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| Number | Title | Issue Date |
| 8436211 | Tetraarylborate process for the preparation of substituted biphenyls The present invention relates to a process for the preparation of substituted biphenyls by reacting aryl halides with tetraarylborates in the presence of palladium catalysts. ... | 05/07/2013 |
| 7342132 | Formoterol tartrate process and polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ... | 03/11/2008 |
| 7272428 | Wireless electrocardiograph system and method A method and system for wireless ECG monitoring is provided. An electrode connector, transmitter and receiver operate with existing electrodes and ECG monitors. The electrode connector includes connectors for attaching to disposable or reusable single electrodes. Th... | 09/18/2007 |
| 7262326 | Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is describe... | 08/28/2007 |
| 7215991 | Wireless medical diagnosis and monitoring equipment A medical diagnosis and monitoring system having at least one sensor for detecting an electrical, physical, chemical, or biological property of a patient such as, but not limited to, EEG- and EKG-signals, respiration, oxygen saturation, temperature, perspiration, et... | 05/08/2007 |
| 7145036 | Formoterol tartrate polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ... | 12/05/2006 |
| RE39072 | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or ... | 04/18/2006 |
| 6964963 | Preparation of 4-amino-1-naphthol ethers The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl g... | 11/15/2005 |
| 6870069 | Phenyloxyaniline derivatives A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1): wherein X1 and X2 are ... | 03/22/2005 |
| 6720453 | Formoterol tartrate polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ... | 04/13/2004 |
| 6706765 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra | 03/16/2004 |
| 6518310 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 02/11/2003 |
| 6472563 | Formoterol tartrate process and polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.... | 10/29/2002 |
| 6423714 | Cyclohexene derivatives useful as antagonists of the motilin receptor The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the ... | 07/23/2002 |
| 6423870 | Tricyclic compounds, preparation method and pharmaceutical compositions containing same The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4 ; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2... | 07/23/2002 |
| 6350902 | Process for the selective N-formylation of N-hydroxylamines The instant invention provides a process for the selective N-formylation of N-hydroxylamines.... | 02/26/2002 |
| 6268533 | Formoterol process A method is disclosed for the preparation of optically pure isomers of formoterol by the reaction of an optically pure 4-benzyloxy-3-formamidostyrene oxide with an optically pure 4-methoxy--methyl-N-(phenylmethyl)benzeneethanamine followed by ... | 07/31/2001 |
| 6262308 | Process for the preparation of racemic sertraline The invention relates to a process for preparing cis-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, or racemic sertraline, corresponding to formula (I) ##STR1## in salt form, starting with 4-(3,4-dichlorophenyl)tetralone of formula (I... | 07/17/2001 |
| 6225499 | Process for preparing aminoarylacetylenes This invention provides a process for preparing aminoarylacetylenes comprising reacting a N-arylmethylidene aminoarylhalide with a terminal acetylene in the presence of a base and a catalyst system comprising a palladium catalyst and a cuprous salt to pro... | 05/01/2001 |
| 6214873 | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same The present invention relates to a compound of the general formula ##STR1## wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof... | 04/10/2001 |
| 6156801 | 2-phenoxyaniline derivatives A 2-phenoxyaniline derivative represented by the formula: ##STR1## wherein R1 is a hydrogen atom, an amino group or an NHCOR3 group, R2 is a halogen atom, an amino group, a cyano group, a C1-6 alkyl group, ... | 12/05/2000 |
| 6100429 | N-benzylidene aminophenylacetylene carbinols This invention provides a process for preparing aminoarylacetylenes comprising reacting a N-arylmethylidene aminoarylhalide with a terminal acetylene in the presence of a base and a catalyst system comprising a palladium catalyst and a cuprous salt to pro... | 08/08/2000 |
| 6096925 | Quaternary ammonium salt for photo-curable antifogging composition, method for preparing the same, and photo-curable antifogging composition Disclosed is a photo-curable antifogging composition which may be applied to substrates such as glass, various plastic materials and the like to give antifogging property on the surface of these substrates. The main ingredient of the composition is a quat... | 08/01/2000 |
| 5959146 | Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.... | 09/28/1999 |
| 5834521 | Substituted dibenz (A F)azulenes and methods of preparation Tetracyclic compounds having the following structure are described: ##STR1## wherein R1 -R10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased ut... | 11/10/1998 |
| 5739337 | Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo3.2.1!octanes Disclosed are a process and novel compounds useful for preparing compounds of formula I ##STR1## wherein R1 and R2 independently represent hydrogen, inorganic or optionally substituted organic substituents; and R3 is ... | 04/14/1998 |
| 5712312 | Tricyclic amides The invention relates to a compound selected from these of formula (I): ##STR1## in which R7, R8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the mela... | 01/27/1998 |
| 5674812 | 5(sulfo-/carbamoylmethyl)cyclohexenone oxime ethers 5-(Sulfo-/carbamoylmethyl)cyclohexenone oxime ethers I ##STR1## where R1 =C1 -C6 -alkyl; R2 =H, C1 -C6 -alkyl, C1 -C3 -alkoxy-C1 -C3 -alkyl, C | 10/07/1997 |
| 5604261 | Arylalkyl (thio)amides A compound which is selected from those of formula (I) : ##STR1## in which A, R1, R2, R3, R4, R5 and R6 are as defined in the description, its optical isomers, and its addition salts t... | 02/18/1997 |
| 5484953 | O-phenylenediamines containing fluoroalkyl(ene) groups Novel o-phenylenediamines of the formula containing fluoroalkyl(ene) groups ##STR1## in which the symbols used have the meaning given in the description, processes for their preparation and their use as intermediates.... | 01/16/1996 |
| 5463126 | Process for preparing sertraline The invention provides the substantially geometrically pure cis-stereoisomeric form of a compound of formula (I) and the substantially geometrically and optically pure cis-stereoisomeric form of a compound of formula (II): ##STR1## wherein R | 10/31/1995 |
| 5434304 | Process for preparing formoterol and related compounds The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to cer... | 07/18/1995 |
| 5430062 | Stilbene derivatives as anticancer agents The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can be utilized in a method of treating such cancers. Pharmaceu... | 07/04/1995 |
| 5384331 | Ketamine analogues for treatment of thrombocytopenia 5,6-Dehydronorketamine and derivatives retaining the ,ଲ-unsaturated carbonyl are disclosed. These end other Michael or Michael-type acceptors and adducts are shown to influence the replication, differentiation or maturation of blood cells, es... | 01/24/1995 |
| 5382682 | Nitroanilides and their preparation Novel aryloxy-nitroanilides of formula ##STR1## wherein R is alkyl from 1 to 5 carbon atoms or unsubstituted or substituted aryl of from 6 to 10 carbon atoms; one of R1 and R2 is a hydrogen atom and the other is aryloxy, wherein... | 01/17/1995 |
| 5349086 | Method for the preparation of 4-phenyl-1,3-benzodiazepins and precursors thereof A compound of the formula ##STR1## is prepared by reacting an N-acylated-o-toluidine of the formula ##STR2## with n-alkyllithium to form a dilithio intermediate of the formula ##STR3## which can then be quenched with N-benzylidenemethylamin... | 09/20/1994 |
| 5250732 | Ketamine analogues for treatment of thrombocytopenia 5,6-Dehydronorketamine and derivatives retaining the ,ଲ-unsaturated carbonyl are disclosed. These and other Michael or Michael-type acceptors and adducts are shown to influence the replication, differentiation or maturation of blood cells, es... | 10/05/1993 |
| 5225601 | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for ... | 07/06/1993 |
| 5214202 | Method for preparing benzoic acid derivatives This invention relates to a synthesis method favorable for the industrial production of a benzoic acid derivative having a retinoid activity of the general formula: ##STR1## wherein the derivative can be obtained by a simple procedure in safety ... | 05/25/1993 |
| 5185465 | Carboxamides of 2-amino-alpha-phenlphenethylamines Novel 4-phenyl-1,3-benzodiazepines and 2-amino--phenylphenethylamines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants. The 2-amino-&... | 02/09/1993 |
