Class 564/180 - Polycyclo ring system in substituent Q

Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the carboxylic acid residue contains a
No. of patents: 195
Last issue date: 11/22/2011

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Number	Title	Issue Date
8063248	Sphingosine kinase inhibitors The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angioge...	11/22/2011
8030518	1,4 diamino bicyclic retigabine analogues as potassium channel modulators This invention is directed to compounds of formula I, where G is —O—, —S—, —C(g1)(g2)-, or —NH—, and n=1, 2, or 3. Such compounds modulate potassium channels. The compounds are useful for...	10/04/2011
7423176	Bicyclic aromatic sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith. ...	09/09/2008
7348449	Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among tho...	03/25/2008
7208528	Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t...	04/24/2007
7160923	Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t...	01/09/2007
7115767	Tetraline derivatives as ghrelin receptor modulators The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the comp...	10/03/2006
7102027	Adamantanetricarboxylic acid derivatives An adamantanetricarboxylic acid derivative is represented by following Formula (1): wherein X is a hydrogen atom or a hydrocarbon group; and R1, R2 and R3 may be the same as or di...	09/05/2006
7049271	Phenyl-substituted 2-enamino-ketonitriles The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I): in which Ar, X, Z, Y and K are each as defined in the description, to a plurality of pro...	05/23/2006
7045660	Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment...	05/16/2006
7015352	Pro drugs for selective drug delivery Prodrug compounds capable of permeating a desired biological compartment and releasing a biologically active molecule in active form to effect a therapeutic functional change in the compartment to which it is introduced. ...	03/21/2006
6984604	Supported bis(phosphorus) ligands and their use in the catalysis Supported bis(phosphorus) ligands are disclosed for use in a variety of catalytic processes, including the isomerization, hydrogenation, hydroformylation, and hydrocyanation of unsaturated organic compounds. Catalysts are formed when the ligands are combined with a ...	01/10/2006
6963011	N-(2-phenyl-3-aminopropyl)naphthamides A compound of the formula: wherein R1, R2, R3, R4, R5, R6, X1 and X2 are as defined in the specification useful for the treatment ...	11/08/2005
6958352	Compounds for inhibiting insulin secretion and methods related thereto Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following structure (I):	10/25/2005
6861132	Porous polypropylene film, process for producing the same, and absorbent article employing the film Disclosed is a porous film made of a resin composition containing (I) (i) a propylene-ethylene copolymer or (ii) a polypropylene-based resin mixture containing a propylene-ethylene copolymer, each having an ethylene content of 3.0 to 7.0 wt. % and an MFR measured at...	03/01/2005
6800658	Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell prolifera...	10/05/2004
6762321	Amide compounds and use thereof An amide compound given by formula [I]: wherein R1 represents a C1-C10 haloalkyl and so on, R2 represents a hydrogen and so on, X represents an oxygen or sulfur, Y represents an oxygen or sulfur, Ar represents...	07/13/2004
6653321	Naphthylsulfonic acids and related compounds as glucose uptake agonists Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptabl...	11/25/2003
6649612	Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them Compounds of formula (I): ##STR1## in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R2 and R3 represent, in particular, H or alkyl, or R	11/18/2003
6620963	TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RAR଱ RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY Compounds of the formula ##STR1## where the variables have the meaning defined in the specification, which bind specifically or selectively to to RAR଱ retinoid receptors....	09/16/2003
6610883	Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass...	08/26/2003
6610877	Aromatic carboxylic acid derivatives Compounds of the formula ##STR1## wherein R1 is a residue of the formula ##STR2## and R2 -R10 have the significance given in the specification can be used as pharmaceuticals, particularly for the repair of photodamaged ...	08/26/2003
6583319	Cyclic compounds having a cycloalkylene chain The invention relates to compounds of for a (I): ##STR1## wherein: R represents ORa, SRa or Ra or a cyclic group A is a cyclic structure G1 and G2 represent an alkylene chain or a single bond B represents --NR	06/24/2003
6555709	Aromatic amides, their preparation process and their use as pesticides Aromatic amides, their preparation process and their use as pesticides. ##STR1##...	04/29/2003
6538149	ARYL OR HETEROARYL SUBSTITUTED 3,4-DIHYDROANTHRACENE AND ARYL OR HETEROARYL SUBSTITUTED BENZO [1,2-G]CHROM-3-ENE, BENZO[1,2-G]-THIOCHROM-3-ENE AND BENZO [1,2-G]-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING RETINOID ANTAGONIST OR RETINOID INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist and/or retinoid inverse-agonist-like biological activity....	03/25/2003
6534652	Intermediates for the preparation of substituted 1,2,3,4-tetrahydronaphthalene derivatives The present invention relates to new piperidyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formula I ##STR1## wherein X is N or CH; Y is NR2 CH2, CH2 --NR2, NR2 --...	03/18/2003
6423870	Tricyclic compounds, preparation method and pharmaceutical compositions containing same The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4 ; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2...	07/23/2002
6388130	Method for producing axial asymmetric compounds, and intermediates for producing the same The invention provides a metal complex comprising a ligand and a metal. The ligand is an aminophosphine compound represented by the following formula (1) ##STR1## The metal is rhodium, ruthenium, iridium or nickel....	05/14/2002
6369110	Substituted guanidine derivatives and process for producing the same A compound represented by the general formula (1): ##STR1## wherein each of R1, R2, R3, R4 and R5 is a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, a c...	04/09/2002
6353109	Certain fused pyrrolecarboxamides; a new class of GABA brain receptor Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: W represents substituted or unsubstituted aryl or heteroaryl; T is hydrogen, halogen, hydroxyl, amino or alkyl; X is hydrogen, hydroxy, or lower alky...	03/05/2002
6310247	7-aryl-6(Z)-heptatrienoic acid retinamides Novel trienoic retinoid compounds of ##STR1## with apoptotic activity useful for the prevention and treatment of cancer....	10/30/2001
6251917	Benzamidoaldehydes and their use as cysteine protease inhibitors Compounds of the formula ##STR1## where R1, R2, R3, X and n are as defined in the description, are inhibitors of cysteine protease....	06/26/2001
6239179	N-aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 and R9 a...	05/29/2001
6235823	Crystalline polypropylene resin composition and amide compounds Disclosed are a crystalline polypropylene resin composition comprising a crystalline polyproplylene resin and a ଲ-nucleating agent, and a method of increasing the proportion of ଲ-form crystals in a crystalline polypropylene resin molding compr...	05/22/2001
6225352	Low molecular weight dendritic compounds as pharmaceutical agents This invention is for low molecular weight dendritic polymers (dendroids) of Formula I ##STR1## are useful as agents in the treatment of cancer, Alzheimers disease, thrombosis, inflammatory diseases, and bacterial resistance....	05/01/2001
6194612	Template for solution phase synthesis of combination libraries This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this inven...	02/27/2001
6177463	Oxime derivatives and their use as pesticides The invention relates to new oxime derivatives, to a plurality of processes for their preparation, and to their use as pesticides....	01/23/2001
6166006	Anilide derivative, production and use thereof This invention is to provide a compound of the formula: ##STR1## wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: ##STR2## wherein the ring A is an optionally substituted 5- to 6-mem...	12/26/2000
6159989	Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both m...	12/12/2000
6133303	Bicyclic inhibitors of protein farnesyl transferase The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable comp...	10/17/2000

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Class 564/180 - Polycyclo ring system in substituent Q