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| Number | Title | Issue Date |
| 8188313 | Analogs of alpha galactosylceramide and uses thereof Compounds of formula wherein the variable are defined in the specification, are used in compositions which stimulate T cell responses. ... | 05/29/2012 |
| 8101801 | Low molecular weight quaternary ammonium salt dispersants Disclosed is a chemical compound having the structure: wherein R1 is an all group, aryl group, alkylaryl group or arylalkyl group with at least 23 carbon atoms, R2 is an alkylene group, arylene group, ... | 01/24/2012 |
| 8097760 | Preparation of chiral amides and amines This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The ena... | 01/17/2012 |
| 8049038 | Carnitine conjugates of adamantanamines derivatives as dual prodrugs for various uses This invention concerns compounds of adamantanamines and neramexane, including their pharmaceutically-acceptable salts, diesterioisomers, and formulations for treating Alzheimer's related dementias, depression, AIDS related dementias, as antivirals, inflammatory dis... | 11/01/2011 |
| 8039670 | Analogs of alpha galactosyceramide and uses thereof There are disclosed compound of formula I, in which R1 represents a hydrophobic moiety adapted to occupy the C′ channel of human CDId, R2 represents a hydrophobic moiety adapted to occupy the A′ channel of human CDId, such that R1 | 10/18/2011 |
| 7977511 | Carnitine conjugates of adamantanamines and neramexane derivatives as dual prodrugs for various uses This invention concerns compounds of adamantanamines and neramexane, including their pharmaceutically-acceptable salts, diesterioisomers, and formulations for treating Alzheimer's related dementias, depression, AIDS related dementias, as antivirals, inflammatory dis... | 07/12/2011 |
| 7847123 | Antimicrobial compositions Compounds of the general formula and to the use thereof for controlling microorganisms are provided. ... | 12/07/2010 |
| RE41135 | Inhibitors of the 11-β-hydroxysteroid dehydrogenase type 1 enzyme The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for treatment of non-insuli... | 02/16/2010 |
| 7439394 | Cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including the... | 10/21/2008 |
| 7423177 | Carboxamide derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 09/09/2008 |
| 7358396 | Preparation of optically active amines A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active amines and optically active amides are described. ... | 04/15/2008 |
| 7348457 | Ketol fatty acid derivatives and plant growth regulators α-Ketol unsaturated fatty acid derivatives represented by the following formula (1), α-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth regulators containing, as the active ingredient, at least one of these ... | 03/25/2008 |
| 7342131 | Levodopa prodrugs, and compositions and uses thereof Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. ... | 03/11/2008 |
| 7323608 | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond between the sulfur atom of a t... | 01/29/2008 |
| 7307191 | Organic peroxyacid precursors This present invention provides materials for use as solid or concentrated chemical precursors for the production of organic peroxy acids (peracids). Organic peroxy acids are formed using a precursor according to the invention when they are combined with hydrogen pe... | 12/11/2007 |
| 7276613 | Retro-anandamides, high affinity and stability cannabinoid receptor ligands Novel retro-anandamides are presented which have high affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or g... | 10/02/2007 |
| 7253282 | Hexafluoroisopropanol substituted cyclohexane derivatives The invention is concerned with novel hexafluoroisopropanol substituted cyclohexane derivatives of formula (I) wherein R1 to R4, X, m and n are as defined in the description and in the claim... | 08/07/2007 |
| 7230018 | Substituted propane-1,3-diamine derivatives and the pharmaceutical use thereof Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or prophylaxis of pain, urinary incontinence, itching, tinitus aurium, or diarrh... | 06/12/2007 |
| 7217845 | Bifunctional polyethylene glycol derivatives The present invention provides novel heterobifunctional and monobifunctional polyethylene glycol derivatives for the pegylation of therapeutically active proteins. The heterobifunctional PEGs which bear two different functional groups as well as the monobifunctional... | 05/15/2007 |
| 7217838 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-in... | 05/15/2007 |
| 7201876 | Ion-detecting sensors comprising plasticizer-free copolymers Ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers having pendent alkyl groups of different length and a functionalized ionophore of sai... | 04/10/2007 |
| 7196119 | Development of new selective estrogen receptor modulators The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclos... | 03/27/2007 |
| 7161016 | Cannabimimetic lipid amides as useful medications Novel analogs of arachidonylethanolamide are presented which have higher affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and s... | 01/09/2007 |
| 7161035 | Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR′ group, or a (C1–C6)alkyl group substit... | 01/09/2007 |
| 7067471 | Process for producing a refined product of polyoxyproylene fatty acid isopropanolamide surfactant A refined product of a polyoxypropylene fatty acid isopropanolamide surfactant, having a high stability in storage and a very small change in smell thereof, is obtained by heat-treating an addition-reaction mixture prepared from a compound of the formula (III) and p... | 06/27/2006 |
| 7041855 | Monofunctional polyethylene glycol aldehydes The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immun... | 05/09/2006 |
| 7015352 | Pro drugs for selective drug delivery Prodrug compounds capable of permeating a desired biological compartment and releasing a biologically active molecule in active form to effect a therapeutic functional change in the compartment to which it is introduced. ... | 03/21/2006 |
| 7015349 | Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth. ... | 03/21/2006 |
| 7005549 | Peracid precursors for antimicrobial use This disclosure describes unique chemical structures for use as solid or concentrated chemical precursors to the production of peroxy acids when combined with hydrogen peroxide or a hydrogen peroxide precursor such as percarbonates or perborates. Peroxy acids (perac... | 02/28/2006 |
| 6962693 | Alkylpolypropyleneoxide amidotriamines and method of using same Alkylpolypropyleneoxide amidotriamines having antimicrobial activity are described. The compounds are useful as antimicrobial preservatives in various types of pharmaceutical compositions. Ophthalmic compositions containing these compounds as disinfecting agents or ... | 11/08/2005 |
| 6956014 | Thickener A thickener which is superior in handling characteristics and blending stability and has a high thickening action is provided, comprising a fatty acid alkanolamide represented by the general formula (1) and a surfactant composition comprising the thickener and at le... | 10/18/2005 |
| 6884911 | Material processing by repeated solvent expansion-contraction A method for repeatedly converting a solvent from a state of solvent to a state of antisolvent with relatively little loss of solvent. The method is used to allow for processing of large amounts of solute material with minimum amounts of solvent. ... | 04/26/2005 |
| 6864386 | Fluorinated compounds Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one em... | 03/08/2005 |
| 6770754 | Universal supports for oligonucleotide synthesis Universal supports for oligonucleotide synthesis include a support material represented by the following formula: In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric or silica base material; su... | 08/03/2004 |
| 6767925 | Sprayable analgesic composition and method of use A sprayable analgesic composition containing an analgesic which is absorbed into the bloodstream through the buccal mucosa and a pharmacologically acceptable liquid carrier. ... | 07/27/2004 |
| 6759554 | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or a... | 07/06/2004 |
| RE38506 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each i... | 04/20/2004 |
| 6696494 | -hydroxyarylbutanamine inhibitors of aspartyl protease Acylated -hydroxyarylbutanamines and related sulfonamides, ureas and carbamates that inhibit aspartyl protease are disclosed, as are methods of treating diseases, particularly HIV, using these compounds. The compounds have the formula: ##STR1#... | 02/24/2004 |
| 6630509 | Phenalkyloxy-phenyl derivatives The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) ##STR1## and analogs, to a process for preparing such compounds, which compounds have utility in treating clinical conditions associated with insulin resistance, ... | 10/07/2003 |
| 6603043 | Process for the preparation of (schiff bases of) -alkyl--amino acid amides Process for the preparation of a Schiff base of an -alkyl--amino acid amide and an aldehyde, wherein the corresponding -aminonitrile is contacted with a base and the aldehyde and wherein it is ensured that the reagents are in good con... | 08/05/2003 |
