Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8168828 | Process for the preparation of pregabalin The present invention encompasses novel intermediates of pregabalin, namely 3-cyano-5-methyl hexanamide (28) and 3-(amino methyl)-5 methyl hexanamide (29), and processes for their preparation. The invention also encompasses a process for converting the novel pregaba... | 05/01/2012 |
| 8138374 | Composition for external application to skin The present invention provides a composition for external application to skin containing one type or two or more types of compounds selected from the group consisting of aminoacetoamide compounds represented by the following general formula (1) and salts thereof. | 03/20/2012 |
| 7612237 | Process for preparing β-amino-α-hydroxycarboxamides The present invention is directed to a process for preparing β-amino-α-hydroxycarboxamides. The process works with epoxycarboxamides of the formula 2 which are reacted with ammonia or other amines. ... | 11/03/2009 |
| 7323594 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/29/2008 |
| 7323297 | Stabilized polynucleotide complexes and methods The invention comprises stabilized polynucleotide complexes that have a cryoprotectant and are lyophilized. Cryoprotectant compounds comprise carbohydrates or sugars, preferably lactose and sucrose, but also glucose, maltodextrins, mannitol, sorbitol, trehalose, and... | 01/29/2008 |
| 7294511 | Methods for delivering nucleic acid molecules into cells and assessment thereof Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial ... | 11/13/2007 |
| 7217845 | Bifunctional polyethylene glycol derivatives The present invention provides novel heterobifunctional and monobifunctional polyethylene glycol derivatives for the pegylation of therapeutically active proteins. The heterobifunctional PEGs which bear two different functional groups as well as the monobifunctional... | 05/15/2007 |
| 7208528 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 04/24/2007 |
| 7189874 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S... | 03/13/2007 |
| 7173154 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 02/06/2007 |
| 7166298 | Genetic immunization with cationic lipids A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic immunization to produce polyclonal and monoclonal antibodies are also di... | 01/23/2007 |
| 7166745 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/23/2007 |
| 7160923 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 01/09/2007 |
| 7145039 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 12/05/2006 |
| 7125825 | Amidoamine salt-based viscosifying agents and methods of use Viscoelastic surfactants are described for use in aqueous systems to generate thickened fluids. The surfactants are alkyl amidoamine salts of inorganic acids and/or organic acids. The fluids may also contain inorganic salts, organic salts or mixtures thereof. Additi... | 10/24/2006 |
| 7053211 | Process for the preparation of α-aminosubstituted carboxylic acid amides The invention relates to a process for the preparation of α-aminosubstituted carboxylic acid amide compounds and/or their salts comprising reacting a carboxylic acid amide of a primary amine with a nitrosylating agent in the presence of a base followed by hydrolysi... | 05/30/2006 |
| 7041855 | Monofunctional polyethylene glycol aldehydes The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immun... | 05/09/2006 |
| 7034110 | Method of identifying chemical compounds having selected properties for a particular application A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reac... | 04/25/2006 |
| 7034176 | Aminopropylphosphinic acids Intermediates used in the preparation of compounds of formula I, or a stereoisomer thereof, or a pharmaceutically acceptable form of either selected from the group consisting of a salt, a solvate and a combination there... | 04/25/2006 |
| 6936469 | Methods for delivering nucleic acid molecules into cells and assessment thereof Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial ... | 08/30/2005 |
| RE38506 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each i... | 04/20/2004 |
| 6703031 | Cysteine derivatives Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic p... | 03/09/2004 |
| 6653436 | Water dispersible epoxy resins A amidoamine composition containing oligomeric amidoamine compounds having the structure: ##STR1## the average of x based on the amidoamine composition is at least 0.2, and Z is the residue of a polyoxyalkylene polyether polycarboxylic acid compound,... | 11/25/2003 |
| 6515174 | Preformed multi-acid adducts useful for grafting polyolefin polymers The present invention relates to reaction products formed from maleic anhydride and amino carboxylic acids. The reaction products are particularly useful for grafting polyolefins to increase their polarity and therefore enhance their physical properties.... | 02/04/2003 |
| 6506910 | Process for preparing discodermolide and analogues thereof A more practical synthesis for preparing discodermolide and structurally related analogues, novel compounds useful in the process and novel compounds prepared by the process.... | 01/14/2003 |
| 6504047 | 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparation thereof and use thereof The present invention is directed towards compounds of the general formula (I) ##STR1## (I) are important intermediates for the preparation of pharmaceuticals. Further intermediates, process for the preparation of (I) and use thereof.... | 01/07/2003 |
| 6455502 | Compounds and compositions as protease inhibitors The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.... | 09/24/2002 |
| 6454818 | Poly(oxyalkylene) amide-amine gasoline additives The present invention is one kind of gasoline additives. The compounds consist of tertiary amine, amide and poly(oxybutylene) backbone in the same molecule. The process of making this type of products required an initiator containing primary amine and ter... | 09/24/2002 |
| 6437121 | Cationic lipids The present invention is directed to new cationic lipids and intermediates in their synthesis that are useful for transfecting nucleic acids or peptides into prokaryotic or eukaryotic cells. The lipids comprise one or two substituted histidine residues, o... | 08/20/2002 |
| 6339173 | Amide-based cationic lipids The present invention provides novel amide-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H or a ... | 01/15/2002 |
| 6331624 | Process for preparing 6-aminocaproamide A process for the production of 6-aminocaproamide comprising reacting 5-cyanovaleramide with hydrogen in the presence of a metal catalyst. The 6-aminocaproamide is useful, for example, in the production of caprolactam and nylon 6.... | 12/18/2001 |
| 6326393 | Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred... | 12/04/2001 |
| 6313346 | Catalyst compositions for the production of polyurethanes A composition having the formula: ##STR1## wherein R is a linear alkyl, branched alkyl, cycloalkyl, polycyclic alkyl, alkylaminoalkyl, or alkyloxyalkyl group having 1 to 20 carbon atoms and at least one primary, secondary, or tertiary amino functional gro... | 11/06/2001 |
| 6300511 | Catalyzed fluorination of carbonyl compounds The present invention provides a method of substituting a carbonyl compound with fluorine at the -position, comprising reaching the carbonyl compound with a fluorinating present of a metal-containing catalyst. The reaction results in replacement of... | 10/09/2001 |
| 6218389 | Acyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of... | 04/17/2001 |
| 6207828 | Process for making 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates This invention provides a convenient, new, one step process for the preparation of 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates and related derivatives thereof by reaction of carbonyl compounds substituted with a trihaloacetyl group with an aceta... | 03/27/2001 |
| 6201023 | Methods and compositions to protect crops against plant parasitic nematodes A method for protecting a crop against plant-parasitic nematode attack by inducing local and systemic resistance of the crop comprising the application of a composition containing an effective amount of ଲ-amino butyric acid or derivatives thereof to... | 03/13/2001 |
| 6194612 | Template for solution phase synthesis of combination libraries This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this inven... | 02/27/2001 |
| 6114391 | -amino acid amides, preparation thereof and the therapeutical use thereof The present invention relates to serinamide, glycinamide, alaninamide and phenylalaninamide derivatives of formula (I) wherein R, R', R1 and R2 are as defined in the disclosure. The compounds (I) are useful for the treatment of neuro... | 09/05/2000 |
| 6077877 | Reactive amine catalysts for use in polyurethane polymers The present invention provides amine/amide catalysts for use in catalyzing the formation of polyurethane. The amine/amide catalysts, which have low fugitivity due to their reactivity with isocyanates, and good catalytic activity, have the structure #... | 06/20/2000 |
