by direct formamide formation of 1,3-dimethyladamantane, the 1,3-dimethyladamantane being reacted with formamide in concentrated acids. ... | 03/20/2012 |
| 7262326 | Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is describe... | 08/28/2007 |
| 7157604 | Selective estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 01/02/2007 |
| 7135502 | Colchinol derivatives as vascular damaging agents The invention relates to the use of compounds of formula (I): wherein X is —C(O)—, —C(S)—, —C═NOH, or —CH(R7)— wherein R7 is hydrogen, hydroxy, C1-7alkoxy, —OR8 or —NR8R9 (wherein ... | 11/14/2006 |
| 6939992 | Polymorphic forms of sertraline hydrochloride A crystalline form of sertraline hydrochloride was found, referred to hereinafter as polymorphic form CSC2 having a dissolution rate which surprisingly will increase rate of absorption of a drug. Furthermore, different crystalline forms of sertraline hydrochl... | 09/06/2005 |
| 6737547 | Compositions containing and methods of using N-acyl-1H-aminoindenes The present invention provides novel aminoindenes having the structure: wherein n is 1 or 2, R1 is hydrogen, linear or branched chain C1-C8 alkyl or linear or branched chain C1... | 05/18/2004 |
| 6683220 | Process for the preparation of optically pure or enriched racemic tetralone A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an optically pure metal-organic complex, and a liquid mobile... | 01/27/2004 |
| 6649796 | Process for the preparation of acetamide derivatives The invention provides a process for the preparation of diphenylmethylthioacetamide (I) as described in Scheme 4 comprising reacting of the isothiouronium salt or its corresponding base of the formula IV with an acetamide of the formula XCH2 CO... | 11/18/2003 |
| 6635783 | Bicyclic 1,3-aminoalcohols, d8-metal complexes and hydrogenation processes Bicyclic amino alcohols, whose amino group and hydroxy group are bonded in positions 1,3 adjacent to the bridge, for example ##STR1## are valuable ligands for metal complexes of the d-8 metals of the periodic table of elements. The metal complexes in ques... | 10/21/2003 |
| 6602903 | Substituted heterocyclic compounds The invention relates to compounds of formula (I): ##STR1## and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.... | 08/05/2003 |
| 6313175 | Meta substituted arylalkylamines and therapeutic and diagnostic uses therefor Novel meta substituted arylalkylamine compounds are disclosed. These compounds can be administered as small molecule drugs to treat diseases or conditions associated with insufficient serotonin mediated nerve transmission (e.g., depression and obesity).... | 11/06/2001 |
| 6297399 | Indane compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity as described, wherein in formula (7) R2 | 10/02/2001 |
| 6262308 | Process for the preparation of racemic sertraline The invention relates to a process for preparing cis-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, or racemic sertraline, corresponding to formula (I) ##STR1## in salt form, starting with 4-(3,4-dichlorophenyl)tetralone of formula (I... | 07/17/2001 |
| 6140372 | Acyl derivatives of melatonin and of melatoninergic analogues and their use as medicinal products The invention relates to derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in particular for the treatment of complaints associated wit... | 10/31/2000 |
| 6028112 | Spirocyclopropyl fluorenes as melatonergic agents There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R1 and X are as defined herein which are useful as melatonergic agents.... | 02/22/2000 |
| 5973204 | Colchicine and thiocolchicine derivatives with antiinflammatory and muscle relaxant activities The present invention relates to 3-demethyl-thiocolchicine derivatives of general formula (I) ##STR1## in which R can be ##STR2## to a process for the preparation thereof, to pharmaceutical compositions containing them and to the use thereo... | 10/26/1999 |
| 5959146 | Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.... | 09/28/1999 |
| 5849945 | Aminotetralone derivatives and preparation process thereof The present invention pertains to a process for the preparation of Compound (4) through the below-described reaction route: ##STR1## wherein R1 and R2 each represents H, halogen, OH or C1-6 alkyl group; X and Y each r... | 12/15/1998 |
| 5834521 | Substituted dibenz (A F)azulenes and methods of preparation Tetracyclic compounds having the following structure are described: ##STR1## wherein R1 -R10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased ut... | 11/10/1998 |
| 5817874 | Process for alkylating and smiles rearrangement of hydroxy aromatics The present invention is a process of converting a hydroxy aromatic into a 2-hydroxy-N-arylacetamide, comprising: (1) treating a reaction mixture comprising a salt of a hydroxy aromatic with an alkylating agent; and (2) treating the reaction mixture with a Smi... | 10/06/1998 |
| 5731352 | Aryl(alkyl)propylamides The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R1, R'1, R2, R3 and n are as defined in the description, and medicinal product containing the same useful for tre... | 03/24/1998 |
| 5663442 | Process for the preparation of sulphones The invention relates to a process for the preparation of compounds of the formula ##STR1## characterized in that the radical X in sulphones of the formula X--(CH2 --CH2 --O)m --(CH2)n --SO2 | 09/02/1997 |
| 5663337 | Pharmaceutically active benzoquinazoline compounds The present invention relates to benzoquinazoline thymidylate synthase inhibitors, processes for preparing them and pharmaceutical formulations containing them.... | 09/02/1997 |
| 5646188 | Polyamine derivatives of 1-aminoindan A compound of general formula I ##STR1## wherein n is 1 or 2; R1 and R2 are each independently hydrogen, hydroxy, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 alkoxy or halogen... | 07/08/1997 |
| 5599985 | Optically pure 1-amido-2-indanols A two-step process for the conversion of a trans-1-amino-2-hydroxycycloalkane stereoselectively to a cis-1-amino-2-hydroxycycloalkane is disclosed. The novel step, a one-step hydrolysis with formal inversion, can be used to convert an amide of a tran... | 02/04/1997 |
| 5530002 | 1-[2-(1H-inden-3-yl)ethyl]-4-(naphth-1-yl)piperazine derivatives, their preparation and their application in therapeutics Compounds of formula: ##STR1## in which X represents a hydrogen atom, a C1 -C3 alkoxy group or a cyclopropylmethoxy group and Y represents a hydrogen atom or a methoxy group, are useful in the therapy of conditions.... | 06/25/1996 |
| 5470977 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at t... | 11/28/1995 |
| 5463126 | Process for preparing sertraline The invention provides the substantially geometrically pure cis-stereoisomeric form of a compound of formula (I) and the substantially geometrically and optically pure cis-stereoisomeric form of a compound of formula (II): ##STR1## wherein R | 10/31/1995 |
| 5442116 | Process for preparing sertraline intermediates The invention provides the substantially geometrically and optically pure trans-stereoisomeric form of a compound of formula (I): ##STR1## wherein R1 is H or C1 -C4 alkyl, together with processes for its preparation. ... | 08/15/1995 |
| 5426229 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at t... | 06/20/1995 |
| 5248823 | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosme... | 09/28/1993 |
| 5225601 | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for ... | 07/06/1993 |
| 5225595 | Arylsulfonyl compounds with unsaturated radicals Sulfonyl compounds of the formula ##STR1## where Ar is the radical of a benzene or naphthalene ring, R1 and R2 are each hydrogen, substituted or unsubstituted C1 -C4 -alkyl, substituted or unsubstituted phenyl, ... | 07/06/1993 |
| 5196454 | Method of treating disorders of the dopaminergic systems using 2,5-diaminotetralines The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical compositions. The novel 2,5-diaminotetralines are useful in treat... | 03/23/1993 |
| 5189065 | Use of derivatives of 9,10-dihydrophenanthrene for the preparation of an anti-tumor medicament The use of products of formula (I) is described, wherein X and Y represent hydrogen, hydroxy or alkoxy; and R1 and R2 represent H, alkyl, alkenyl or alkynyl, arylalkyl, acyl or R1 and R2 together with nitrogen f... | 02/23/1993 |
| 5153227 | Phenylsulfonyl nitromethanes as aldose reductase inhibitors The invention concerns novel pharmaceutical compositions for use in the treatment of certain complications of diabetes and galactosemia and which contain a nitromethane derivative (or its non-toxic salt) as active ingredient. The nitromethane derivatives ... | 10/06/1992 |
| 5128479 | Oxidized diphenylheteroalkanes Oxidized diphenylheteroalkanes of the formula I ##STR1## where R1 to R6 and A have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as... | 07/07/1992 |
| 5114975 | Anilinophenyl carbodiimides compositions containing them, and the use thereof in pest control The invention relates to novel substituted aryloxyphenylthioureas, aryloxyphenylisothioureas and aryloxyphenylcarobodiimides of formula I ##STR1## wherein R1 is C1 -C12 alkyl, unsubstituted or substituted by one or mo... | 05/19/1992 |
| 5071875 | Substituted 2-amidotetralins as melatonin agonists and antagonists The present invention relates generally to compounds having melatonin receptor activities and in particular to substituted 2-amidotetralin derivatives; to pharmaceutical preparations comprising such compounds; and to methods for using these compounds as t... | 12/10/1991 |
| 5026730 | Anilinophenylthioureas, compositions containing them, and the use thereof in pest control The invention relates to novel substituted anilinophenylthioureas, anilinophenylisothioureas and anilinophenylcarbodiimides of formula I ##STR1## wherein R1 is C1 -C12 alkyl, unsubstituted or substituted by one or mor... | 06/25/1991 |
