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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 6458781 | Substituted diarylalkyl amides as calcium channel antagonists The present invention provides compounds that block calcium channels and have the Formula I: ##STR1## The present invention also provides pharmaceutical compositions containing the compounds of Formula I and methods of using them to treat stroke, cer... | 10/01/2002 |
| 6194612 | Template for solution phase synthesis of combination libraries This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this inven... | 02/27/2001 |
| 6063962 | Process for the preparation of NMDA antagonists This invention relates to an improved process for the production of known amine compounds which are useful as medicaments.... | 05/16/2000 |
| 5760087 | Glycylanilide derivatives, their preparation and their application in therapy The invention relates to new derivatives of glycylanilides having general formula (I), wherein, particularly, R1, R3, R4, R8, R9 represent CH3 ; R2, R5, R6, R | 06/02/1998 |
| 5532259 | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use Isoxazole-4-carboxamide derivatives and hydroxyalkylidene-cyanoacetamide derivatives are suitable for the treatment of carcinoses. These com... | 07/02/1996 |
| 5494911 | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use Isoxazole-4-carboxamide derivatives and hydroxyalkylidene-cyanoacetamide derivatives are suitable for the treatment of carcinoses. These compounds can be prepared by known processes. Some of the compounds are novel and are additionally suitable for the tr... | 02/27/1996 |
| 4476061 | 2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents. The compounds of the invention have the general formula I ##STR1## in which R represent... | 10/09/1984 |
| 4472435 | Benzophenone derivatives useful in treating heart failure There is presented novel benzophenone derivatives of the formula ##STR1## wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or aminoacetyl, R3 is hydrogen or lower alkyl, R4 is hydrogen or halogen, R | 09/18/1984 |
| 4454107 | Tc99m-Phenida, radioscintigraphic agent for diagnosis of hepatoniliary disease This invention relates to novel derivatives of imino diacetic acid of the formula: ##STR1## wherein R1 is selected from the group consisting of: ##STR2## wherein X is halo (chloro, bromo or iodo) and R2 is lower alkyl of ... | 06/12/1984 |
| 4380667 | 2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and use as medicaments The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents. The compounds of the invention have the general formula I ##STR1## in which R represent... | 04/19/1983 |
| 4374773 | Triazolo-benzodiazepine derivatives There are presented compounds of the formula ##STR1## wherein R1 is a hydrogen atom or a lower alkyl group, R2 and R3 each are a hydrogen atom or a lower alkyl group, R4 is a halogen atom and either R5... | 02/22/1983 |
| 4372975 | Substituted 2-benzoyl-4-chloroglycinanilide derivatives, a process for their production, and their use as medicaments The invention relates to new substituted 2-benzoyl-4-chloroglycinanilide derivatives, to a process for their production and to their use as medicaments. The new derivatives according to the invention correspond to the general formula ##STR1## in... | 02/08/1983 |
| 4310429 | Stabilized polymers, novel stabilizers, and synthesis thereof Novel -aminoacetamides are powerful stabilizers for organic materials subject to oxygen and heat degradation, and particularly for synthetic natural rubber and synthetic ester lubricants. A wide range of substituents on the amine and amide N atoms,... | 01/12/1982 |
| 4289770 | 2-Benzoyl-4-nitroanilides and their use as medicaments New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments. The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a... | 09/15/1981 |
| 4232016 | 3-Fluorobenzodiazepines 3-Fluoro-2,3-dihydro-1H-1,4-benzodiazepin-2-ones of the formula ##STR1## wherein R1 is H, alkyl or fluorinated alkyl of 1-4 carbon atoms and up to 9 fluorine atoms or cycloalkylalkyl of 4-8 carbon atoms; R2 is phenyl; monohaloph... | 11/04/1980 |
| 4083868 | 2-(-Amidobenzyl)-5-alkylresorcinols A compound of the formula ##STR1## wherein R is a C6 -C20 alkyl, arylalkyl or cycloalkyl alkyl; R' is phenyl or substituted phenyl; and X is H, halogen, N(R")2 where R" is H or C1 -C7 alkyl, or a grou... | 04/11/1978 |
| 4075409 | Benzophenone derivatives The present invention relates to pharmacologically valuable new benzophenone derivatives having a pronounced sedative action on the central nervous system and some of which also possess muscle-relaxing and aggression-inhibiting properties. These new deriv... | 02/21/1978 |
| 4046890 | Benzodiazepine derivatives This invention is directed to pharmacologically active compounds of the formula ##STR1## wherein R1 represents a hydrogen atom or lower alkyl group and R2 represents a halogen atom. The compounds of formula I are optically activ... | 09/06/1977 |
| 4022832 | 2-Aminoacetamido--phenylbenzylideneaminoalkanol derivatives and process for the preparation thereof Aminoalkanol derivatives having the formula ##STR1## wherein R1 represents hydrogen atoms or a halogen atom, R2 represents hydrogen atom or fluorine atom and A represents an alkylene group having 1-4 carbon atoms. The aminoalkan... | 05/10/1977 |
| 4010153 | Preparation of chiral 1,4-benzodiazepin-2-one-derivatives by reaction of (s)--amino acid chloride hydrochlorides etc. A process is disclosed for preparing optically active 1,4-diazepine-2-ones by reacting an acid chloride-hydrochloride of an optically active -amino acid with a substituted o-amino benzophenone, to form an intermediate product and subsequently cycli... | 03/01/1977 |
| 4010154 | Benzodiazepinones Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R2 is a ... | 03/01/1977 |
| 3998811 | Optically active 1,4-benzodiazepines and process for the preparation thereof Optically active compounds having the formula ##STR1## having an asymmetric carbon atom in position 3 having the S configuration and wherein R1 is selected from the class consisting of hydrogen, halogen, nitro, and trifluoromethyl groups, ... | 12/21/1976 |
| 3996209 | Process for preparing benzodiazepines 1,4-Benzodiazepin-2-ones are prepared via the reaction of a haloacetamidophenyl ketone with hexamethylenetetramine in the presence of ammonia. The 1,4-benzodiazepin-2-ones so prepared are known compounds useful as muscle relaxant and anti-convulsant agent... | 12/07/1976 |
| 3965151 | Intermediates for tricyclic benzodiazepines Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom... | 06/22/1976 |
| 3963777 | 1-Polyhydroxy alkyl-1,4-benzodiazepin-2-ones Novel 1,4-benzodiazepin-2-ones bearing a polyhydroxyalkyl group in the 1-position are disclosed. These 1-substituted benzodiazepins are useful as muscle relaxant, anti-convulsant and sedative agents.... | 06/15/1976 |
| 3954838 | Process for preparing alkyl (n-phenylsulfonyloxy) carbamates 1,4-Benzodiazepin-2-ones bearing an acylamidoalkyl-substituent in the 1-position and methods for the preparation thereof are disclosed. These 1,4-benzodiazepin-2-ones exhibit sedative, anti-convulsant and muscle relaxant activity.... | 05/04/1976 |
