Class 564/220 - Amino nitrogen in the substituent E (i.e.,plural amino nitrogens containing)

Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the amino nitrogen containing residue
No. of patents: 165
Last issue date: 05/29/2012

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Number	Title	Issue Date
8188314	Benzyloxy anilide derivatives useful as potassium channel modulators The present invention relates to benzyloxyanilide derivatives having the following structural formula: The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are a...	05/29/2012
7378448	Diphenylether amide derivatives as opioid receptor antagonists A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7 including R3′, p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mi...	05/27/2008
7342132	Formoterol tartrate process and polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ...	03/11/2008
7211695	β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor....	05/01/2007
7145036	Formoterol tartrate polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ...	12/05/2006
7105701	β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor....	09/12/2006
6916956	Calcium receptor antagonist A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 c...	07/12/2005
6720453	Formoterol tartrate polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ...	04/13/2004
6635650	Substituted dimeric compounds The invention relates to compounds of formula (I): wherein: A represents NR1 C(Q)R2, C(Q)NR2 R3 or NR1 C(Q)NR2 R3, B represents NR1 C(Q)R2, C(Q)NR2...	10/21/2003
6576793	댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and p...	06/10/2003
6537524	Combinations of formoterol and a tiotropium salt A medicament containing, separately or together, (A) formoterol or a pharmaceutically acceptable salt thereof or a solvate of formoterol or said salt and (B) a tiotropium salt of a pharmaceutically acceptable acid, for simultaneous, sequential or separate...	03/25/2003
6472393	Serine protease inhibitors Compounds having the structure shown below wherein A, B, N1, N2, X, Y, Q, R2, R5 and R6 are as defined herein are useful to inhibit serine protease enzymes, such as TF/factor VIIa factor Xa, thrombin ...	10/29/2002
6472563	Formoterol tartrate process and polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph....	10/29/2002
6423714	Cyclohexene derivatives useful as antagonists of the motilin receptor The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the ...	07/23/2002
6319930	Substituted dimeric compounds The invention relates to compounds of formula (I): A--G1 --Cy--G2 --Cy--G3 --B (I) wherein: A represents NR1 C(Q)R2, C(Q)NR2 R3 or NR1 C(Q)NR2 R3, B repre...	11/20/2001
6268533	Formoterol process A method is disclosed for the preparation of optically pure isomers of formoterol by the reaction of an optically pure 4-benzyloxy-3-formamidostyrene oxide with an optically pure 4-methoxy-଱-methyl-N-(phenylmethyl)benzeneethanamine followed by ...	07/31/2001
6258852	Aryl nitrone therapeutics for the treatment of inflammatory bowel disease Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for the treatment or prophylaxis of IBD are also disclosed....	07/10/2001
6232498	Process for the preparation of benzothiazolone compounds There are described processes for the preparation of a compound of formula I ##STR1## and novel intermediates in the preparative process....	05/15/2001
6194614	Process for the preparation of benzothiazolone compounds There are described processes for the preparation of a compound of formula I ##STR1## and novel intermediates in the preparative process....	02/27/2001
6133315	Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically ac...	10/17/2000
6028112	Spirocyclopropyl fluorenes as melatonergic agents There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R1 and X are as defined herein which are useful as melatonergic agents....	02/22/2000
6018069	2-isoxazoline derivative and process for producing the same and process for producing related derivatives from the same A purified acid addition salt of a (2S, 3S, 5S)-2,5-diamino-1,6-diphenyl-3-hydroxyhexane, e.g., (2S, 3S, 5S)-2-tert-butoxycarbonylamino-3-hydroxy-5-amino-1,6-diphenylhexane, is obtained from its mixture, in an arbitrary ratio, with its (2S, 3S, 5R) s...	01/25/2000
5922771	Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a...	07/13/1999
5801195	Immunotherapeutic aryl amides Novel aryl amides are inhibitors of tumor necrosis factor ଱ and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is N-benzoyl-3-amino-3-(3',4'-dimethoxyphenyl)propanamide....	09/01/1998
5731352	Aryl(alkyl)propylamides The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R1, R'1, R2, R3 and n are as defined in the description, and medicinal product containing the same useful for tre...	03/24/1998
5686609	Aromatic amine compounds, Their method of preparation and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: m is 2 or 3; Ar and Ar' independently are a thienyl group; a substituted or unsubstituted phenyl group; or an imidazolyl group; it also being possible for Ar' to be a benzothienyl g...	11/11/1997
5684199	Process for the preparation of an optically pure enantiomer of formoterol The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to cer...	11/04/1997
5668257	Phenylboronic acid complexing reagents derived from aminolalicylic acid The present invention relates to a novel class of phenylboronic acid complexing reagents useful for the preparation of bioconjugates, and the method of making and using such reagents. In the present invention, in the place of prior art Avidin-Biotin and D...	09/16/1997
5631397	Process for producing optically active diaminohexanone derivative Disclosed herein is a process for producing a (2S,5S)-2,5-diamino-1,6-diphenyl-3-hexanone derivative represented by the formula (1): ##STR1## wherein R1 means a lower alkylcarbonyl group, a halogen-substituted lower alkylcarbonyl grou...	05/20/1997
5624961	Benzylaminoethoxybenzene derivatives, production thereof and use thereof Novel benzylaminoethoxybenzene derivatives of the formula (I) ##STR1## wherein R1 is a hydrogen atom, a lower alkyl, a lower hydroxyalkyl, a lower alkoxyalkyl, an allyl or a benzyl; R2 is a hydrogen atom, a lower alkyl, a lower ...	04/29/1997
5604261	Arylalkyl (thio)amides A compound which is selected from those of formula (I) : ##STR1## in which A, R1, R2, R3, R4, R5 and R6 are as defined in the description, its optical isomers, and its addition salts t...	02/18/1997
5594151	Phenylboronic acid complexing reagents derived from aminosalicylic acid The present invention relates to a novel class of phenylboronic acid complexing reagents useful for the preparation of bioconjugates, and the method of making and using such reagents. In the present invention, in the place of prior art Avidin-Biotin and D...	01/14/1997
5543570	Intermediates for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2-(1H)-thiones Process for preparing enantiomerically pure imidazo[4,5,1 -jk][1,4]benzodiazepin -2(1H)-thiones of formula ##STR1## starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) ##STR2## Novel en...	08/06/1996
5536877	Preparation of arylbenzylamines A process for the preparation of arylbenzylamines by the reaction of arylamines with a benzyl chloride, wherein the reaction is carried out in the presence of both a phase-transfer catalyst and a base selected from the group consisting of the inorganic ba...	07/16/1996
5466873	Process for preparing arylketoamines Arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and a liquid carboxylic acid at a temperature of less than about 600° C....	11/14/1995
5434304	Process for preparing formoterol and related compounds The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to cer...	07/18/1995
5362747	2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase 2-Nitroaryl or 2-cyanoaryl compounds of the formula ##STR1## pharmaceutical compositions thereof, intermediates useful in the preparation of these compounds, and methods for treating disorders of vascular smooth muscles or diseases of the cartilage, ...	11/08/1994
5349090	Process for preparing arylketoamines Arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and a liquid carboxylic acid at a temperature of less than about 60° C....	09/20/1994
5349086	Method for the preparation of 4-phenyl-1,3-benzodiazepins and precursors thereof A compound of the formula ##STR1## is prepared by reacting an N-acylated-o-toluidine of the formula ##STR2## with n-alkyllithium to form a dilithio intermediate of the formula ##STR3## which can then be quenched with N-benzylidenemethylamin...	09/20/1994
5331099	Process for preparing p-nitroaromatic amides and products thereof A process for preparing p-nitroaromatic amides is provided which comprises contacting an amide and nitrobenzene in the presence of a suitable solvent system, and reacting the amide and nitrobenzene in the presence of a suitable base and a controlled amoun...	07/19/1994

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Class 564/220 - Amino nitrogen in the substituent E (i.e.,plural amino nitrogens containing)